2lui - Revision history

OCA at 06:57, 1 May 2024

2024-05-01T06:57:35Z

←Older revision		Revision as of 06:57, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [https://pdbe.org/2lui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [https://www.ebi.ac.uk/pdbsum/2lui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lui ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [https://pdbe.org/2lui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [https://www.ebi.ac.uk/pdbsum/2lui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lui ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>		[https://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	PDZ domain proteins control multiple cellular functions by governing assembly of protein complexes. It remains unknown why individual PDZ domains can bind the extreme C terminus of very diverse binding partners and maintain selectivity. By employing NMR spectroscopy, together with molecular modeling, mutational analysis, and fluorescent polarization binding experiments, we identify here three structural mechanisms explaining why the PDZ domain of PICK1 selectively binds >30 receptors, transporters, and kinases. Class II ligands, including the dopamine transporter, adopt a canonical binding mode with promiscuity obtained via differential packing in the binding groove. Class I ligands, such as protein kinase Calpha, depend on residues upstream from the canonical binding sequence that are likely to interact with flexible loop residues of the PDZ domain. Finally, we obtain evidence that the unconventional ligand ASIC1a has a dual binding mode involving a canonical insertion and a noncanonical internal insertion with the two C-terminal residues forming interactions outside the groove. Together with an evolutionary analysis, the data show how unconventional binding modes might evolve for a protein recognition domain to expand the repertoire of functionally important interactions.
-
-	Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.,Erlendsson S, Rathje M, Heidarsson PO, Poulsen FM, Madsen KL, Teilum K, Gether U J Biol Chem. 2014 Sep 5;289(36):25327-40. doi: 10.1074/jbc.M114.548743. Epub 2014, Jul 13. PMID:25023278<ref>PMID:25023278</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2lui" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:11, 22 February 2023

2023-02-22T13:11:15Z

←Older revision		Revision as of 13:11, 22 February 2023
Line 1:		Line 1:

	==Structure of the PICK PDZ domain in complex with the DAT C-terminal==		==Structure of the PICK PDZ domain in complex with the DAT C-terminal==
-	<StructureSection load='2lui' size='340' side='right'caption='[[2lui~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2lui' size='340' side='right'caption='[[2lui]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUI FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pick1, Prkcabp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [https://pdbe.org/2lui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [https://www.ebi.ac.uk/pdbsum/2lui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lui ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [https://pdbe.org/2lui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [https://www.ebi.ac.uk/pdbsum/2lui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lui ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>	+	[https://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Erlendsson, S]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Gether, U]]	+	[[Category: Erlendsson S]]
-	[[Category: Heidarsson~~, P O~~]]	+	[[Category: Gether U]]
-	[[Category: Madsen~~, K L~~]]	+	[[Category: Heidarsson PO]]
-	[[Category: Poulsen~~, F M~~]]	+	[[Category: Madsen KL]]
-	[[Category: Rathje, M]]	+	[[Category: Poulsen FM]]
-	[[Category: Teilum, K]]	+	[[Category: Rathje M]]
-	~~[[Category: Dat c-terminal]]~~	+	[[Category: Teilum K]]
-	~~[[Category: Pdz]]~~	+
-	~~[[Category: Pick1]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 10:53, 19 May 2021

2021-05-19T10:53:52Z

←Older revision		Revision as of 10:53, 19 May 2021
Line 1:		Line 1:

	==Structure of the PICK PDZ domain in complex with the DAT C-terminal==		==Structure of the PICK PDZ domain in complex with the DAT C-terminal==
-	<StructureSection load='2lui' size='340' side='right' caption='[[2lui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2lui' size='340' side='right'caption='[[2lui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LUI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUI FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pick1, Prkcabp ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pick1, Prkcabp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [~~http~~://pdbe.org/2lui PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2lui PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2lui ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [https://pdbe.org/2lui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [https://www.ebi.ac.uk/pdbsum/2lui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lui ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>	+	[[https://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PDZ domain proteins control multiple cellular functions by governing assembly of protein complexes. It remains unknown why individual PDZ domains can bind the extreme C terminus of very diverse binding partners and maintain selectivity. By employing NMR spectroscopy, together with molecular modeling, mutational analysis, and fluorescent polarization binding experiments, we identify here three structural mechanisms explaining why the PDZ domain of PICK1 selectively binds >30 receptors, transporters, and kinases. Class II ligands, including the dopamine transporter, adopt a canonical binding mode with promiscuity obtained via differential packing in the binding groove. Class I ligands, such as protein kinase Calpha, depend on residues upstream from the canonical binding sequence that are likely to interact with flexible loop residues of the PDZ domain. Finally, we obtain evidence that the unconventional ligand ASIC1a has a dual binding mode involving a canonical insertion and a noncanonical internal insertion with the two C-terminal residues forming interactions outside the groove. Together with an evolutionary analysis, the data show how unconventional binding modes might evolve for a protein recognition domain to expand the repertoire of functionally important interactions.
		+
		+	Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.,Erlendsson S, Rathje M, Heidarsson PO, Poulsen FM, Madsen KL, Teilum K, Gether U J Biol Chem. 2014 Sep 5;289(36):25327-40. doi: 10.1074/jbc.M114.548743. Epub 2014, Jul 13. PMID:25023278<ref>PMID:25023278</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2lui" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 14:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Erlendsson, S]]		[[Category: Erlendsson, S]]
	[[Category: Gether, U]]		[[Category: Gether, U]]

OCA at 23:09, 9 August 2018

2018-08-09T23:09:32Z

←Older revision		Revision as of 23:09, 9 August 2018
Line 1:		Line 1:
		+
	==Structure of the PICK PDZ domain in complex with the DAT C-terminal==		==Structure of the PICK PDZ domain in complex with the DAT C-terminal==
	<StructureSection load='2lui' size='340' side='right' caption='[[2lui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lui' size='340' side='right' caption='[[2lui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUI FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pick1, Prkcabp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pick1, Prkcabp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [http://pdbe.org/2lui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [http://www.ebi.ac.uk/pdbsum/2lui PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [http://pdbe.org/2lui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [http://www.ebi.ac.uk/pdbsum/2lui PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lui ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:12, 12 September 2015

2015-09-12T00:12:49Z

←Older revision		Revision as of 00:12, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2lui' size='340' side='right' caption='[[2lui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2lui' size='340' side='right' caption='[[2lui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUI FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pick1, Prkcabp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pick1, Prkcabp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [http://www.ebi.ac.uk/pdbsum/2lui PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [http://pdbe.org/2lui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [http://www.ebi.ac.uk/pdbsum/2lui PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 12:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Erlendsson, S]]		[[Category: Erlendsson, S]]
	[[Category: Gether, U]]		[[Category: Gether, U]]

OCA at 21:15, 25 December 2014

2014-12-25T21:15:08Z

←Older revision		Revision as of 21:15, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2lui\| PDB=2lui \| SCENE= }}~~	+	==Structure of the PICK PDZ domain in complex with the DAT C-terminal==
-	===Structure of the PICK PDZ domain in complex with the DAT C-terminal===	+	<StructureSection load='2lui' size='340' side='right' caption='[[2lui]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[2lui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LUI FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pick1, Prkcabp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lui RCSB], [http://www.ebi.ac.uk/pdbsum/2lui PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>		[[http://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[2lui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Erlendsson, S.]]	+	[[Category: Erlendsson, S]]
-	[[Category: Gether, U.]]	+	[[Category: Gether, U]]
-	[[Category: Heidarsson, P O.]]	+	[[Category: Heidarsson, P O]]
-	[[Category: Madsen, K L.]]	+	[[Category: Madsen, K L]]
-	[[Category: Poulsen, F M.]]	+	[[Category: Poulsen, F M]]
-	[[Category: Rathje, M.]]	+	[[Category: Rathje, M]]
-	[[Category: Teilum, K.]]	+	[[Category: Teilum, K]]
	[[Category: Dat c-terminal]]		[[Category: Dat c-terminal]]
	[[Category: Pdz]]		[[Category: Pdz]]
	[[Category: Pick1]]		[[Category: Pick1]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 07:16, 20 June 2013

2013-06-20T07:16:18Z

←Older revision		Revision as of 07:16, 20 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_2lui\| PDB=2lui \| SCENE= }}
		+	===Structure of the PICK PDZ domain in complex with the DAT C-terminal===

-	~~The entry 2lui is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>

-	~~Authors~~: ~~Erlendsson, S~~.~~, Teilum, K~~.	+	==About this Structure==
		+	[[2lui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA].

-	~~Description~~: ~~Chemical Shift Assignments for the PICK1 PDZ domain fused to the C10 DAT ligand~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Erlendsson, S.]]
		+	[[Category: Gether, U.]]
		+	[[Category: Heidarsson, P O.]]
		+	[[Category: Madsen, K L.]]
		+	[[Category: Poulsen, F M.]]
		+	[[Category: Rathje, M.]]
		+	[[Category: Teilum, K.]]
		+	[[Category: Dat c-terminal]]
		+	[[Category: Pdz]]
		+	[[Category: Pick1]]
		+	[[Category: Protein binding]]

OCA at 06:35, 10 October 2012

2012-10-10T06:35:13Z

←Older revision		Revision as of 06:35, 10 October 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2lui is ON HOLD	+	The entry 2lui is ON HOLD until Paper Publication

	Authors: Erlendsson, S., Teilum, K.		Authors: Erlendsson, S., Teilum, K.

	Description: Chemical Shift Assignments for the PICK1 PDZ domain fused to the C10 DAT ligand		Description: Chemical Shift Assignments for the PICK1 PDZ domain fused to the C10 DAT ligand

OCA: Protected "2lui" [edit=sysop:move=sysop]

2012-06-20T07:09:05Z

Protected "2lui" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:09, 20 June 2012

OCA: New page: '''Unreleased structure''' The entry 2lui is ON HOLD Authors: Erlendsson, S., Teilum, K. Description: Chemical Shift Assignments for the PICK1 PDZ domain fused to the C10 DAT ligand

2012-06-20T07:09:04Z

New page: '''Unreleased structure''' The entry 2lui is ON HOLD Authors: Erlendsson, S., Teilum, K. Description: Chemical Shift Assignments for the PICK1 PDZ domain fused to the C10 DAT ligand

New page

'''Unreleased structure'''

The entry 2lui is ON HOLD

Authors: Erlendsson, S., Teilum, K.

Description: Chemical Shift Assignments for the PICK1 PDZ domain fused to the C10 DAT ligand