2lew - Revision history

OCA at 10:55, 15 February 2023

2023-02-15T10:55:38Z

←Older revision		Revision as of 10:55, 15 February 2023
Line 1:		Line 1:

	==Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4==		==Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4==
-	<StructureSection load='2lew' size='340' side='right'caption='[[2lew~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lew' size='340' side='right'caption='[[2lew]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LEW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ley\|2ley]], [[2gw9\|2gw9]], [[2gwp\|2gwp]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [https://pdbe.org/2lew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [https://www.ebi.ac.uk/pdbsum/2lew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lew ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Defa4, Defcr4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [https://pdbe.org/2lew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [https://www.ebi.ac.uk/pdbsum/2lew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lew ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DEFA4_MOUSE DEFA4_MOUSE]] Probably contributes to the antimicrobial barrier function of the small bowel mucosa.	+	[https://www.uniprot.org/uniprot/DEFA4_MOUSE DEFA4_MOUSE] Probably contributes to the antimicrobial barrier function of the small bowel mucosa.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Andersson~~, H S~~]]	+	[[Category: Andersson HS]]
-	[[Category: Bengtsson, E]]	+	[[Category: Bengtsson E]]
-	[[Category: Craik~~, D J~~]]	+	[[Category: Craik DJ]]
-	[[Category: Daly~~, N L~~]]	+	[[Category: Daly NL]]
-	[[Category: Haugaard-Kedstrom~~, L M~~]]	+	[[Category: Haugaard-Kedstrom LM]]
-	[[Category: Rosengren, K]]	+	[[Category: Rosengren K]]
-	~~[[Category: Antimicrobial protein~~]]	+

OCA at 10:09, 12 May 2021

2021-05-12T10:09:31Z

←Older revision		Revision as of 10:09, 12 May 2021
Line 1:		Line 1:

	==Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4==		==Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4==
-	<StructureSection load='2lew' size='340' side='right' caption='[[2lew]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lew' size='340' side='right'caption='[[2lew]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lew]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LEW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ley\|2ley]], [[2gw9\|2gw9]], [[2gwp\|2gwp]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ley\|2ley]], [[2gw9\|2gw9]], [[2gwp\|2gwp]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Defa4, Defcr4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Defa4, Defcr4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [~~http~~://pdbe.org/2lew PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lew PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lew ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [https://pdbe.org/2lew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [https://www.ebi.ac.uk/pdbsum/2lew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lew ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DEFA4_MOUSE DEFA4_MOUSE]] Probably contributes to the antimicrobial barrier function of the small bowel mucosa.	+	[[https://www.uniprot.org/uniprot/DEFA4_MOUSE DEFA4_MOUSE]] Probably contributes to the antimicrobial barrier function of the small bowel mucosa.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Defensin\|Defensin]]	+	*[[Defensin 3D structures\|Defensin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Andersson, H S]]		[[Category: Andersson, H S]]

OCA at 19:22, 1 August 2018

2018-08-01T19:22:02Z

←Older revision		Revision as of 19:22, 1 August 2018
Line 1:		Line 1:
		+
	==Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4==		==Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4==
	<StructureSection load='2lew' size='340' side='right' caption='[[2lew]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lew' size='340' side='right' caption='[[2lew]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ley\|2ley]], [[2gw9\|2gw9]], [[2gwp\|2gwp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ley\|2ley]], [[2gw9\|2gw9]], [[2gwp\|2gwp]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Defa4, Defcr4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Defa4, Defcr4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [http://pdbe.org/2lew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [http://www.ebi.ac.uk/pdbsum/2lew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [http://pdbe.org/2lew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [http://www.ebi.ac.uk/pdbsum/2lew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lew ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:24, 12 September 2015

2015-09-12T00:24:18Z

←Older revision		Revision as of 00:24, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2lew' size='340' side='right' caption='[[2lew]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lew' size='340' side='right' caption='[[2lew]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LEW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ley\|2ley]], [[2gw9\|2gw9]], [[2gwp\|2gwp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ley\|2ley]], [[2gw9\|2gw9]], [[2gwp\|2gwp]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Defa4, Defcr4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Defa4, Defcr4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [http://www.ebi.ac.uk/pdbsum/2lew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [http://pdbe.org/2lew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [http://www.ebi.ac.uk/pdbsum/2lew PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lew" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Andersson, H S]]		[[Category: Andersson, H S]]
	[[Category: Bengtsson, E]]		[[Category: Bengtsson, E]]

OCA at 21:22, 25 December 2014

2014-12-25T21:22:54Z

←Older revision		Revision as of 21:22, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [http://www.ebi.ac.uk/pdbsum/2lew PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [http://www.ebi.ac.uk/pdbsum/2lew PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DEFA4_MOUSE DEFA4_MOUSE]] Probably contributes to the antimicrobial barrier function of the small bowel mucosa.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:30, 18 December 2014

2014-12-18T11:30:25Z

←Older revision		Revision as of 11:30, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2lew\| PDB=2lew \| SCENE= }}~~	+	==Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4==
-	===Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4===	+	<StructureSection load='2lew' size='340' side='right' caption='[[2lew]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_22286872}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LEW FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ley\|2ley]], [[2gw9\|2gw9]], [[2gwp\|2gwp]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Defa4, Defcr4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lew RCSB], [http://www.ebi.ac.uk/pdbsum/2lew PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Salt-bridge interactions between acidic and basic amino acids contribute to the structural stability of proteins and to protein-protein interactions. A conserved salt-bridge is a canonical feature of the alpha-defensin antimicrobial peptide family, but the role of this common structural element has not been fully elucidated. We have investigated mouse Paneth cell alpha-defensin cryptdin-4 (Crp4) and peptide variants with mutations at Arg(7) or Glu(15) residue positions to disrupt the salt-bridge and assess the consequences on Crp4 structure, function, and stability. NMR analyses showed that both (R7G)-Crp4 and (E15G)-Crp4 adopt native-like structures, evidence of fold plasticity that allows peptides to reshuffle side chains and stabilize the structure in the absence of the salt-bridge. In contrast, introduction of a large hydrophobic side chain at position 15, as in (E15L)-Crp4 cannot be accommodated in the context of the Crp4 primary structure. Regardless of which side of the salt-bridge was mutated, salt-bridge variants retained bactericidal peptide activity with differential microbicidal effects against certain bacterial cell targets, confirming that the salt-bridge does not determine bactericidal activity per se. The increased structural flexibility induced by salt-bridge disruption enhanced peptide sensitivity to proteolysis. Although sensitivity to proteolysis by MMP7 was unaffected by most Arg(7) and Glu(15) substitutions, every salt-bridge variant was degraded extensively by trypsin. Moreover, the salt-bridge facilitates adoption of the characteristic alpha-defensin fold as shown by the impaired in vitro refolding of (E15D)-proCrp4, the most conservative salt-bridge disrupting replacement. In Crp4, therefore, the canonical alpha-defensin salt-bridge facilitates adoption of the characteristic alpha-defensin fold, which decreases structural flexibility and confers resistance to degradation by proteinases.

-	~~==Function==~~	+	The alpha-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance.,Andersson HS, Figueredo SM, Haugaard-Kedstrom LM, Bengtsson E, Daly NL, Qu X, Craik DJ, Ouellette AJ, Rosengren KJ Amino Acids. 2012 Jan 29. PMID:22286872<ref>PMID:22286872</ref>
-	~~[[http://www~~.~~uniprot~~.~~org~~/~~uniprot/DEFA4_MOUSE DEFA4_MOUSE]] Probably contributes to the antimicrobial barrier function of the small bowel mucosa.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2lew]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LEW OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:022286872</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Defensin\|Defensin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Andersson, H S.]]	+	[[Category: Andersson, H S]]
-	[[Category: Bengtsson, E.]]	+	[[Category: Bengtsson, E]]
-	[[Category: Craik, D J.]]	+	[[Category: Craik, D J]]
-	[[Category: Daly, N L.]]	+	[[Category: Daly, N L]]
-	[[Category: Haugaard-Kedstrom, L M.]]	+	[[Category: Haugaard-Kedstrom, L M]]
-	[[Category: Rosengren, K.]]	+	[[Category: Rosengren, K]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]

OCA at 07:30, 20 June 2013

2013-06-20T07:30:16Z

←Older revision		Revision as of 07:30, 20 June 2013
Line 1:		Line 1:
-	[[Image:2lew.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2lew", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2lew\| PDB=2lew \| SCENE= }}		{{STRUCTURE_2lew\| PDB=2lew \| SCENE= }}
-
	===Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4===		===Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4===
		+	{{ABSTRACT_PUBMED_22286872}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/DEFA4_MOUSE DEFA4_MOUSE]] Probably contributes to the antimicrobial barrier function of the small bowel mucosa.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22286872}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 22286872 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_22286872}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022286872</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022286872</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Andersson, H S.]]		[[Category: Andersson, H S.]]

OCA at 05:05, 23 May 2012

2012-05-23T05:05:53Z

←Older revision		Revision as of 05:05, 23 May 2012
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-	[[Image:2lew.~~jpg~~\|left\|200px]]	+	[[Image:2lew.png\|left\|200px]]

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OCA at 09:11, 16 May 2012

2012-05-16T09:11:30Z

←Older revision		Revision as of 09:11, 16 May 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:2lew.jpg\|left\|200px]]

-	The ~~entry 2lew~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2lew", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2lew\| PDB=2lew \| SCENE= }}

-	~~Authors~~: ~~Rosengren, K., Andersson, H.S., Haugaard~~-~~Kedstrom, L.M., Bengtsson, E., Daly, N.L., Craik, D.J.~~	+	===Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4===

-	~~Description~~: ~~Structural Plasticity of Paneth cell alpha~~-~~Defensins~~: ~~Characterization of Salt~~-~~Bridge Deficient Analogues of Mouse Cryptdin~~-4	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22286872}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22286872 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22286872}}
		+
		+	==About this Structure==
		+	[[2lew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022286872</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Andersson, H S.]]
		+	[[Category: Bengtsson, E.]]
		+	[[Category: Craik, D J.]]
		+	[[Category: Daly, N L.]]
		+	[[Category: Haugaard-Kedstrom, L M.]]
		+	[[Category: Rosengren, K.]]
		+	[[Category: Antimicrobial protein]]

OCA at 05:18, 10 August 2011

2011-08-10T05:18:32Z

←Older revision		Revision as of 05:18, 10 August 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lew is ON HOLD	+	The entry 2lew is ON HOLD until Paper Publication

	Authors: Rosengren, K., Andersson, H.S., Haugaard-Kedstrom, L.M., Bengtsson, E., Daly, N.L., Craik, D.J.		Authors: Rosengren, K., Andersson, H.S., Haugaard-Kedstrom, L.M., Bengtsson, E., Daly, N.L., Craik, D.J.

	Description: Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4		Description: Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4