2kz5 - Revision history

OCA at 05:37, 15 May 2024

2024-05-15T05:37:54Z

←Older revision		Revision as of 05:37, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [https://pdbe.org/2kz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2kz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz5 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [https://pdbe.org/2kz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2kz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:49, 14 June 2023

2023-06-14T08:49:46Z

←Older revision		Revision as of 08:49, 14 June 2023
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	==Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B==		==Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B==
-	<StructureSection load='2kz5' size='340' side='right'caption='[[2kz5~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kz5' size='340' side='right'caption='[[2kz5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFE2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [https://pdbe.org/2kz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2kz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz5 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [https://pdbe.org/2kz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2kz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NFE2_HUMAN NFE2_HUMAN]] Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.<ref>PMID:11154691</ref> <ref>PMID:16287851</ref>	+	[https://www.uniprot.org/uniprot/NFE2_HUMAN NFE2_HUMAN] Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.<ref>PMID:11154691</ref> <ref>PMID:16287851</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Acton~~, T B~~]]	+	[[Category: Acton TB]]
-	[[Category: Ciccosanti, C]]	+	[[Category: Ciccosanti C]]
-	[[Category: Everett~~, J K~~]]	+	[[Category: Everett JK]]
-	[[Category: Janjua, H]]	+	[[Category: Janjua H]]
-	[[Category: Liu, G]]	+	[[Category: Liu G]]
-	[[Category: Montelione~~, G T]]~~	+	[[Category: Montelione GT]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shastry R]]
-	[[Category: Shastry, R]]	+	[[Category: Tong S]]
-	[[Category: Tong, S]]	+	[[Category: Xiao R]]
-	[[Category: Xiao, R]]	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 08:31, 10 November 2021

2021-11-10T08:31:38Z

←Older revision		Revision as of 08:31, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='2kz5' size='340' side='right'caption='[[2kz5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kz5' size='340' side='right'caption='[[2kz5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFE2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFE2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [~~http~~://pdbe.org/2kz5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kz5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [https://pdbe.org/2kz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2kz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NFE2_HUMAN NFE2_HUMAN]] Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.<ref>PMID:11154691</ref> <ref>PMID:16287851</ref>	+	[[https://www.uniprot.org/uniprot/NFE2_HUMAN NFE2_HUMAN]] Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.<ref>PMID:11154691</ref> <ref>PMID:16287851</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:29, 5 February 2020

2020-02-05T08:29:03Z

←Older revision		Revision as of 08:29, 5 February 2020
Line 1:		Line 1:

	==Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B==		==Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B==
-	<StructureSection load='2kz5' size='340' side='right' caption='[[2kz5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kz5' size='340' side='right'caption='[[2kz5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Acton, T B]]		[[Category: Acton, T B]]
	[[Category: Ciccosanti, C]]		[[Category: Ciccosanti, C]]

OCA at 07:50, 25 July 2018

2018-07-25T07:50:38Z

←Older revision		Revision as of 07:50, 25 July 2018
Line 1:		Line 1:
		+
	==Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B==		==Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B==
	<StructureSection load='2kz5' size='340' side='right' caption='[[2kz5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kz5' size='340' side='right' caption='[[2kz5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [http://pdbe.org/2kz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [http://pdbe.org/2kz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/2kz5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/2kz5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kz5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 19:08, 10 September 2015

2015-09-10T19:08:01Z

←Older revision		Revision as of 19:08, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2kz5' size='340' side='right' caption='[[2kz5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kz5' size='340' side='right' caption='[[2kz5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [http://pdbe.org/2kz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Acton, T B]]		[[Category: Acton, T B]]
	[[Category: Ciccosanti, C]]		[[Category: Ciccosanti, C]]

OCA at 04:46, 25 December 2014

2014-12-25T04:46:32Z

←Older revision		Revision as of 04:46, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NFE2_HUMAN NFE2_HUMAN]] Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.<ref>PMID:11154691</ref> <ref>PMID:16287851</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 18:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Acton, T B.]]	+	[[Category: Acton, T B]]
-	[[Category: Ciccosanti, C.]]	+	[[Category: Ciccosanti, C]]
-	[[Category: Everett, J K.]]	+	[[Category: Everett, J K]]
-	[[Category: Janjua, H.]]	+	[[Category: Janjua, H]]
-	[[Category: Liu, G.]]	+	[[Category: Liu, G]]
-	[[Category: Montelione, G T~~.]]~~	+	[[Category: Montelione, G T]]
-	~~[[Category: NESG, Northeast Structural Genomics Consortium.]]~~	+
-	~~[[Category: Shastry, R.]]~~	+
-	~~[[Category: Tong, S.]]~~	+
-	~~[[Category: Xiao, R.]]~~	+
-	~~[[Category: Protein structure initiative]]~~	+
-	~~[[Category: Psi-2~~]]	+
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: Shastry, R]]
		+	[[Category: Tong, S]]
		+	[[Category: Xiao, R]]
		+	[[Category: PSI, Protein structure initiative]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 11:19, 20 October 2014

2014-10-20T11:19:50Z

←Older revision		Revision as of 11:19, 20 October 2014
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-	~~[[Image:2kz5.png\|left\|200px]]~~	+	==Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B==
-		+	<StructureSection load='2kz5' size='340' side='right' caption='[[2kz5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{STRUCTURE_2kz5\| PDB=2kz5 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br>
-	===Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B===	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz5 PDBsum]</span></td></tr>
-		+	</table>
-	==~~About this Structure~~==	+	== Evolutionary Conservation ==
-	[[2kz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA].	+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/2kz5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Acton, T B.]]		[[Category: Acton, T B.]]

OCA: Protected "2kz5" [edit=sysop:move=sysop]

2013-01-07T12:51:32Z

Protected "2kz5" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:51, 7 January 2013

OCA at 12:51, 7 January 2013

2013-01-07T12:51:27Z

←Older revision		Revision as of 12:51, 7 January 2013
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-	{{Seed}}
	[[Image:2kz5.png\|left\|200px]]		[[Image:2kz5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2kz5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2kz5\| PDB=2kz5 \| SCENE= }}		{{STRUCTURE_2kz5\| PDB=2kz5 \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~2KZ5~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA].	+	[[2kz5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Acton, T B.]]		[[Category: Acton, T B.]]
Line 30:		Line 23:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Transcription]]		[[Category: Transcription]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:53:30 2010''