2mhk - Revision history

OCA at 06:05, 15 May 2024

2024-05-15T06:05:43Z

←Older revision		Revision as of 06:05, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [https://pdbe.org/2mhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [https://www.ebi.ac.uk/pdbsum/2mhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [https://pdbe.org/2mhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [https://www.ebi.ac.uk/pdbsum/2mhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:57, 8 March 2023

2023-03-08T07:57:45Z

←Older revision		Revision as of 07:57, 8 March 2023
Line 1:		Line 1:

	==E. coli LpoA N-terminal domain==		==E. coli LpoA N-terminal domain==
-	<StructureSection load='2mhk' size='340' side='right'caption='[[2mhk~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2mhk' size='340' side='right'caption='[[2mhk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHK FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ckm\|3ckm]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [https://pdbe.org/2mhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [https://www.ebi.ac.uk/pdbsum/2mhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhk ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b3147, JW3116, lpoA, yraM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [https://pdbe.org/2mhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [https://www.ebi.ac.uk/pdbsum/2mhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LPOA_ECOLI LPOA_ECOLI]] Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro.<ref>PMID:21183073</ref> <ref>PMID:21183074</ref>	+	[https://www.uniprot.org/uniprot/LPOA_ECOLI LPOA_ECOLI] Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro.<ref>PMID:21183073</ref> <ref>PMID:21183074</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bougault, C]]	+	[[Category: Bougault C]]
-	[[Category: Callens, G]]	+	[[Category: Callens G]]
-	[[Category: Derouaux, A]]	+	[[Category: Derouaux A]]
-	[[Category: Egan, A]]	+	[[Category: Egan A]]
-	[[Category: Jean~~, N L~~]]	+	[[Category: Jean NL]]
-	[[Category: Lewis~~, R J~~]]	+	[[Category: Lewis RJ]]
-	[[Category: Lodge, A]]	+	[[Category: Lodge A]]
-	[[Category: Simorre, J]]	+	[[Category: Simorre J]]
-	[[Category: Vollmer, W]]	+	[[Category: Vollmer W]]
-	~~[[Category: Lpoa]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Tpr-like fold~~]]	+

OCA at 15:14, 2 June 2021

2021-06-02T15:14:48Z

←Older revision		Revision as of 15:14, 2 June 2021
Line 1:		Line 1:

	==E. coli LpoA N-terminal domain==		==E. coli LpoA N-terminal domain==
-	<StructureSection load='2mhk' size='340' side='right' caption='[[2mhk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2mhk' size='340' side='right'caption='[[2mhk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MHK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHK FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckm\|3ckm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ckm\|3ckm]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b3147, JW3116, lpoA, yraM ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b3147, JW3116, lpoA, yraM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [~~http~~://pdbe.org/2mhk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mhk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [https://pdbe.org/2mhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [https://www.ebi.ac.uk/pdbsum/2mhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LPOA_ECOLI LPOA_ECOLI]] Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro.<ref>PMID:21183073</ref> <ref>PMID:21183074</ref>	+	[[https://www.uniprot.org/uniprot/LPOA_ECOLI LPOA_ECOLI]] Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro.<ref>PMID:21183073</ref> <ref>PMID:21183074</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Bougault, C]]		[[Category: Bougault, C]]
	[[Category: Callens, G]]		[[Category: Callens, G]]

OCA at 22:38, 9 August 2018

2018-08-09T22:38:27Z

←Older revision		Revision as of 22:38, 9 August 2018
Line 1:		Line 1:
		+
	==E. coli LpoA N-terminal domain==		==E. coli LpoA N-terminal domain==
	<StructureSection load='2mhk' size='340' side='right' caption='[[2mhk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mhk' size='340' side='right' caption='[[2mhk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckm\|3ckm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckm\|3ckm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [http://pdbe.org/2mhk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [http://www.ebi.ac.uk/pdbsum/2mhk PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b3147, JW3116, lpoA, yraM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [http://pdbe.org/2mhk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [http://www.ebi.ac.uk/pdbsum/2mhk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mhk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: Bougault, C]]		[[Category: Bougault, C]]
	[[Category: Callens, G]]		[[Category: Callens, G]]

OCA at 16:37, 11 September 2015

2015-09-11T16:37:59Z

←Older revision		Revision as of 16:37, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckm\|3ckm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckm\|3ckm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [http://www.ebi.ac.uk/pdbsum/2mhk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [http://pdbe.org/2mhk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [http://www.ebi.ac.uk/pdbsum/2mhk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mhk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:06, 25 December 2014

2014-12-25T19:06:34Z

←Older revision		Revision as of 19:06, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckm\|3ckm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckm\|3ckm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [http://www.ebi.ac.uk/pdbsum/2mhk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [http://www.ebi.ac.uk/pdbsum/2mhk PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LPOA_ECOLI LPOA_ECOLI]] Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro.<ref>PMID:21183073</ref> <ref>PMID:21183074</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bougault, C.]]	+	[[Category: Bougault, C]]
-	[[Category: Callens, G.]]	+	[[Category: Callens, G]]
-	[[Category: Derouaux, A.]]	+	[[Category: Derouaux, A]]
-	[[Category: Egan, A.]]	+	[[Category: Egan, A]]
-	[[Category: Jean, N L.]]	+	[[Category: Jean, N L]]
-	[[Category: Lewis, R J.]]	+	[[Category: Lewis, R J]]
-	[[Category: Lodge, A.]]	+	[[Category: Lodge, A]]
-	[[Category: Simorre, J.]]	+	[[Category: Simorre, J]]
-	[[Category: Vollmer, W.]]	+	[[Category: Vollmer, W]]
	[[Category: Lpoa]]		[[Category: Lpoa]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Tpr-like fold]]		[[Category: Tpr-like fold]]

OCA at 09:19, 16 July 2014

2014-07-16T09:19:41Z

←Older revision		Revision as of 09:19, 16 July 2014
Line 6:		Line 6:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [http://www.ebi.ac.uk/pdbsum/2mhk PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [http://www.ebi.ac.uk/pdbsum/2mhk PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial cell envelope contains the stress-bearing peptidoglycan layer, which is enlarged during cell growth and division by membrane-anchored synthases guided by cytoskeletal elements. In Escherichia coli, the major peptidoglycan synthase PBP1A requires stimulation by the outer-membrane-anchored lipoprotein LpoA. Whereas the C-terminal domain of LpoA interacts with PBP1A to stimulate its peptide crosslinking activity, little is known about the role of the N-terminal domain. Herein we report its NMR structure, which adopts an all-alpha-helical fold comprising a series of helix-turn-helix tetratricopeptide-repeat (TPR)-like motifs. NMR spectroscopy of full-length LpoA revealed two extended flexible regions in the C-terminal domain and limited, if any, flexibility between the N- and C-terminal domains. Analytical ultracentrifugation and small-angle X-ray scattering results are consistent with LpoA adopting an elongated shape, with dimensions sufficient to span from the outer membrane through the periplasm to interact with the peptidoglycan synthase PBP1A.
		+
		+	Elongated Structure of the Outer-Membrane Activator of Peptidoglycan Synthesis LpoA: Implications for PBP1A Stimulation.,Jean NL, Bougault CM, Lodge A, Derouaux A, Callens G, Egan AJ, Ayala I, Lewis RJ, Vollmer W, Simorre JP Structure. 2014 Jul 8;22(7):1047-54. doi: 10.1016/j.str.2014.04.017. Epub 2014, Jun 19. PMID:24954617<ref>PMID:24954617</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:29, 25 June 2014

2014-06-25T06:29:25Z

←Older revision		Revision as of 06:29, 25 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==E. coli LpoA N-terminal domain==
-		+	<StructureSection load='2mhk' size='340' side='right' caption='[[2mhk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~The entry~~ 2mhk is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2mhk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MHK FirstGlance]. <br>
-	~~Authors~~: ~~Jean, N~~.L.~~, Bougault, C~~., ~~Lodge~~, A., ~~Derouaux, A~~., Callens, G., Egan, A., Lewis, R.J., ~~Vollmer, W~~., Simorre, J.	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckm\|3ckm]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mhk RCSB], [http://www.ebi.ac.uk/pdbsum/2mhk PDBsum]</span></td></tr>
-	~~Description~~: E. ~~coli LpoA N~~-~~terminal domain~~	+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bougault, C.]]
		+	[[Category: Callens, G.]]
		+	[[Category: Derouaux, A.]]
		+	[[Category: Egan, A.]]
		+	[[Category: Jean, N L.]]
		+	[[Category: Lewis, R J.]]
		+	[[Category: Lodge, A.]]
		+	[[Category: Simorre, J.]]
		+	[[Category: Vollmer, W.]]
		+	[[Category: Lpoa]]
		+	[[Category: Protein binding]]
		+	[[Category: Tpr-like fold]]

OCA at 12:40, 11 December 2013

2013-12-11T12:40:11Z

←Older revision		Revision as of 12:40, 11 December 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mhk is ON HOLD	+	The entry 2mhk is ON HOLD until Paper Publication

	Authors: Jean, N.L., Bougault, C., Lodge, A., Derouaux, A., Callens, G., Egan, A., Lewis, R.J., Vollmer, W., Simorre, J.		Authors: Jean, N.L., Bougault, C., Lodge, A., Derouaux, A., Callens, G., Egan, A., Lewis, R.J., Vollmer, W., Simorre, J.

	Description: E. coli LpoA N-terminal domain		Description: E. coli LpoA N-terminal domain

OCA: Protected "2mhk" [edit=sysop:move=sysop]

2013-12-04T06:22:28Z

Protected "2mhk" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:22, 4 December 2013