2mbx - Revision history

OCA at 06:03, 15 May 2024

2024-05-15T06:03:44Z

←Older revision		Revision as of 06:03, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gadus_morhua Gadus morhua]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gadus_morhua Gadus morhua]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [https://pdbe.org/2mbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [https://www.ebi.ac.uk/pdbsum/2mbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [https://pdbe.org/2mbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [https://www.ebi.ac.uk/pdbsum/2mbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:32, 14 June 2023

2023-06-14T09:32:58Z

←Older revision		Revision as of 09:32, 14 June 2023
Line 1:		Line 1:

	==Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high-pressure NMR.==		==Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high-pressure NMR.==
-	<StructureSection load='2mbx' size='340' side='right'caption='[[2mbx~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2mbx' size='340' side='right'caption='[[2mbx]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atlantic_cod Atlantic cod~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gadus_morhua Gadus morhua]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [https://pdbe.org/2mbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [https://www.ebi.ac.uk/pdbsum/2mbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [https://pdbe.org/2mbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [https://www.ebi.ac.uk/pdbsum/2mbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRVB_GADMO PRVB_GADMO]] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).	+	[https://www.uniprot.org/uniprot/PRVB_GADMO PRVB_GADMO] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atlantic cod~~]]	+	[[Category: Gadus morhua]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ackerbauer, D]]	+	[[Category: Ackerbauer D]]
-	[[Category: Almeida~~, F C.L~~]]	+	[[Category: Almeida FCL]]
-	[[Category: Breiteneder, H]]	+	[[Category: Breiteneder H]]
-	[[Category: Bublin, M]]	+	[[Category: Bublin M]]
-	[[Category: Ferreira, F]]	+	[[Category: Ferreira F]]
-	[[Category: Moraes~~, A H~~]]	+	[[Category: Moraes AH]]
-	[[Category: Valente, A]]	+	[[Category: Valente A]]
-	~~[[Category: Allergen]]~~	+
-	~~[[Category: Contractile protein]]~~	+
-	~~[[Category: Ef-hand]]~~	+
-	~~[[Category: Parvalbumin~~]]	+

OCA at 11:34, 16 February 2022

2022-02-16T11:34:39Z

←Older revision		Revision as of 11:34, 16 February 2022
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	<StructureSection load='2mbx' size='340' side='right'caption='[[2mbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mbx' size='340' side='right'caption='[[2mbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atlantic_cod Atlantic cod]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2MBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atlantic_cod Atlantic cod]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [~~http~~://pdbe.org/2mbx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mbx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [https://pdbe.org/2mbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [https://www.ebi.ac.uk/pdbsum/2mbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PRVB_GADMO PRVB_GADMO]] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).	+	[[https://www.uniprot.org/uniprot/PRVB_GADMO PRVB_GADMO]] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:21, 13 May 2020

2020-05-13T06:21:45Z

←Older revision		Revision as of 06:21, 13 May 2020
Line 1:		Line 1:

	==Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high-pressure NMR.==		==Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high-pressure NMR.==
-	<StructureSection load='2mbx' size='340' side='right' caption='[[2mbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2mbx' size='340' side='right'caption='[[2mbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atlantic_cod Atlantic cod]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atlantic_cod Atlantic cod]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MBX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://pdbe.org/2mbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://pdbe.org/2mbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Atlantic cod]]		[[Category: Atlantic cod]]
		+	[[Category: Large Structures]]
	[[Category: Ackerbauer, D]]		[[Category: Ackerbauer, D]]
	[[Category: Almeida, F C.L]]		[[Category: Almeida, F C.L]]

OCA at 23:01, 9 August 2018

2018-08-09T23:01:20Z

←Older revision		Revision as of 23:01, 9 August 2018
Line 1:		Line 1:
		+
	==Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high-pressure NMR.==		==Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high-pressure NMR.==
	<StructureSection load='2mbx' size='340' side='right' caption='[[2mbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mbx' size='340' side='right' caption='[[2mbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atlantic_cod Atlantic cod]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://pdbe.org/2mbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://pdbe.org/2mbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atlantic cod]]
	[[Category: Ackerbauer, D]]		[[Category: Ackerbauer, D]]
	[[Category: Almeida, F C.L]]		[[Category: Almeida, F C.L]]

OCA at 10:24, 10 September 2015

2015-09-10T10:24:05Z

←Older revision		Revision as of 10:24, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://pdbe.org/2mbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mbx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Parvalbumin\|Parvalbumin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:27, 24 December 2014

2014-12-24T22:27:55Z

←Older revision		Revision as of 22:27, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRVB_GADMO PRVB_GADMO]] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:40, 19 November 2014

2014-11-19T10:40:32Z

←Older revision		Revision as of 10:40, 19 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
-	~~Gad m 1 is the major allergen from Atlantic cod. It belongs to beta~~-~~parvalbumin protein family and is characterized by~~ the ~~presence~~ of ~~two calcium~~-~~binding sites so called EF-hand motifs. beta-Parvalbumins such as Gad m 1 are the most important~~ fish ~~allergens and their high cross~~-~~reactivity is the cause of the observed polysensitization to various fish species in~~ allergic patients. Despite extensive efforts, the complete elucidation of beta-parvalbumin-IgE complexes has not been achieved yet. Allergen structural studies are essential for the development of novel immunotherapy strategies, including vaccination with hypoallergenic derivatives and chimeric molecules. Here, we report for the first time the NMR ~~study~~ of ~~a beta-parvalbumin:~~ Gad m 1. ~~This report includes: (~~1~~)H, (13)C~~ and ~~(15)N resonance assignments~~ of Gad m 1 ~~as well as the second~~ structure information ~~based on~~ the (13)~~C chemical shifts~~.	+	Beta-parvalbumins from different fish species have been identified as the main elicitors of IgE-mediated reactions in fish-allergic individuals. Here, we report for the first time the NMR determination of the structure and dynamics of the major Atlantic cod (Gadus morhua) allergen Gad m 1 and compare them with other known parvalbumins. Although the Gad m 1 structure and accessibility of putative IgE epitopes are similar to parvalbumins in mackerel and carp, the charge distribution at the putative epitopes is different. The determination of the Gad m 1 structure contributes to a better understanding of cross-reactivity among fish parvalbumins. In addition, the high-pressure NMR and temperature variation experiments revealed the important contribution of the AB motif and other regions to the protein folding. This structural information could assist the future identification of hot spots for targeted mutations to develop hypoallergenic Ca(2+) -free forms for potential use in immunotherapy. Proteins 2014; 82:3032-3042. (c) 2014 Wiley Periodicals, Inc.

-	~~(1)H~~, ~~(1)(3)C~~ and ~~(1)(5)N resonance assignments and second structure information~~ of Gad m 1~~: a beta-parvalbumin allergen from Atlantic cod (Gadus morhua)~~.,Moraes AH, Ackerbauer D, Kostadinova M, Bublin M, Ferreira F, Almeida FC, Breiteneder H, Valente AP ~~Biomol NMR Assign~~. ~~2013 Oct~~;7(2):~~133~~-6. doi: 10.~~1007~~/~~s12104-012-9393-y~~. Epub ~~2012, May 15~~. PMID:~~22585088~~<ref>PMID:~~22585088~~</ref>	+	Solution and high-pressure NMR studies of the structure, dynamics, and stability of the cross-reactive allergenic cod parvalbumin Gad m 1.,Moraes AH, Ackerbauer D, Kostadinova M, Bublin M, de Oliveira GA, Ferreira F, Almeida FC, Breiteneder H, Valente AP Proteins. 2014 Nov;82(11):3032-42. doi: 10.1002/prot.24664. Epub 2014 Aug 30. PMID:25116395<ref>PMID:25116395</ref>

	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ackerbauer, D.]]	+	[[Category: Ackerbauer, D]]
-	[[Category: Almeida, F C.L.]]	+	[[Category: Almeida, F C.L]]
-	[[Category: Breiteneder, H.]]	+	[[Category: Breiteneder, H]]
-	[[Category: Bublin, M.]]	+	[[Category: Bublin, M]]
-	[[Category: Ferreira, F.]]	+	[[Category: Ferreira, F]]
-	[[Category: Moraes, A H.]]	+	[[Category: Moraes, A H]]
-	[[Category: Valente, A.]]	+	[[Category: Valente, A]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Contractile protein]]		[[Category: Contractile protein]]
	[[Category: Ef-hand]]		[[Category: Ef-hand]]
	[[Category: Parvalbumin]]		[[Category: Parvalbumin]]

OCA at 16:21, 20 August 2014

2014-08-20T16:21:51Z

←Older revision		Revision as of 16:21, 20 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high-pressure NMR.==
		+	<StructureSection load='2mbx' size='340' side='right' caption='[[2mbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2mbx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mbx RCSB], [http://www.ebi.ac.uk/pdbsum/2mbx PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gad m 1 is the major allergen from Atlantic cod. It belongs to beta-parvalbumin protein family and is characterized by the presence of two calcium-binding sites so called EF-hand motifs. beta-Parvalbumins such as Gad m 1 are the most important fish allergens and their high cross-reactivity is the cause of the observed polysensitization to various fish species in allergic patients. Despite extensive efforts, the complete elucidation of beta-parvalbumin-IgE complexes has not been achieved yet. Allergen structural studies are essential for the development of novel immunotherapy strategies, including vaccination with hypoallergenic derivatives and chimeric molecules. Here, we report for the first time the NMR study of a beta-parvalbumin: Gad m 1. This report includes: (1)H, (13)C and (15)N resonance assignments of Gad m 1 as well as the second structure information based on the (13)C chemical shifts.

-	~~The entry 2mbx is ON HOLD until Nov 07 2015~~	+	(1)H, (1)(3)C and (1)(5)N resonance assignments and second structure information of Gad m 1: a beta-parvalbumin allergen from Atlantic cod (Gadus morhua).,Moraes AH, Ackerbauer D, Kostadinova M, Bublin M, Ferreira F, Almeida FC, Breiteneder H, Valente AP Biomol NMR Assign. 2013 Oct;7(2):133-6. doi: 10.1007/s12104-012-9393-y. Epub 2012, May 15. PMID:22585088<ref>PMID:22585088</ref>

-	~~Authors: Moraes~~, A.H., Ackerbauer, D.~~, Bublin, M., Ferreira, F.,~~ Almeida, F.C.L., Breiteneder, H., Valente, A.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high~~-~~pressure NMR.~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ackerbauer, D.]]
		+	[[Category: Almeida, F C.L.]]
		+	[[Category: Breiteneder, H.]]
		+	[[Category: Bublin, M.]]
		+	[[Category: Ferreira, F.]]
		+	[[Category: Moraes, A H.]]
		+	[[Category: Valente, A.]]
		+	[[Category: Allergen]]
		+	[[Category: Contractile protein]]
		+	[[Category: Ef-hand]]
		+	[[Category: Parvalbumin]]

OCA at 06:52, 13 August 2014

2014-08-13T06:52:57Z

←Older revision		Revision as of 06:52, 13 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mbx is ON HOLD until ~~Paper Publication~~	+	The entry 2mbx is ON HOLD until Nov 07 2015

	Authors: Moraes, A.H., Ackerbauer, D., Bublin, M., Ferreira, F., Almeida, F.C.L., Breiteneder, H., Valente, A.		Authors: Moraes, A.H., Ackerbauer, D., Bublin, M., Ferreira, F., Almeida, F.C.L., Breiteneder, H., Valente, A.

	Description: Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high-pressure NMR.		Description: Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high-pressure NMR.