2kgr - Revision history

OCA at 09:38, 22 May 2024

2024-05-22T09:38:47Z

←Older revision		Revision as of 09:38, 22 May 2024
Line 1:		Line 1:

	==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==		==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==
-	<StructureSection load='2kgr' size='340' side='right'caption='[[2kgr~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kgr' size='340' side='right'caption='[[2kgr]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ITSN1, ITSN, SH3D1A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [https://pdbe.org/2kgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [https://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgr ProSAT], [https://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [https://pdbe.org/2kgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [https://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgr ProSAT], [https://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>	+	[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Acton, T]]	+	[[Category: Acton T]]
-	[[Category: Ciccosanti, C]]	+	[[Category: Ciccosanti C]]
-	[[Category: Everett, J]]	+	[[Category: Everett J]]
-	[[Category: Ghosh, A]]	+	[[Category: Ghosh A]]
-	[[Category: Hua, J]]	+	[[Category: Hua J]]
-	[[Category: Jiang, M]]	+	[[Category: Jiang M]]
-	[[Category: Montelione, G]]	+	[[Category: Montelione G]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shastry R]]
-	[[Category: Shastry, R]]	+	[[Category: Swapna G]]
-	[[Category: Swapna, G]]	+	[[Category: Szyperski T]]
-	[[Category: Szyperski, T]]	+	[[Category: Wu Y]]
-	[[Category: Wu, Y]]	+	[[Category: Xiao R]]
-	[[Category: Xiao, R]]	+	[[Category: Zhang Q]]
-	[[Category: Zhang, Q]]	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Calcium]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Cell projection]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Nesg]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Synapse]]~~	+
-	~~[[Category: Synaptosome~~]]	+

OCA at 08:21, 7 April 2021

2021-04-07T08:21:25Z

←Older revision		Revision as of 08:21, 7 April 2021
Line 1:		Line 1:

	==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==		==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==
-	<StructureSection load='2kgr' size='340' side='right' caption='[[2kgr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kgr' size='340' side='right'caption='[[2kgr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [~~http~~://pdbe.org/2kgr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgr ProSAT], [~~http~~://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [https://pdbe.org/2kgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [https://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgr ProSAT], [https://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>	+	[[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kgr ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kgr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Intersectin\|Intersectin]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Acton, T]]		[[Category: Acton, T]]
	[[Category: Ciccosanti, C]]		[[Category: Ciccosanti, C]]

OCA at 10:20, 18 July 2018

2018-07-18T10:20:03Z

←Older revision		Revision as of 10:20, 18 July 2018
Line 1:		Line 1:
		+
	==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==		==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==
	<StructureSection load='2kgr' size='340' side='right' caption='[[2kgr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kgr' size='340' side='right' caption='[[2kgr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [http://pdbe.org/2kgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [http://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [http://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [http://pdbe.org/2kgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [http://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgr ProSAT], [http://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kgr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kgr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kgr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==
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	[[Category: Xiao, R]]		[[Category: Xiao, R]]
	[[Category: Zhang, Q]]		[[Category: Zhang, Q]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Calcium]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Cell projection]]		[[Category: Cell projection]]
		+	[[Category: Coiled coil]]
	[[Category: Endocytosis]]		[[Category: Endocytosis]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 09:04, 11 September 2015

2015-09-11T09:04:56Z

←Older revision		Revision as of 09:04, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2kgr' size='340' side='right' caption='[[2kgr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kgr' size='340' side='right' caption='[[2kgr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [http://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [http://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [http://pdbe.org/2kgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [http://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [http://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Acton, T]]		[[Category: Acton, T]]
	[[Category: Ciccosanti, C]]		[[Category: Ciccosanti, C]]

OCA at 14:14, 25 December 2014

2014-12-25T14:14:26Z

←Older revision		Revision as of 14:14, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [http://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [http://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [http://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [http://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 18:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Acton, T.]]	+	[[Category: Acton, T]]
-	[[Category: Ciccosanti, C.]]	+	[[Category: Ciccosanti, C]]
-	[[Category: Everett, J.]]	+	[[Category: Everett, J]]
-	[[Category: Ghosh, A.]]	+	[[Category: Ghosh, A]]
-	[[Category: Hua, J.]]	+	[[Category: Hua, J]]
-	[[Category: Jiang, M.]]	+	[[Category: Jiang, M]]
-	[[Category: Montelione, G.]]	+	[[Category: Montelione, G]]
-	[[Category: ~~NESG, Northeast~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Shastry, R.]]	+	[[Category: Shastry, R]]
-	[[Category: Swapna, G.]]	+	[[Category: Swapna, G]]
-	[[Category: Szyperski, T.]]	+	[[Category: Szyperski, T]]
-	[[Category: Wu, Y.]]	+	[[Category: Wu, Y]]
-	[[Category: Xiao, R.]]	+	[[Category: Xiao, R]]
-	[[Category: Zhang, Q.]]	+	[[Category: Zhang, Q]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Cell projection]]		[[Category: Cell projection]]
Line 38:		Line 42:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Nesg]]		[[Category: Nesg]]
-	[[Category: Northeast structural genomics consortium]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi-2~~]]	+
	[[Category: Sh3 domain]]		[[Category: Sh3 domain]]
-	[[Category: Structural genomic]]
	[[Category: Synapse]]		[[Category: Synapse]]
	[[Category: Synaptosome]]		[[Category: Synaptosome]]

OCA at 05:33, 29 September 2014

2014-09-29T05:33:53Z

←Older revision		Revision as of 05:33, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:2kgr.png\|left\|200px]]~~	+	==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==
-		+	<StructureSection load='2kgr' size='340' side='right' caption='[[2kgr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{STRUCTURE_2kgr\| PDB=2kgr \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
-	===Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A===	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [http://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [http://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
-		+	<table>
-	==~~About this Structure~~==	+	== Evolutionary Conservation ==
-	[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA].	+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kgr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Acton, T.]]		[[Category: Acton, T.]]

OCA: Protected "2kgr" [edit=sysop:move=sysop]

2012-10-21T11:28:16Z

Protected "2kgr" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:28, 21 October 2012

OCA at 11:28, 21 October 2012

2012-10-21T11:28:14Z

←Older revision		Revision as of 11:28, 21 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2kgr.png\|left\|200px]]

-	~~The entry~~ 2kgr ~~is ON HOLD~~	+	{{STRUCTURE_2kgr\| PDB=2kgr \| SCENE= }}

-	~~Authors: Wu, Y., Ghosh, A., Shastry, R., Hua, J., Ciccosanti, C., Zhang, Q., Jiang, M., Swapna, G., Acton, T., Xiao, R., Everett, J., Montelione, G., SZYPERSKI, T~~.	+	===Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A===

-	Description: Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Thu Apr 9 12~~:14:~~48 2009''~~	+	==About this Structure==
		+	[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Acton, T.]]
		+	[[Category: Ciccosanti, C.]]
		+	[[Category: Everett, J.]]
		+	[[Category: Ghosh, A.]]
		+	[[Category: Hua, J.]]
		+	[[Category: Jiang, M.]]
		+	[[Category: Montelione, G.]]
		+	[[Category: NESG, Northeast Structural Genomics Consortium.]]
		+	[[Category: Shastry, R.]]
		+	[[Category: Swapna, G.]]
		+	[[Category: Szyperski, T.]]
		+	[[Category: Wu, Y.]]
		+	[[Category: Xiao, R.]]
		+	[[Category: Zhang, Q.]]
		+	[[Category: Cell junction]]
		+	[[Category: Cell projection]]
		+	[[Category: Endocytosis]]
		+	[[Category: Membrane]]
		+	[[Category: Nesg]]
		+	[[Category: Northeast structural genomics consortium]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-2]]
		+	[[Category: Sh3 domain]]
		+	[[Category: Structural genomic]]
		+	[[Category: Synapse]]
		+	[[Category: Synaptosome]]

OCA at 09:14, 9 April 2009

2009-04-09T09:14:48Z

←Older revision		Revision as of 09:14, 9 April 2009
Line 1:		Line 1:
-	~~{{Seed}}~~	+	'''Unreleased structure'''
-	~~[[Image:2kgr.jpg\|left\|200px]]~~	+

-	~~<!--~~	+	The entry 2kgr is ON HOLD
-	The ~~line below this paragraph, containing "STRUCTURE_2kgr", creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	~~-->~~	+
-	~~{{STRUCTURE_2kgr\| PDB=~~2kgr ~~\| SCENE= }}~~	+

-	~~===Solution structure of protein ITSN1 from Homo sapiens~~. ~~Northeast Structural Genomics Consortium target HR5524A===~~	+	Authors: Wu, Y., Ghosh, A., Shastry, R., Hua, J., Ciccosanti, C., Zhang, Q., Jiang, M., Swapna, G., Acton, T., Xiao, R., Everett, J., Montelione, G., SZYPERSKI, T.

		+	Description: Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A

-	~~==About this Structure==~~	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 9 12:14:48 2009''
-	2KGR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA].	+
-	~~[[Category: Homo sapiens]]~~	+
-	~~[[Category: Acton, T.]]~~	+
-	~~[[Category: Ciccosanti, C.]]~~	+
-	~~[[Category: Everett, J.]]~~	+
-	~~[[Category: Ghosh, A.]]~~	+
-	~~[[Category: Hua, J.]]~~	+
-	~~[[Category: Jiang, M.]]~~	+
-	~~[[Category: Montelione, G.]]~~	+
-	~~[[Category: NESG, Northeast Structural Genomics Consortium.]]~~	+
-	~~[[Category: Shastry, R.]]~~	+
-	~~[[Category: Swapna, G.]]~~	+
-	~~[[Category: Szyperski, T.]]~~	+
-	~~[[Category: Wu, Y.]]~~	+
-	~~[[Category: Xiao, R.]]~~	+
-	~~[[Category: Zhang, Q.]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Calcium]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Cell projection]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Nesg]]~~	+
-	~~[[Category: Nmr]]~~	+
-	~~[[Category: Northeast structural genomics consortium]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein structure initiative]]~~	+
-	~~[[Category: Psi-2]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Structure]]~~	+
-	~~[[Category: Synapse]]~~	+
-	~~[[Category: Synaptosome]]~~	+
-		+
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr ~~2 16~~:09:28 2009''	+

OCA at 13:09, 2 April 2009

2009-04-02T13:09:29Z

←Older revision		Revision as of 13:09, 2 April 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2kgr.jpg\|left\|200px]]

-	The ~~entry 2kgr~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2kgr", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2kgr\| PDB=2kgr \| SCENE= }}

-	~~Authors: Wu, Y., Ghosh, A., Shastry, R., Hua, J., Ciccosanti, C., Zhang, Q., Jiang, M., Swapna, G., Acton, T., Xiao, R., Everett, J., Montelione, G., SZYPERSKI, T~~.	+	===Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A===

-	Description: Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Mar 25 11~~:59:08 2009''	+	==About this Structure==
		+	2KGR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Acton, T.]]
		+	[[Category: Ciccosanti, C.]]
		+	[[Category: Everett, J.]]
		+	[[Category: Ghosh, A.]]
		+	[[Category: Hua, J.]]
		+	[[Category: Jiang, M.]]
		+	[[Category: Montelione, G.]]
		+	[[Category: NESG, Northeast Structural Genomics Consortium.]]
		+	[[Category: Shastry, R.]]
		+	[[Category: Swapna, G.]]
		+	[[Category: Szyperski, T.]]
		+	[[Category: Wu, Y.]]
		+	[[Category: Xiao, R.]]
		+	[[Category: Zhang, Q.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Calcium]]
		+	[[Category: Cell junction]]
		+	[[Category: Cell projection]]
		+	[[Category: Coiled coil]]
		+	[[Category: Endocytosis]]
		+	[[Category: Membrane]]
		+	[[Category: Nesg]]
		+	[[Category: Nmr]]
		+	[[Category: Northeast structural genomics consortium]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-2]]
		+	[[Category: Sh3 domain]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structure]]
		+	[[Category: Synapse]]
		+	[[Category: Synaptosome]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 16:09:28 2009''