2mul - Revision history

OCA at 07:02, 1 May 2024

2024-05-01T07:02:23Z

←Older revision		Revision as of 07:02, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mul]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mul]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mul OCA], [https://pdbe.org/2mul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mul RCSB], [https://www.ebi.ac.uk/pdbsum/2mul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mul ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mul OCA], [https://pdbe.org/2mul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mul RCSB], [https://www.ebi.ac.uk/pdbsum/2mul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mul ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 08:07, 8 March 2023

2023-03-08T08:07:19Z

←Older revision		Revision as of 08:07, 8 March 2023
Line 1:		Line 1:

	==Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1==		==Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1==
-	<StructureSection load='2mul' size='340' side='right'caption='[[2mul~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2mul' size='340' side='right'caption='[[2mul]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mul]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mul]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUL FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mul OCA], [https://pdbe.org/2mul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mul RCSB], [https://www.ebi.ac.uk/pdbsum/2mul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mul ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mul OCA], [https://pdbe.org/2mul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mul RCSB], [https://www.ebi.ac.uk/pdbsum/2mul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mul ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN]] Defects in HUWE1 are the cause of mental retardation syndromic X-linked Turner type (MRXST) [MIM:[https://omim.org/entry/300706 300706]]; also known as mental retardation and macrocephaly syndrome. MRXST shows clinical variability. Associated phenotypes include macrocephaly and variable contractures. A chromosomal microduplication involving HUWE1 and HSD17B10 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:[https://omim.org/entry/300705 300705]]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.<ref>PMID:18252223</ref>	+	[https://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN] Defects in HUWE1 are the cause of mental retardation syndromic X-linked Turner type (MRXST) [MIM:[https://omim.org/entry/300706 300706]; also known as mental retardation and macrocephaly syndrome. MRXST shows clinical variability. Associated phenotypes include macrocephaly and variable contractures. A chromosomal microduplication involving HUWE1 and HSD17B10 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:[https://omim.org/entry/300705 300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.<ref>PMID:18252223</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN]] E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.<ref>PMID:15989956</ref> <ref>PMID:15989957</ref> <ref>PMID:15767685</ref> <ref>PMID:15567145</ref> <ref>PMID:17567951</ref> <ref>PMID:18488021</ref> <ref>PMID:19713937</ref>	+	[https://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN] E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.<ref>PMID:15989956</ref> <ref>PMID:15989957</ref> <ref>PMID:15767685</ref> <ref>PMID:15567145</ref> <ref>PMID:17567951</ref> <ref>PMID:18488021</ref> <ref>PMID:19713937</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Farhadi, S]]	+	[[Category: Farhadi S]]
-	[[Category: Hunter, H]]	+	[[Category: Hunter H]]
-	[[Category: Kaustov, L]]	+	[[Category: Kaustov L]]
-	[[Category: Khatun, R]]	+	[[Category: Khatun R]]
-	[[Category: Lemak, A]]	+	[[Category: Lemak A]]
-	[[Category: Ramabadran, R]]	+	[[Category: Ramabadran R]]
-	[[Category: Sheng, Y]]	+	[[Category: Sheng Y]]
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Ubiquitin binding motif~~]]	+

OCA at 15:21, 2 June 2021

2021-06-02T15:21:14Z

←Older revision		Revision as of 15:21, 2 June 2021
Line 3:		Line 3:
	<StructureSection load='2mul' size='340' side='right'caption='[[2mul]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mul' size='340' side='right'caption='[[2mul]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mul]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mul]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mul OCA], [~~http~~://pdbe.org/2mul PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mul RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mul PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mul ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mul OCA], [https://pdbe.org/2mul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mul RCSB], [https://www.ebi.ac.uk/pdbsum/2mul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mul ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN]] Defects in HUWE1 are the cause of mental retardation syndromic X-linked Turner type (MRXST) [MIM:[~~http~~://omim.org/entry/300706 300706]]; also known as mental retardation and macrocephaly syndrome. MRXST shows clinical variability. Associated phenotypes include macrocephaly and variable contractures. A chromosomal microduplication involving HUWE1 and HSD17B10 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:[~~http~~://omim.org/entry/300705 300705]]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.<ref>PMID:18252223</ref>	+	[[https://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN]] Defects in HUWE1 are the cause of mental retardation syndromic X-linked Turner type (MRXST) [MIM:[https://omim.org/entry/300706 300706]]; also known as mental retardation and macrocephaly syndrome. MRXST shows clinical variability. Associated phenotypes include macrocephaly and variable contractures. A chromosomal microduplication involving HUWE1 and HSD17B10 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:[https://omim.org/entry/300705 300705]]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.<ref>PMID:18252223</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN]] E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.<ref>PMID:15989956</ref> <ref>PMID:15989957</ref> <ref>PMID:15767685</ref> <ref>PMID:15567145</ref> <ref>PMID:17567951</ref> <ref>PMID:18488021</ref> <ref>PMID:19713937</ref>	+	[[https://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN]] E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.<ref>PMID:15989956</ref> <ref>PMID:15989957</ref> <ref>PMID:15767685</ref> <ref>PMID:15567145</ref> <ref>PMID:17567951</ref> <ref>PMID:18488021</ref> <ref>PMID:19713937</ref>

	==See Also==		==See Also==
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]	+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:27, 21 August 2019

2019-08-21T07:27:29Z

←Older revision		Revision as of 07:27, 21 August 2019
Line 1:		Line 1:

	==Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1==		==Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1==
-	<StructureSection load='2mul' size='340' side='right' caption='[[2mul]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2mul' size='340' side='right'caption='[[2mul]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mul]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MUL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mul]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MUL FirstGlance]. <br>
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN]] E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.<ref>PMID:15989956</ref> <ref>PMID:15989957</ref> <ref>PMID:15767685</ref> <ref>PMID:15567145</ref> <ref>PMID:17567951</ref> <ref>PMID:18488021</ref> <ref>PMID:19713937</ref>		[[http://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN]] E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.<ref>PMID:15989956</ref> <ref>PMID:15989957</ref> <ref>PMID:15767685</ref> <ref>PMID:15567145</ref> <ref>PMID:17567951</ref> <ref>PMID:18488021</ref> <ref>PMID:19713937</ref>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Farhadi, S]]		[[Category: Farhadi, S]]
	[[Category: Hunter, H]]		[[Category: Hunter, H]]

OCA at 16:47, 16 November 2017

2017-11-16T16:47:46Z

←Older revision		Revision as of 16:47, 16 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 2mul ~~is ON HOLD until Sep 12 2016~~	+	==Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1==
-		+	<StructureSection load='2mul' size='340' side='right' caption='[[2mul]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~: ~~Farhadi~~, S., ~~Khatun~~, R., ~~Lemak~~, A.~~, Kaustov, L~~.~~, Ramabadran, R~~., ~~Hunter~~, ~~H., Sheng, Y~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2mul]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MUL FirstGlance]. <br>
-	~~Description~~: ~~Solution Structure~~ of the ~~UBM1 domain~~ of ~~human HUWE1~~/~~ARF~~-~~BP1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mul OCA], [http://pdbe.org/2mul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mul RCSB], [http://www.ebi.ac.uk/pdbsum/2mul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mul ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN]] Defects in HUWE1 are the cause of mental retardation syndromic X-linked Turner type (MRXST) [MIM:[http://omim.org/entry/300706 300706]]; also known as mental retardation and macrocephaly syndrome. MRXST shows clinical variability. Associated phenotypes include macrocephaly and variable contractures. A chromosomal microduplication involving HUWE1 and HSD17B10 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:[http://omim.org/entry/300705 300705]]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.<ref>PMID:18252223</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN]] E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.<ref>PMID:15989956</ref> <ref>PMID:15989957</ref> <ref>PMID:15767685</ref> <ref>PMID:15567145</ref> <ref>PMID:17567951</ref> <ref>PMID:18488021</ref> <ref>PMID:19713937</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Farhadi, S]]		[[Category: Farhadi, S]]
		+	[[Category: Hunter, H]]
		+	[[Category: Kaustov, L]]
		+	[[Category: Khatun, R]]
	[[Category: Lemak, A]]		[[Category: Lemak, A]]
	[[Category: Ramabadran, R]]		[[Category: Ramabadran, R]]
-	[[Category: Kaustov, L]]
-	[[Category: Hunter, H]]
-	[[Category: Khatun, R]]
	[[Category: Sheng, Y]]		[[Category: Sheng, Y]]
		+	[[Category: Protein binding]]
		+	[[Category: Ubiquitin binding motif]]

OCA at 13:58, 5 August 2015

2015-08-05T13:58:10Z

←Older revision		Revision as of 13:58, 5 August 2015
Line 9:		Line 9:
	[[Category: Farhadi, S]]		[[Category: Farhadi, S]]
	[[Category: Lemak, A]]		[[Category: Lemak, A]]
-	[[Category: Khatun, R]]
	[[Category: Ramabadran, R]]		[[Category: Ramabadran, R]]
	[[Category: Kaustov, L]]		[[Category: Kaustov, L]]
	[[Category: Hunter, H]]		[[Category: Hunter, H]]
		+	[[Category: Khatun, R]]
	[[Category: Sheng, Y]]		[[Category: Sheng, Y]]

OCA at 12:26, 24 December 2014

2014-12-24T12:26:18Z

←Older revision		Revision as of 12:26, 24 December 2014
Line 6:		Line 6:

	Description: Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1		Description: Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1
		+	[[Category: Unreleased Structures]]
		+	[[Category: Farhadi, S]]
		+	[[Category: Lemak, A]]
		+	[[Category: Khatun, R]]
		+	[[Category: Ramabadran, R]]
		+	[[Category: Kaustov, L]]
		+	[[Category: Hunter, H]]
		+	[[Category: Sheng, Y]]

OCA at 13:47, 12 October 2014

2014-10-12T13:47:55Z

←Older revision		Revision as of 13:47, 12 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mul is ON HOLD	+	The entry 2mul is ON HOLD until Sep 12 2016

	Authors: Farhadi, S., Khatun, R., Lemak, A., Kaustov, L., Ramabadran, R., Hunter, H., Sheng, Y.		Authors: Farhadi, S., Khatun, R., Lemak, A., Kaustov, L., Ramabadran, R., Hunter, H., Sheng, Y.

	Description: Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1		Description: Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1

OCA: Protected "2mul" [edit=sysop:move=sysop]

2014-09-24T07:29:25Z

Protected "2mul" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:29, 24 September 2014

OCA: New page: '''Unreleased structure''' The entry 2mul is ON HOLD Authors: Farhadi, S., Khatun, R., Lemak, A., Kaustov, L., Ramabadran, R., Hunter, H., Sheng, Y. Description: Solution Structure of ...

2014-09-24T07:29:23Z

New page: '''Unreleased structure''' The entry 2mul is ON HOLD Authors: Farhadi, S., Khatun, R., Lemak, A., Kaustov, L., Ramabadran, R., Hunter, H., Sheng, Y. Description: Solution Structure of ...

New page

'''Unreleased structure'''

The entry 2mul is ON HOLD

Authors: Farhadi, S., Khatun, R., Lemak, A., Kaustov, L., Ramabadran, R., Hunter, H., Sheng, Y.

Description: Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1