2lgf - Revision history

OCA at 05:43, 15 May 2024

2024-05-15T05:43:08Z

←Older revision		Revision as of 05:43, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [https://pdbe.org/2lgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [https://www.ebi.ac.uk/pdbsum/2lgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [https://pdbe.org/2lgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [https://www.ebi.ac.uk/pdbsum/2lgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:58, 15 February 2023

2023-02-15T10:58:42Z

←Older revision		Revision as of 10:58, 15 February 2023
Line 1:		Line 1:

	==Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin==		==Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin==
-	<StructureSection load='2lgf' size='340' side='right'caption='[[2lgf~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='2lgf' size='340' side='right'caption='[[2lgf]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [https://pdbe.org/2lgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [https://www.ebi.ac.uk/pdbsum/2lgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [https://pdbe.org/2lgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [https://www.ebi.ac.uk/pdbsum/2lgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~LYAM1_HUMAN LYAM1_HUMAN~~]~~] Cell surface adhesion protein. Mediates~~ the ~~adherence~~ of ~~lymphocytes~~ to ~~endothelial cells~~ of ~~high endothelial venules in peripheral lymph nodes~~. ~~Promotes initial tethering~~ and ~~rolling of leukocytes~~ in ~~endothelia~~.<ref>PMID:~~12403782~~</ref>	+	[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gifford~~, J L~~]]	+	[[Category: Gifford JL]]
-	[[Category: Ishida, H]]	+	[[Category: Ishida H]]
-	[[Category: Vogel~~, H J]]~~	+	[[Category: Vogel HJ]]
-	~~[[Category: Metal binding protein~~]]	+

OCA at 10:10, 12 May 2021

2021-05-12T10:10:24Z

←Older revision		Revision as of 10:10, 12 May 2021
Line 1:		Line 1:

	==Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin==		==Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin==
-	<StructureSection load='2lgf' size='340' side='right' caption='[[2lgf]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='2lgf' size='340' side='right'caption='[[2lgf]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LGF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [~~http~~://pdbe.org/2lgf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lgf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [https://pdbe.org/2lgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [https://www.ebi.ac.uk/pdbsum/2lgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LYAM1_HUMAN LYAM1_HUMAN]] Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.<ref>PMID:12403782</ref>	+	[[https://www.uniprot.org/uniprot/LYAM1_HUMAN LYAM1_HUMAN]] Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.<ref>PMID:12403782</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Calmodulin\|Calmodulin]]	+	*[[Calmodulin 3D structures\|Calmodulin 3D structures]]
	*[[Selectin\|Selectin]]		*[[Selectin\|Selectin]]
	== References ==		== References ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gifford, J L]]		[[Category: Gifford, J L]]
	[[Category: Ishida, H]]		[[Category: Ishida, H]]
	[[Category: Vogel, H J]]		[[Category: Vogel, H J]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 19:39, 1 August 2018

2018-08-01T19:39:58Z

←Older revision		Revision as of 19:39, 1 August 2018
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [http://pdbe.org/2lgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [http://www.ebi.ac.uk/pdbsum/2lgf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [http://pdbe.org/2lgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [http://www.ebi.ac.uk/pdbsum/2lgf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 18:28, 10 May 2016

2016-05-10T18:28:00Z

←Older revision		Revision as of 18:28, 10 May 2016
Line 1:		Line 1:
		+
	==Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin==		==Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin==
	<StructureSection load='2lgf' size='340' side='right' caption='[[2lgf]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2lgf' size='340' side='right' caption='[[2lgf]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>

OCA at 05:29, 11 September 2015

2015-09-11T05:29:55Z

←Older revision		Revision as of 05:29, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2lgf' size='340' side='right' caption='[[2lgf]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2lgf' size='340' side='right' caption='[[2lgf]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LGF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LGF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [http://www.ebi.ac.uk/pdbsum/2lgf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [http://pdbe.org/2lgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [http://www.ebi.ac.uk/pdbsum/2lgf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lgf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gifford, J L]]		[[Category: Gifford, J L]]
	[[Category: Ishida, H]]		[[Category: Ishida, H]]
	[[Category: Vogel, H J]]		[[Category: Vogel, H J]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 11:52, 25 December 2014

2014-12-25T11:52:33Z

←Older revision		Revision as of 11:52, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [http://www.ebi.ac.uk/pdbsum/2lgf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [http://www.ebi.ac.uk/pdbsum/2lgf PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYAM1_HUMAN LYAM1_HUMAN]] Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.<ref>PMID:12403782</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:16, 22 December 2014

2014-12-22T06:16:44Z

←Older revision		Revision as of 06:16, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LGF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LGF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [http://www.ebi.ac.uk/pdbsum/2lgf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [http://www.ebi.ac.uk/pdbsum/2lgf PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gifford, J L.]]	+	[[Category: Gifford, J L]]
-	[[Category: Ishida, H.]]	+	[[Category: Ishida, H]]
-	[[Category: Vogel, H J.]]	+	[[Category: Vogel, H J]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 06:58, 9 June 2014

2014-06-09T06:58:17Z

←Older revision		Revision as of 06:58, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~2lgf.~~png~~\|~~left~~\|~~200px~~]]	+	==Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin==
		+	<StructureSection load='2lgf' size='340' side='right' caption='[[2lgf]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LGF FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lgf RCSB], [http://www.ebi.ac.uk/pdbsum/2lgf PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The L-selectin glycoprotein receptor mediates the initial steps of leukocyte migration into secondary lymphoid organs and sites of inflammation. Following cell activation through the engagement of G-protein-coupled receptors or immunoreceptors, the extracellular domains of L-selectin are rapidly shed, a process negatively controlled via the binding of the ubiquitous eukaryotic calcium-binding protein calmodulin to the cytoplasmic tail of L-selectin. Here we present the solution structure of calcium-calmodulin bound to a peptide encompassing the cytoplasmic tail and part of the transmembrane domain of L-selectin. The structure and accompanying biophysical study highlight the importance of both calcium and the transmembrane segment of L-selectin in the interaction between these two proteins, suggesting that by binding this region, calmodulin regulates in an "inside-out" fashion the ectodomain shedding of the receptor. Our structure provides the first molecular insight into the emerging new role for calmodulin as a transmembrane signaling partner.

-	~~{{STRUCTURE_2lgf\| PDB=2lgf \| SCENE= }}~~	+	Structural Insights into Calmodulin-regulated L-selectin Ectodomain Shedding.,Gifford JL, Ishida H, Vogel HJ J Biol Chem. 2012 Aug 3;287(32):26513-27. Epub 2012 Jun 18. PMID:22711531<ref>PMID:22711531</ref>

-	~~===Solution structure of Ca2+~~/~~calmodulin complexed with~~ a ~~peptide representing~~ the ~~calmodulin-binding domain~~ of ~~L-selectin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22711531}}~~	+	==See Also==
-		+	*[[Calmodulin\|Calmodulin]]
-	==~~About this Structure~~==	+	*[[Selectin\|Selectin]]
-	[[~~2lgf~~]] ~~is a 2 chain structure with sequence from~~ [~~http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA~~].	+	== References ==
-		+	<references/>
-	==~~Reference~~==	+	__TOC__
-	<~~ref group="xtra">PMID:022711531<~~/~~ref~~><~~references group="xtra"~~/>	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gifford, J L.]]		[[Category: Gifford, J L.]]

OCA at 05:07, 22 August 2012

2012-08-22T05:07:31Z

←Older revision		Revision as of 05:07, 22 August 2012
Line 1:		Line 1:
-	[[Image:2lgf.~~jpg~~\|left\|200px]]	+	[[Image:2lgf.png\|left\|200px]]

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	{{STRUCTURE_2lgf\| PDB=2lgf \| SCENE= }}		{{STRUCTURE_2lgf\| PDB=2lgf \| SCENE= }}

	===Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin===		===Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin===

		+	{{ABSTRACT_PUBMED_22711531}}

	==About this Structure==		==About this Structure==
	[[2lgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA].		[[2lgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022711531</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gifford, J L.]]		[[Category: Gifford, J L.]]