2nld - Revision history

OCA at 10:16, 30 August 2023

2023-08-30T10:16:29Z

←Older revision		Revision as of 10:16, 30 August 2023
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	<StructureSection load='2nld' size='340' side='right'caption='[[2nld]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='2nld' size='340' side='right'caption='[[2nld]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nld]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NLD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nld]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NLD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.49Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2nlb\|2nlb]], [[2nlc\|2nlc]], [[2nle\|2nle]], [[2nlf\|2nlf]], [[2nlg\|2nlg]], [[2nlh\|2nlh]], [[2nlp\|2nlp]], [[2nlq\|2nlq]], [[2nls\|2nls]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">DEFB1, BD1, HBD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [https://pdbe.org/2nld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [https://www.ebi.ac.uk/pdbsum/2nld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nld ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [https://pdbe.org/2nld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [https://www.ebi.ac.uk/pdbsum/2nld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nld ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DEFB1_HUMAN DEFB1_HUMAN]] Has bactericidal activity (By similarity).	+	[https://www.uniprot.org/uniprot/DEFB1_HUMAN DEFB1_HUMAN] Has bactericidal activity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lubkowski, J]]	+	[[Category: Lubkowski J]]
-	[[Category: Pazgier, M]]	+	[[Category: Pazgier M]]
-	~~[[Category: Antimicrobial]]~~	+
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: Chemotactic]]~~	+
-	~~[[Category: Defensin]]~~	+
-	~~[[Category: Mutant~~]]	+

OCA at 15:45, 8 June 2021

2021-06-08T15:45:01Z

←Older revision		Revision as of 15:45, 8 June 2021
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	==Human beta-defensin-1 (Mutant Gln11Ala)==		==Human beta-defensin-1 (Mutant Gln11Ala)==
-	<StructureSection load='2nld' size='340' side='right' caption='[[2nld]], [[Resolution\|resolution]] 1.49Å' scene=''>	+	<StructureSection load='2nld' size='340' side='right'caption='[[2nld]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nld]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NLD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nld]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NLD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nlb\|2nlb]], [[2nlc\|2nlc]], [[2nle\|2nle]], [[2nlf\|2nlf]], [[2nlg\|2nlg]], [[2nlh\|2nlh]], [[2nlp\|2nlp]], [[2nlq\|2nlq]], [[2nls\|2nls]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nlb\|2nlb]], [[2nlc\|2nlc]], [[2nle\|2nle]], [[2nlf\|2nlf]], [[2nlg\|2nlg]], [[2nlh\|2nlh]], [[2nlp\|2nlp]], [[2nlq\|2nlq]], [[2nls\|2nls]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFB1, BD1, HBD1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFB1, BD1, HBD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [~~http~~://pdbe.org/2nld PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nld PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nld ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [https://pdbe.org/2nld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [https://www.ebi.ac.uk/pdbsum/2nld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nld ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DEFB1_HUMAN DEFB1_HUMAN]] Has bactericidal activity (By similarity).	+	[[https://www.uniprot.org/uniprot/DEFB1_HUMAN DEFB1_HUMAN]] Has bactericidal activity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/2nld_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/2nld_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2nld" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2nld" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Defensin 3D structures\|Defensin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lubkowski, J]]		[[Category: Lubkowski, J]]
	[[Category: Pazgier, M]]		[[Category: Pazgier, M]]

OCA at 08:36, 18 October 2017

2017-10-18T08:36:03Z

←Older revision		Revision as of 08:36, 18 October 2017
Line 1:		Line 1:
		+
	==Human beta-defensin-1 (Mutant Gln11Ala)==		==Human beta-defensin-1 (Mutant Gln11Ala)==
	<StructureSection load='2nld' size='340' side='right' caption='[[2nld]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='2nld' size='340' side='right' caption='[[2nld]], [[Resolution\|resolution]] 1.49Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nlb\|2nlb]], [[2nlc\|2nlc]], [[2nle\|2nle]], [[2nlf\|2nlf]], [[2nlg\|2nlg]], [[2nlh\|2nlh]], [[2nlp\|2nlp]], [[2nlq\|2nlq]], [[2nls\|2nls]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nlb\|2nlb]], [[2nlc\|2nlc]], [[2nle\|2nle]], [[2nlf\|2nlf]], [[2nlg\|2nlg]], [[2nlh\|2nlh]], [[2nlp\|2nlp]], [[2nlq\|2nlq]], [[2nls\|2nls]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFB1, BD1, HBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFB1, BD1, HBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [http://pdbe.org/2nld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [http://www.ebi.ac.uk/pdbsum/2nld PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [http://pdbe.org/2nld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [http://www.ebi.ac.uk/pdbsum/2nld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nld ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nld ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2nld" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2nld" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Defensin\|Defensin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:30, 11 September 2015

2015-09-11T17:30:02Z

←Older revision		Revision as of 17:30, 11 September 2015
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	<StructureSection load='2nld' size='340' side='right' caption='[[2nld]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='2nld' size='340' side='right' caption='[[2nld]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nlb\|2nlb]], [[2nlc\|2nlc]], [[2nle\|2nle]], [[2nlf\|2nlf]], [[2nlg\|2nlg]], [[2nlh\|2nlh]], [[2nlp\|2nlp]], [[2nlq\|2nlq]], [[2nls\|2nls]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nlb\|2nlb]], [[2nlc\|2nlc]], [[2nle\|2nle]], [[2nlf\|2nlf]], [[2nlg\|2nlg]], [[2nlh\|2nlh]], [[2nlp\|2nlp]], [[2nlq\|2nlq]], [[2nls\|2nls]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFB1, BD1, HBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFB1, BD1, HBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [http://www.ebi.ac.uk/pdbsum/2nld PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [http://pdbe.org/2nld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [http://www.ebi.ac.uk/pdbsum/2nld PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DEFB1_HUMAN DEFB1_HUMAN]] Has bactericidal activity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2nld" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Lubkowski, J]]		[[Category: Lubkowski, J]]
	[[Category: Pazgier, M]]		[[Category: Pazgier, M]]

OCA at 15:12, 19 January 2015

2015-01-19T15:12:43Z

←Older revision		Revision as of 15:12, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nlb\|2nlb]], [[2nlc\|2nlc]], [[2nle\|2nle]], [[2nlf\|2nlf]], [[2nlg\|2nlg]], [[2nlh\|2nlh]], [[2nlp\|2nlp]], [[2nlq\|2nlq]], [[2nls\|2nls]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nlb\|2nlb]], [[2nlc\|2nlc]], [[2nle\|2nle]], [[2nlf\|2nlf]], [[2nlg\|2nlg]], [[2nlh\|2nlh]], [[2nlp\|2nlp]], [[2nlq\|2nlq]], [[2nls\|2nls]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFB1, BD1, HBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFB1, BD1, HBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [http://www.ebi.ac.uk/pdbsum/2nld PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [http://www.ebi.ac.uk/pdbsum/2nld PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Lubkowski, J.]]	+	[[Category: Lubkowski, J]]
-	[[Category: Pazgier, M.]]	+	[[Category: Pazgier, M]]
	[[Category: Antimicrobial]]		[[Category: Antimicrobial]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]

OCA at 18:42, 30 September 2014

2014-09-30T18:42:56Z

←Older revision		Revision as of 18:42, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2nld\| PDB=2nld \| SCENE= }}~~	+	==Human beta-defensin-1 (Mutant Gln11Ala)==
-	===Human beta-defensin-1 (Mutant Gln11Ala)===	+	<StructureSection load='2nld' size='340' side='right' caption='[[2nld]], [[Resolution\|resolution]] 1.49Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17071614}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nlb\|2nlb]], [[2nlc\|2nlc]], [[2nle\|2nle]], [[2nlf\|2nlf]], [[2nlg\|2nlg]], [[2nlh\|2nlh]], [[2nlp\|2nlp]], [[2nlq\|2nlq]], [[2nls\|2nls]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFB1, BD1, HBD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nld RCSB], [http://www.ebi.ac.uk/pdbsum/2nld PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/2nld_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Defensins are small (30-45 amino acid residues) cationic proteins with broad antimicrobial activity against many bacteria and fungi, some enveloped viruses, and other activities such as chemoattraction of a range of different cell types to the sites of inflammation. These proteins represent attractive targets for developing novel antimicrobial agents and modulators of immune responses with therapeutic applicability. In this report, we present the results of functional and structural studies of 26 single-site mutants of human beta-defensin 1 (hBD1). All mutants were assayed for antimicrobial activity against Escherichia coli (ATCC strain 25922) and for chemotactic activity with CCR6-transfected HEK293 cells. To analyze the structural implications of mutagenesis and to verify the correctness of the disulfide connectivity, we used x-ray crystallography to conduct complete structural studies for 10 mutants in which the topology of disulfides was the same as in the native hBD1. Mutations did not induce significant changes of the tertiary structure, suggesting that the observed alterations of biological properties of the mutants were solely associated with changes in the respective side chains. We found that cationic residues located near the C terminus (Arg(29), Lys(31), Lys(33), and Lys(36)) of hBD1 define most of the anti-E. coli in vitro activity of this protein. In turn, nearly all mutations altering the CCR6-mediated chemotaxis are located at one area of the protein, defined by the N-terminal alpha-helical region (Asp(1)... Ser(8)) and a few topologically adjacent residues (Lys(22), Arg(29), and Lys(33)). These experimental results allow for the first time drafting of the CCR6-epitope for a defensin molecule.

-	~~==About this Structure==~~	+	Studies of the biological properties of human beta-defensin 1.,Pazgier M, Prahl A, Hoover DM, Lubkowski J J Biol Chem. 2007 Jan 19;282(3):1819-29. Epub 2006 Oct 27. PMID:17071614<ref>PMID:17071614</ref>
-	~~[[2nld]] is a 2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2NLD OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Defensin\|Defensin]]		*[[Defensin\|Defensin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017071614<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lubkowski, J.]]		[[Category: Lubkowski, J.]]

OCA at 09:48, 11 March 2013

2013-03-11T09:48:25Z

←Older revision		Revision as of 09:48, 11 March 2013
Line 1:		Line 1:
-	[[Image:2nld.png\|left\|200px]]
-
	{{STRUCTURE_2nld\| PDB=2nld \| SCENE= }}		{{STRUCTURE_2nld\| PDB=2nld \| SCENE= }}
-
	===Human beta-defensin-1 (Mutant Gln11Ala)===		===Human beta-defensin-1 (Mutant Gln11Ala)===
-
	{{ABSTRACT_PUBMED_17071614}}		{{ABSTRACT_PUBMED_17071614}}

OCA: Protected "2nld" [edit=sysop:move=sysop]

2013-01-07T11:00:20Z

Protected "2nld" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:00, 7 January 2013

OCA at 11:00, 7 January 2013

2013-01-07T11:00:15Z

←Older revision		Revision as of 11:00, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2nld.png\|left\|200px]]		[[Image:2nld.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2nld", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2nld\| PDB=2nld \| SCENE= }}		{{STRUCTURE_2nld\| PDB=2nld \| SCENE= }}

	===Human beta-defensin-1 (Mutant Gln11Ala)===		===Human beta-defensin-1 (Mutant Gln11Ala)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17071614}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17071614 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17071614}}		{{ABSTRACT_PUBMED_17071614}}

	==About this Structure==		==About this Structure==
-	~~2NLD~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA].	+	[[2nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA].
		+
		+	==See Also==
		+	*[[Defensin\|Defensin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17071614~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017071614</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lubkowski, J.]]		[[Category: Lubkowski, J.]]
	[[Category: Pazgier, M.]]		[[Category: Pazgier, M.]]
	[[Category: Antimicrobial]]		[[Category: Antimicrobial]]
		+	[[Category: Antimicrobial protein]]
	[[Category: Chemotactic]]		[[Category: Chemotactic]]
	[[Category: Defensin]]		[[Category: Defensin]]
	[[Category: Mutant]]		[[Category: Mutant]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:46:41 2009''

OCA at 02:46, 18 February 2009

2009-02-18T02:46:43Z

←Older revision		Revision as of 02:46, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2NLD is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA].	+	2NLD is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLD OCA].

	==Reference==		==Reference==
-	~~Studies of the biological properties of human beta-defensin 1., Pazgier M, Prahl A, Hoover DM, Lubkowski J, J Biol Chem. 2007 Jan 19;282(3):1819-29. Epub 2006 Oct 27.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17071614 17071614]~~	+	<ref group="xtra">PMID:17071614</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Lubkowski, J.]]		[[Category: Lubkowski, J.]]
	[[Category: Pazgier, M.]]		[[Category: Pazgier, M.]]
Line 33:		Line 32:
	[[Category: Mutant]]		[[Category: Mutant]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 11~~:33:~~22 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:46:41 2009''