2kby - Revision history

OCA at 19:11, 29 May 2024

2024-05-29T19:11:27Z

←Older revision		Revision as of 19:11, 29 May 2024
Line 1:		Line 1:

	==The Tetramerization Domain of Human p73==		==The Tetramerization Domain of Human p73==
-	<StructureSection load='2kby' size='340' side='right'caption='[[2kby~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kby' size='340' side='right'caption='[[2kby]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBY FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>P73, TP73 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [https://pdbe.org/2kby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [https://www.ebi.ac.uk/pdbsum/2kby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kby ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [https://pdbe.org/2kby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [https://www.ebi.ac.uk/pdbsum/2kby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>	+	[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Coutandin, D]]	+	[[Category: Coutandin D]]
-	[[Category: Doetsch, V]]	+	[[Category: Doetsch V]]
-	[[Category: Guntert, P]]	+	[[Category: Guntert P]]
-	[[Category: Ikeya, T]]	+	[[Category: Ikeya T]]
-	[[Category: Loehr, F]]	+	[[Category: Loehr F]]
-	[[Category: Ou~~, H D]]~~	+	[[Category: Ou HD]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Anti-oncogene]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Tetramerization domain]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Ubl conjugation]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 08:15, 7 April 2021

2021-04-07T08:15:55Z

←Older revision		Revision as of 08:15, 7 April 2021
Line 1:		Line 1:

	==The Tetramerization Domain of Human p73==		==The Tetramerization Domain of Human p73==
-	<StructureSection load='2kby' size='340' side='right' caption='[[2kby]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kby' size='340' side='right'caption='[[2kby]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P73, TP73 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P73, TP73 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [~~http~~://pdbe.org/2kby PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kby PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kby ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [https://pdbe.org/2kby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [https://www.ebi.ac.uk/pdbsum/2kby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>	+	[[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Coutandin, D]]		[[Category: Coutandin, D]]
	[[Category: Doetsch, V]]		[[Category: Doetsch, V]]

OCA at 10:17, 18 July 2018

2018-07-18T10:17:49Z

←Older revision		Revision as of 10:17, 18 July 2018
Line 1:		Line 1:
		+
	==The Tetramerization Domain of Human p73==		==The Tetramerization Domain of Human p73==
	<StructureSection load='2kby' size='340' side='right' caption='[[2kby]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kby' size='340' side='right' caption='[[2kby]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBY FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P73, TP73 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P73, TP73 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [http://pdbe.org/2kby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [http://www.ebi.ac.uk/pdbsum/2kby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [http://pdbe.org/2kby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [http://www.ebi.ac.uk/pdbsum/2kby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kby_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kby_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 42:		Line 43:
	[[Category: Ou, H D]]		[[Category: Ou, H D]]
	[[Category: Activator]]		[[Category: Activator]]
		+	[[Category: Alternative splicing]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
Line 52:		Line 54:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
		+	[[Category: Ubl conjugation]]
		+	[[Category: Zinc]]

OCA at 09:02, 8 February 2016

2016-02-08T09:02:32Z

←Older revision		Revision as of 09:02, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kby ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:00, 10 September 2015

2015-09-10T10:00:13Z

←Older revision		Revision as of 10:00, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2kby' size='340' side='right' caption='[[2kby]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kby' size='340' side='right' caption='[[2kby]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P73, TP73 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P73, TP73 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [http://www.ebi.ac.uk/pdbsum/2kby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [http://pdbe.org/2kby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [http://www.ebi.ac.uk/pdbsum/2kby PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2kby" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Coutandin, D]]		[[Category: Coutandin, D]]
	[[Category: Doetsch, V]]		[[Category: Doetsch, V]]

OCA at 22:08, 24 December 2014

2014-12-24T22:08:47Z

←Older revision		Revision as of 22:08, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P73, TP73 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P73, TP73 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [http://www.ebi.ac.uk/pdbsum/2kby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [http://www.ebi.ac.uk/pdbsum/2kby PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Coutandin, D.]]	+	[[Category: Coutandin, D]]
-	[[Category: Doetsch, V.]]	+	[[Category: Doetsch, V]]
-	[[Category: Guntert, P.]]	+	[[Category: Guntert, P]]
-	[[Category: Ikeya, T.]]	+	[[Category: Ikeya, T]]
-	[[Category: Loehr, F.]]	+	[[Category: Loehr, F]]
-	[[Category: Ou, H D.]]	+	[[Category: Ou, H D]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]

OCA at 02:12, 29 September 2014

2014-09-29T02:12:24Z

←Older revision		Revision as of 02:12, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2kby.~~png\|left~~\|200px]]	+	==The Tetramerization Domain of Human p73==
		+	<StructureSection load='2kby' size='340' side='right' caption='[[2kby]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2kby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P73, TP73 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kby RCSB], [http://www.ebi.ac.uk/pdbsum/2kby PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kby_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	p73 and p63, the two ancestral members of the p53 family, are involved in neurogenesis, epithelial stem cell maintenance and quality control of female germ cells. The highly conserved oligomerization domain (OD) of tumor suppressor p53 is essential for its biological functions, and its structure was believed to be the prototype for all three proteins. However, we report that the ODs of p73 and p63 differ from the OD of p53 by containing an additional alpha-helix that is not present in the structure of the p53 OD. Deletion of this helix causes a dissociation of the OD into dimers; it also causes conformational instability and reduces the transcriptional activity of p73. Moreover, we show that ODs of p73 and p63 strongly interact and that a large number of different heterotetramers are supported by the additional helix. Detailed analysis shows that the heterotetramer consisting of two homodimers is thermodynamically more stable than the two homotetramers. No heterooligomerization between p53 and the p73/p63 subfamily was observed, supporting the notion of functional orthogonality within the p53 family.

-	~~{{STRUCTURE_2kby\| PDB=2kby \| SCENE= }}~~	+	Conformational stability and activity of p73 require a second helix in the tetramerization domain.,Coutandin D, Lohr F, Niesen FH, Ikeya T, Weber TA, Schafer B, Zielonka EM, Bullock AN, Yang A, Guntert P, Knapp S, McKeon F, Ou HD, Dotsch V Cell Death Differ. 2009 Dec;16(12):1582-9. Epub 2009 Sep 18. PMID:19763140<ref>PMID:19763140</ref>

-	~~===The Tetramerization Domain~~ of ~~Human p73===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19763140}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2kby]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA].~~	+

	==See Also==		==See Also==
	*[[P73\|P73]]		*[[P73\|P73]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019763140<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Coutandin, D.]]		[[Category: Coutandin, D.]]

OCA at 09:38, 20 October 2012

2012-10-20T09:38:08Z

←Older revision		Revision as of 09:38, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2kby]] is a 4 chain structure ~~of [[P73]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA].	+	[[2kby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA].

	==See Also==		==See Also==

OCA: Protected "2kby" [edit=sysop:move=sysop]

2012-07-25T23:30:44Z

Protected "2kby" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:30, 25 July 2012

OCA at 23:30, 25 July 2012

2012-07-25T23:30:42Z

←Older revision		Revision as of 23:30, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2kby.png\|left\|200px]]		[[Image:2kby.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2kby", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2kby\| PDB=2kby \| SCENE= }}		{{STRUCTURE_2kby\| PDB=2kby \| SCENE= }}

	===The Tetramerization Domain of Human p73===		===The Tetramerization Domain of Human p73===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19763140}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19763140 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19763140}}		{{ABSTRACT_PUBMED_19763140}}

	==About this Structure==		==About this Structure==
-	~~2KBY~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA].	+	[[2kby]] is a 4 chain structure of [[P73]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBY OCA].
		+
		+	==See Also==
		+	*[[P73\|P73]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19763140~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019763140</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Coutandin, D.]]		[[Category: Coutandin, D.]]
Line 32:		Line 23:
	[[Category: Ou, H D.]]		[[Category: Ou, H D.]]
	[[Category: Activator]]		[[Category: Activator]]
-	[[Category: Alternative splicing]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
Line 43:		Line 33:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-	[[Category: Ubl conjugation]]
-	[[Category: Zinc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 2 09:04:15 2009''