2mux - Revision history

OCA at 06:10, 15 May 2024

2024-05-15T06:10:47Z

←Older revision		Revision as of 06:10, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [https://pdbe.org/2mux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [https://www.ebi.ac.uk/pdbsum/2mux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mux ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [https://pdbe.org/2mux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [https://www.ebi.ac.uk/pdbsum/2mux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mux ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:07, 8 March 2023

2023-03-08T08:07:34Z

←Older revision		Revision as of 08:07, 8 March 2023
Line 1:		Line 1:

	==SUMO2 non-covalently interacts with USP25 and downregulates its activity==		==SUMO2 non-covalently interacts with USP25 and downregulates its activity==
-	<StructureSection load='2mux' size='340' side='right'caption='[[2mux~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='2mux' size='340' side='right'caption='[[2mux]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">USP25, USP21 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [https://pdbe.org/2mux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [https://www.ebi.ac.uk/pdbsum/2mux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mux ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [https://pdbe.org/2mux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [https://www.ebi.ac.uk/pdbsum/2mux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mux ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/UBP25_HUMAN UBP25_HUMAN]] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.	+	[https://www.uniprot.org/uniprot/UBP25_HUMAN UBP25_HUMAN] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.

	==See Also==		==See Also==
Line 15:		Line 13:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Ubiquitinyl hydrolase 1]]~~	+	[[Category: Shi L]]
-	[[Category: Shi, L]]	+	[[Category: Wen Y]]
-	[[Category: Wen, Y]]	+	[[Category: Zhang N]]
-	[[Category: Zhang, N]]	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 15:21, 2 June 2021

2021-06-02T15:21:25Z

←Older revision		Revision as of 15:21, 2 June 2021
Line 1:		Line 1:

	==SUMO2 non-covalently interacts with USP25 and downregulates its activity==		==SUMO2 non-covalently interacts with USP25 and downregulates its activity==
-	<StructureSection load='2mux' size='340' side='right' caption='[[2mux]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='2mux' size='340' side='right'caption='[[2mux]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mux]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MUX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">USP25, USP21 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">USP25, USP21 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [~~http~~://pdbe.org/2mux PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mux PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mux ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [https://pdbe.org/2mux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [https://www.ebi.ac.uk/pdbsum/2mux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mux ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/UBP25_HUMAN UBP25_HUMAN]] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.	+	[[https://www.uniprot.org/uniprot/UBP25_HUMAN UBP25_HUMAN]] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
		+
		+	==See Also==
		+	*[[Thioesterase 3D structures\|Thioesterase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ubiquitinyl hydrolase 1]]		[[Category: Ubiquitinyl hydrolase 1]]
	[[Category: Shi, L]]		[[Category: Shi, L]]

OCA at 12:22, 16 November 2017

2017-11-16T12:22:29Z

←Older revision		Revision as of 12:22, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='2mux' size='340' side='right' caption='[[2mux]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2mux' size='340' side='right' caption='[[2mux]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mux]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MUX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mux]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MUX FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">USP25, USP21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [http://pdbe.org/2mux PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [http://www.ebi.ac.uk/pdbsum/2mux PDBsum]</span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [http://pdbe.org/2mux PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [http://www.ebi.ac.uk/pdbsum/2mux PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mux ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Ubiquitinyl hydrolase 1]]		[[Category: Ubiquitinyl hydrolase 1]]
	[[Category: Shi, L]]		[[Category: Shi, L]]

OCA at 18:36, 12 May 2016

2016-05-12T18:36:37Z

←Older revision		Revision as of 18:36, 12 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 2mux is ~~ON HOLD until Paper Publication~~	+	==SUMO2 non-covalently interacts with USP25 and downregulates its activity==
-		+	<StructureSection load='2mux' size='340' side='right' caption='[[2mux]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
-	~~Authors~~: ~~Shi~~, L., ~~Zhang~~, N., ~~Wen, Y~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2mux]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MUX FirstGlance]. <br>
-	~~Description~~: ~~SUMO2 non~~-~~covalently interacts with USP25~~ and ~~downregulates its activity~~	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [http://pdbe.org/2mux PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [http://www.ebi.ac.uk/pdbsum/2mux PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UBP25_HUMAN UBP25_HUMAN]] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ubiquitinyl hydrolase 1]]
		+	[[Category: Shi, L]]
		+	[[Category: Wen, Y]]
	[[Category: Zhang, N]]		[[Category: Zhang, N]]
-	[[Category: ~~Wen, Y]]~~	+	[[Category: Hydrolase]]
-	~~[[Category: Shi, L~~]]	+

OCA at 12:27, 24 December 2014

2014-12-24T12:27:51Z

←Older revision		Revision as of 12:27, 24 December 2014
Line 6:		Line 6:

	Description: SUMO2 non-covalently interacts with USP25 and downregulates its activity		Description: SUMO2 non-covalently interacts with USP25 and downregulates its activity
		+	[[Category: Unreleased Structures]]
		+	[[Category: Zhang, N]]
		+	[[Category: Wen, Y]]
		+	[[Category: Shi, L]]

OCA at 08:58, 20 October 2014

2014-10-20T08:58:20Z

←Older revision		Revision as of 08:58, 20 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2mux is ON HOLD	+	The entry 2mux is ON HOLD until Paper Publication

	Authors: Shi, L., Zhang, N., Wen, Y.		Authors: Shi, L., Zhang, N., Wen, Y.

	Description: SUMO2 non-covalently interacts with USP25 and downregulates its activity		Description: SUMO2 non-covalently interacts with USP25 and downregulates its activity

OCA: Protected "2mux" [edit=sysop:move=sysop]

2014-09-24T07:30:08Z

Protected "2mux" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:30, 24 September 2014

OCA: New page: '''Unreleased structure''' The entry 2mux is ON HOLD Authors: Shi, L., Zhang, N., Wen, Y. Description: SUMO2 non-covalently interacts with USP25 and downregulates its activity

2014-09-24T07:30:06Z

New page: '''Unreleased structure''' The entry 2mux is ON HOLD Authors: Shi, L., Zhang, N., Wen, Y. Description: SUMO2 non-covalently interacts with USP25 and downregulates its activity

New page

'''Unreleased structure'''

The entry 2mux is ON HOLD

Authors: Shi, L., Zhang, N., Wen, Y.

Description: SUMO2 non-covalently interacts with USP25 and downregulates its activity