2ju1 - Revision history

OCA at 19:05, 29 May 2024

2024-05-29T19:05:39Z

←Older revision		Revision as of 19:05, 29 May 2024
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	==Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS)==		==Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS)==
-	<StructureSection load='2ju1' size='340' side='right'caption='[[2ju1~~]], [[NMR_Ensembles_of_Models \| 30 NMR models~~]]' scene=''>	+	<StructureSection load='2ju1' size='340' side='right'caption='[[2ju1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ju1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JU1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ju1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JU1 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2ju2\|2ju2]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [https://pdbe.org/2ju1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ju1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ju1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [https://pdbe.org/2ju1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ju1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ju1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ERYA1_SACER ERYA1_SACER]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 6-deoxyerythronolide-B synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Alekseyev, V Y~~]]	+	[[Category: Saccharopolyspora erythraea]]
-	[[Category: ~~Khosla, C~~]]	+	[[Category: Alekseyev VY]]
-	[[Category: ~~Liu,~~ C W]]	+	[[Category: Khosla C]]
-	[[Category: ~~Puglisi, J D~~]]	+	[[Category: Liu CW]]
-	[[Category: ~~Acyltransferase]]~~	+	[[Category: Puglisi JD]]
-	~~[[Category: Alpha-helical bundle]]~~	+
-	~~[[Category: Antibiotic biosynthesis]]~~	+
-	~~[[Category: Carrier protein domain]]~~	+
-	~~[[Category: Modular polyketide synthase]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Phosphopantetheine]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:57, 7 April 2021

2021-04-07T07:57:11Z

←Older revision		Revision as of 07:57, 7 April 2021
Line 1:		Line 1:

	==Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS)==		==Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS)==
-	<StructureSection load='2ju1' size='340' side='right' caption='[[2ju1]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>	+	<StructureSection load='2ju1' size='340' side='right'caption='[[2ju1]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ju1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JU1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ju1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JU1 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ju2\|2ju2]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ju2\|2ju2]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [~~http~~://pdbe.org/2ju1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ju1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ju1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [https://pdbe.org/2ju1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ju1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ju1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Molecular Playground/ACP apo\|Molecular Playground/ACP apo]]
	*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]		*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]
		+	*[[6-deoxyerythronolide B synthase 3D structures\|6-deoxyerythronolide B synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
		+	[[Category: Large Structures]]
	[[Category: Alekseyev, V Y]]		[[Category: Alekseyev, V Y]]
	[[Category: Khosla, C]]		[[Category: Khosla, C]]

OCA at 10:34, 18 July 2018

2018-07-18T10:34:52Z

←Older revision		Revision as of 10:34, 18 July 2018
Line 1:		Line 1:
		+
	==Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS)==		==Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS)==
	<StructureSection load='2ju1' size='340' side='right' caption='[[2ju1]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2ju1' size='340' side='right' caption='[[2ju1]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [http://pdbe.org/2ju1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ju1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [http://pdbe.org/2ju1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ju1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ju1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2ju1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2ju1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:

	==See Also==		==See Also==
		+	*[[Molecular Playground/ACP apo\|Molecular Playground/ACP apo]]
	*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]		*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]
	== References ==		== References ==

OCA at 02:31, 8 February 2016

2016-02-08T02:31:54Z

←Older revision		Revision as of 02:31, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ju1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:01, 10 September 2015

2015-09-10T07:01:54Z

←Older revision		Revision as of 07:01, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2ju1' size='340' side='right' caption='[[2ju1]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2ju1' size='340' side='right' caption='[[2ju1]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ju1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharopolyspora_erythraea Saccharopolyspora erythraea~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JU1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ju1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JU1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ju2\|2ju2]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ju2\|2ju2]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 ~~Saccharopolyspora erythraea~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ju1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [http://pdbe.org/2ju1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ju1 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ju1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
-	[[Category: Saccharopolyspora erythraea]]
	[[Category: Alekseyev, V Y]]		[[Category: Alekseyev, V Y]]
	[[Category: Khosla, C]]		[[Category: Khosla, C]]

OCA at 13:36, 19 January 2015

2015-01-19T13:36:18Z

←Older revision		Revision as of 13:36, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ju1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JU1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ju1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JU1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ju2\|2ju2]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ju2\|2ju2]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 Saccharopolyspora erythraea])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 Saccharopolyspora erythraea])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ju1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ju1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
	[[Category: Saccharopolyspora erythraea]]		[[Category: Saccharopolyspora erythraea]]
-	[[Category: Alekseyev, V Y.]]	+	[[Category: Alekseyev, V Y]]
-	[[Category: Khosla, C.]]	+	[[Category: Khosla, C]]
-	[[Category: Liu, C W.]]	+	[[Category: Liu, C W]]
-	[[Category: Puglisi, J D.]]	+	[[Category: Puglisi, J D]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Alpha-helical bundle]]		[[Category: Alpha-helical bundle]]

OCA at 04:36, 29 September 2014

2014-09-29T04:36:11Z

←Older revision		Revision as of 04:36, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2ju1.~~png~~\|~~left~~\|200px]]	+	==Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS)==
		+	<StructureSection load='2ju1' size='340' side='right' caption='[[2ju1]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ju1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JU1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ju2\|2ju2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 Saccharopolyspora erythraea])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ju1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ju1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ju1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ju1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2ju1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Polyketides are a medicinally important class of natural products. The architecture of modular polyketide synthases (PKSs), composed of multiple covalently linked domains grouped into modules, provides an attractive framework for engineering novel polyketide-producing assemblies. However, impaired domain-domain interactions can compromise the efficiency of engineered polyketide biosynthesis. To facilitate the study of these domain-domain interactions, we have used nuclear magnetic resonance (NMR) spectroscopy to determine the first solution structure of an acyl carrier protein (ACP) domain from a modular PKS, 6-deoxyerythronolide B synthase (DEBS). The tertiary fold of this 10-kD domain is a three-helical bundle; an additional short helix in the second loop also contributes to the core helical packing. Superposition of residues 14-94 of the ensemble on the mean structure yields an average atomic RMSD of 0.64 +/- 0.09 Angstrom for the backbone atoms (1.21 +/- 0.13 Angstrom for all non-hydrogen atoms). The three major helices superimpose with a backbone RMSD of 0.48 +/- 0.10 Angstrom (0.99 +/- 0.11 Angstrom for non-hydrogen atoms). Based on this solution structure, homology models were constructed for five other DEBS ACP domains. Comparison of their steric and electrostatic surfaces at the putative interaction interface (centered on helix II) suggests a model for protein-protein recognition of ACP domains, consistent with the previously observed specificity. Site-directed mutagenesis experiments indicate that two of the identified residues influence the specificity of ACP recognition.

-	~~{{STRUCTURE_2ju1\| PDB=2ju1 \| SCENE= }}~~	+	Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase.,Alekseyev VY, Liu CW, Cane DE, Puglisi JD, Khosla C Protein Sci. 2007 Oct;16(10):2093-107. PMID:17893358<ref>PMID:17893358</ref>

-	~~===Solution structure~~ of ~~acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17893358}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2ju1]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA].~~	+

	==See Also==		==See Also==
	*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]		*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017893358<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
	[[Category: Saccharopolyspora erythraea]]		[[Category: Saccharopolyspora erythraea]]

OCA at 08:36, 20 October 2012

2012-10-20T08:36:27Z

←Older revision		Revision as of 08:36, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2ju1]] is a 1 chain structure ~~of [[6-deoxyerythronolide B synthase (DEBS)]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA].	+	[[2ju1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA].

	==See Also==		==See Also==

OCA at 20:08, 25 July 2012

2012-07-25T20:08:05Z

←Older revision		Revision as of 20:08, 25 July 2012
Line 1:		Line 1:
	[[Image:2ju1.png\|left\|200px]]		[[Image:2ju1.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2ju1\| PDB=2ju1 \| SCENE= }}		{{STRUCTURE_2ju1\| PDB=2ju1 \| SCENE= }}

	===Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS)===		===Solution structure of acyl carrier protein domain from module 2 of 6-deoxyerythronolide B synthase (DEBS)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17893358}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17893358 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17893358}}		{{ABSTRACT_PUBMED_17893358}}

	==About this Structure==		==About this Structure==
-	[[2ju1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA].	+	[[2ju1]] is a 1 chain structure of [[6-deoxyerythronolide B synthase (DEBS)]] with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JU1 OCA].

	==See Also==		==See Also==
-	*[[6-deoxyerythronolide B synthase (DEBS)]]	+	*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17893358~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017893358</ref><references group="xtra"/>
	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
	[[Category: Saccharopolyspora erythraea]]		[[Category: Saccharopolyspora erythraea]]

OCA: Protected "2ju1" [edit=sysop:move=sysop]

2010-12-28T13:15:38Z

Protected "2ju1" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:15, 28 December 2010