2kzk - Revision history

OCA at 05:37, 15 May 2024

2024-05-15T05:37:59Z

←Older revision		Revision as of 05:37, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [https://pdbe.org/2kzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [https://www.ebi.ac.uk/pdbsum/2kzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [https://pdbe.org/2kzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [https://www.ebi.ac.uk/pdbsum/2kzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:49, 14 June 2023

2023-06-14T08:49:54Z

←Older revision		Revision as of 08:49, 14 June 2023
Line 1:		Line 1:

	==Solution structure of alpha-mannosidase binding domain of Atg34==		==Solution structure of alpha-mannosidase binding domain of Atg34==
-	<StructureSection load='2kzk' size='340' side='right'caption='[[2kzk~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2kzk' size='340' side='right'caption='[[2kzk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YOL083W, O0957 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [https://pdbe.org/2kzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [https://www.ebi.ac.uk/pdbsum/2kzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzk ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [https://pdbe.org/2kzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [https://www.ebi.ac.uk/pdbsum/2kzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ATG34_YEAST ATG34_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole.<ref>PMID:20639194</ref> <ref>PMID:20659891</ref>	+	[https://www.uniprot.org/uniprot/ATG34_YEAST ATG34_YEAST] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole.<ref>PMID:20639194</ref> <ref>PMID:20659891</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Inagaki, F]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Kumeta, H]]	+	[[Category: Inagaki F]]
-	[[Category: Noda, N]]	+	[[Category: Kumeta H]]
-	[[Category: Ohsumi, Y]]	+	[[Category: Noda N]]
-	[[Category: Suzuki, K]]	+	[[Category: Ohsumi Y]]
-	[[Category: Watanabe, Y]]	+	[[Category: Suzuki K]]
-	~~[[Category: Alpha-mannosidase]]~~	+	[[Category: Watanabe Y]]
-	~~[[Category: Atg19]]~~	+
-	~~[[Category: Atg34]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Selective autophagy~~]]	+

OCA at 07:10, 1 December 2021

2021-12-01T07:10:37Z

←Older revision		Revision as of 07:10, 1 December 2021
Line 3:		Line 3:
	<StructureSection load='2kzk' size='340' side='right'caption='[[2kzk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kzk' size='340' side='right'caption='[[2kzk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KZK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YOL083W, O0957 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YOL083W, O0957 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [~~http~~://pdbe.org/2kzk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kzk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [https://pdbe.org/2kzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [https://www.ebi.ac.uk/pdbsum/2kzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ATG34_YEAST ATG34_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole.<ref>PMID:20639194</ref> <ref>PMID:20659891</ref>	+	[[https://www.uniprot.org/uniprot/ATG34_YEAST ATG34_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole.<ref>PMID:20639194</ref> <ref>PMID:20659891</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:46, 26 February 2020

2020-02-26T09:46:05Z

←Older revision		Revision as of 09:46, 26 February 2020
Line 1:		Line 1:

	==Solution structure of alpha-mannosidase binding domain of Atg34==		==Solution structure of alpha-mannosidase binding domain of Atg34==
-	<StructureSection load='2kzk' size='340' side='right' caption='[[2kzk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2kzk' size='340' side='right'caption='[[2kzk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZK FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Inagaki, F]]		[[Category: Inagaki, F]]
	[[Category: Kumeta, H]]		[[Category: Kumeta, H]]

OCA at 14:32, 15 November 2017

2017-11-15T14:32:28Z

←Older revision		Revision as of 14:32, 15 November 2017
Line 1:		Line 1:
		+
	==Solution structure of alpha-mannosidase binding domain of Atg34==		==Solution structure of alpha-mannosidase binding domain of Atg34==
	<StructureSection load='2kzk' size='340' side='right' caption='[[2kzk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kzk' size='340' side='right' caption='[[2kzk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZK FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YOL083W, O0957 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YOL083W, O0957 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [http://pdbe.org/2kzk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [http://www.ebi.ac.uk/pdbsum/2kzk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [http://pdbe.org/2kzk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [http://www.ebi.ac.uk/pdbsum/2kzk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 05:38, 10 September 2015

2015-09-10T05:38:54Z

←Older revision		Revision as of 05:38, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZK FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YOL083W, O0957 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YOL083W, O0957 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [http://www.ebi.ac.uk/pdbsum/2kzk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [http://pdbe.org/2kzk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [http://www.ebi.ac.uk/pdbsum/2kzk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2kzk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:47, 24 December 2014

2014-12-24T18:47:08Z

←Older revision		Revision as of 18:47, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [http://www.ebi.ac.uk/pdbsum/2kzk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [http://www.ebi.ac.uk/pdbsum/2kzk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATG34_YEAST ATG34_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole.<ref>PMID:20639194</ref> <ref>PMID:20659891</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 05:25, 22 December 2014

2014-12-22T05:25:20Z

←Older revision		Revision as of 05:25, 22 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2kzk\| PDB=2kzk \| SCENE= }}~~	+	==Solution structure of alpha-mannosidase binding domain of Atg34==
-	===Solution structure of alpha-mannosidase binding domain of Atg34===	+	<StructureSection load='2kzk' size='340' side='right' caption='[[2kzk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_20659891}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2kzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZK FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YOL083W, O0957 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzk RCSB], [http://www.ebi.ac.uk/pdbsum/2kzk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the yeast Saccharomyces cerevisiae, a precursor form of aminopeptidase I (prApe1) and alpha-mannosidase (Ams1) are selectively transported to the vacuole through the cytoplasm-to-vacuole targeting pathway under vegetative conditions and through autophagy under starvation conditions. Atg19 plays a central role in these processes by linking Ams1 and prApe1 to Atg8 and Atg11. However, little is known about the molecular mechanisms of cargo recognition by Atg19. Here, we report structural and functional analyses of Atg19 and its paralog, Atg34. A protease-resistant domain was identified in the C-terminal region of Atg19, which was also conserved in Atg34. In vitro pulldown assays showed that the C-terminal domains of both Atg19 and Atg34 are responsible for Ams1 binding; these domains are hereafter referred to as Ams1-binding domains (ABDs). The transport of Ams1, but not prApe1, was blocked in atg19Deltaatg34Delta cells expressing Atg19(DeltaABD), indicating that ABD is specifically required for Ams1 transport. We then determined the solution structures of the ABDs of Atg19 and Atg34 using NMR spectroscopy. Both ABD structures have a canonical immunoglobulin fold consisting of eight beta-strands with highly conserved loops clustered at one side of the fold. These facts, together with the results of a mutational analysis, suggest that ABD recognizes Ams1 using these conserved loops.

-	~~==Function==~~	+	Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.,Watanabe Y, Noda NN, Kumeta H, Suzuki K, Ohsumi Y, Inagaki F J Biol Chem. 2010 Sep 24;285(39):30026-33. Epub 2010 Jul 21. PMID:20659891<ref>PMID:20659891</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/ATG34_YEAST ATG34_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport~~ (~~Cvt~~) ~~and in autophagy~~. ~~Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole~~.~~<ref>~~PMID:~~20639194</ref>~~ <ref>PMID:20659891</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2kzk]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Atcc_18824 Atcc 18824]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020659891</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
-	[[Category: Inagaki, F.]]	+	[[Category: Inagaki, F]]
-	[[Category: Kumeta, H.]]	+	[[Category: Kumeta, H]]
-	[[Category: Noda, N.]]	+	[[Category: Noda, N]]
-	[[Category: Ohsumi, Y.]]	+	[[Category: Ohsumi, Y]]
-	[[Category: Suzuki, K.]]	+	[[Category: Suzuki, K]]
-	[[Category: Watanabe, Y.]]	+	[[Category: Watanabe, Y]]
	[[Category: Alpha-mannosidase]]		[[Category: Alpha-mannosidase]]
	[[Category: Atg19]]		[[Category: Atg19]]

OCA at 13:48, 12 March 2014

2014-03-12T13:48:30Z

←Older revision		Revision as of 13:48, 12 March 2014
Line 1:		Line 1:
-	[[Image:2kzk.png\|left\|200px]]
-
	{{STRUCTURE_2kzk\| PDB=2kzk \| SCENE= }}		{{STRUCTURE_2kzk\| PDB=2kzk \| SCENE= }}
-
	===Solution structure of alpha-mannosidase binding domain of Atg34===		===Solution structure of alpha-mannosidase binding domain of Atg34===
		+	{{ABSTRACT_PUBMED_20659891}}

-	~~{{ABSTRACT_PUBMED_020659891}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ATG34_YEAST ATG34_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole.<ref>PMID:20639194</ref> <ref>PMID:20659891</ref>

	==About this Structure==		==About this Structure==
-	[[2kzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA].	+	[[2kzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZK OCA].
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:020659891</ref><references group="xtra"/><references/>
		+	[[Category: Atcc 18824]]
	[[Category: Inagaki, F.]]		[[Category: Inagaki, F.]]
	[[Category: Kumeta, H.]]		[[Category: Kumeta, H.]]

OCA: Protected "2kzk" [edit=sysop:move=sysop]

2013-01-07T11:45:43Z

Protected "2kzk" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:45, 7 January 2013