2klx - Revision history

OCA at 08:45, 14 June 2023

2023-06-14T08:45:46Z

←Older revision		Revision as of 08:45, 14 June 2023
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	==Solution structure of glutaredoxin from Bartonella henselae str. Houston==		==Solution structure of glutaredoxin from Bartonella henselae str. Houston==
-	<StructureSection load='2klx' size='340' side='right'caption='[[2klx~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2klx' size='340' side='right'caption='[[2klx]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Barhe Barhe~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bartonella_henselae_str._Houston-1 Bartonella henselae str. Houston-1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KLX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=283166 BARHE])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [https://pdbe.org/2klx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [https://www.ebi.ac.uk/pdbsum/2klx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2klx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [https://pdbe.org/2klx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [https://www.ebi.ac.uk/pdbsum/2klx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2klx ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3LXP0_BARHE A0A0H3LXP0_BARHE] Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.[ARBA:ARBA00002549][RuleBase:RU364065]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Barhe~~]]	+	[[Category: Bartonella henselae str. Houston-1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Leeper~~, T C]]~~	+	[[Category: Leeper TC]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Varani G]]
-	[[Category: Varani, G]]	+	[[Category: Zheng S]]
-	[[Category: Zheng, S]]	+
-	~~[[Category: Electron transport]]~~	+
-	~~[[Category: Glutaredoxin]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Thioredoxin type domain~~]]	+

OCA at 07:07, 1 December 2021

2021-12-01T07:07:28Z

←Older revision		Revision as of 07:07, 1 December 2021
Line 3:		Line 3:
	<StructureSection load='2klx' size='340' side='right'caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2klx' size='340' side='right'caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Barhe Barhe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Barhe Barhe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KLX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=283166 BARHE])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=283166 BARHE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [~~http~~://pdbe.org/2klx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2klx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2klx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [https://pdbe.org/2klx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [https://www.ebi.ac.uk/pdbsum/2klx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2klx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:39, 26 February 2020

2020-02-26T09:39:54Z

←Older revision		Revision as of 09:39, 26 February 2020
Line 1:		Line 1:

	==Solution structure of glutaredoxin from Bartonella henselae str. Houston==		==Solution structure of glutaredoxin from Bartonella henselae str. Houston==
-	<StructureSection load='2klx' size='340' side='right' caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2klx' size='340' side='right'caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Barhe Barhe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Barhe Barhe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KLX FirstGlance]. <br>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Barhe]]		[[Category: Barhe]]
		+	[[Category: Large Structures]]
	[[Category: Leeper, T C]]		[[Category: Leeper, T C]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 08:32, 25 July 2018

2018-07-25T08:32:30Z

←Older revision		Revision as of 08:32, 25 July 2018
Line 1:		Line 1:
		+
	==Solution structure of glutaredoxin from Bartonella henselae str. Houston==		==Solution structure of glutaredoxin from Bartonella henselae str. Houston==
	<StructureSection load='2klx' size='340' side='right' caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2klx' size='340' side='right' caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Barhe Barhe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Barhe Barhe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KLX FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=283166 BARHE])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=283166 BARHE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://pdbe.org/2klx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://pdbe.org/2klx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2klx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2klx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2klx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2klx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:21, 11 September 2015

2015-09-11T13:21:15Z

←Older revision		Revision as of 13:21, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2klx' size='340' side='right' caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2klx' size='340' side='right' caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bartonella_henselae Bartonella henselae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Barhe Barhe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KLX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~38323 Bartonella henselae~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=283166 BARHE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://pdbe.org/2klx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2klx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bartonella henselae~~]]	+	[[Category: Barhe]]
	[[Category: Leeper, T C]]		[[Category: Leeper, T C]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 18:36, 19 January 2015

2015-01-19T18:36:33Z

←Older revision		Revision as of 18:36, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KLX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KLX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=38323 Bartonella henselae])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=38323 Bartonella henselae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Bartonella henselae]]		[[Category: Bartonella henselae]]
-	[[Category: Leeper, T C.]]	+	[[Category: Leeper, T C]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Varani, G.]]	+	[[Category: Varani, G]]
-	[[Category: Zheng, S.]]	+	[[Category: Zheng, S]]
	[[Category: Electron transport]]		[[Category: Electron transport]]
	[[Category: Glutaredoxin]]		[[Category: Glutaredoxin]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]
	[[Category: Thioredoxin type domain]]		[[Category: Thioredoxin type domain]]

OCA at 10:06, 3 October 2014

2014-10-03T10:06:54Z

←Older revision		Revision as of 10:06, 3 October 2014
Line 2:		Line 2:
	<StructureSection load='2klx' size='340' side='right' caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2klx' size='340' side='right' caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. <br>	+	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KLX FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=38323 Bartonella henselae])</td></tr>		</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=38323 Bartonella henselae])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum]</span></td></tr>
	<table>		<table>
Line 23:		Line 22:
	Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens.,Leeper T, Zhang S, Van Voorhis WC, Myler PJ, Varani G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1141-7. Epub 2011 Aug 16. PMID:21904064<ref>PMID:21904064</ref>		Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens.,Leeper T, Zhang S, Van Voorhis WC, Myler PJ, Varani G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1141-7. Epub 2011 Aug 16. PMID:21904064<ref>PMID:21904064</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 09:56, 1 May 2014

2014-05-01T09:56:54Z

←Older revision		Revision as of 09:56, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2klx' size='340' side='right' caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2klx' size='340' side='right' caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. <br>	+	<table><tr><td colspan='2'>[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. <br>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">grxC, BH04010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=38323 Bartonella henselae])</td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum]</span></td></tr>
		+	<table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
-	[[Image:Consurf_key_small.gif\|right]]	+	[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
Line 15:		Line 17:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Glutaredoxin proteins (GLXRs) are essential components of the glutathione system that reductively detoxify substances such as arsenic and peroxides and are important in the synthesis of DNA via ribonucleotide reductases. NMR solution structures of glutaredoxin domains from two Gram-negative opportunistic pathogens, Brucella melitensis and Bartonella henselae, are presented. These domains lack the N-terminal helix that is frequently present in eukaryotic GLXRs. The conserved active-site cysteines adopt canonical proline/tyrosine-stabilized geometries. A difference in the angle of alpha-helix 2 relative to the beta-sheet surface and the presence of an extended loop in the human sequence suggests potential regulatory regions and/or protein-protein interaction motifs. This observation is consistent with mutations in this region that suppress defects in GLXR-ribonucleotide reductase interactions. These differences between the human and bacterial forms are adjacent to the dithiol active site and may permit species-selective drug design.		Glutaredoxin proteins (GLXRs) are essential components of the glutathione system that reductively detoxify substances such as arsenic and peroxides and are important in the synthesis of DNA via ribonucleotide reductases. NMR solution structures of glutaredoxin domains from two Gram-negative opportunistic pathogens, Brucella melitensis and Bartonella henselae, are presented. These domains lack the N-terminal helix that is frequently present in eukaryotic GLXRs. The conserved active-site cysteines adopt canonical proline/tyrosine-stabilized geometries. A difference in the angle of alpha-helix 2 relative to the beta-sheet surface and the presence of an extended loop in the human sequence suggests potential regulatory regions and/or protein-protein interaction motifs. This observation is consistent with mutations in this region that suppress defects in GLXR-ribonucleotide reductase interactions. These differences between the human and bacterial forms are adjacent to the dithiol active site and may permit species-selective drug design.
Line 21:		Line 24:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:22, 30 April 2014

2014-04-30T10:22:40Z

←Older revision		Revision as of 10:22, 30 April 2014
Line 4:		Line 4:
	[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. <br>		[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. <br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2klx RCSB], [http://www.ebi.ac.uk/pdbsum/2klx PDBsum]</span><br>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|right]]		[[Image:Consurf_key_small.gif\|right]]

OCA at 08:39, 30 April 2014

2014-04-30T08:39:47Z

←Older revision		Revision as of 08:39, 30 April 2014
Line 1:		Line 1:
-	[[Image:~~2klx~~.~~png~~\|~~left~~\|~~200px~~]]	+	==Solution structure of glutaredoxin from Bartonella henselae str. Houston==
		+	<StructureSection load='2klx' size='340' side='right' caption='[[2klx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	[[2klx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA]. <br>
		+	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2klx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	== Publication Abstract from PubMed ==
		+	Glutaredoxin proteins (GLXRs) are essential components of the glutathione system that reductively detoxify substances such as arsenic and peroxides and are important in the synthesis of DNA via ribonucleotide reductases. NMR solution structures of glutaredoxin domains from two Gram-negative opportunistic pathogens, Brucella melitensis and Bartonella henselae, are presented. These domains lack the N-terminal helix that is frequently present in eukaryotic GLXRs. The conserved active-site cysteines adopt canonical proline/tyrosine-stabilized geometries. A difference in the angle of alpha-helix 2 relative to the beta-sheet surface and the presence of an extended loop in the human sequence suggests potential regulatory regions and/or protein-protein interaction motifs. This observation is consistent with mutations in this region that suppress defects in GLXR-ribonucleotide reductase interactions. These differences between the human and bacterial forms are adjacent to the dithiol active site and may permit species-selective drug design.

-	~~<!--~~	+	Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens.,Leeper T, Zhang S, Van Voorhis WC, Myler PJ, Varani G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1141-7. Epub 2011 Aug 16. PMID:21904064<ref>PMID:21904064</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2klx"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_2klx\| PDB=2klx \| SCENE= }}~~	+

-	~~===Solution structure~~ of ~~glutaredoxin from Bartonella henselae str. Houston===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	== References ==
-		+	<references/>
-	~~<!--~~	+	__TOC__
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21904064}}, adds~~ the ~~Publication Abstract to the page~~	+	</StructureSection>
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21904064 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21904064}}~~	+
-		+
-	==~~About this Structure~~==	+
-	~~[[2klx]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Bartonella_henselae Bartonella henselae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLX OCA].~~	+
-		+
-	~~==Reference==~~	+
-	<~~ref group="xtra">PMID:021904064</ref><references group="xtra"~~/>	+
	[[Category: Bartonella henselae]]		[[Category: Bartonella henselae]]
	[[Category: Leeper, T C.]]		[[Category: Leeper, T C.]]