2m7w - Revision history

OCA at 06:01, 15 May 2024

2024-05-15T06:01:42Z

←Older revision		Revision as of 06:01, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M7W FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M7W FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [https://pdbe.org/2m7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [https://www.ebi.ac.uk/pdbsum/2m7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7w ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [https://pdbe.org/2m7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [https://www.ebi.ac.uk/pdbsum/2m7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:30, 14 June 2023

2023-06-14T09:30:13Z

←Older revision		Revision as of 09:30, 14 June 2023
Line 1:		Line 1:

	==Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41==		==Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41==
-	<StructureSection load='2m7w' size='340' side='right'caption='[[2m7w~~]], [[NMR_Ensembles_of_Models \| 18 NMR models~~]]' scene=''>	+	<StructureSection load='2m7w' size='340' side='right'caption='[[2m7w]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M7W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M7W FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lp7\|2lp7]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [https://pdbe.org/2m7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [https://www.ebi.ac.uk/pdbsum/2m7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7w ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [https://pdbe.org/2m7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [https://www.ebi.ac.uk/pdbsum/2m7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7w ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/M1E1E4_9HIV1 M1E1E4_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Donald~~, B R~~]]	+	[[Category: Donald BR]]
-	[[Category: Haynes~~, B F~~]]	+	[[Category: Haynes BF]]
-	[[Category: Martin~~, J W~~]]	+	[[Category: Martin JW]]
-	[[Category: Moses~~, D S~~]]	+	[[Category: Moses DS]]
-	[[Category: Munir~~, A S~~]]	+	[[Category: Munir AS]]
-	[[Category: Reardon~~, P N~~]]	+	[[Category: Reardon PN]]
-	[[Category: Sage~~, H S~~]]	+	[[Category: Sage HS]]
-	[[Category: Spicer~~, L D]]~~	+	[[Category: Spicer LD]]
-	~~[[Category: Gp41]]~~	+
-	~~[[Category: Mper]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 11:33, 16 February 2022

2022-02-16T11:33:30Z

←Older revision		Revision as of 11:33, 16 February 2022
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	<StructureSection load='2m7w' size='340' side='right'caption='[[2m7w]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>		<StructureSection load='2m7w' size='340' side='right'caption='[[2m7w]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2M7W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M7W FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lp7\|2lp7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lp7\|2lp7]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [~~http~~://pdbe.org/2m7w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2m7w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [https://pdbe.org/2m7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [https://www.ebi.ac.uk/pdbsum/2m7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7w ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:20, 13 May 2020

2020-05-13T06:20:12Z

←Older revision		Revision as of 06:20, 13 May 2020
Line 1:		Line 1:

	==Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41==		==Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41==
-	<StructureSection load='2m7w' size='340' side='right' caption='[[2m7w]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>	+	<StructureSection load='2m7w' size='340' side='right'caption='[[2m7w]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2M7W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2M7W FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lp7\|2lp7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lp7\|2lp7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [http://pdbe.org/2m7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [http://www.ebi.ac.uk/pdbsum/2m7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [http://pdbe.org/2m7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [http://www.ebi.ac.uk/pdbsum/2m7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7w ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Donald, B R]]		[[Category: Donald, B R]]
	[[Category: Haynes, B F]]		[[Category: Haynes, B F]]

OCA at 22:55, 9 August 2018

2018-08-09T22:55:54Z

←Older revision		Revision as of 22:55, 9 August 2018
Line 1:		Line 1:
		+
	==Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41==		==Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41==
	<StructureSection load='2m7w' size='340' side='right' caption='[[2m7w]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>		<StructureSection load='2m7w' size='340' side='right' caption='[[2m7w]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M7W FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M7W FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lp7\|2lp7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lp7\|2lp7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [http://pdbe.org/2m7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [http://www.ebi.ac.uk/pdbsum/2m7w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [http://pdbe.org/2m7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [http://www.ebi.ac.uk/pdbsum/2m7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7w ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:21, 11 September 2015

2015-09-11T03:21:06Z

←Older revision		Revision as of 03:21, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M7W FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M7W FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lp7\|2lp7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lp7\|2lp7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [http://www.ebi.ac.uk/pdbsum/2m7w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [http://pdbe.org/2m7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [http://www.ebi.ac.uk/pdbsum/2m7w PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2m7w" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:46, 3 January 2015

2015-01-03T21:46:03Z

←Older revision		Revision as of 21:46, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M7W FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M7W FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lp7\|2lp7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lp7\|2lp7]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [http://www.ebi.ac.uk/pdbsum/2m7w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [http://www.ebi.ac.uk/pdbsum/2m7w PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 12:		Line 12:
	Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer.,Reardon PN, Sage H, Dennison SM, Martin JW, Donald BR, Alam SM, Haynes BF, Spicer LD Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1391-6. doi:, 10.1073/pnas.1309842111. Epub 2014 Jan 13. PMID:24474763<ref>PMID:24474763</ref>		Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer.,Reardon PN, Sage H, Dennison SM, Martin JW, Donald BR, Alam SM, Haynes BF, Spicer LD Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1391-6. doi:, 10.1073/pnas.1309842111. Epub 2014 Jan 13. PMID:24474763<ref>PMID:24474763</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	~~[[Category: 9hiv1]]~~	+	[[Category: Donald, B R]]
-	[[Category: Donald, B R.]]	+	[[Category: Haynes, B F]]
-	[[Category: Haynes, B F.]]	+	[[Category: Martin, J W]]
-	[[Category: Martin, J W.]]	+	[[Category: Moses, D S]]
-	[[Category: Moses, D S.]]	+	[[Category: Munir, A S]]
-	[[Category: Munir, A S.]]	+	[[Category: Reardon, P N]]
-	[[Category: Reardon, P N.]]	+	[[Category: Sage, H S]]
-	[[Category: Sage, H S.]]	+	[[Category: Spicer, L D]]
-	[[Category: Spicer, L D.]]	+
	[[Category: Gp41]]		[[Category: Gp41]]
	[[Category: Mper]]		[[Category: Mper]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 12:51, 18 May 2014

2014-05-18T12:51:47Z

←Older revision		Revision as of 12:51, 18 May 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2m7w\| PDB=2m7w \| SCENE= }}~~	+	==Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41==
-	===Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41===	+	<StructureSection load='2m7w' size='340' side='right' caption='[[2m7w]], [[NMR_Ensembles_of_Models \| 18 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M7W FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lp7\|2lp7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m7w RCSB], [http://www.ebi.ac.uk/pdbsum/2m7w PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The membrane proximal external region (MPER) of HIV-1 glycoprotein (gp) 41 is involved in viral-host cell membrane fusion. It contains short amino acid sequences that are binding sites for the HIV-1 broadly neutralizing antibodies 2F5, 4E10, and 10E8, making these binding sites important targets for HIV-1 vaccine development. We report a high-resolution structure of a designed MPER trimer assembled on a detergent micelle. The NMR solution structure of this trimeric domain, designated gp41-M-MAT, shows that the three MPER peptides each adopt symmetric alpha-helical conformations exposing the amino acid side chains of the antibody binding sites. The helices are closely associated at their N termini, bend between the 2F5 and 4E10 epitopes, and gradually separate toward the C termini, where they associate with the membrane. The mAbs 2F5 and 4E10 bind gp41-M-MAT with nanomolar affinities, consistent with the substantial exposure of their respective epitopes in the trimer structure. The traditional structure determination of gp41-M-MAT using the Xplor-NIH protocol was validated by independently determining the structure using the DISCO sparse-data protocol, which exploits geometric arrangement algorithms that guarantee to compute all structures and assignments that satisfy the data.

-	~~==About this~~ Structure==	+	Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer.,Reardon PN, Sage H, Dennison SM, Martin JW, Donald BR, Alam SM, Haynes BF, Spicer LD Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1391-6. doi:, 10.1073/pnas.1309842111. Epub 2014 Jan 13. PMID:24474763<ref>PMID:24474763</ref>
-	~~[[2m7w]] is a 3 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/9hiv1 9hiv1]~~. ~~Full experimental information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~2M7W OCA].~~	+
		+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: 9hiv1]]		[[Category: 9hiv1]]
	[[Category: Donald, B R.]]		[[Category: Donald, B R.]]

OCA at 05:44, 22 January 2014

2014-01-22T05:44:12Z

←Older revision		Revision as of 05:44, 22 January 2014
Line 3:		Line 3:

	==About this Structure==		==About this Structure==
-	[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_immunodeficiency_virus_1 Human immunodeficiency virus 1~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA].	+	[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA].
-	[[Category: ~~Human immunodeficiency virus 1~~]]	+	[[Category: 9hiv1]]
	[[Category: Donald, B R.]]		[[Category: Donald, B R.]]
	[[Category: Haynes, B F.]]		[[Category: Haynes, B F.]]

OCA at 07:25, 16 May 2013

2013-05-16T07:25:25Z

←Older revision		Revision as of 07:25, 16 May 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_2m7w\| PDB=2m7w \| SCENE= }}
		+	===Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41===

-	~~The entry~~ 2m7w is ~~ON HOLD~~	+	==About this Structure==
-		+	[[2m7w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7W OCA].
-	~~Authors~~: ~~Martin, J~~.W.~~, Reardon, P~~.N., ~~Sage~~, ~~H.S~~., Moses, D.S., Munir, A.S., ~~Haynes, B.F~~., Spicer, L.D.~~, Donald, B.R.~~	+	[[Category: Human immunodeficiency virus 1]]
-		+	[[Category: Donald, B R.]]
-	~~Description~~: ~~Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41~~	+	[[Category: Haynes, B F.]]
		+	[[Category: Martin, J W.]]
		+	[[Category: Moses, D S.]]
		+	[[Category: Munir, A S.]]
		+	[[Category: Reardon, P N.]]
		+	[[Category: Sage, H S.]]
		+	[[Category: Spicer, L D.]]
		+	[[Category: Gp41]]
		+	[[Category: Mper]]
		+	[[Category: Viral protein]]