2l3y - Revision history

OCA at 08:17, 18 January 2023

2023-01-18T08:17:30Z

←Older revision		Revision as of 08:17, 18 January 2023
Line 1:		Line 1:

	==Solution structure of mouse IL-6==		==Solution structure of mouse IL-6==
-	<StructureSection load='2l3y' size='340' side='right'caption='[[2l3y~~]], [[NMR_Ensembles_of_Models \| 52 NMR models~~]]' scene=''>	+	<StructureSection load='2l3y' size='340' side='right'caption='[[2l3y]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il6, Il-6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [https://pdbe.org/2l3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [https://www.ebi.ac.uk/pdbsum/2l3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3y ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [https://pdbe.org/2l3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [https://www.ebi.ac.uk/pdbsum/2l3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3y ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IL6_MOUSE IL6_MOUSE]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.<ref>PMID:16990136</ref>	+	[https://www.uniprot.org/uniprot/IL6_MOUSE IL6_MOUSE] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.<ref>PMID:16990136</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Carr~~, M D~~]]	+	[[Category: Carr MD]]
-	[[Category: Carrington, B]]	+	[[Category: Carrington B]]
-	[[Category: Henry~~, A J~~]]	+	[[Category: Henry AJ]]
-	[[Category: Muskett~~, F W~~]]	+	[[Category: Muskett FW]]
-	[[Category: Redpath~~, N T~~]]	+	[[Category: Redpath NT]]
-	[[Category: Taylor~~, R J~~]]	+	[[Category: Taylor RJ]]
-	[[Category: Veverka, V]]	+	[[Category: Veverka V]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Gp-130]]~~	+
-	~~[[Category: Interleukin]]~~	+
-	~~[[Category: Signaling]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:36, 14 April 2021

2021-04-14T07:36:03Z

←Older revision		Revision as of 07:36, 14 April 2021
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Solution structure of mouse IL-6==		==Solution structure of mouse IL-6==
-	<StructureSection load='2l3y' size='340' side='right' caption='[[2l3y]], [[NMR_Ensembles_of_Models \| 52 NMR models]]' scene=''>	+	<StructureSection load='2l3y' size='340' side='right'caption='[[2l3y]], [[NMR_Ensembles_of_Models \| 52 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il6, Il-6 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il6, Il-6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [~~http~~://pdbe.org/2l3y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2l3y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [https://pdbe.org/2l3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [https://www.ebi.ac.uk/pdbsum/2l3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3y ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IL6_MOUSE IL6_MOUSE]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.<ref>PMID:16990136</ref>	+	[[https://www.uniprot.org/uniprot/IL6_MOUSE IL6_MOUSE]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.<ref>PMID:16990136</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Interleukin\|Interleukin]]	+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Carr, M D]]		[[Category: Carr, M D]]

OCA at 19:53, 1 August 2018

2018-08-01T19:53:57Z

←Older revision		Revision as of 19:53, 1 August 2018
Line 1:		Line 1:
		+	{{Large structure}}
	==Solution structure of mouse IL-6==		==Solution structure of mouse IL-6==
	<StructureSection load='2l3y' size='340' side='right' caption='[[2l3y]], [[NMR_Ensembles_of_Models \| 52 NMR models]]' scene=''>		<StructureSection load='2l3y' size='340' side='right' caption='[[2l3y]], [[NMR_Ensembles_of_Models \| 52 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il6, Il-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il6, Il-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [http://pdbe.org/2l3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [http://www.ebi.ac.uk/pdbsum/2l3y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [http://pdbe.org/2l3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [http://www.ebi.ac.uk/pdbsum/2l3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3y ProSAT]</span></td></tr>
	</table>		</table>
	{{Large structure}}		{{Large structure}}

OCA at 05:47, 10 September 2015

2015-09-10T05:47:40Z

←Older revision		Revision as of 05:47, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2l3y' size='340' side='right' caption='[[2l3y]], [[NMR_Ensembles_of_Models \| 52 NMR models]]' scene=''>		<StructureSection load='2l3y' size='340' side='right' caption='[[2l3y]], [[NMR_Ensembles_of_Models \| 52 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il6, Il-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il6, Il-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [http://www.ebi.ac.uk/pdbsum/2l3y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [http://pdbe.org/2l3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [http://www.ebi.ac.uk/pdbsum/2l3y PDBsum]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/IL6_MOUSE IL6_MOUSE]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.<ref>PMID:16990136</ref>		[[http://www.uniprot.org/uniprot/IL6_MOUSE IL6_MOUSE]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.<ref>PMID:16990136</ref>
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2l3y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Carr, M D]]		[[Category: Carr, M D]]
	[[Category: Carrington, B]]		[[Category: Carrington, B]]

OCA at 18:54, 24 December 2014

2014-12-24T18:54:42Z

←Older revision		Revision as of 18:54, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [http://www.ebi.ac.uk/pdbsum/2l3y PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [http://www.ebi.ac.uk/pdbsum/2l3y PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IL6_MOUSE IL6_MOUSE]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.<ref>PMID:16990136</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:57, 17 December 2014

2014-12-17T13:57:05Z

←Older revision		Revision as of 13:57, 17 December 2014
Line 1:		Line 1:
-	~~{{Large~~ structure}}	+	==Solution structure of mouse IL-6==
-	~~{{STRUCTURE_2l3y\| PDB~~=2l3y \| ~~SCENE~~= }}	+	<StructureSection load='2l3y' size='340' side='right' caption='[[2l3y]], [[NMR_Ensembles_of_Models \| 52 NMR models]]' scene=''>
-	===~~Solution~~ structure ~~of mouse IL~~-6===	+	== Structural highlights ==
-	~~{{ABSTRACT_PUBMED_23027872}}~~	+	<table><tr><td colspan='2'>[[2l3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3Y FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Il6, Il-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l3y RCSB], [http://www.ebi.ac.uk/pdbsum/2l3y PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A number of secreted cytokines, such as interleukin-6 (IL-6), are attractive targets for the treatment of inflammatory diseases. We have determined the solution structure of mouse IL-6 to assess the functional significance of apparent differences in the receptor interaction sites (IL-6Ralpha and gp130) suggested by the fairly low degree of sequence similarity with human IL-6. Structure-based sequence alignment of mouse IL-6 and human IL-6 revealed surprising differences in the conservation of the two distinct gp130 binding sites (IIa and IIIa), which suggests a primacy for site III-mediated interactions in driving initial assembly of the IL-6/IL-6Ralpha/gp130 ternary complex. This is further supported by a series of direct binding experiments, which clearly demonstrate a high affinity IL-6/IL-6Ralpha-gp130 interaction via site III but only weak binding via site II. Collectively, our findings suggest a pathway for the evolution of the hexameric, IL-6/IL-6Ralpha/gp130 signaling complex and strategies for therapeutic targeting. We propose that the signaling complex originally involved specific interactions between IL-6 and IL-6Ralpha (site I) and between the D1 domain of gp130 and IL-6/IL-6Ralpha (site III), with the later inclusion of interactions between the D2 and D3 domains of gp130 and IL-6/IL-6Ralpha (site II) through serendipity. It seems likely that IL-6 signaling benefited from the evolution of a multipurpose, nonspecific protein interaction surface on gp130, now known as the cytokine binding homology region (site II contact surface), which fortuitously contributes to stabilization of the IL-6/IL-6Ralpha/gp130 signaling complex.

-	~~==About this Structure==~~	+	Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.,Veverka V, Baker T, Redpath NT, Carrington B, Muskett FW, Taylor RJ, Lawson AD, Henry AJ, Carr MD J Biol Chem. 2012 Nov 16;287(47):40043-50. doi: 10.1074/jbc.M112.405597. Epub, 2012 Oct 1. PMID:23027872<ref>PMID:23027872</ref>
-	~~[[2l3y]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2L3Y OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Interleukin\|Interleukin]]		*[[Interleukin\|Interleukin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Carr, M D.]]	+	[[Category: Carr, M D]]
-	[[Category: Carrington, B.]]	+	[[Category: Carrington, B]]
-	[[Category: Henry, A J.]]	+	[[Category: Henry, A J]]
-	[[Category: Muskett, F W.]]	+	[[Category: Muskett, F W]]
-	[[Category: Redpath, N T.]]	+	[[Category: Redpath, N T]]
-	[[Category: Taylor, R J.]]	+	[[Category: Taylor, R J]]
-	[[Category: Veverka, V.]]	+	[[Category: Veverka, V]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Gp-130]]		[[Category: Gp-130]]

OCA at 08:26, 11 March 2013

2013-03-11T08:26:13Z

←Older revision		Revision as of 08:26, 11 March 2013
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-	~~[[Image:2l3y.png\|left\|200px]]~~	+	{{Large structure}}
-		+
	{{STRUCTURE_2l3y\| PDB=2l3y \| SCENE= }}		{{STRUCTURE_2l3y\| PDB=2l3y \| SCENE= }}
-
	===Solution structure of mouse IL-6===		===Solution structure of mouse IL-6===
-
	{{ABSTRACT_PUBMED_23027872}}		{{ABSTRACT_PUBMED_23027872}}

OCA at 09:37, 21 November 2012

2012-11-21T09:37:16Z

←Older revision		Revision as of 09:37, 21 November 2012
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	===Solution structure of mouse IL-6===		===Solution structure of mouse IL-6===

		+	{{ABSTRACT_PUBMED_23027872}}

	==About this Structure==		==About this Structure==

OCA at 08:08, 20 October 2012

2012-10-20T08:08:50Z

←Older revision		Revision as of 08:08, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2l3y]] is a 1 chain structure ~~of [[Interleukin]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA].	+	[[2l3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA].

	==See Also==		==See Also==

OCA at 18:36, 25 July 2012

2012-07-25T18:36:08Z

←Older revision		Revision as of 18:36, 25 July 2012
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-	[[Image:2l3y.~~jpg~~\|left\|200px]]	+	[[Image:2l3y.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2l3y", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2l3y\| PDB=2l3y \| SCENE= }}		{{STRUCTURE_2l3y\| PDB=2l3y \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	[[2l3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA].	+	[[2l3y]] is a 1 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3Y OCA].
		+
		+	==See Also==
		+	*[[Interleukin\|Interleukin]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Carr, M D.]]		[[Category: Carr, M D.]]