2mty - Revision history

OCA at 06:10, 15 May 2024

2024-05-15T06:10:21Z

←Older revision		Revision as of 06:10, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [https://pdbe.org/2mty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [https://www.ebi.ac.uk/pdbsum/2mty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mty ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [https://pdbe.org/2mty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [https://www.ebi.ac.uk/pdbsum/2mty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mty ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:46, 14 June 2023

2023-06-14T09:46:08Z

←Older revision		Revision as of 09:46, 14 June 2023
Line 1:		Line 1:

	==3D structure determination of STARP peptides implicated in P. falciparum Invasion of hepatic cells==		==3D structure determination of STARP peptides implicated in P. falciparum Invasion of hepatic cells==
-	<StructureSection load='2mty' size='340' side='right'caption='[[2mty~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='2mty' size='340' side='right'caption='[[2mty]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTY FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mu6\|2mu6]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [https://pdbe.org/2mty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [https://www.ebi.ac.uk/pdbsum/2mty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mty ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [https://pdbe.org/2mty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [https://www.ebi.ac.uk/pdbsum/2mty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mty ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9U3Y8_PLAFA Q9U3Y8_PLAFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Alba, M P~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: ~~Bermudez, A~~]]	+	[[Category: Alba MP]]
-	[[Category: ~~Patarroyo, M E~~]]	+	[[Category: Bermudez A]]
-	[[Category: ~~Vanegas, M~~]]	+	[[Category: Patarroyo ME]]
-	[[Category: ~~Malaria vaccine]]~~	+	[[Category: Vanegas M]]
-	~~[[Category: Peptide binding]]~~	+
-	~~[[Category: Sporozoite]]~~	+
-	~~[[Category: Starp~~]]	+

OCA at 09:03, 23 February 2022

2022-02-23T09:03:13Z

←Older revision		Revision as of 09:03, 23 February 2022
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	<StructureSection load='2mty' size='340' side='right'caption='[[2mty]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2mty' size='340' side='right'caption='[[2mty]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2MTY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTY FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu6\|2mu6]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mu6\|2mu6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [~~http~~://pdbe.org/2mty PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mty PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mty ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [https://pdbe.org/2mty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [https://www.ebi.ac.uk/pdbsum/2mty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mty ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:28, 20 May 2020

2020-05-20T06:28:21Z

←Older revision		Revision as of 06:28, 20 May 2020
Line 1:		Line 1:

	==3D structure determination of STARP peptides implicated in P. falciparum Invasion of hepatic cells==		==3D structure determination of STARP peptides implicated in P. falciparum Invasion of hepatic cells==
-	<StructureSection load='2mty' size='340' side='right' caption='[[2mty]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='2mty' size='340' side='right'caption='[[2mty]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MTY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MTY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu6\|2mu6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu6\|2mu6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [http://pdbe.org/2mty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [http://www.ebi.ac.uk/pdbsum/2mty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mty ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [http://pdbe.org/2mty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [http://www.ebi.ac.uk/pdbsum/2mty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mty ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Alba, M P]]		[[Category: Alba, M P]]
	[[Category: Bermudez, A]]		[[Category: Bermudez, A]]

OCA at 16:58, 15 August 2018

2018-08-15T16:58:27Z

←Older revision		Revision as of 16:58, 15 August 2018
Line 1:		Line 1:
		+
	==3D structure determination of STARP peptides implicated in P. falciparum Invasion of hepatic cells==		==3D structure determination of STARP peptides implicated in P. falciparum Invasion of hepatic cells==
	<StructureSection load='2mty' size='340' side='right' caption='[[2mty]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2mty' size='340' side='right' caption='[[2mty]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu6\|2mu6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu6\|2mu6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [http://pdbe.org/2mty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [http://www.ebi.ac.uk/pdbsum/2mty PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [http://pdbe.org/2mty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [http://www.ebi.ac.uk/pdbsum/2mty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mty ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:48, 11 September 2015

2015-09-11T09:48:45Z

←Older revision		Revision as of 09:48, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu6\|2mu6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu6\|2mu6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [http://www.ebi.ac.uk/pdbsum/2mty PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [http://pdbe.org/2mty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [http://www.ebi.ac.uk/pdbsum/2mty PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mty" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:48, 17 December 2014

2014-12-17T12:48:58Z

←Older revision		Revision as of 12:48, 17 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==3D structure determination of STARP peptides implicated in P. falciparum Invasion of hepatic cells==
		+	<StructureSection load='2mty' size='340' side='right' caption='[[2mty]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2mty]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTY FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mu6\|2mu6]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mty OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mty RCSB], [http://www.ebi.ac.uk/pdbsum/2mty PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To block the different stages of Plasmodium falciparum invasion into human hepatocytes and red blood cells, we have focused on those proteins belonging to the pre-erythrocytic stage. One of these proteins is Sporozoite Threonine and Asparagine Rich Protein (STARP), which is a ligand used by P. falciparum parasites to bind Hepatic cells (HepG2). Previous studies on this protein identified two conserved peptides binding with high activity to HepG2 cells (namely 20546 and 20570) with corresponding critical hepatic-cell binding residues and determined an important role for these two peptides in the invasion process. This study shows the results of immunization trials in Aotus monkeys with native STARP peptides and analogues modified in critical hepatic-cell binding residues. The results show that native peptides are not immunogenic but can induce high-antibody titers when their critical residues are replaced by other with similar volume and mass but different polarity. Nuclear Magnetic Resonance ((1)H NMR) studies revealed that native peptides (non-immunogenic) displayed shorter alpha-helical regions compared to their highly immunogenic modified analogues. Binding assays with HLA-DRbeta1* molecules showed that 20546 modified peptides inducing high-antibody titers (24972, 24320 and 24486) bound to HLA-DRbeta10301 molecules, while the 20570 modified analogue (24322) bound to HLA-DRbeta10101. The results support including these high-immunogenic STARP-derived modified peptides as pre-erythrocytic candidates to be included in the design of a synthetic antimalarial vaccine.

-	~~The entry 2mty is ON HOLD~~	+	3D structure determination of STARP peptides implicated in P. falciparum invasion of hepatic cells.,Bermudez A, Alba MP, Vanegas M, Patarroyo ME Vaccine. 2010 Jul 12;28(31):4989-96. doi: 10.1016/j.vaccine.2010.05.025. Epub, 2010 May 22. PMID:20580741<ref>PMID:20580741</ref>

-	~~Authors: Adriana~~, B.~~, Martha, A~~.~~, Magnolia, V~~., ~~Manuel~~, E~~.P.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~3D structure determination of STARP peptides implicated in P. falciparum Invasion of hepatic cells~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alba, M P]]
		+	[[Category: Bermudez, A]]
		+	[[Category: Patarroyo, M E]]
		+	[[Category: Vanegas, M]]
		+	[[Category: Malaria vaccine]]
		+	[[Category: Peptide binding]]
		+	[[Category: Sporozoite]]
		+	[[Category: Starp]]

OCA at 07:28, 24 September 2014

2014-09-24T07:28:28Z

←Older revision		Revision as of 07:28, 24 September 2014
Line 3:		Line 3:
	The entry 2mty is ON HOLD		The entry 2mty is ON HOLD

-	Authors: Adriana, B., Martha, A., Magnolia, V., Manuel E., P.	+	Authors: Adriana, B., Martha, A., Magnolia, V., Manuel, E.P.

-	Description: 3D structure determination of STARP peptides implicated in P. falciparum ~~invasion~~ of hepatic cells	+	Description: 3D structure determination of STARP peptides implicated in P. falciparum Invasion of hepatic cells

OCA: Protected "2mty" [edit=sysop:move=sysop]

2014-09-10T07:42:21Z

Protected "2mty" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:42, 10 September 2014

OCA: New page: '''Unreleased structure''' The entry 2mty is ON HOLD Authors: Adriana, B., Martha, A., Magnolia, V., Manuel E., P. Description: 3D structure determination of STARP peptides implicated ...

2014-09-10T07:42:19Z

New page: '''Unreleased structure''' The entry 2mty is ON HOLD Authors: Adriana, B., Martha, A., Magnolia, V., Manuel E., P. Description: 3D structure determination of STARP peptides implicated ...

New page

'''Unreleased structure'''

The entry 2mty is ON HOLD

Authors: Adriana, B., Martha, A., Magnolia, V., Manuel E., P.

Description: 3D structure determination of STARP peptides implicated in P. falciparum invasion of hepatic cells