2k9e - Revision history

OCA at 08:33, 15 November 2023

2023-11-15T08:33:17Z

←Older revision		Revision as of 08:33, 15 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene>, <scene name='pdbligand=ZV4:(2S)-2-azanyl-3-(4-phosphonophenyl)propanoic+acid'>ZV4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene>, <scene name='pdbligand=ZV4:(2S)-2-azanyl-3-(4-phosphonophenyl)propanoic+acid'>ZV4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [https://pdbe.org/2k9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [https://www.ebi.ac.uk/pdbsum/2k9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [https://pdbe.org/2k9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [https://www.ebi.ac.uk/pdbsum/2k9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9e ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:36, 19 April 2023

2023-04-19T09:36:10Z

←Older revision		Revision as of 09:36, 19 April 2023
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	==NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide==		==NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide==
-	<StructureSection load='2k9e' size='340' side='right'caption='[[2k9e~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2k9e' size='340' side='right'caption='[[2k9e]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9E FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene>, <scene name='pdbligand=ZV4:(2S)-2-azanyl-3-(4-phosphonophenyl)propanoic+acid'>ZV4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [https://pdbe.org/2k9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [https://www.ebi.ac.uk/pdbsum/2k9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [https://pdbe.org/2k9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [https://www.ebi.ac.uk/pdbsum/2k9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~TXSHK_STOHE TXSHK_STOHE]~~] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref>	+	[https://www.uniprot.org/uniprot/K1A_STIHL K1A_STIHL] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Galea, C A~~]]	+	[[Category: Stichodactyla helianthus]]
-	[[Category: ~~Ionic channel inhibitor]]~~	+	[[Category: Galea CA]]
-	~~[[Category: Nematocyst]]~~	+
-	~~[[Category: Neurotoxin]]~~	+
-	~~[[Category: Potassium channel inhibitor]]~~	+
-	~~[[Category: Protein]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 07:02, 10 November 2021

2021-11-10T07:02:56Z

←Older revision		Revision as of 07:02, 10 November 2021
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	<StructureSection load='2k9e' size='340' side='right'caption='[[2k9e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2k9e' size='340' side='right'caption='[[2k9e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2K9E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9E FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [~~http~~://pdbe.org/2k9e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2k9e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [https://pdbe.org/2k9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [https://www.ebi.ac.uk/pdbsum/2k9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TXSHK_STOHE TXSHK_STOHE]] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref>	+	[[https://www.uniprot.org/uniprot/TXSHK_STOHE TXSHK_STOHE]] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:33, 26 February 2020

2020-02-26T09:33:51Z

←Older revision		Revision as of 09:33, 26 February 2020
Line 1:		Line 1:

	==NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide==		==NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide==
-	<StructureSection load='2k9e' size='340' side='right' caption='[[2k9e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2k9e' size='340' side='right'caption='[[2k9e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9E FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Potassium channel toxin\|Potassium channel toxin]]	+	*[[Potassium channel toxin 3D structures\|Potassium channel toxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Galea, C A]]		[[Category: Galea, C A]]
	[[Category: Ionic channel inhibitor]]		[[Category: Ionic channel inhibitor]]

OCA at 10:14, 18 July 2018

2018-07-18T10:14:43Z

←Older revision		Revision as of 10:14, 18 July 2018
Line 1:		Line 1:
		+
	==NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide==		==NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide==
	<StructureSection load='2k9e' size='340' side='right' caption='[[2k9e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2k9e' size='340' side='right' caption='[[2k9e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9E FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [http://pdbe.org/2k9e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [http://www.ebi.ac.uk/pdbsum/2k9e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [http://pdbe.org/2k9e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [http://www.ebi.ac.uk/pdbsum/2k9e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:46, 11 September 2015

2015-09-11T15:46:50Z

←Older revision		Revision as of 15:46, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9E FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [http://www.ebi.ac.uk/pdbsum/2k9e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [http://pdbe.org/2k9e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [http://www.ebi.ac.uk/pdbsum/2k9e PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2k9e" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:35, 25 December 2014

2014-12-25T18:35:15Z

←Older revision		Revision as of 18:35, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [http://www.ebi.ac.uk/pdbsum/2k9e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [http://www.ebi.ac.uk/pdbsum/2k9e PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TXSHK_STOHE TXSHK_STOHE]] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:50, 17 December 2014

2014-12-17T13:50:30Z

←Older revision		Revision as of 13:50, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2k9e\| PDB=2k9e \| SCENE= }}~~	+	==NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide==
-	===NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide===	+	<StructureSection load='2k9e' size='340' side='right' caption='[[2k9e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	{~~{ABSTRACT_PUBMED_19122005}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9E FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [http://www.ebi.ac.uk/pdbsum/2k9e PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kv1.3 potassium channels maintain the membrane potential of effector memory (T(EM)) T cells that are important mediators of multiple sclerosis, type 1 diabetes mellitus, and rheumatoid arthritis. The polypeptide ShK-170 (ShK-L5), containing an N-terminal phosphotyrosine extension of the Stichodactyla helianthus ShK toxin, is a potent and selective blocker of these channels. However, a stability study of ShK-170 showed minor pH-related hydrolysis and oxidation byproducts that were exacerbated by increasing temperatures. We therefore engineered a series of analogs to minimize the formation of these byproducts. The analog with the greatest stability, ShK-192, contains a nonhydrolyzable phosphotyrosine surrogate, a methionine isostere, and a C-terminal amide. ShK-192 shows the same overall fold as ShK, and there is no evidence of any interaction between the N-terminal adduct and the rest of the peptide. The docking configuration of ShK-192 in Kv1.3 shows the N-terminal para-phosphonophenylalanine group lying at the junction of two channel monomers to form a salt bridge with Lys(411) of the channel. ShK-192 blocks Kv1.3 with an IC(50) of 140 pM and exhibits greater than 100-fold selectivity over closely related channels. After a single subcutaneous injection of 100 microg/kg, approximately 100 to 200 pM concentrations of active peptide is detectable in the blood of Lewis rats 24, 48, and 72 h after the injection. ShK-192 effectively inhibits the proliferation of T(EM) cells and suppresses delayed type hypersensitivity when administered at 10 or 100 microg/kg by subcutaneous injection once daily. ShK-192 has potential as a therapeutic for autoimmune diseases mediated by T(EM) cells.

-	~~==About this Structure==~~	+	Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes.,Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG Mol Pharmacol. 2009 Apr;75(4):762-73. Epub 2009 Jan 2. PMID:19122005<ref>PMID:19122005</ref>
-	~~[[2k9e]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2K9E OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Potassium channel toxin\|Potassium channel toxin]]		*[[Potassium channel toxin\|Potassium channel toxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019122005<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
-	[[Category: Galea, C A.]]	+	</StructureSection>
		+	[[Category: Galea, C A]]
	[[Category: Ionic channel inhibitor]]		[[Category: Ionic channel inhibitor]]
	[[Category: Nematocyst]]		[[Category: Nematocyst]]

OCA at 10:47, 11 March 2013

2013-03-11T10:47:31Z

←Older revision		Revision as of 10:47, 11 March 2013
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	{{STRUCTURE_2k9e\| PDB=2k9e \| SCENE= }}		{{STRUCTURE_2k9e\| PDB=2k9e \| SCENE= }}
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	===NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide===		===NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide===
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	{{ABSTRACT_PUBMED_19122005}}		{{ABSTRACT_PUBMED_19122005}}

OCA: Protected "2k9e" [edit=sysop:move=sysop]

2013-01-07T14:51:15Z

Protected "2k9e" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:51, 7 January 2013