2ljh - Revision history

OCA at 05:44, 15 May 2024

2024-05-15T05:44:29Z

←Older revision		Revision as of 05:44, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [https://pdbe.org/2ljh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [https://www.ebi.ac.uk/pdbsum/2ljh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljh ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [https://pdbe.org/2ljh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [https://www.ebi.ac.uk/pdbsum/2ljh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:03, 15 February 2023

2023-02-15T11:03:15Z

←Older revision		Revision as of 11:03, 15 February 2023
Line 1:		Line 1:

	==NMR structure of Double-stranded RNA-specific editase Adar==		==NMR structure of Double-stranded RNA-specific editase Adar==
-	<StructureSection load='2ljh' size='340' side='right'caption='[[2ljh~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2ljh' size='340' side='right'caption='[[2ljh]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJH FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [https://pdbe.org/2ljh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [https://www.ebi.ac.uk/pdbsum/2ljh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljh ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [https://pdbe.org/2ljh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [https://www.ebi.ac.uk/pdbsum/2ljh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ADAR_DROME ADAR_DROME]] Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.<ref>PMID:10917596</ref> <ref>PMID:11254668</ref> <ref>PMID:10966106</ref> <ref>PMID:12756328</ref>	+	[https://www.uniprot.org/uniprot/ADAR_DROME ADAR_DROME] Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.<ref>PMID:10917596</ref> <ref>PMID:11254668</ref> <ref>PMID:10966106</ref> <ref>PMID:12756328</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Allain~~, F H.~~T]]	+	[[Category: Allain FH-T]]
-	[[Category: Barraud, P]]	+	[[Category: Barraud P]]
-	~~[[Category: Dsrbd]]~~	+
-	~~[[Category: Dsrbm]]~~	+
-	~~[[Category: Editing]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 10:11, 12 May 2021

2021-05-12T10:11:52Z

←Older revision		Revision as of 10:11, 12 May 2021
Line 1:		Line 1:

	==NMR structure of Double-stranded RNA-specific editase Adar==		==NMR structure of Double-stranded RNA-specific editase Adar==
-	<StructureSection load='2ljh' size='340' side='right' caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2ljh' size='340' side='right'caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJH FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [~~http~~://pdbe.org/2ljh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ljh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [https://pdbe.org/2ljh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [https://www.ebi.ac.uk/pdbsum/2ljh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ADAR_DROME ADAR_DROME]] Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.<ref>PMID:10917596</ref> <ref>PMID:11254668</ref> <ref>PMID:10966106</ref> <ref>PMID:12756328</ref>	+	[[https://www.uniprot.org/uniprot/ADAR_DROME ADAR_DROME]] Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.<ref>PMID:10917596</ref> <ref>PMID:11254668</ref> <ref>PMID:10966106</ref> <ref>PMID:12756328</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Adenosine deaminase\|Adenosine deaminase]]	+	*[[Adenosine deaminase 3D structures\|Adenosine deaminase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Barraud, P]]		[[Category: Barraud, P]]

OCA at 19:56, 1 August 2018

2018-08-01T19:56:41Z

←Older revision		Revision as of 19:56, 1 August 2018
Line 1:		Line 1:
		+
	==NMR structure of Double-stranded RNA-specific editase Adar==		==NMR structure of Double-stranded RNA-specific editase Adar==
	<StructureSection load='2ljh' size='340' side='right' caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ljh' size='340' side='right' caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJH FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://pdbe.org/2ljh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://pdbe.org/2ljh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:36, 11 September 2015

2015-09-11T11:36:46Z

←Older revision		Revision as of 11:36, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ljh' size='340' side='right' caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ljh' size='340' side='right' caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJH FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 ~~Drosophila melanogaster~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://pdbe.org/2ljh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ljh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Adenosine deaminase\|Adenosine deaminase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Barraud, P]]		[[Category: Barraud, P]]

OCA at 15:56, 25 December 2014

2014-12-25T15:56:12Z

←Older revision		Revision as of 15:56, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADAR_DROME ADAR_DROME]] Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.<ref>PMID:10917596</ref> <ref>PMID:11254668</ref> <ref>PMID:10966106</ref> <ref>PMID:12756328</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:41, 22 December 2014

2014-12-22T06:41:32Z

←Older revision		Revision as of 06:41, 22 December 2014
Line 2:		Line 2:
	<StructureSection load='2ljh' size='340' side='right' caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ljh' size='340' side='right' caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. <br>	+	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 12:
	Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA.,Barraud P, Heale BS, O'Connell MA, Allain FH Biochimie. 2011 Dec 23. PMID:22210494<ref>PMID:22210494</ref>		Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA.,Barraud P, Heale BS, O'Connell MA, Allain FH Biochimie. 2011 Dec 23. PMID:22210494<ref>PMID:22210494</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Allain, F H.T.]]	+	[[Category: Allain, F H.T]]
-	[[Category: Barraud, P.]]	+	[[Category: Barraud, P]]
	[[Category: Dsrbd]]		[[Category: Dsrbd]]
	[[Category: Dsrbm]]		[[Category: Dsrbm]]
	[[Category: Editing]]		[[Category: Editing]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:49, 1 May 2014

2014-05-01T09:49:41Z

←Older revision		Revision as of 09:49, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2ljh' size='340' side='right' caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ljh' size='340' side='right' caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. <br>	+	<table><tr><td colspan='2'>[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. <br>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Adar, hypnos-2, CG12598 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Adenosine deaminases that act on RNA (ADAR) catalyze adenosine to inosine (A-to-I) editing in double-stranded RNA (dsRNA) substrates. Inosine is read as guanosine by the translation machinery; therefore A-to-I editing events in coding sequences may result in recoding genetic information. Whereas vertebrates have two catalytically active enzymes, namely ADAR1 and ADAR2, Drosophila has a single ADAR protein (dADAR) related to ADAR2. The structural determinants controlling substrate recognition and editing of a specific adenosine within dsRNA substrates are only partially understood. Here, we report the solution structure of the N-terminal dsRNA binding domain (dsRBD) of dADAR and use NMR chemical shift perturbations to identify the protein surface involved in RNA binding. Additionally, we show that Drosophila ADAR edits the R/G site in the mammalian GluR-2 pre-mRNA which is naturally modified by both ADAR1 and ADAR2. We then constructed a model showing how dADAR dsRBD1 binds to the GluR-2 R/G stem-loop. This model revealed that most side chains interacting with the RNA sugar-phosphate backbone need only small displacement to adapt for dsRNA binding and are thus ready to bind to their dsRNA target. It also predicts that dADAR dsRBD1 would bind to dsRNA with less sequence specificity than dsRBDs of ADAR2. Altogether, this study gives new insights into dsRNA substrate recognition by Drosophila ADAR.		Adenosine deaminases that act on RNA (ADAR) catalyze adenosine to inosine (A-to-I) editing in double-stranded RNA (dsRNA) substrates. Inosine is read as guanosine by the translation machinery; therefore A-to-I editing events in coding sequences may result in recoding genetic information. Whereas vertebrates have two catalytically active enzymes, namely ADAR1 and ADAR2, Drosophila has a single ADAR protein (dADAR) related to ADAR2. The structural determinants controlling substrate recognition and editing of a specific adenosine within dsRNA substrates are only partially understood. Here, we report the solution structure of the N-terminal dsRNA binding domain (dsRBD) of dADAR and use NMR chemical shift perturbations to identify the protein surface involved in RNA binding. Additionally, we show that Drosophila ADAR edits the R/G site in the mammalian GluR-2 pre-mRNA which is naturally modified by both ADAR1 and ADAR2. We then constructed a model showing how dADAR dsRBD1 binds to the GluR-2 R/G stem-loop. This model revealed that most side chains interacting with the RNA sugar-phosphate backbone need only small displacement to adapt for dsRNA binding and are thus ready to bind to their dsRNA target. It also predicts that dADAR dsRBD1 would bind to dsRNA with less sequence specificity than dsRBDs of ADAR2. Altogether, this study gives new insights into dsRNA substrate recognition by Drosophila ADAR.
Line 11:		Line 14:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:12, 30 April 2014

2014-04-30T10:12:25Z

←Older revision		Revision as of 10:12, 30 April 2014
Line 4:		Line 4:
	[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. <br>		[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. <br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljh RCSB], [http://www.ebi.ac.uk/pdbsum/2ljh PDBsum]</span><br>
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Adenosine deaminases that act on RNA (ADAR) catalyze adenosine to inosine (A-to-I) editing in double-stranded RNA (dsRNA) substrates. Inosine is read as guanosine by the translation machinery; therefore A-to-I editing events in coding sequences may result in recoding genetic information. Whereas vertebrates have two catalytically active enzymes, namely ADAR1 and ADAR2, Drosophila has a single ADAR protein (dADAR) related to ADAR2. The structural determinants controlling substrate recognition and editing of a specific adenosine within dsRNA substrates are only partially understood. Here, we report the solution structure of the N-terminal dsRNA binding domain (dsRBD) of dADAR and use NMR chemical shift perturbations to identify the protein surface involved in RNA binding. Additionally, we show that Drosophila ADAR edits the R/G site in the mammalian GluR-2 pre-mRNA which is naturally modified by both ADAR1 and ADAR2. We then constructed a model showing how dADAR dsRBD1 binds to the GluR-2 R/G stem-loop. This model revealed that most side chains interacting with the RNA sugar-phosphate backbone need only small displacement to adapt for dsRNA binding and are thus ready to bind to their dsRNA target. It also predicts that dADAR dsRBD1 would bind to dsRNA with less sequence specificity than dsRBDs of ADAR2. Altogether, this study gives new insights into dsRNA substrate recognition by Drosophila ADAR.		Adenosine deaminases that act on RNA (ADAR) catalyze adenosine to inosine (A-to-I) editing in double-stranded RNA (dsRNA) substrates. Inosine is read as guanosine by the translation machinery; therefore A-to-I editing events in coding sequences may result in recoding genetic information. Whereas vertebrates have two catalytically active enzymes, namely ADAR1 and ADAR2, Drosophila has a single ADAR protein (dADAR) related to ADAR2. The structural determinants controlling substrate recognition and editing of a specific adenosine within dsRNA substrates are only partially understood. Here, we report the solution structure of the N-terminal dsRNA binding domain (dsRBD) of dADAR and use NMR chemical shift perturbations to identify the protein surface involved in RNA binding. Additionally, we show that Drosophila ADAR edits the R/G site in the mammalian GluR-2 pre-mRNA which is naturally modified by both ADAR1 and ADAR2. We then constructed a model showing how dADAR dsRBD1 binds to the GluR-2 R/G stem-loop. This model revealed that most side chains interacting with the RNA sugar-phosphate backbone need only small displacement to adapt for dsRNA binding and are thus ready to bind to their dsRNA target. It also predicts that dADAR dsRBD1 would bind to dsRNA with less sequence specificity than dsRBDs of ADAR2. Altogether, this study gives new insights into dsRNA substrate recognition by Drosophila ADAR.

OCA at 08:32, 30 April 2014

2014-04-30T08:32:25Z

←Older revision		Revision as of 08:32, 30 April 2014
Line 1:		Line 1:
-	[[~~Image:~~2ljh~~.png~~\|~~left\|200px~~]]	+	==NMR structure of Double-stranded RNA-specific editase Adar==
		+	<StructureSection load='2ljh' size='340' side='right' caption='[[2ljh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	[[2ljh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA]. <br>
		+	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	== Publication Abstract from PubMed ==
		+	Adenosine deaminases that act on RNA (ADAR) catalyze adenosine to inosine (A-to-I) editing in double-stranded RNA (dsRNA) substrates. Inosine is read as guanosine by the translation machinery; therefore A-to-I editing events in coding sequences may result in recoding genetic information. Whereas vertebrates have two catalytically active enzymes, namely ADAR1 and ADAR2, Drosophila has a single ADAR protein (dADAR) related to ADAR2. The structural determinants controlling substrate recognition and editing of a specific adenosine within dsRNA substrates are only partially understood. Here, we report the solution structure of the N-terminal dsRNA binding domain (dsRBD) of dADAR and use NMR chemical shift perturbations to identify the protein surface involved in RNA binding. Additionally, we show that Drosophila ADAR edits the R/G site in the mammalian GluR-2 pre-mRNA which is naturally modified by both ADAR1 and ADAR2. We then constructed a model showing how dADAR dsRBD1 binds to the GluR-2 R/G stem-loop. This model revealed that most side chains interacting with the RNA sugar-phosphate backbone need only small displacement to adapt for dsRNA binding and are thus ready to bind to their dsRNA target. It also predicts that dADAR dsRBD1 would bind to dsRNA with less sequence specificity than dsRBDs of ADAR2. Altogether, this study gives new insights into dsRNA substrate recognition by Drosophila ADAR.

-	~~{{STRUCTURE_2ljh\| PDB=2ljh \| SCENE= }}~~	+	Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA.,Barraud P, Heale BS, O'Connell MA, Allain FH Biochimie. 2011 Dec 23. PMID:22210494<ref>PMID:22210494</ref>

-	~~===NMR structure~~ of ~~Double-stranded RNA-specific editase Adar===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	== References ==
-	~~{{ABSTRACT_PUBMED_22210494}}~~	+	<references/>
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	~~[[2ljh]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJH OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022210494<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Allain, F H.T.]]		[[Category: Allain, F H.T.]]