2lah - Revision history

OCA at 05:40, 15 May 2024

2024-05-15T05:40:46Z

←Older revision		Revision as of 05:40, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LAH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [https://pdbe.org/2lah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [https://www.ebi.ac.uk/pdbsum/2lah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lah ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [https://pdbe.org/2lah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [https://www.ebi.ac.uk/pdbsum/2lah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:28, 18 January 2023

2023-01-18T08:28:41Z

←Older revision		Revision as of 08:28, 18 January 2023
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	==Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)==		==Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)==
-	<StructureSection load='2lah' size='340' side='right'caption='[[2lah~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lah' size='340' side='right'caption='[[2lah]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LAH FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BUB1, BUB1L ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [https://pdbe.org/2lah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [https://www.ebi.ac.uk/pdbsum/2lah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lah ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [https://pdbe.org/2lah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [https://www.ebi.ac.uk/pdbsum/2lah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lah ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BUB1_HUMAN BUB1_HUMAN]] Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.<ref>PMID:10198256</ref> <ref>PMID:15020684</ref> <ref>PMID:15525512</ref> <ref>PMID:15723797</ref> <ref>PMID:16760428</ref> <ref>PMID:17158872</ref> <ref>PMID:19487456</ref>	+	[https://www.uniprot.org/uniprot/BUB1_HUMAN BUB1_HUMAN] Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.<ref>PMID:10198256</ref> <ref>PMID:15020684</ref> <ref>PMID:15525512</ref> <ref>PMID:15723797</ref> <ref>PMID:16760428</ref> <ref>PMID:17158872</ref> <ref>PMID:19487456</ref>

	==See Also==		==See Also==
Line 17:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Non-specific serine/threonine protein kinase~~]]	+	[[Category: Acton TB]]
-	[[Category: ~~Acton, T B~~]]	+	[[Category: Ciccosanti C]]
-	[[Category: ~~Ciccosanti, C~~]]	+	[[Category: Everett JK]]
		+	[[Category: Hamilton K]]
		+	[[Category: Huang YJ]]
		+	[[Category: Lee H]]
		+	[[Category: Liu G]]
		+	[[Category: Montelione GT]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-	~~[[Category: Everett, J K]]~~	+	[[Category: Shastry RT]]
-	~~[[Category: Hamilton, K]]~~	+	[[Category: Xiao R]]
-	~~[[Category: Huang, Y J]]~~	+
-	~~[[Category: Lee, H]]~~	+
-	~~[[Category: Liu, G]]~~	+
-	~~[[Category: Montelione, G T]]~~	+
-	[[Category: Shastry~~, R T~~]]	+
-	[[Category: Xiao, R]]	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Methods development]]~~	+
-	~~[[Category: Protein nmr]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Target hr5460a~~]]	+

OCA at 07:39, 14 April 2021

2021-04-14T07:39:15Z

←Older revision		Revision as of 07:39, 14 April 2021
Line 1:		Line 1:

	==Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)==		==Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)==
-	<StructureSection load='2lah' size='340' side='right' caption='[[2lah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lah' size='340' side='right'caption='[[2lah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lah]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LAH FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BUB1, BUB1L ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BUB1, BUB1L ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [~~http~~://pdbe.org/2lah PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lah PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lah ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [https://pdbe.org/2lah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [https://www.ebi.ac.uk/pdbsum/2lah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BUB1_HUMAN BUB1_HUMAN]] Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.<ref>PMID:10198256</ref> <ref>PMID:15020684</ref> <ref>PMID:15525512</ref> <ref>PMID:15723797</ref> <ref>PMID:16760428</ref> <ref>PMID:17158872</ref> <ref>PMID:19487456</ref>	+	[[https://www.uniprot.org/uniprot/BUB1_HUMAN BUB1_HUMAN]] Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.<ref>PMID:10198256</ref> <ref>PMID:15020684</ref> <ref>PMID:15525512</ref> <ref>PMID:15723797</ref> <ref>PMID:16760428</ref> <ref>PMID:17158872</ref> <ref>PMID:19487456</ref>

	==See Also==		==See Also==
-	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]	+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Acton, T B]]		[[Category: Acton, T B]]

OCA at 19:21, 1 August 2018

2018-08-01T19:21:53Z

←Older revision		Revision as of 19:21, 1 August 2018
Line 1:		Line 1:
		+
	==Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)==		==Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)==
	<StructureSection load='2lah' size='340' side='right' caption='[[2lah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lah' size='340' side='right' caption='[[2lah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BUB1, BUB1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BUB1, BUB1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [http://pdbe.org/2lah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [http://www.ebi.ac.uk/pdbsum/2lah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [http://pdbe.org/2lah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [http://www.ebi.ac.uk/pdbsum/2lah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:29, 10 September 2015

2015-09-10T21:29:27Z

←Older revision		Revision as of 21:29, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2lah' size='340' side='right' caption='[[2lah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lah' size='340' side='right' caption='[[2lah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LAH FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BUB1, BUB1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BUB1, BUB1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [http://www.ebi.ac.uk/pdbsum/2lah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [http://pdbe.org/2lah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [http://www.ebi.ac.uk/pdbsum/2lah PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Acton, T B]]		[[Category: Acton, T B]]

OCA at 06:20, 25 December 2014

2014-12-25T06:20:00Z

←Older revision		Revision as of 06:20, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [http://www.ebi.ac.uk/pdbsum/2lah PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [http://www.ebi.ac.uk/pdbsum/2lah PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BUB1_HUMAN BUB1_HUMAN]] Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.<ref>PMID:10198256</ref> <ref>PMID:15020684</ref> <ref>PMID:15525512</ref> <ref>PMID:15723797</ref> <ref>PMID:16760428</ref> <ref>PMID:17158872</ref> <ref>PMID:19487456</ref>

	==See Also==		==See Also==
	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]		*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:50, 17 December 2014

2014-12-17T13:50:08Z

←Older revision		Revision as of 13:50, 17 December 2014
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-	~~{{STRUCTURE_2lah\| PDB=2lah \| SCENE= }}~~	+	==Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)==
-	===Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)===	+	<StructureSection load='2lah' size='340' side='right' caption='[[2lah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LAH FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BUB1, BUB1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lah RCSB], [http://www.ebi.ac.uk/pdbsum/2lah PDBsum]</span></td></tr>
		+	</table>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~2lah]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA].~~	+	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Acton, T B.]]	+	[[Category: Acton, T B]]
-	[[Category: Ciccosanti, C.]]	+	[[Category: Ciccosanti, C]]
-	[[Category: ~~Consortium, n Northeast~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Everett, J K.]]	+	[[Category: Everett, J K]]
-	[[Category: Hamilton, K.]]	+	[[Category: Hamilton, K]]
-	[[Category: Huang, Y J.]]	+	[[Category: Huang, Y J]]
-	[[Category: Lee, H.]]	+	[[Category: Lee, H]]
-	[[Category: Liu, G.]]	+	[[Category: Liu, G]]
-	[[Category: Montelione, G T~~.]]~~	+	[[Category: Montelione, G T]]
-	~~[[Category: NESG, Northeast Structural Genomics Consortium.~~]]	+	[[Category: Shastry, R T]]
-	[[Category: Shastry, R T.]]	+	[[Category: Xiao, R]]
-	[[Category: Xiao, R.]]	+
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Methods development]]		[[Category: Methods development]]
	[[Category: Protein nmr]]		[[Category: Protein nmr]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
	[[Category: Psi-biology]]		[[Category: Psi-biology]]
-	[[Category: Structural genomic]]
	[[Category: Target hr5460a]]		[[Category: Target hr5460a]]

OCA at 10:44, 13 March 2013

2013-03-13T10:44:09Z

←Older revision		Revision as of 10:44, 13 March 2013
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-	[[Image:2lah.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2lah", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2lah\| PDB=2lah \| SCENE= }}		{{STRUCTURE_2lah\| PDB=2lah \| SCENE= }}
-
	===Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)===		===Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)===
-

	==About this Structure==		==About this Structure==
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	[[Category: Shastry, R T.]]		[[Category: Shastry, R T.]]
	[[Category: Xiao, R.]]		[[Category: Xiao, R.]]
		+	[[Category: Apoptosis]]
		+	[[Category: Cell cycle]]
		+	[[Category: Methods development]]
		+	[[Category: Protein nmr]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-biology]]
		+	[[Category: Structural genomic]]
		+	[[Category: Target hr5460a]]

OCA at 04:46, 12 May 2011

2011-05-12T04:46:39Z

←Older revision		Revision as of 04:46, 12 May 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:2lah.jpg\|left\|200px]]

-	The ~~entry 2lah~~ is ~~ON HOLD~~ ~~until May 09 2012~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2lah", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2lah\| PDB=2lah \| SCENE= }}

-	~~Authors: Liu, G., Xiao, R., Lee, H., Hamilton, K., Acton, T.B., Ciccosanti, C., Everett, J.K., Shastry, R.T., Huang, Y.J., Montelione, G.T., Northeast Structural Genomics Consortium, n.~~, Northeast Structural Genomics Consortium (~~NESG~~)	+	===Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)===

-	~~Description: Solution NMR~~ Structure ~~of Mitotic checkpoint~~ serine/threonine-protein kinase ~~BUB1 N-terminal domain from Homo sapiens~~, Northeast Structural Genomics Consortium ~~Target HR5460A (Methods Development)~~	+
		+	==About this Structure==
		+	[[2lah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAH OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Acton, T B.]]
		+	[[Category: Ciccosanti, C.]]
		+	[[Category: Consortium, n Northeast Structural Genomics.]]
		+	[[Category: Everett, J K.]]
		+	[[Category: Hamilton, K.]]
		+	[[Category: Huang, Y J.]]
		+	[[Category: Lee, H.]]
		+	[[Category: Liu, G.]]
		+	[[Category: Montelione, G T.]]
		+	[[Category: NESG, Northeast Structural Genomics Consortium.]]
		+	[[Category: Shastry, R T.]]
		+	[[Category: Xiao, R.]]

OCA at 08:23, 6 April 2011

2011-04-06T08:23:20Z

←Older revision		Revision as of 08:23, 6 April 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lah is ON HOLD	+	The entry 2lah is ON HOLD until May 09 2012

-	Authors: Liu, G., Xiao, R., Lee, H., Hamilton, K., Acton, T.B., Ciccosanti, C., Everett, J.K., Shastry, R.T., Huang, Y.J., Montelione, G.T., Northeast Structural Genomics Consortium, n.	+	Authors: Liu, G., Xiao, R., Lee, H., Hamilton, K., Acton, T.B., Ciccosanti, C., Everett, J.K., Shastry, R.T., Huang, Y.J., Montelione, G.T., Northeast Structural Genomics Consortium, n., Northeast Structural Genomics Consortium (NESG)

-	Description: Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (~~CASP Target~~)	+	Description: Solution NMR Structure of Mitotic checkpoint serine/threonine-protein kinase BUB1 N-terminal domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR5460A (Methods Development)