2kzb - Revision history

OCA at 05:37, 15 May 2024

2024-05-15T05:37:56Z

←Older revision		Revision as of 05:37, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [https://pdbe.org/2kzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [https://www.ebi.ac.uk/pdbsum/2kzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzb ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [https://pdbe.org/2kzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [https://www.ebi.ac.uk/pdbsum/2kzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:49, 14 June 2023

2023-06-14T08:49:49Z

←Older revision		Revision as of 08:49, 14 June 2023
Line 1:		Line 1:

	==Solution structure of alpha-mannosidase binding domain of Atg19==		==Solution structure of alpha-mannosidase binding domain of Atg19==
-	<StructureSection load='2kzb' size='340' side='right'caption='[[2kzb~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kzb' size='340' side='right'caption='[[2kzb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZB FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATG19, CVT19, YOL082W, YOL01, O0980 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [https://pdbe.org/2kzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [https://www.ebi.ac.uk/pdbsum/2kzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzb ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [https://pdbe.org/2kzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [https://www.ebi.ac.uk/pdbsum/2kzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ATG19_YEAST ATG19_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Plays also a role in regulation of filamentous growth.<ref>PMID:11382752</ref> <ref>PMID:11430817</ref> <ref>PMID:12479807</ref> <ref>PMID:12479808</ref> <ref>PMID:15138258</ref> <ref>PMID:15801807</ref> <ref>PMID:16186126</ref> <ref>PMID:15659643</ref> <ref>PMID:17132049</ref> <ref>PMID:17700056</ref> <ref>PMID:17192412</ref> <ref>PMID:17238920</ref> <ref>PMID:19061865</ref> <ref>PMID:21228276</ref> <ref>PMID:19021777</ref> <ref>PMID:20659891</ref>	+	[https://www.uniprot.org/uniprot/ATG19_YEAST ATG19_YEAST] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Plays also a role in regulation of filamentous growth.<ref>PMID:11382752</ref> <ref>PMID:11430817</ref> <ref>PMID:12479807</ref> <ref>PMID:12479808</ref> <ref>PMID:15138258</ref> <ref>PMID:15801807</ref> <ref>PMID:16186126</ref> <ref>PMID:15659643</ref> <ref>PMID:17132049</ref> <ref>PMID:17700056</ref> <ref>PMID:17192412</ref> <ref>PMID:17238920</ref> <ref>PMID:19061865</ref> <ref>PMID:21228276</ref> <ref>PMID:19021777</ref> <ref>PMID:20659891</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Inagaki, F]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Kumeta, H]]	+	[[Category: Inagaki F]]
-	[[Category: Noda, N]]	+	[[Category: Kumeta H]]
-	[[Category: Ohsumi, Y]]	+	[[Category: Noda N]]
-	[[Category: Suzuki, K]]	+	[[Category: Ohsumi Y]]
-	[[Category: Watanabe, Y]]	+	[[Category: Suzuki K]]
-	~~[[Category: Alpha-mannosidase]]~~	+	[[Category: Watanabe Y]]
-	~~[[Category: Atg19]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Selective autophagy~~]]	+

OCA at 07:10, 1 December 2021

2021-12-01T07:10:33Z

←Older revision		Revision as of 07:10, 1 December 2021
Line 3:		Line 3:
	<StructureSection load='2kzb' size='340' side='right'caption='[[2kzb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kzb' size='340' side='right'caption='[[2kzb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZB FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATG19, CVT19, YOL082W, YOL01, O0980 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATG19, CVT19, YOL082W, YOL01, O0980 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [~~http~~://pdbe.org/2kzb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kzb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [https://pdbe.org/2kzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [https://www.ebi.ac.uk/pdbsum/2kzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ATG19_YEAST ATG19_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Plays also a role in regulation of filamentous growth.<ref>PMID:11382752</ref> <ref>PMID:11430817</ref> <ref>PMID:12479807</ref> <ref>PMID:12479808</ref> <ref>PMID:15138258</ref> <ref>PMID:15801807</ref> <ref>PMID:16186126</ref> <ref>PMID:15659643</ref> <ref>PMID:17132049</ref> <ref>PMID:17700056</ref> <ref>PMID:17192412</ref> <ref>PMID:17238920</ref> <ref>PMID:19061865</ref> <ref>PMID:21228276</ref> <ref>PMID:19021777</ref> <ref>PMID:20659891</ref>	+	[[https://www.uniprot.org/uniprot/ATG19_YEAST ATG19_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Plays also a role in regulation of filamentous growth.<ref>PMID:11382752</ref> <ref>PMID:11430817</ref> <ref>PMID:12479807</ref> <ref>PMID:12479808</ref> <ref>PMID:15138258</ref> <ref>PMID:15801807</ref> <ref>PMID:16186126</ref> <ref>PMID:15659643</ref> <ref>PMID:17132049</ref> <ref>PMID:17700056</ref> <ref>PMID:17192412</ref> <ref>PMID:17238920</ref> <ref>PMID:19061865</ref> <ref>PMID:21228276</ref> <ref>PMID:19021777</ref> <ref>PMID:20659891</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:45, 26 February 2020

2020-02-26T09:45:55Z

←Older revision		Revision as of 09:45, 26 February 2020
Line 1:		Line 1:

	==Solution structure of alpha-mannosidase binding domain of Atg19==		==Solution structure of alpha-mannosidase binding domain of Atg19==
-	<StructureSection load='2kzb' size='340' side='right' caption='[[2kzb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kzb' size='340' side='right'caption='[[2kzb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZB FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 2kzb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2kzb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Autophagy-related protein 3D structures\|Autophagy-related protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Inagaki, F]]		[[Category: Inagaki, F]]
	[[Category: Kumeta, H]]		[[Category: Kumeta, H]]

OCA at 14:32, 15 November 2017

2017-11-15T14:32:17Z

←Older revision		Revision as of 14:32, 15 November 2017
Line 1:		Line 1:
		+
	==Solution structure of alpha-mannosidase binding domain of Atg19==		==Solution structure of alpha-mannosidase binding domain of Atg19==
	<StructureSection load='2kzb' size='340' side='right' caption='[[2kzb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kzb' size='340' side='right' caption='[[2kzb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZB FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATG19, CVT19, YOL082W, YOL01, O0980 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATG19, CVT19, YOL082W, YOL01, O0980 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [http://pdbe.org/2kzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [http://www.ebi.ac.uk/pdbsum/2kzb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [http://pdbe.org/2kzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [http://www.ebi.ac.uk/pdbsum/2kzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 2kzb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2kzb" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Autophagy-related protein\|Autophagy-related protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:12, 11 September 2015

2015-09-11T02:12:00Z

←Older revision		Revision as of 02:12, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZB FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATG19, CVT19, YOL082W, YOL01, O0980 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATG19, CVT19, YOL082W, YOL01, O0980 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [http://www.ebi.ac.uk/pdbsum/2kzb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [http://pdbe.org/2kzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [http://www.ebi.ac.uk/pdbsum/2kzb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2kzb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Autophagy-related protein\|Autophagy-related protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:39, 25 December 2014

2014-12-25T09:39:08Z

←Older revision		Revision as of 09:39, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2kzb\| PDB=2kzb \| SCENE= }}~~	+	==Solution structure of alpha-mannosidase binding domain of Atg19==
-	===Solution structure of alpha-mannosidase binding domain of Atg19===	+	<StructureSection load='2kzb' size='340' side='right' caption='[[2kzb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_20659891}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2kzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZB FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATG19, CVT19, YOL082W, YOL01, O0980 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzb RCSB], [http://www.ebi.ac.uk/pdbsum/2kzb PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/ATG19_YEAST ATG19_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Plays also a role in regulation of filamentous growth.<ref>PMID:11382752</ref> <ref>PMID:11430817</ref> <ref>PMID:12479807</ref> <ref>PMID:12479808</ref> <ref>PMID:15138258</ref> <ref>PMID:15801807</ref> <ref>PMID:16186126</ref> <ref>PMID:15659643</ref> <ref>PMID:17132049</ref> <ref>PMID:17700056</ref> <ref>PMID:17192412</ref> <ref>PMID:17238920</ref> <ref>PMID:19061865</ref> <ref>PMID:21228276</ref> <ref>PMID:19021777</ref> <ref>PMID:20659891</ref>		[[http://www.uniprot.org/uniprot/ATG19_YEAST ATG19_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Plays also a role in regulation of filamentous growth.<ref>PMID:11382752</ref> <ref>PMID:11430817</ref> <ref>PMID:12479807</ref> <ref>PMID:12479808</ref> <ref>PMID:15138258</ref> <ref>PMID:15801807</ref> <ref>PMID:16186126</ref> <ref>PMID:15659643</ref> <ref>PMID:17132049</ref> <ref>PMID:17700056</ref> <ref>PMID:17192412</ref> <ref>PMID:17238920</ref> <ref>PMID:19061865</ref> <ref>PMID:21228276</ref> <ref>PMID:19021777</ref> <ref>PMID:20659891</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the yeast Saccharomyces cerevisiae, a precursor form of aminopeptidase I (prApe1) and alpha-mannosidase (Ams1) are selectively transported to the vacuole through the cytoplasm-to-vacuole targeting pathway under vegetative conditions and through autophagy under starvation conditions. Atg19 plays a central role in these processes by linking Ams1 and prApe1 to Atg8 and Atg11. However, little is known about the molecular mechanisms of cargo recognition by Atg19. Here, we report structural and functional analyses of Atg19 and its paralog, Atg34. A protease-resistant domain was identified in the C-terminal region of Atg19, which was also conserved in Atg34. In vitro pulldown assays showed that the C-terminal domains of both Atg19 and Atg34 are responsible for Ams1 binding; these domains are hereafter referred to as Ams1-binding domains (ABDs). The transport of Ams1, but not prApe1, was blocked in atg19Deltaatg34Delta cells expressing Atg19(DeltaABD), indicating that ABD is specifically required for Ams1 transport. We then determined the solution structures of the ABDs of Atg19 and Atg34 using NMR spectroscopy. Both ABD structures have a canonical immunoglobulin fold consisting of eight beta-strands with highly conserved loops clustered at one side of the fold. These facts, together with the results of a mutational analysis, suggest that ABD recognizes Ams1 using these conserved loops.

-	~~==About this Structure==~~	+	Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.,Watanabe Y, Noda NN, Kumeta H, Suzuki K, Ohsumi Y, Inagaki F J Biol Chem. 2010 Sep 24;285(39):30026-33. Epub 2010 Jul 21. PMID:20659891<ref>PMID:20659891</ref>
-	~~[[2kzb]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2KZB OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020659891</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
-	[[Category: Inagaki, F.]]	+	[[Category: Inagaki, F]]
-	[[Category: Kumeta, H.]]	+	[[Category: Kumeta, H]]
-	[[Category: Noda, N.]]	+	[[Category: Noda, N]]
-	[[Category: Ohsumi, Y.]]	+	[[Category: Ohsumi, Y]]
-	[[Category: Suzuki, K.]]	+	[[Category: Suzuki, K]]
-	[[Category: Watanabe, Y.]]	+	[[Category: Watanabe, Y]]
	[[Category: Alpha-mannosidase]]		[[Category: Alpha-mannosidase]]
	[[Category: Atg19]]		[[Category: Atg19]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Selective autophagy]]		[[Category: Selective autophagy]]

OCA at 13:51, 12 March 2014

2014-03-12T13:51:37Z

←Older revision		Revision as of 13:51, 12 March 2014
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-	[[Image:2kzb.png\|left\|200px]]
-
	{{STRUCTURE_2kzb\| PDB=2kzb \| SCENE= }}		{{STRUCTURE_2kzb\| PDB=2kzb \| SCENE= }}
-
	===Solution structure of alpha-mannosidase binding domain of Atg19===		===Solution structure of alpha-mannosidase binding domain of Atg19===
		+	{{ABSTRACT_PUBMED_20659891}}

-	~~{{ABSTRACT_PUBMED_020659891}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ATG19_YEAST ATG19_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Plays also a role in regulation of filamentous growth.<ref>PMID:11382752</ref> <ref>PMID:11430817</ref> <ref>PMID:12479807</ref> <ref>PMID:12479808</ref> <ref>PMID:15138258</ref> <ref>PMID:15801807</ref> <ref>PMID:16186126</ref> <ref>PMID:15659643</ref> <ref>PMID:17132049</ref> <ref>PMID:17700056</ref> <ref>PMID:17192412</ref> <ref>PMID:17238920</ref> <ref>PMID:19061865</ref> <ref>PMID:21228276</ref> <ref>PMID:19021777</ref> <ref>PMID:20659891</ref>

	==About this Structure==		==About this Structure==
-	[[2kzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA].	+	[[2kzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA].
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:020659891</ref><references group="xtra"/><references/>
		+	[[Category: Atcc 18824]]
	[[Category: Inagaki, F.]]		[[Category: Inagaki, F.]]
	[[Category: Kumeta, H.]]		[[Category: Kumeta, H.]]

OCA: Protected "2kzb" [edit=sysop:move=sysop]

2013-01-07T13:25:45Z

Protected "2kzb" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:25, 7 January 2013

OCA at 13:25, 7 January 2013

2013-01-07T13:25:41Z

←Older revision		Revision as of 13:25, 7 January 2013
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-	~~{{Seed}}~~	+	[[Image:2kzb.png\|left\|200px]]
-	[[Image:2kzb.~~jpg~~\|left\|200px]]	+

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_2kzb\| PDB=2kzb \| SCENE= }}		{{STRUCTURE_2kzb\| PDB=2kzb \| SCENE= }}

	===Solution structure of alpha-mannosidase binding domain of Atg19===		===Solution structure of alpha-mannosidase binding domain of Atg19===

		+	{{ABSTRACT_PUBMED_020659891}}

	==About this Structure==		==About this Structure==
-	~~2KZB~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA].	+	[[2kzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZB OCA].
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Inagaki, F.]]		[[Category: Inagaki, F.]]
Line 26:		Line 20:
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Selective autophagy]]		[[Category: Selective autophagy]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:13:01 2010''