2k8u - Revision history

OCA at 12:50, 20 December 2023

2023-12-20T12:50:01Z

←Older revision		Revision as of 12:50, 20 December 2023
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	==Solution NMR structure of trans-4-hydroxynonenal derived dG adduct of (6S,8R,11S)-configuration matched with dC==		==Solution NMR structure of trans-4-hydroxynonenal derived dG adduct of (6S,8R,11S)-configuration matched with dC==
-	<StructureSection load='2k8u' size='340' side='right'caption='[[2k8u~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='2k8u' size='340' side='right'caption='[[2k8u]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2k8u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K8U FirstGlance]. <br>		<table><tr><td colspan='2'>[[2k8u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K8U FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2k8t\|2k8t]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [https://pdbe.org/2k8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [https://www.ebi.ac.uk/pdbsum/2k8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k8u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [https://pdbe.org/2k8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [https://www.ebi.ac.uk/pdbsum/2k8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k8u ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huang, H]]	+	[[Category: Huang H]]
-	[[Category: Lloyd~~, R S~~]]	+	[[Category: Lloyd RS]]
-	[[Category: Qi, N]]	+	[[Category: Qi N]]
-	[[Category: Rizzo~~, C J~~]]	+	[[Category: Rizzo CJ]]
-	[[Category: Stone~~, M P~~]]	+	[[Category: Stone MP]]
-	[[Category: Wang, H]]	+	[[Category: Wang H]]
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Hne derived dg adduct]]~~	+
-	~~[[Category: Trans-4-hydroxynonenal~~]]	+

OCA at 07:32, 27 January 2022

2022-01-27T07:32:35Z

←Older revision		Revision as of 07:32, 27 January 2022
Line 3:		Line 3:
	<StructureSection load='2k8u' size='340' side='right'caption='[[2k8u]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2k8u' size='340' side='right'caption='[[2k8u]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2k8u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2K8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2k8u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K8U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k8t\|2k8t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2k8t\|2k8t]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [~~http~~://pdbe.org/2k8u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2k8u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2k8u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [https://pdbe.org/2k8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [https://www.ebi.ac.uk/pdbsum/2k8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k8u ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:32, 22 April 2020

2020-04-22T06:32:37Z

←Older revision		Revision as of 06:32, 22 April 2020
Line 1:		Line 1:

	==Solution NMR structure of trans-4-hydroxynonenal derived dG adduct of (6S,8R,11S)-configuration matched with dC==		==Solution NMR structure of trans-4-hydroxynonenal derived dG adduct of (6S,8R,11S)-configuration matched with dC==
-	<StructureSection load='2k8u' size='340' side='right' caption='[[2k8u]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='2k8u' size='340' side='right'caption='[[2k8u]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2k8u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2K8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2k8u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2K8U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k8t\|2k8t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k8t\|2k8t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [http://pdbe.org/2k8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [http://www.ebi.ac.uk/pdbsum/2k8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k8u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [http://pdbe.org/2k8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [http://www.ebi.ac.uk/pdbsum/2k8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k8u ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Huang, H]]		[[Category: Huang, H]]
	[[Category: Lloyd, R S]]		[[Category: Lloyd, R S]]

OCA at 11:12, 18 July 2018

2018-07-18T11:12:11Z

←Older revision		Revision as of 11:12, 18 July 2018
Line 1:		Line 1:
		+
	==Solution NMR structure of trans-4-hydroxynonenal derived dG adduct of (6S,8R,11S)-configuration matched with dC==		==Solution NMR structure of trans-4-hydroxynonenal derived dG adduct of (6S,8R,11S)-configuration matched with dC==
	<StructureSection load='2k8u' size='340' side='right' caption='[[2k8u]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2k8u' size='340' side='right' caption='[[2k8u]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k8t\|2k8t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k8t\|2k8t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [http://pdbe.org/2k8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [http://www.ebi.ac.uk/pdbsum/2k8u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [http://pdbe.org/2k8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [http://www.ebi.ac.uk/pdbsum/2k8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k8u ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:41, 10 September 2015

2015-09-10T16:41:30Z

←Older revision		Revision as of 16:41, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k8t\|2k8t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k8t\|2k8t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [http://www.ebi.ac.uk/pdbsum/2k8u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [http://pdbe.org/2k8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [http://www.ebi.ac.uk/pdbsum/2k8u PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2k8u" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:23, 19 January 2015

2015-01-19T14:23:11Z

←Older revision		Revision as of 14:23, 19 January 2015
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Huang, H.]]	+	[[Category: Huang, H]]
-	[[Category: Lloyd, R S.]]	+	[[Category: Lloyd, R S]]
-	[[Category: Qi, N.]]	+	[[Category: Qi, N]]
-	[[Category: Rizzo, C J.]]	+	[[Category: Rizzo, C J]]
-	[[Category: Stone, M P.]]	+	[[Category: Stone, M P]]
-	[[Category: Wang, H~~.]]~~	+	[[Category: Wang, H]]
-	~~[[Category: 8r~~]]	+
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Hne derived dg adduct]]		[[Category: Hne derived dg adduct]]
	[[Category: Trans-4-hydroxynonenal]]		[[Category: Trans-4-hydroxynonenal]]

OCA at 15:36, 12 October 2014

2014-10-12T15:36:21Z

←Older revision		Revision as of 15:36, 12 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2k8u.~~png~~\|~~left~~\|~~200px~~]]	+	==Solution NMR structure of trans-4-hydroxynonenal derived dG adduct of (6S,8R,11S)-configuration matched with dC==
		+	<StructureSection load='2k8u' size='340' side='right' caption='[[2k8u]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2k8u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K8U FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HNB:(2S,5R)-5-PENTYLTETRAHYDROFURAN-2-OL'>HNB</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k8t\|2k8t]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k8u RCSB], [http://www.ebi.ac.uk/pdbsum/2k8u PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The trans-4-hydroxynonenal (HNE)-derived exocyclic 1, N(2)-dG adduct with (6S,8R,11S) stereochemistry forms interstrand N(2)-dG-N(2)-dG cross-links in the 5'-CpG-3' DNA sequence context, but the corresponding adduct possessing (6R,8S,11R) stereochemistry does not. Both exist primarily as diastereomeric cyclic hemiacetals when placed into duplex DNA [Huang, H., Wang, H., Qi, N., Kozekova, A., Rizzo, C. J., and Stone, M. P. (2008) J. Am. Chem. Soc. 130, 10898-10906]. To explore the structural basis for this difference, the HNE-derived diastereomeric (6S,8R,11S) and (6R,8S,11R) cyclic hemiacetals were examined with respect to conformation when incorporated into 5'-d(GCTAGC XAGTCC)-3' x 5'-d(GGACTCGCTAGC)-3', containing the 5'-CpX-3' sequence [X = (6S,8R,11S)- or (6R,8S,11R)-HNE-dG]. At neutral pH, both adducts exhibited minimal structural perturbations to the DNA duplex that were localized to the site of the adduction at X(7) x C(18) and its neighboring base pair, A(8) x T(17). Both the (6S,8R,11S) and (6R,8S,11R) cyclic hemiacetals were located within the minor groove of the duplex. However, the respective orientations of the two cyclic hemiacetals within the minor groove were dependent upon (6S) versus (6R) stereochemistry. The (6S,8R,11S) cyclic hemiacetal was oriented in the 5'-direction, while the (6R,8S,11R) cyclic hemiacetal was oriented in the 3'-direction. These cyclic hemiacetals effectively mask the reactive aldehydes necessary for initiation of interstrand cross-link formation. From the refined structures of the two cyclic hemiacetals, the conformations of the corresponding diastereomeric aldehydes were predicted, using molecular mechanics calculations. Potential energy minimizations of the duplexes containing the two diastereomeric aldehydes predicted that the (6S,8R,11S) aldehyde was oriented in the 5'-direction while the (6R,8S,11R) aldehyde was oriented in the 3'-direction. These stereochemical differences in orientation suggest a kinetic basis that explains, in part, why the (6S,8R,11S) stereoisomer forms interchain cross-links in the 5'-CpG-3' sequence whereas the (6R,8S,11R) stereoisomer does not.

-	~~{{STRUCTURE_2k8u\| PDB=2k8u \| SCENE= }}~~	+	The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N2-2'-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5'-CpG-3' sequence.,Huang H, Wang H, Qi N, Lloyd RS, Rizzo CJ, Stone MP Biochemistry. 2008 Nov 4;47(44):11457-72. Epub 2008 Oct 11. PMID:18847226<ref>PMID:18847226</ref>

-	~~===Solution NMR structure~~ of ~~trans-4-hydroxynonenal derived dG adduct~~ of ~~(6S,8R,11S)-configuration matched with dC===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18847226}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2k8u]] is a 2 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA].~~	+	</StructureSection>
	[[Category: Huang, H.]]		[[Category: Huang, H.]]
	[[Category: Lloyd, R S.]]		[[Category: Lloyd, R S.]]

OCA: Protected "2k8u" [edit=sysop:move=sysop]

2013-01-07T10:43:42Z

Protected "2k8u" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:43, 7 January 2013

OCA at 10:43, 7 January 2013

2013-01-07T10:43:40Z

←Older revision		Revision as of 10:43, 7 January 2013
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-	{{Seed}}
	[[Image:2k8u.png\|left\|200px]]		[[Image:2k8u.png\|left\|200px]]

-	<!--
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-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2k8u\| PDB=2k8u \| SCENE= }}		{{STRUCTURE_2k8u\| PDB=2k8u \| SCENE= }}

	===Solution NMR structure of trans-4-hydroxynonenal derived dG adduct of (6S,8R,11S)-configuration matched with dC===		===Solution NMR structure of trans-4-hydroxynonenal derived dG adduct of (6S,8R,11S)-configuration matched with dC===

-
-	<!--
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-	(as it appears on PubMed at http://www.pubmed.gov), where 18847226 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18847226}}		{{ABSTRACT_PUBMED_18847226}}

	==About this Structure==		==About this Structure==
-	~~2K8U is a~~ [[~~Protein complex~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA].	+	[[2k8u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA].
-		+
-	~~==Reference==~~	+
-	The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N2-2'-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5'-CpG-3' sequence., Huang H, Wang H, Qi N, Lloyd RS, Rizzo CJ, Stone MP, Biochemistry. 2008 Nov 4;47(44):11457-72. Epub 2008 Oct 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18847226 18847226]	+
-	~~[[Category: Protein complex]]~~	+
	[[Category: Huang, H.]]		[[Category: Huang, H.]]
	[[Category: Lloyd, R S.]]		[[Category: Lloyd, R S.]]
Line 35:		Line 19:
	[[Category: Hne derived dg adduct]]		[[Category: Hne derived dg adduct]]
	[[Category: Trans-4-hydroxynonenal]]		[[Category: Trans-4-hydroxynonenal]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 20:42:27 2008''

OCA at 19:12, 12 November 2008

2008-11-12T19:12:43Z

←Older revision		Revision as of 19:12, 12 November 2008
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2K8U is a ~~2 chains~~ structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA].	+	2K8U is a [[Protein complex]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K8U OCA].

	==Reference==		==Reference==
	The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N2-2'-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5'-CpG-3' sequence., Huang H, Wang H, Qi N, Lloyd RS, Rizzo CJ, Stone MP, Biochemistry. 2008 Nov 4;47(44):11457-72. Epub 2008 Oct 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18847226 18847226]		The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N2-2'-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5'-CpG-3' sequence., Huang H, Wang H, Qi N, Lloyd RS, Rizzo CJ, Stone MP, Biochemistry. 2008 Nov 4;47(44):11457-72. Epub 2008 Oct 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18847226 18847226]
		+	[[Category: Protein complex]]
	[[Category: Huang, H.]]		[[Category: Huang, H.]]
	[[Category: Lloyd, R S.]]		[[Category: Lloyd, R S.]]
Line 35:		Line 36:
	[[Category: Trans-4-hydroxynonenal]]		[[Category: Trans-4-hydroxynonenal]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 10:03:47 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 20:42:27 2008''