2mwl - Revision history

OCA at 06:11, 15 May 2024

2024-05-15T06:11:25Z

←Older revision		Revision as of 06:11, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MWL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MWL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [https://pdbe.org/2mwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [https://www.ebi.ac.uk/pdbsum/2mwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mwl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [https://pdbe.org/2mwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [https://www.ebi.ac.uk/pdbsum/2mwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mwl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:49, 14 June 2023

2023-06-14T09:49:22Z

←Older revision		Revision as of 09:49, 14 June 2023
Line 1:		Line 1:

	==NMR structure of VG16KRKP, an antimicrobial peptide in LPS==		==NMR structure of VG16KRKP, an antimicrobial peptide in LPS==
-	<StructureSection load='2mwl' size='340' side='right'caption='[[2mwl~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2mwl' size='340' side='right'caption='[[2mwl]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MWL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MWL FirstGlance]. <br>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bhunia, A]]	+	[[Category: Bhunia A]]
-	[[Category: Datta, A]]	+	[[Category: Datta A]]
-	~~[[Category: Antiendotoxic molecule]]~~	+
-	~~[[Category: Antimicrobial peptide]]~~	+
-	~~[[Category: Antimicrobial protein~~]]	+

OCA at 05:23, 10 August 2022

2022-08-10T05:23:56Z

←Older revision		Revision as of 05:23, 10 August 2022
Line 3:		Line 3:
	<StructureSection load='2mwl' size='340' side='right'caption='[[2mwl]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mwl' size='340' side='right'caption='[[2mwl]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2MWL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MWL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [~~http~~://pdbe.org/2mwl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mwl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mwl ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [https://pdbe.org/2mwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [https://www.ebi.ac.uk/pdbsum/2mwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mwl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:56, 4 November 2020

2020-11-04T07:56:33Z

←Older revision		Revision as of 07:56, 4 November 2020
Line 1:		Line 1:

	==NMR structure of VG16KRKP, an antimicrobial peptide in LPS==		==NMR structure of VG16KRKP, an antimicrobial peptide in LPS==
-	<StructureSection load='2mwl' size='340' side='right' caption='[[2mwl]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2mwl' size='340' side='right'caption='[[2mwl]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MWL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MWL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [http://pdbe.org/2mwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [http://www.ebi.ac.uk/pdbsum/2mwl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mwl ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [http://pdbe.org/2mwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [http://www.ebi.ac.uk/pdbsum/2mwl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mwl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bhunia, A]]		[[Category: Bhunia, A]]
	[[Category: Datta, A]]		[[Category: Datta, A]]

OCA at 14:17, 27 April 2017

2017-04-27T14:17:05Z

←Older revision		Revision as of 14:17, 27 April 2017
Line 1:		Line 1:
		+
	==NMR structure of VG16KRKP, an antimicrobial peptide in LPS==		==NMR structure of VG16KRKP, an antimicrobial peptide in LPS==
	<StructureSection load='2mwl' size='340' side='right' caption='[[2mwl]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mwl' size='340' side='right' caption='[[2mwl]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MWL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MWL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [http://www.ebi.ac.uk/pdbsum/2mwl PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [http://pdbe.org/2mwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [http://www.ebi.ac.uk/pdbsum/2mwl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mwl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2mwl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:04, 22 July 2015

2015-07-22T08:04:56Z

←Older revision		Revision as of 08:04, 22 July 2015
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [http://www.ebi.ac.uk/pdbsum/2mwl PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [http://www.ebi.ac.uk/pdbsum/2mwl PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The recent increase in multidrug resistance against bacterial infections has become a major concern to human health and global food security. Synthetic antimicrobial peptides (AMPs) have recently received substantial attention as potential alternatives to conventional antibiotics because of their potent broad-spectrum antimicrobial activity. These peptides have also been implicated in plant disease control for replacing conventional treatment methods that are polluting and hazardous to the environment and to human health. Here, we report de novo design and antimicrobial studies of VG16, a 16-residue active fragment of Dengue virus fusion peptide. Our results reveal that VG16KRKP, a non-toxic and non-hemolytic analogue of VG16, shows significant antimicrobial activity against Gram-negative E. coli and plant pathogens X. oryzae and X. campestris, as well as against human fungal pathogens C. albicans and C. grubii. VG16KRKP is also capable of inhibiting bacterial disease progression in plants. The solution-NMR structure of VG16KRKP in lipopolysaccharide features a folded conformation with a centrally located turn-type structure stabilized by aromatic-aromatic packing interactions with extended N- and C-termini. The de novo design of VG16KRKP provides valuable insights into the development of more potent antibacterial and antiendotoxic peptides for the treatment of human and plant infections.
		+
		+	Antimicrobial Peptides: Insights into Membrane Permeabilization, Lipopolysaccharide Fragmentation and Application in Plant Disease Control.,Datta A, Ghosh A, Airoldi C, Sperandeo P, Mroue KH, Jimenez-Barbero J, Kundu P, Ramamoorthy A, Bhunia A Sci Rep. 2015 Jul 6;5:11951. doi: 10.1038/srep11951. PMID:26144972<ref>PMID:26144972</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:02, 24 December 2014

2014-12-24T11:02:59Z

←Older revision		Revision as of 11:02, 24 December 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==NMR structure of VG16KRKP, an antimicrobial peptide in LPS==
-		+	<StructureSection load='2mwl' size='340' side='right' caption='[[2mwl]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~The entry~~ 2mwl is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2mwl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MWL FirstGlance]. <br>
-	~~Authors~~: Bhunia, A., Datta, A.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mwl RCSB], [http://www.ebi.ac.uk/pdbsum/2mwl PDBsum]</span></td></tr>
-		+	</table>
-	~~Description~~: ~~Backbone and 1H assignments for VG16KRKP, an antimicrobial~~ peptide ~~in LPS~~	+	__TOC__
		+	</StructureSection>
		+	[[Category: Bhunia, A]]
		+	[[Category: Datta, A]]
		+	[[Category: Antiendotoxic molecule]]
		+	[[Category: Antimicrobial peptide]]
		+	[[Category: Antimicrobial protein]]

OCA: Protected "2mwl" [edit=sysop:move=sysop]

2014-11-19T11:00:29Z

Protected "2mwl" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:00, 19 November 2014

OCA: New page: '''Unreleased structure''' The entry 2mwl is ON HOLD Authors: Bhunia, A., Datta, A. Description: Backbone and 1H assignments for VG16KRKP, an antimicrobial peptide in LPS

2014-11-19T11:00:28Z

New page: '''Unreleased structure''' The entry 2mwl is ON HOLD Authors: Bhunia, A., Datta, A. Description: Backbone and 1H assignments for VG16KRKP, an antimicrobial peptide in LPS

New page

'''Unreleased structure'''

The entry 2mwl is ON HOLD

Authors: Bhunia, A., Datta, A.

Description: Backbone and 1H assignments for VG16KRKP, an antimicrobial peptide in LPS