2nbr - Revision history

OCA at 10:26, 15 March 2023

2023-03-15T10:26:37Z

←Older revision

Revision as of 10:26, 15 March 2023

OCA at 15:43, 8 June 2021

2021-06-08T15:43:54Z

←Older revision		Revision as of 15:43, 8 June 2021
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	<StructureSection load='2nbr' size='340' side='right'caption='[[2nbr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2nbr' size='340' side='right'caption='[[2nbr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nbr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NBR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NBR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nbr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NBR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nbr OCA], [~~http~~://pdbe.org/2nbr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nbr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nbr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nbr ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nbr OCA], [https://pdbe.org/2nbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nbr RCSB], [https://www.ebi.ac.uk/pdbsum/2nbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nbr ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CRGC_HUMAN CRGC_HUMAN]] Pulverulent cataract;Coppock-like cataract;Zonular cataract;Cataract-microcornea syndrome. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/CRGC_HUMAN CRGC_HUMAN]] Pulverulent cataract;Coppock-like cataract;Zonular cataract;Cataract-microcornea syndrome. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CRGC_HUMAN CRGC_HUMAN]] Crystallins are the dominant structural components of the vertebrate eye lens.	+	[[https://www.uniprot.org/uniprot/CRGC_HUMAN CRGC_HUMAN]] Crystallins are the dominant structural components of the vertebrate eye lens.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:20, 21 August 2019

2019-08-21T07:20:05Z

←Older revision		Revision as of 07:20, 21 August 2019
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	==The Solution Structure of Human gammaC-crystallin==		==The Solution Structure of Human gammaC-crystallin==
-	<StructureSection load='2nbr' size='340' side='right' caption='[[2nbr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2nbr' size='340' side='right'caption='[[2nbr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nbr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NBR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nbr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NBR FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 2nbr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2nbr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Crystallin 3D structures\|Crystallin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Dixit, K]]		[[Category: Dixit, K]]
	[[Category: Pande, A]]		[[Category: Pande, A]]

OCA at 08:49, 3 August 2017

2017-08-03T08:49:16Z

←Older revision		Revision as of 08:49, 3 August 2017
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nbr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NBR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nbr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NBR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nbr OCA], [http://pdbe.org/2nbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nbr RCSB], [http://www.ebi.ac.uk/pdbsum/2nbr PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nbr OCA], [http://pdbe.org/2nbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nbr RCSB], [http://www.ebi.ac.uk/pdbsum/2nbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nbr ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 15:42, 1 June 2016

2016-06-01T15:42:11Z

←Older revision		Revision as of 15:42, 1 June 2016
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-	'''Unreleased structure'''

-	The ~~entry~~ 2nbr is ~~ON HOLD~~	+	==The Solution Structure of Human gammaC-crystallin==
		+	<StructureSection load='2nbr' size='340' side='right' caption='[[2nbr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2nbr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NBR FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nbr OCA], [http://pdbe.org/2nbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nbr RCSB], [http://www.ebi.ac.uk/pdbsum/2nbr PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CRGC_HUMAN CRGC_HUMAN]] Pulverulent cataract;Coppock-like cataract;Zonular cataract;Cataract-microcornea syndrome. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CRGC_HUMAN CRGC_HUMAN]] Crystallins are the dominant structural components of the vertebrate eye lens.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A hallmark of the crystallin proteins is their exceptionally high solubility, which is vital for maintaining the high refractive index of the eye lens. Human gammaC-crystallin is a major gamma-crystallin whose mutant forms are associated with congenital cataracts but whose three-dimensional structure is not known. An earlier study of a homology model concluded that human gammaC-crystallin has low intrinsic solubility, mainly because of the atypical magnitude and fluctuations of its dipole moment. On the contrary, the high-resolution tertiary structure of human gammaC-crystallin determined here shows unequivocally that it is a highly soluble, monomeric molecule in solution. Notable differences between the orientations and interactions of several side chains are observed upon comparison to those in the model. No evidence of the pivotal role ascribed to the effect of dipole moment on protein solubility was found. The nuclear magnetic resonance structure should facilitate a comprehensive understanding of the deleterious effects of cataract-associated mutations in human gammaC-crystallin.

-	~~Authors~~: Dixit, K., Pande, A., Pande, J., Sarma~~, S~~.P.	+	Nuclear Magnetic Resonance Structure of a Major Lens Protein, Human gammaC-Crystallin: Role of the Dipole Moment in Protein Solubility.,Dixit K, Pande A, Pande J, Sarma SP Biochemistry. 2016 May 23. PMID:27187112<ref>PMID:27187112</ref>

-	~~Description: The Solution Structure~~ of ~~Human gammaC~~-~~crystallin~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 2nbr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dixit, K]]
	[[Category: Pande, A]]		[[Category: Pande, A]]
	[[Category: Pande, J]]		[[Category: Pande, J]]
-	[[Category: Sarma, S.P]]	+	[[Category: Sarma, S P]]
-	[[Category: ~~Dixit, K~~]]	+	[[Category: Human gammac-crystallin]]
		+	[[Category: Structural protein]]

OCA: Protected "2nbr" [edit=sysop:move=sysop]

2016-05-10T20:04:28Z

Protected "2nbr" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:04, 10 May 2016

OCA: New page: '''Unreleased structure''' The entry 2nbr is ON HOLD Authors: Dixit, K., Pande, A., Pande, J., Sarma, S.P. Description: The Solution Structure of Human gammaC-crystallin [[Category: Un...

2016-05-10T20:04:27Z

New page: '''Unreleased structure''' The entry 2nbr is ON HOLD Authors: Dixit, K., Pande, A., Pande, J., Sarma, S.P. Description: The Solution Structure of Human gammaC-crystallin [[Category: Un...

New page

'''Unreleased structure'''

The entry 2nbr is ON HOLD

Authors: Dixit, K., Pande, A., Pande, J., Sarma, S.P.

Description: The Solution Structure of Human gammaC-crystallin
[[Category: Unreleased Structures]]
[[Category: Pande, A]]
[[Category: Pande, J]]
[[Category: Sarma, S.P]]
[[Category: Dixit, K]]