2jxo - Revision history

OCA at 19:07, 29 May 2024

2024-05-29T19:07:04Z

←Older revision		Revision as of 19:07, 29 May 2024
Line 1:		Line 1:

	==Structure of the second PDZ domain of NHERF-1==		==Structure of the second PDZ domain of NHERF-1==
-	<StructureSection load='2jxo' size='340' side='right'caption='[[2jxo~~]], [[NMR_Ensembles_of_Models \| 12 NMR models~~]]' scene=''>	+	<StructureSection load='2jxo' size='340' side='right'caption='[[2jxo]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXO FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>SLC9A3R1, NHERF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [https://pdbe.org/2jxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [https://www.ebi.ac.uk/pdbsum/2jxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [https://pdbe.org/2jxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [https://www.ebi.ac.uk/pdbsum/2jxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[https://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>	+	[https://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[https://omim.org/entry/612287 612287]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref> <ref>PMID:9096337</ref> <ref>PMID:10499588</ref> <ref>PMID:18784102</ref>	+	[https://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref> <ref>PMID:9096337</ref> <ref>PMID:10499588</ref> <ref>PMID:18784102</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Sodium-hydrogen exchange regulatory factor\|Sodium-hydrogen exchange regulatory factor]]	+	*[[Sodium-hydrogen exchange regulatory factor 3D structures\|Sodium-hydrogen exchange regulatory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bu, Z]]	+	[[Category: Bu Z]]
-	[[Category: Cheng, H]]	+	[[Category: Cheng H]]
-	[[Category: Dai, Z]]	+	[[Category: Dai Z]]
-	[[Category: Li, J]]	+	[[Category: Li J]]
-	[[Category: Roder, H]]	+	[[Category: Roder H]]
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Cell projection]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Nherf-1]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Pdz2]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Wnt signaling pathway~~]]	+

OCA at 08:01, 7 April 2021

2021-04-07T08:01:36Z

←Older revision		Revision as of 08:01, 7 April 2021
Line 1:		Line 1:

	==Structure of the second PDZ domain of NHERF-1==		==Structure of the second PDZ domain of NHERF-1==
-	<StructureSection load='2jxo' size='340' side='right' caption='[[2jxo]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>	+	<StructureSection load='2jxo' size='340' side='right'caption='[[2jxo]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JXO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC9A3R1, NHERF ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC9A3R1, NHERF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [~~http~~://pdbe.org/2jxo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jxo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [https://pdbe.org/2jxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [https://www.ebi.ac.uk/pdbsum/2jxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[~~http~~://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>	+	[[https://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[https://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref> <ref>PMID:9096337</ref> <ref>PMID:10499588</ref> <ref>PMID:18784102</ref>	+	[[https://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref> <ref>PMID:9096337</ref> <ref>PMID:10499588</ref> <ref>PMID:18784102</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bu, Z]]		[[Category: Bu, Z]]
	[[Category: Cheng, H]]		[[Category: Cheng, H]]

OCA at 10:54, 18 July 2018

2018-07-18T10:54:26Z

←Older revision		Revision as of 10:54, 18 July 2018
Line 1:		Line 1:
		+
	==Structure of the second PDZ domain of NHERF-1==		==Structure of the second PDZ domain of NHERF-1==
	<StructureSection load='2jxo' size='340' side='right' caption='[[2jxo]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>		<StructureSection load='2jxo' size='340' side='right' caption='[[2jxo]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXO FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC9A3R1, NHERF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC9A3R1, NHERF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [http://pdbe.org/2jxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [http://www.ebi.ac.uk/pdbsum/2jxo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [http://pdbe.org/2jxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [http://www.ebi.ac.uk/pdbsum/2jxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2jxo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2jxo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sodium-hydrogen exchange regulatory factor\|Sodium-hydrogen exchange regulatory factor]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 43:
	[[Category: Li, J]]		[[Category: Li, J]]
	[[Category: Roder, H]]		[[Category: Roder, H]]
		+	[[Category: Acetylation]]
	[[Category: Cell projection]]		[[Category: Cell projection]]
	[[Category: Membrane]]		[[Category: Membrane]]
Line 45:		Line 50:
	[[Category: Pdz2]]		[[Category: Pdz2]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Wnt signaling pathway]]		[[Category: Wnt signaling pathway]]

OCA at 21:08, 7 February 2016

2016-02-07T21:08:55Z

←Older revision		Revision as of 21:08, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jxo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:00, 10 September 2015

2015-09-10T05:00:25Z

←Older revision		Revision as of 05:00, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jxo' size='340' side='right' caption='[[2jxo]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>		<StructureSection load='2jxo' size='340' side='right' caption='[[2jxo]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXO FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC9A3R1, NHERF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC9A3R1, NHERF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [http://www.ebi.ac.uk/pdbsum/2jxo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [http://pdbe.org/2jxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [http://www.ebi.ac.uk/pdbsum/2jxo PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[http://www.uniprot.org/uniprot/~~NHERF_HUMAN NHERF_HUMAN~~]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[http://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>	+	[[http://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[http://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~NHERF_HUMAN NHERF_HUMAN~~]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref> <ref>PMID:9096337</ref> <ref>PMID:10499588</ref> <ref>PMID:18784102</ref>	+	[[http://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref> <ref>PMID:9096337</ref> <ref>PMID:10499588</ref> <ref>PMID:18784102</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jxo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bu, Z]]		[[Category: Bu, Z]]
	[[Category: Cheng, H]]		[[Category: Cheng, H]]

OCA at 15:42, 19 January 2015

2015-01-19T15:42:16Z

←Older revision		Revision as of 15:42, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC9A3R1, NHERF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC9A3R1, NHERF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [http://www.ebi.ac.uk/pdbsum/2jxo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [http://www.ebi.ac.uk/pdbsum/2jxo PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/NHERF_HUMAN NHERF_HUMAN]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[http://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>		[[http://www.uniprot.org/uniprot/NHERF_HUMAN NHERF_HUMAN]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[http://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bu, Z.]]	+	[[Category: Bu, Z]]
-	[[Category: Cheng, H.]]	+	[[Category: Cheng, H]]
-	[[Category: Dai, Z.]]	+	[[Category: Dai, Z]]
-	[[Category: Li, J.]]	+	[[Category: Li, J]]
-	[[Category: Roder, H.]]	+	[[Category: Roder, H]]
	[[Category: Cell projection]]		[[Category: Cell projection]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 08:51, 30 September 2014

2014-09-30T08:51:40Z

←Older revision		Revision as of 08:51, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2jxo~~\| ~~PDB~~=2jxo \| ~~SCENE~~= }}	+	==Structure of the second PDZ domain of NHERF-1==
-	===~~Structure~~ of the ~~second PDZ domain~~ of ~~NHERF~~-1===	+	<StructureSection load='2jxo' size='340' side='right' caption='[[2jxo]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_19446522}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jxo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JXO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLC9A3R1, NHERF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jxo RCSB], [http://www.ebi.ac.uk/pdbsum/2jxo PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/NHERF_HUMAN NHERF_HUMAN]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[http://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NHERF_HUMAN NHERF_HUMAN]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref> <ref>PMID:9096337</ref> <ref>PMID:10499588</ref> <ref>PMID:18784102</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Na(+)/H(+) exchanger regulatory factor (NHERF1) is a signaling adaptor protein comprising two PDZ domains and a C-terminal ezrin-binding (EB) motif. To understand the role of intramolecular interactions in regulating its binding properties, we characterized the complex between the second PDZ domain PDZ2 and the C-terminal 242-358 fragment of NHERF1 using NMR and fluorescence methods. NMR chemical shift and relaxation data implicate 11 C-terminal residues in binding and, together with a thermodynamic analysis of mutant proteins, indicate that the EB region becomes helical when bound to PDZ2. Both specific contacts between PDZ2 and EB as well as nonspecific interactions involving a 100-residue flexible linker contribute to stabilizing two structurally distinct closed conformations of NHERF1. The affinity of mutant proteins for an extrinsic ligand is inversely related to the helix-forming propensity of the EB motif. The findings provide a structural framework for understanding how autoinhibitory interactions modulated the binding properties of NHERF1.

-	~~==Disease==~~	+	Autoinhibitory interactions between the PDZ2 and C-terminal domains in the scaffolding protein NHERF1.,Cheng H, Li J, Fazlieva R, Dai Z, Bu Z, Roder H Structure. 2009 May 13;17(5):660-9. PMID:19446522<ref>PMID:19446522</ref>
-	~~[[http://www.uniprot.org/uniprot/NHERF_HUMAN NHERF_HUMAN]] Defects~~ in ~~SLC9A3R1 are~~ the ~~cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[http://omim~~.~~org/entry/612287 612287]]~~. ~~Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis~~ (~~formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization~~).~~<ref>~~PMID:~~18784102</ref>~~<ref>PMID:~~22506049~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~//www.uniprot.org/uniprot/NHERF_HUMAN NHERF_HUMAN]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a ~~role in the regulation~~ of the ~~activity and subcellular location of SLC9A3~~. ~~Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3~~. ~~May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation~~ of ~~phosphate reabsorption in the renal proximal tubules~~.<~~ref~~>~~PMID:9430655~~</~~ref~~>~~<ref>PMID:9096337</ref><ref>PMID:10499588</ref><ref>PMID:18784102</ref>~~	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[2jxo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:019446522</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bu, Z.]]		[[Category: Bu, Z.]]

OCA at 00:27, 25 March 2013

2013-03-25T00:27:33Z

←Older revision		Revision as of 00:27, 25 March 2013
Line 1:		Line 1:
-	[[Image:2jxo.png\|left\|200px]]
-
	{{STRUCTURE_2jxo\| PDB=2jxo \| SCENE= }}		{{STRUCTURE_2jxo\| PDB=2jxo \| SCENE= }}
-
	===Structure of the second PDZ domain of NHERF-1===		===Structure of the second PDZ domain of NHERF-1===
		+	{{ABSTRACT_PUBMED_19446522}}

-	~~{{ABSTRACT_PUBMED_19446522}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/NHERF_HUMAN NHERF_HUMAN]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[http://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref><ref>PMID:22506049</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/NHERF_HUMAN NHERF_HUMAN]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref><ref>PMID:9096337</ref><ref>PMID:10499588</ref><ref>PMID:18784102</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019446522</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019446522</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bu, Z.]]		[[Category: Bu, Z.]]

OCA: Protected "2jxo" [edit=sysop:move=sysop]

2013-01-07T11:12:23Z

Protected "2jxo" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:12, 7 January 2013

OCA at 11:12, 7 January 2013

2013-01-07T11:12:20Z

←Older revision		Revision as of 11:12, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jxo.png\|left\|200px]]		[[Image:2jxo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jxo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jxo\| PDB=2jxo \| SCENE= }}		{{STRUCTURE_2jxo\| PDB=2jxo \| SCENE= }}

	===Structure of the second PDZ domain of NHERF-1===		===Structure of the second PDZ domain of NHERF-1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19446522}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19446522 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19446522}}		{{ABSTRACT_PUBMED_19446522}}

	==About this Structure==		==About this Structure==
-	~~2JXO~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA].	+	[[2jxo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19446522~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019446522</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bu, Z.]]		[[Category: Bu, Z.]]
Line 30:		Line 18:
	[[Category: Li, J.]]		[[Category: Li, J.]]
	[[Category: Roder, H.]]		[[Category: Roder, H.]]
-	[[Category: Acetylation]]
	[[Category: Cell projection]]		[[Category: Cell projection]]
	[[Category: Membrane]]		[[Category: Membrane]]
Line 37:		Line 24:
	[[Category: Pdz2]]		[[Category: Pdz2]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Wnt signaling pathway]]		[[Category: Wnt signaling pathway]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 18:54:07 2009''