2ms5 - Revision history

OCA at 06:09, 15 May 2024

2024-05-15T06:09:44Z

←Older revision		Revision as of 06:09, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [https://pdbe.org/2ms5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ms5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ms5 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [https://pdbe.org/2ms5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ms5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ms5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:43, 14 June 2023

2023-06-14T09:43:49Z

←Older revision		Revision as of 09:43, 14 June 2023
Line 1:		Line 1:

	==Structural dynamics of double-helical RNA having CAG motif==		==Structural dynamics of double-helical RNA having CAG motif==
-	<StructureSection load='2ms5' size='340' side='right'caption='[[2ms5~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='2ms5' size='340' side='right'caption='[[2ms5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nj6\|3nj6]], [[3nj7\|3nj7]], [[4j50\|4j50]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [https://pdbe.org/2ms5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ms5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ms5 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [https://pdbe.org/2ms5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ms5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ms5 ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kumar, A]]	+	[[Category: Kumar A]]
-	[[Category: Tawani, A]]	+	[[Category: Tawani A]]
-	~~[[Category: Cag repeat expansion]]~~	+
-	~~[[Category: Huntington's disease]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Trinucleotide repeat~~]]	+

OCA at 05:23, 10 August 2022

2022-08-10T05:23:56Z

←Older revision		Revision as of 05:23, 10 August 2022
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	<StructureSection load='2ms5' size='340' side='right'caption='[[2ms5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2ms5' size='340' side='right'caption='[[2ms5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nj6\|3nj6]], [[3nj7\|3nj7]], [[4j50\|4j50]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nj6\|3nj6]], [[3nj7\|3nj7]], [[4j50\|4j50]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [~~http~~://pdbe.org/2ms5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ms5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ms5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [https://pdbe.org/2ms5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ms5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ms5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:56, 4 November 2020

2020-11-04T07:56:31Z

←Older revision		Revision as of 07:56, 4 November 2020
Line 1:		Line 1:

	==Structural dynamics of double-helical RNA having CAG motif==		==Structural dynamics of double-helical RNA having CAG motif==
-	<StructureSection load='2ms5' size='340' side='right' caption='[[2ms5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='2ms5' size='340' side='right'caption='[[2ms5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nj6\|3nj6]], [[3nj7\|3nj7]], [[4j50\|4j50]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nj6\|3nj6]], [[3nj7\|3nj7]], [[4j50\|4j50]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [http://pdbe.org/2ms5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ms5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ms5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [http://pdbe.org/2ms5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ms5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ms5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kumar, A]]		[[Category: Kumar, A]]
	[[Category: Tawani, A]]		[[Category: Tawani, A]]

OCA at 13:27, 19 April 2017

2017-04-19T13:27:58Z

←Older revision		Revision as of 13:27, 19 April 2017
Line 1:		Line 1:
		+
	==Structural dynamics of double-helical RNA having CAG motif==		==Structural dynamics of double-helical RNA having CAG motif==
	<StructureSection load='2ms5' size='340' side='right' caption='[[2ms5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2ms5' size='340' side='right' caption='[[2ms5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nj6\|3nj6]], [[3nj7\|3nj7]], [[4j50\|4j50]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nj6\|3nj6]], [[3nj7\|3nj7]], [[4j50\|4j50]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ms5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [http://pdbe.org/2ms5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ms5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ms5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ms5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:33, 15 July 2015

2015-07-15T07:33:48Z

←Older revision		Revision as of 07:33, 15 July 2015
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ms5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ms5 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In humans, neurodegenerative disorders such as Huntington's disease (HD) and many spinocerebellar ataxias (SCAs) have been found to be associated with CAG trinucleotide repeat expansion. An important RNA-mediated mechanism that causes these diseases involves the binding of the splicing regulator protein MBNL1 (Muscleblind-like 1 protein) to expanded r(CAG) repeats. Moreover, mutant huntingtin protein translated from expanded r(CAG) also yields toxic effects. To discern the role of mutant RNA in these diseases, it is essential to gather information about its structure. Detailed insight into the different structures and conformations adopted by these mutant transcripts is vital for developing therapeutics targeting them. Here, we report the crystal structure of an RNA model with a r(CAG) motif, which is complemented by an NMR-based solution structure obtained from restrained Molecular Dynamics (rMD) simulation studies. Crystal structure data of the RNA model resolved at 2.3 A reveals non-canonical pairing of adenine in 5 -CAG/3 -GAC motif samples in different syn and anti conformations. The overall RNA structure has helical parameters intermediate to the A- and B-forms of nucleic acids due to the global widening of major grooves and base-pair preferences near internal AA loops. The comprehension of structural behaviour by studying the spectral features and the dynamics also supports the flexible nature of the r(CAG) motif.
		+
		+	Structural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington's Disease (HD) and Spinocerebellar Ataxias (SCAs).,Tawani A, Kumar A PLoS One. 2015 Jul 6;10(7):e0131788. doi: 10.1371/journal.pone.0131788., eCollection 2015. PMID:26148061<ref>PMID:26148061</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:42, 28 January 2015

2015-01-28T16:42:18Z

←Older revision		Revision as of 16:42, 28 January 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structural dynamics of double-helical RNA having CAG motif==
-		+	<StructureSection load='2ms5' size='340' side='right' caption='[[2ms5]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~The entry~~ 2ms5 is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2ms5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MS5 FirstGlance]. <br>
-	~~Authors~~: ~~Kumar, A~~.~~, Tawani, A~~.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nj6\|3nj6]], [[3nj7\|3nj7]], [[4j50\|4j50]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ms5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ms5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ms5 PDBsum]</span></td></tr>
-	~~Description~~: ~~Structural dynamics of double~~-~~helical RNA having CAG motif~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	__TOC__
-	[[~~Category~~: ~~Tawani~~, A]]	+	</StructureSection>
	[[Category: Kumar, A]]		[[Category: Kumar, A]]
		+	[[Category: Tawani, A]]
		+	[[Category: Cag repeat expansion]]
		+	[[Category: Huntington's disease]]
		+	[[Category: Rna]]
		+	[[Category: Trinucleotide repeat]]

OCA at 12:19, 24 December 2014

2014-12-24T12:19:26Z

←Older revision		Revision as of 12:19, 24 December 2014
Line 6:		Line 6:

	Description: Structural dynamics of double-helical RNA having CAG motif		Description: Structural dynamics of double-helical RNA having CAG motif
		+	[[Category: Unreleased Structures]]
		+	[[Category: Tawani, A]]
		+	[[Category: Kumar, A]]

OCA at 07:41, 10 September 2014

2014-09-10T07:41:21Z

←Older revision		Revision as of 07:41, 10 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2ms5 is ON HOLD ~~until Paper Publication~~	+	The entry 2ms5 is ON HOLD

	Authors: Kumar, A., Tawani, A.		Authors: Kumar, A., Tawani, A.

	Description: Structural dynamics of double-helical RNA having CAG motif		Description: Structural dynamics of double-helical RNA having CAG motif

OCA at 06:05, 27 August 2014

2014-08-27T06:05:07Z

←Older revision		Revision as of 06:05, 27 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2ms5 is ON HOLD	+	The entry 2ms5 is ON HOLD until Paper Publication

	Authors: Kumar, A., Tawani, A.		Authors: Kumar, A., Tawani, A.

	Description: Structural dynamics of double-helical RNA having CAG motif		Description: Structural dynamics of double-helical RNA having CAG motif