2lc5 - Revision history

OCA at 06:55, 1 May 2024

2024-05-01T06:55:04Z

←Older revision		Revision as of 06:55, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS Entamoeba histolytica HM-1:IMSS]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS Entamoeba histolytica HM-1:IMSS]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [https://pdbe.org/2lc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [https://pdbe.org/2lc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/C4M0U8_ENTH1 C4M0U8_ENTH1]		[https://www.uniprot.org/uniprot/C4M0U8_ENTH1 C4M0U8_ENTH1]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The mechanism of Ca(2+)-signaling in the protozoan parasite Entamoeba histolytica is yet to be understood as many of the key regulators are still to be identified. E. histolytica encodes a number of multi-EF-hand Ca(2+)-binding proteins (EhCaBPs). Functionally only one of these molecules, EhCaBP1, has been characterized to date. The calmodulin-like protein from E. histolytica (abbreviated as EhCaM or EhCaBP3) is a 17.23 kDa monomeric protein that shows maximum sequence identity with heterologous calmodulins (CaMs). Though CaM activity has been biochemically shown in E. histolytica, there are no reports on the presence of a typical CaM. In an attempt to understand the structural and functional similarity of EhCaM with CaM, we have determined the three-dimensional (3D) solution structure of EhCaM using NMR. The EhCaM has a well-folded N-terminal domain and an unstructured C-terminal counterpart. Further, it sequentially binds only two calcium ions, an unusual mode of Ca(2+)-binding among the known CaBPs, notably both in the N-terminal domain of EhCaM. Further, EhCaM is present in the nucleus in addition to the cytoplasm as detected by immunofluorescence staining, unlike other EhCaBPs that are detected only in the cytoplasm. Therefore, this protein is likely to have a different function. The presence of unusual and a diverse set of CaBPs in E. histolytica suggests a distinct Ca(2+)-signaling process in E. histolytica. The results reported here help in understanding the structure-function relationship of CaBPs including their Ca(2+)-binding properties.
-
-	Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein.,Rout AK, Padhan N, Barnwal RP, Bhattacharya A, Chary KV Biochemistry. 2010 Dec 21. PMID:21114322<ref>PMID:21114322</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2lc5" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:31, 18 January 2023

2023-01-18T08:31:50Z

←Older revision		Revision as of 08:31, 18 January 2023
Line 1:		Line 1:

	==Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein==		==Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein==
-	<StructureSection load='2lc5' size='340' side='right'caption='[[2lc5~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lc5' size='340' side='right'caption='[[2lc5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Entamoeba_histolytica_hm~~-1:~~imss~~ Entamoeba histolytica hm-1:~~imss~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS Entamoeba histolytica HM-1:IMSS]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHI_100270 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294381 Entamoeba histolytica HM-1:IMSS])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [https://pdbe.org/2lc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [https://pdbe.org/2lc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C4M0U8_ENTH1 C4M0U8_ENTH1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Entamoeba histolytica hm-1:~~imss~~]]	+	[[Category: Entamoeba histolytica HM-1:IMSS]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barnwal~~, R P~~]]	+	[[Category: Barnwal RP]]
-	[[Category: Bhattacharya, A]]	+	[[Category: Bhattacharya A]]
-	[[Category: Chary~~, K V~~]]	+	[[Category: Chary KV]]
-	[[Category: Padhan, N]]	+	[[Category: Padhan N]]
-	[[Category: Rout~~, A K]]~~	+	[[Category: Rout AK]]
-	~~[[Category: Ca-binding protein]]~~	+
-	~~[[Category: Cam-like]]~~	+
-	~~[[Category: Ehcam]]~~	+
-	~~[[Category: Entamoeba histolytica]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Partially structured protein~~]]	+

OCA at 07:40, 14 April 2021

2021-04-14T07:40:18Z

←Older revision		Revision as of 07:40, 14 April 2021
Line 1:		Line 1:

	==Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein==		==Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein==
-	<StructureSection load='2lc5' size='340' side='right' caption='[[2lc5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lc5' size='340' side='right'caption='[[2lc5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lc5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Entamoeba_histolytica_hm-1:imss Entamoeba histolytica hm-1:imss]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LC5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_hm-1:imss Entamoeba histolytica hm-1:imss]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHI_100270 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294381 Entamoeba histolytica HM-1:IMSS])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHI_100270 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294381 Entamoeba histolytica HM-1:IMSS])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [~~http~~://pdbe.org/2lc5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lc5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [https://pdbe.org/2lc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Entamoeba histolytica hm-1:imss]]		[[Category: Entamoeba histolytica hm-1:imss]]
		+	[[Category: Large Structures]]
	[[Category: Barnwal, R P]]		[[Category: Barnwal, R P]]
	[[Category: Bhattacharya, A]]		[[Category: Bhattacharya, A]]

OCA at 19:57, 1 August 2018

2018-08-01T19:57:32Z

←Older revision		Revision as of 19:57, 1 August 2018
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHI_100270 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294381 Entamoeba histolytica HM-1:IMSS])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHI_100270 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294381 Entamoeba histolytica HM-1:IMSS])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [http://pdbe.org/2lc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [http://pdbe.org/2lc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:09, 10 May 2016

2016-05-10T17:09:09Z

←Older revision		Revision as of 17:09, 10 May 2016
Line 1:		Line 1:
		+
	==Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein==		==Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein==
	<StructureSection load='2lc5' size='340' side='right' caption='[[2lc5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lc5' size='340' side='right' caption='[[2lc5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>

OCA at 21:10, 10 September 2015

2015-09-10T21:10:54Z

←Older revision		Revision as of 21:10, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2lc5' size='340' side='right' caption='[[2lc5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lc5' size='340' side='right' caption='[[2lc5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Entamoeba_histolytica~~ Entamoeba histolytica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LC5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entamoeba_histolytica_hm-1:imss Entamoeba histolytica hm-1:imss]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LC5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHI_100270 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~5759~~ Entamoeba histolytica])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHI_100270 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294381 Entamoeba histolytica HM-1:IMSS])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [http://pdbe.org/2lc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc5 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lc5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Entamoeba histolytica]]	+	[[Category: Entamoeba histolytica hm-1:imss]]
	[[Category: Barnwal, R P]]		[[Category: Barnwal, R P]]
	[[Category: Bhattacharya, A]]		[[Category: Bhattacharya, A]]
Line 28:		Line 29:
	[[Category: Cam-like]]		[[Category: Cam-like]]
	[[Category: Ehcam]]		[[Category: Ehcam]]
		+	[[Category: Entamoeba histolytica]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]
	[[Category: Partially structured protein]]		[[Category: Partially structured protein]]

OCA at 05:54, 22 December 2014

2014-12-22T05:54:42Z

←Older revision		Revision as of 05:54, 22 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2lc5\| PDB=2lc5 \| SCENE= }}~~	+	==Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein==
-	===Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein===	+	<StructureSection load='2lc5' size='340' side='right' caption='[[2lc5]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_21114322}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LC5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHI_100270 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5759 Entamoeba histolytica])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lc5 RCSB], [http://www.ebi.ac.uk/pdbsum/2lc5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mechanism of Ca(2+)-signaling in the protozoan parasite Entamoeba histolytica is yet to be understood as many of the key regulators are still to be identified. E. histolytica encodes a number of multi-EF-hand Ca(2+)-binding proteins (EhCaBPs). Functionally only one of these molecules, EhCaBP1, has been characterized to date. The calmodulin-like protein from E. histolytica (abbreviated as EhCaM or EhCaBP3) is a 17.23 kDa monomeric protein that shows maximum sequence identity with heterologous calmodulins (CaMs). Though CaM activity has been biochemically shown in E. histolytica, there are no reports on the presence of a typical CaM. In an attempt to understand the structural and functional similarity of EhCaM with CaM, we have determined the three-dimensional (3D) solution structure of EhCaM using NMR. The EhCaM has a well-folded N-terminal domain and an unstructured C-terminal counterpart. Further, it sequentially binds only two calcium ions, an unusual mode of Ca(2+)-binding among the known CaBPs, notably both in the N-terminal domain of EhCaM. Further, EhCaM is present in the nucleus in addition to the cytoplasm as detected by immunofluorescence staining, unlike other EhCaBPs that are detected only in the cytoplasm. Therefore, this protein is likely to have a different function. The presence of unusual and a diverse set of CaBPs in E. histolytica suggests a distinct Ca(2+)-signaling process in E. histolytica. The results reported here help in understanding the structure-function relationship of CaBPs including their Ca(2+)-binding properties.

-	~~==About this Structure==~~	+	Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein.,Rout AK, Padhan N, Barnwal RP, Bhattacharya A, Chary KV Biochemistry. 2010 Dec 21. PMID:21114322<ref>PMID:21114322</ref>
-	~~[[2lc5]] is a 1 chain structure with sequence~~ from ~~[http://en.wikipedia.org/wiki/Entamoeba_histolytica~~ Entamoeba histolytica~~]. This structure supersedes the now removed PDB entry [http~~:~~//oca~~.~~weizmann~~.ac.~~il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021114322</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Entamoeba histolytica]]		[[Category: Entamoeba histolytica]]
-	[[Category: Barnwal, R P.]]	+	[[Category: Barnwal, R P]]
-	[[Category: Bhattacharya, A.]]	+	[[Category: Bhattacharya, A]]
-	[[Category: Chary, K V.]]	+	[[Category: Chary, K V]]
-	[[Category: Padhan, N.]]	+	[[Category: Padhan, N]]
-	[[Category: Rout, A K.]]	+	[[Category: Rout, A K]]
	[[Category: Ca-binding protein]]		[[Category: Ca-binding protein]]
	[[Category: Cam-like]]		[[Category: Cam-like]]
	[[Category: Ehcam]]		[[Category: Ehcam]]
-	[[Category: Entamoeba histolytica]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]
	[[Category: Partially structured protein]]		[[Category: Partially structured protein]]

OCA at 23:19, 10 April 2013

2013-04-10T23:19:03Z

←Older revision		Revision as of 23:19, 10 April 2013
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-	[[Image:2lc5.jpg\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_2lc5\| PDB=2lc5 \| SCENE= }}		{{STRUCTURE_2lc5\| PDB=2lc5 \| SCENE= }}
-
	===Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein===		===Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein===
-
-
-	<!--
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-	(as it appears on PubMed at http://www.pubmed.gov), where 21114322 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21114322}}		{{ABSTRACT_PUBMED_21114322}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:021114322</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021114322</ref><references group="xtra"/><references/>
	[[Category: Entamoeba histolytica]]		[[Category: Entamoeba histolytica]]
	[[Category: Barnwal, R P.]]		[[Category: Barnwal, R P.]]
Line 29:		Line 14:
	[[Category: Padhan, N.]]		[[Category: Padhan, N.]]
	[[Category: Rout, A K.]]		[[Category: Rout, A K.]]
		+	[[Category: Ca-binding protein]]
		+	[[Category: Cam-like]]
		+	[[Category: Ehcam]]
		+	[[Category: Entamoeba histolytica]]
		+	[[Category: Metal binding protein]]
		+	[[Category: Partially structured protein]]

OCA at 05:05, 8 June 2011

2011-06-08T05:05:41Z

←Older revision		Revision as of 05:05, 8 June 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:2lc5.jpg\|left\|200px]]

-	The ~~entry 2lc5~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2lc5", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2lc5\| PDB=2lc5 \| SCENE= }}

-	~~Authors~~: ~~Rout, A.K., Padhan, N., Barnwal, R.P., Bhattacharya, A., Chary, K.V.~~	+	===Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein===

-	~~Description~~: ~~Calmodulin~~-~~like Protein~~ from Entamoeba histolytica: ~~Solution Structure and Calcium~~-~~Binding Properties of a Partially Folded Protein~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21114322}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21114322 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21114322}}
		+
		+	==About this Structure==
		+	[[2lc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ktg 2ktg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC5 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021114322</ref><references group="xtra"/>
		+	[[Category: Entamoeba histolytica]]
		+	[[Category: Barnwal, R P.]]
		+	[[Category: Bhattacharya, A.]]
		+	[[Category: Chary, K V.]]
		+	[[Category: Padhan, N.]]
		+	[[Category: Rout, A K.]]

OCA: Protected "2lc5" [edit=sysop:move=sysop]

2011-05-04T06:18:09Z

Protected "2lc5" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:18, 4 May 2011