2kxs - Revision history

OCA at 08:07, 10 April 2024

2024-04-10T08:07:27Z

←Older revision		Revision as of 08:07, 10 April 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [https://pdbe.org/2kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [https://www.ebi.ac.uk/pdbsum/2kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxs ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [https://pdbe.org/2kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [https://www.ebi.ac.uk/pdbsum/2kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [https://www.uniprot.org/uniprot/MYZAP_HUMAN MYZAP_HUMAN] Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).		[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [https://www.uniprot.org/uniprot/MYZAP_HUMAN MYZAP_HUMAN] Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Zonula occludens (ZO)-1 is a multi-domain scaffold protein known to have critical roles in the establishment of cell-cell adhesions and the maintenance of stable tissue structures through the targeting, anchoring, and clustering of transmembrane adhesion molecules and cytoskeletal proteins. Here, we report that ZO-1 directly binds to MRCKbeta, a Cdc42 effector kinase that modulates cell protrusion and migration, at the leading edge of migrating cells. Structural studies reveal that the binding of a beta hairpin from GRINL1A converts ZO-1 ZU5 into a complete ZU5-fold. A similar interaction mode is likely to occur between ZO-1 ZU5 and MRCKbeta. The interaction between ZO-1 and MRCKbeta requires the kinase to be primed by Cdc42 due to the closed conformation of the kinase. Formation of the ZO-1/MRCKbeta complex enriches the kinase at the lamellae of migrating cells. Disruption of the ZO-1/MRCKbeta complex inhibits MRCKbeta-mediated cell migration. These results demonstrate that ZO-1, a classical scaffold protein with accepted roles in maintaining cell-cell adhesions in stable tissues, also has an active role in cell migration during processes such as tissue development and remodelling.
-
-	Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration.,Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M EMBO J. 2011 Feb 16;30(4):665-78. Epub 2011 Jan 14. PMID:21240187<ref>PMID:21240187</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2kxs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:08, 18 January 2023

2023-01-18T08:08:50Z

←Older revision		Revision as of 08:08, 18 January 2023
Line 1:		Line 1:

	==ZO1 ZU5 domain in complex with GRINL1A peptide==		==ZO1 ZU5 domain in complex with GRINL1A peptide==
-	<StructureSection load='2kxs' size='340' side='right'caption='[[2kxs~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kxs' size='340' side='right'caption='[[2kxs]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXS FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kxr\|2kxr]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [https://pdbe.org/2kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [https://www.ebi.ac.uk/pdbsum/2kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxs ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [https://pdbe.org/2kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [https://www.ebi.ac.uk/pdbsum/2kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>	+	[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [https://www.uniprot.org/uniprot/MYZAP_HUMAN MYZAP_HUMAN] Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Wen, W~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Zhang, M~~]]	+	[[Category: Wen W]]
-	[[Category: ~~Beta-barrel]]~~	+	[[Category: Zhang M]]
-	~~[[Category: Protein binding~~]]	+

OCA at 07:33, 14 April 2021

2021-04-14T07:33:43Z

←Older revision		Revision as of 07:33, 14 April 2021
Line 1:		Line 1:

	==ZO1 ZU5 domain in complex with GRINL1A peptide==		==ZO1 ZU5 domain in complex with GRINL1A peptide==
-	<StructureSection load='2kxs' size='340' side='right' caption='[[2kxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kxs' size='340' side='right'caption='[[2kxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXS FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxr\|2kxr]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kxr\|2kxr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [~~http~~://pdbe.org/2kxs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kxs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [https://pdbe.org/2kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [https://www.ebi.ac.uk/pdbsum/2kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>	+	[[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Wen, W]]		[[Category: Wen, W]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 08:07, 25 July 2018

2018-07-25T08:07:06Z

←Older revision		Revision as of 08:07, 25 July 2018
Line 1:		Line 1:
		+
	==ZO1 ZU5 domain in complex with GRINL1A peptide==		==ZO1 ZU5 domain in complex with GRINL1A peptide==
	<StructureSection load='2kxs' size='340' side='right' caption='[[2kxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kxs' size='340' side='right' caption='[[2kxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxr\|2kxr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxr\|2kxr]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [http://pdbe.org/2kxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [http://www.ebi.ac.uk/pdbsum/2kxs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [http://pdbe.org/2kxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [http://www.ebi.ac.uk/pdbsum/2kxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 13:28, 10 September 2015

2015-09-10T13:28:59Z

←Older revision		Revision as of 13:28, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2kxs' size='340' side='right' caption='[[2kxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kxs' size='340' side='right' caption='[[2kxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KXS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxr\|2kxr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxr\|2kxr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [http://www.ebi.ac.uk/pdbsum/2kxs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [http://pdbe.org/2kxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [http://www.ebi.ac.uk/pdbsum/2kxs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2kxs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Wen, W]]		[[Category: Wen, W]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 00:43, 25 December 2014

2014-12-25T00:43:48Z

←Older revision		Revision as of 00:43, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [http://www.ebi.ac.uk/pdbsum/2kxs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [http://www.ebi.ac.uk/pdbsum/2kxs PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:17, 12 November 2014

2014-11-12T08:17:57Z

←Older revision		Revision as of 08:17, 12 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2kxs.~~png~~\|~~left~~\|~~200px~~]]	+	==ZO1 ZU5 domain in complex with GRINL1A peptide==
		+	<StructureSection load='2kxs' size='340' side='right' caption='[[2kxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KXS FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kxr\|2kxr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [http://www.ebi.ac.uk/pdbsum/2kxs PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Zonula occludens (ZO)-1 is a multi-domain scaffold protein known to have critical roles in the establishment of cell-cell adhesions and the maintenance of stable tissue structures through the targeting, anchoring, and clustering of transmembrane adhesion molecules and cytoskeletal proteins. Here, we report that ZO-1 directly binds to MRCKbeta, a Cdc42 effector kinase that modulates cell protrusion and migration, at the leading edge of migrating cells. Structural studies reveal that the binding of a beta hairpin from GRINL1A converts ZO-1 ZU5 into a complete ZU5-fold. A similar interaction mode is likely to occur between ZO-1 ZU5 and MRCKbeta. The interaction between ZO-1 and MRCKbeta requires the kinase to be primed by Cdc42 due to the closed conformation of the kinase. Formation of the ZO-1/MRCKbeta complex enriches the kinase at the lamellae of migrating cells. Disruption of the ZO-1/MRCKbeta complex inhibits MRCKbeta-mediated cell migration. These results demonstrate that ZO-1, a classical scaffold protein with accepted roles in maintaining cell-cell adhesions in stable tissues, also has an active role in cell migration during processes such as tissue development and remodelling.

-	~~{{STRUCTURE_2kxs\| PDB=2kxs \| SCENE= }}~~	+	Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration.,Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M EMBO J. 2011 Feb 16;30(4):665-78. Epub 2011 Jan 14. PMID:21240187<ref>PMID:21240187</ref>

-	~~===ZO1 ZU5 domain in complex with GRINL1A peptide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21240187}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2kxs]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021240187<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Wen, W.]]	+	[[Category: Wen, W]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 13:41, 6 February 2013

2013-02-06T13:41:15Z

←Older revision		Revision as of 13:41, 6 February 2013
Line 1:		Line 1:
-	[[Image:2kxs.~~jpg~~\|left\|200px]]	+	[[Image:2kxs.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2kxs", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2kxs\| PDB=2kxs \| SCENE= }}		{{STRUCTURE_2kxs\| PDB=2kxs \| SCENE= }}

	===ZO1 ZU5 domain in complex with GRINL1A peptide===		===ZO1 ZU5 domain in complex with GRINL1A peptide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21240187}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21240187 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21240187}}		{{ABSTRACT_PUBMED_21240187}}

	==About this Structure==		==About this Structure==
-	[[2kxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens~~,_synthetic,_homo_sapiens~~ Homo ~~sapiens, synthetic, homo~~ sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA].	+	[[2kxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21240187~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021240187</ref><references group="xtra"/>
-	[[Category: Homo ~~sapiens, synthetic, homo~~ sapiens]]	+	[[Category: Homo sapiens]]
	[[Category: Wen, W.]]		[[Category: Wen, W.]]
	[[Category: Zhang, M.]]		[[Category: Zhang, M.]]
		+	[[Category: Beta-barrel]]
		+	[[Category: Protein binding]]

OCA: Protected "2kxs" [edit=sysop:move=sysop]

2011-03-30T08:08:21Z

Protected "2kxs" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:08, 30 March 2011

OCA at 08:08, 30 March 2011

2011-03-30T08:08:19Z

←Older revision		Revision as of 08:08, 30 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2kxs.jpg\|left\|200px]]

-	The ~~entry 2kxs~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2kxs", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2kxs\| PDB=2kxs \| SCENE= }}

-	~~Authors: Wen, W., Zhang, M.~~	+	===ZO1 ZU5 domain in complex with GRINL1A peptide===

-	Description: ZO1 ZU5 domain in complex with GRINL1A peptide

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed May 26 08~~:12:~~56 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21240187}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21240187 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21240187}}
		+
		+	==About this Structure==
		+	[[2kxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_synthetic,_homo_sapiens Homo sapiens, synthetic, homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21240187</ref><references group="xtra"/>
		+	[[Category: Homo sapiens, synthetic, homo sapiens]]
		+	[[Category: Wen, W.]]
		+	[[Category: Zhang, M.]]