2lkk - Revision history

OCA at 06:56, 1 May 2024

2024-05-01T06:56:01Z

←Older revision		Revision as of 06:56, 1 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [https://pdbe.org/2lkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [https://www.ebi.ac.uk/pdbsum/2lkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [https://pdbe.org/2lkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [https://www.ebi.ac.uk/pdbsum/2lkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.		[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Liver fatty acid binding protein (L-FABP), a cytosolic protein most abundant in liver, is associated with intracellular transport of fatty acids, nuclear signaling, and regulation of intracellular lipolysis. Among the members of the intracellular lipid binding protein family, L-FABP is of particular interest as it can i), bind two fatty acid molecules simultaneously and ii), accommodate a variety of bulkier physiological ligands such as bilirubin and fatty acyl CoA. To better understand the promiscuous binding and transport properties of L-FABP, we investigated structure and dynamics of human L-FABP with and without bound ligands by means of heteronuclear NMR. The overall conformation of human L-FABP shows the typical beta-clam motif. Binding of two oleic acid (OA) molecules does not alter the protein conformation substantially, but perturbs the chemical shift of certain backbone and side-chain protons that are involved in OA binding according to the structure of the human L-FABP/OA complex. Comparison of the human apo and holo L-FABP structures revealed no evidence for an "open-cap" conformation or a "swivel-back" mechanism of the K90 side chain upon ligand binding, as proposed for rat L-FABP. Instead, we postulate that the lipid binding process in L-FABP is associated with backbone dynamics.
-
-	Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.,Cai J, Lucke C, Chen Z, Qiao Y, Klimtchuk E, Hamilton JA Biophys J. 2012 Jun 6;102(11):2585-94. doi: 10.1016/j.bpj.2012.04.039. Epub 2012 , Jun 5. PMID:22713574<ref>PMID:22713574</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2lkk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]		*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:05, 15 February 2023

2023-02-15T11:05:31Z

←Older revision		Revision as of 11:05, 15 February 2023
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	==Human L-FABP in complex with oleate==		==Human L-FABP in complex with oleate==
-	<StructureSection load='2lkk' size='340' side='right'caption='[[2lkk~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2lkk' size='340' side='right'caption='[[2lkk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]], [[2l67\|2l67]], [[2l68\|2l68]], [[3stn\|3stn]], [[3stk\|3stk]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [https://pdbe.org/2lkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [https://www.ebi.ac.uk/pdbsum/2lkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [https://pdbe.org/2lkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [https://www.ebi.ac.uk/pdbsum/2lkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.	+	[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cai, J]]	+	[[Category: Cai J]]
-	[[Category: Chen, Z]]	+	[[Category: Chen Z]]
-	[[Category: Hamilton~~, J A~~]]	+	[[Category: Hamilton JA]]
-	[[Category: Klimtchuk~~, E S~~]]	+	[[Category: Klimtchuk ES]]
-	[[Category: Luecke, C]]	+	[[Category: Luecke C]]
-	[[Category: Qiao, Y]]	+	[[Category: Qiao Y]]
-	~~[[Category: Fatty acid carrier]]~~	+
-	~~[[Category: Holo form]]~~	+
-	~~[[Category: Lipid binding protein~~]]	+

OCA at 10:12, 12 May 2021

2021-05-12T10:12:27Z

←Older revision		Revision as of 10:12, 12 May 2021
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	==Human L-FABP in complex with oleate==		==Human L-FABP in complex with oleate==
-	<StructureSection load='2lkk' size='340' side='right' caption='[[2lkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2lkk' size='340' side='right'caption='[[2lkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lkk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]], [[2l67\|2l67]], [[2l68\|2l68]], [[3stn\|3stn]], [[3stk\|3stk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]], [[2l67\|2l67]], [[2l68\|2l68]], [[3stn\|3stn]], [[3stk\|3stk]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [~~http~~://pdbe.org/2lkk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lkk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [https://pdbe.org/2lkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [https://www.ebi.ac.uk/pdbsum/2lkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.	+	[[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]	+	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cai, J]]		[[Category: Cai, J]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]

OCA at 19:28, 1 August 2018

2018-08-01T19:28:46Z

←Older revision		Revision as of 19:28, 1 August 2018
Line 1:		Line 1:
		+
	==Human L-FABP in complex with oleate==		==Human L-FABP in complex with oleate==
	<StructureSection load='2lkk' size='340' side='right' caption='[[2lkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2lkk' size='340' side='right' caption='[[2lkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]], [[2l67\|2l67]], [[2l68\|2l68]], [[3stn\|3stn]], [[3stk\|3stk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]], [[2l67\|2l67]], [[2l68\|2l68]], [[3stn\|3stn]], [[3stk\|3stk]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [http://pdbe.org/2lkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [http://www.ebi.ac.uk/pdbsum/2lkk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [http://pdbe.org/2lkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [http://www.ebi.ac.uk/pdbsum/2lkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:24, 12 September 2015

2015-09-12T01:24:30Z

←Older revision		Revision as of 01:24, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2lkk' size='340' side='right' caption='[[2lkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2lkk' size='340' side='right' caption='[[2lkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lkk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lkk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LKK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]], [[2l67\|2l67]], [[2l68\|2l68]], [[3stn\|3stn]], [[3stk\|3stk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]], [[2l67\|2l67]], [[2l68\|2l68]], [[3stn\|3stn]], [[3stk\|3stk]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [http://www.ebi.ac.uk/pdbsum/2lkk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [http://pdbe.org/2lkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [http://www.ebi.ac.uk/pdbsum/2lkk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2lkk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cai, J]]		[[Category: Cai, J]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]

OCA at 21:57, 25 December 2014

2014-12-25T21:57:47Z

←Older revision		Revision as of 21:57, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [http://www.ebi.ac.uk/pdbsum/2lkk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [http://www.ebi.ac.uk/pdbsum/2lkk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cai, J.]]	+	[[Category: Cai, J]]
-	[[Category: Chen, Z.]]	+	[[Category: Chen, Z]]
-	[[Category: Hamilton, J A.]]	+	[[Category: Hamilton, J A]]
-	[[Category: Klimtchuk, E S.]]	+	[[Category: Klimtchuk, E S]]
-	[[Category: Luecke, C.]]	+	[[Category: Luecke, C]]
-	[[Category: Qiao, Y.]]	+	[[Category: Qiao, Y]]
	[[Category: Fatty acid carrier]]		[[Category: Fatty acid carrier]]
	[[Category: Holo form]]		[[Category: Holo form]]
	[[Category: Lipid binding protein]]		[[Category: Lipid binding protein]]

OCA at 09:26, 5 November 2014

2014-11-05T09:26:13Z

←Older revision		Revision as of 09:26, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2lkk.~~png~~\|~~left~~\|~~200px~~]]	+	==Human L-FABP in complex with oleate==
		+	<StructureSection load='2lkk' size='340' side='right' caption='[[2lkk]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2lkk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LKK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]], [[2l67\|2l67]], [[2l68\|2l68]], [[3stn\|3stn]], [[3stk\|3stk]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lkk RCSB], [http://www.ebi.ac.uk/pdbsum/2lkk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Liver fatty acid binding protein (L-FABP), a cytosolic protein most abundant in liver, is associated with intracellular transport of fatty acids, nuclear signaling, and regulation of intracellular lipolysis. Among the members of the intracellular lipid binding protein family, L-FABP is of particular interest as it can i), bind two fatty acid molecules simultaneously and ii), accommodate a variety of bulkier physiological ligands such as bilirubin and fatty acyl CoA. To better understand the promiscuous binding and transport properties of L-FABP, we investigated structure and dynamics of human L-FABP with and without bound ligands by means of heteronuclear NMR. The overall conformation of human L-FABP shows the typical beta-clam motif. Binding of two oleic acid (OA) molecules does not alter the protein conformation substantially, but perturbs the chemical shift of certain backbone and side-chain protons that are involved in OA binding according to the structure of the human L-FABP/OA complex. Comparison of the human apo and holo L-FABP structures revealed no evidence for an "open-cap" conformation or a "swivel-back" mechanism of the K90 side chain upon ligand binding, as proposed for rat L-FABP. Instead, we postulate that the lipid binding process in L-FABP is associated with backbone dynamics.

-	~~{{STRUCTURE_2lkk\| PDB=2lkk \| SCENE= }}~~	+	Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.,Cai J, Lucke C, Chen Z, Qiao Y, Klimtchuk E, Hamilton JA Biophys J. 2012 Jun 6;102(11):2585-94. doi: 10.1016/j.bpj.2012.04.039. Epub 2012 , Jun 5. PMID:22713574<ref>PMID:22713574</ref>

-	~~===Human L-FABP in complex with oleate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22713574}}~~	+	==See Also==
-		+	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2lkk~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cai, J.]]		[[Category: Cai, J.]]

OCA at 11:40, 23 January 2013

2013-01-23T11:40:45Z

←Older revision		Revision as of 11:40, 23 January 2013
Line 1:		Line 1:
-	[[Image:2lkk.~~jpg~~\|left\|200px]]	+	[[Image:2lkk.png\|left\|200px]]

	{{STRUCTURE_2lkk\| PDB=2lkk \| SCENE= }}		{{STRUCTURE_2lkk\| PDB=2lkk \| SCENE= }}
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	===Human L-FABP in complex with oleate===		===Human L-FABP in complex with oleate===

		+	{{ABSTRACT_PUBMED_22713574}}

	==About this Structure==		==About this Structure==

OCA at 07:52, 20 June 2012

2012-06-20T07:52:50Z

←Older revision		Revision as of 07:52, 20 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2lkk.jpg\|left\|200px]]

-	~~The entry~~ 2lkk ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2lkk\| PDB=2lkk \| SCENE= }}

-	~~Authors: Cai, J., Luecke, C., Chen, Z., Qiao, Y., Klimtchuk, E.S., Hamilton, J.A.~~	+	===Human L-FABP in complex with oleate===

-	~~Description~~: ~~Human L~~-~~FABP in complex with oleate~~	+
		+	==About this Structure==
		+	[[2lkk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKK OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Cai, J.]]
		+	[[Category: Chen, Z.]]
		+	[[Category: Hamilton, J A.]]
		+	[[Category: Klimtchuk, E S.]]
		+	[[Category: Luecke, C.]]
		+	[[Category: Qiao, Y.]]
		+	[[Category: Fatty acid carrier]]
		+	[[Category: Holo form]]
		+	[[Category: Lipid binding protein]]

OCA at 11:37, 16 November 2011

2011-11-16T11:37:29Z

←Older revision		Revision as of 11:37, 16 November 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lkk is ON HOLD	+	The entry 2lkk is ON HOLD until Paper Publication

	Authors: Cai, J., Luecke, C., Chen, Z., Qiao, Y., Klimtchuk, E.S., Hamilton, J.A.		Authors: Cai, J., Luecke, C., Chen, Z., Qiao, Y., Klimtchuk, E.S., Hamilton, J.A.

-	Description: ~~1H and 15N resonance assignment of human holo~~ L-FABP	+	Description: Human L-FABP in complex with oleate