2nlu - Revision history

OCA at 00:08, 28 December 2023

2023-12-28T00:08:35Z

←Older revision		Revision as of 00:08, 28 December 2023
Line 1:		Line 1:

	==Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor==		==Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor==
-	<StructureSection load='2nlu' size='340' side='right'caption='[[2nlu~~]], [[NMR_Ensembles_of_Models \| 16 NMR models~~]]' scene=''>	+	<StructureSection load='2nlu' size='340' side='right'caption='[[2nlu]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NLU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NLU FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [https://pdbe.org/2nlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [https://www.ebi.ac.uk/pdbsum/2nlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nlu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [https://pdbe.org/2nlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [https://www.ebi.ac.uk/pdbsum/2nlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nlu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HDGF_HUMAN HDGF_HUMAN]] Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.<ref>PMID:17974029</ref>	+	[https://www.uniprot.org/uniprot/HDGF_HUMAN HDGF_HUMAN] Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.<ref>PMID:17974029</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huang~~, T H~~]]	+	[[Category: Huang TH]]
-	[[Category: Lee~~, W T~~]]	+	[[Category: Lee WT]]
-	[[Category: Sue~~, S C]]~~	+	[[Category: Sue SC]]
-	~~[[Category: Domain-swapping]]~~	+
-	~~[[Category: Hath]]~~	+
-	~~[[Category: Hdgf]]~~	+
-	~~[[Category: Heparin]]~~	+
-	~~[[Category: Hhdgf]]~~	+
-	~~[[Category: Hormone-growth factor complex]]~~	+
-	~~[[Category: Hrp]]~~	+
-	~~[[Category: Pwwp~~]]	+

OCA at 09:06, 23 February 2022

2022-02-23T09:06:35Z

←Older revision		Revision as of 09:06, 23 February 2022
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	<StructureSection load='2nlu' size='340' side='right'caption='[[2nlu]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>		<StructureSection load='2nlu' size='340' side='right'caption='[[2nlu]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2NLU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NLU FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [~~http~~://pdbe.org/2nlu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nlu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nlu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [https://pdbe.org/2nlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [https://www.ebi.ac.uk/pdbsum/2nlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nlu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HDGF_HUMAN HDGF_HUMAN]] Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.<ref>PMID:17974029</ref>	+	[[https://www.uniprot.org/uniprot/HDGF_HUMAN HDGF_HUMAN]] Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.<ref>PMID:17974029</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:33, 20 May 2020

2020-05-20T06:33:25Z

←Older revision		Revision as of 06:33, 20 May 2020
Line 1:		Line 1:

	==Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor==		==Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor==
-	<StructureSection load='2nlu' size='340' side='right' caption='[[2nlu]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>	+	<StructureSection load='2nlu' size='340' side='right'caption='[[2nlu]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NLU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2NLU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [http://pdbe.org/2nlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [http://www.ebi.ac.uk/pdbsum/2nlu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nlu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [http://pdbe.org/2nlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [http://www.ebi.ac.uk/pdbsum/2nlu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nlu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Huang, T H]]		[[Category: Huang, T H]]
	[[Category: Lee, W T]]		[[Category: Lee, W T]]

OCA at 17:04, 15 August 2018

2018-08-15T17:04:19Z

←Older revision		Revision as of 17:04, 15 August 2018
Line 1:		Line 1:
		+
	==Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor==		==Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor==
	<StructureSection load='2nlu' size='340' side='right' caption='[[2nlu]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>		<StructureSection load='2nlu' size='340' side='right' caption='[[2nlu]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [http://pdbe.org/2nlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [http://www.ebi.ac.uk/pdbsum/2nlu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [http://pdbe.org/2nlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [http://www.ebi.ac.uk/pdbsum/2nlu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nlu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/2nlu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/2nlu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:21, 10 February 2016

2016-02-10T01:21:43Z

←Older revision		Revision as of 01:21, 10 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nlu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:57, 11 September 2015

2015-09-11T03:57:28Z

←Older revision		Revision as of 03:57, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2nlu' size='340' side='right' caption='[[2nlu]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>		<StructureSection load='2nlu' size='340' side='right' caption='[[2nlu]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [http://www.ebi.ac.uk/pdbsum/2nlu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [http://pdbe.org/2nlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [http://www.ebi.ac.uk/pdbsum/2nlu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2nlu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Huang, T H]]		[[Category: Huang, T H]]
	[[Category: Lee, W T]]		[[Category: Lee, W T]]

OCA at 10:48, 25 December 2014

2014-12-25T10:48:44Z

←Older revision		Revision as of 10:48, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [http://www.ebi.ac.uk/pdbsum/2nlu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [http://www.ebi.ac.uk/pdbsum/2nlu PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HDGF_HUMAN HDGF_HUMAN]] Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.<ref>PMID:17974029</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Huang, T H.]]	+	[[Category: Huang, T H]]
-	[[Category: Lee, W T.]]	+	[[Category: Lee, W T]]
-	[[Category: Sue, S C.]]	+	[[Category: Sue, S C]]
	[[Category: Domain-swapping]]		[[Category: Domain-swapping]]
	[[Category: Hath]]		[[Category: Hath]]

OCA at 20:00, 30 September 2014

2014-09-30T20:00:30Z

←Older revision		Revision as of 20:00, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2nlu.~~png~~\|~~left~~\|200px]]	+	==Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor==
		+	<StructureSection load='2nlu' size='340' side='right' caption='[[2nlu]], [[NMR_Ensembles_of_Models \| 16 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2nlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NLU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ri0\|1ri0]], [[2b8a\|2b8a]], [[1n27\|1n27]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nlu RCSB], [http://www.ebi.ac.uk/pdbsum/2nlu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/2nlu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hepatoma-derived growth factor (hHDGF)-related proteins (HRPs) comprise a new growth factor family sharing a highly conserved and ordered N-terminal PWWP module (residues 1-100, previously referred to as a HATH domain) and a variable disordered C-terminal domain. We have shown that the PWWP module is responsible for heparin binding and have solved its structure in solution. Here, we show that under physiological conditions, both the PWWP module and hHDGF can form dimers. Surface plasmon resonance (SPR) studies revealed that the PWWP dimer binds to heparin with affinity that is two orders of magnitude higher (K(d)=13 nM) than that of the monomeric PWWP module (K(d)=1.2 microM). The monomer-dimer equilibrium properties and NMR structural data together suggest that the PWWP dimer is formed through a domain-swapping mechanism. The domain-swapped PWWP dimer structures were calculated on the basis of the NMR data. The results show that the two PWWP protomers exchange their N-terminal hairpin to form a domain-swapped dimer. The two monomers in a dimer are linked by the long flexible L2 loops, a feature supported by NMR relaxation data for the monomer and dimer. The enhanced heparin-binding affinity of the dimer can be rationalized in the framework of the dimer structure.

-	~~{{STRUCTURE_2nlu\| PDB=2nlu \| SCENE= }}~~	+	PWWP module of human hepatoma-derived growth factor forms a domain-swapped dimer with much higher affinity for heparin.,Sue SC, Lee WT, Tien SC, Lee SC, Yu JG, Wu WJ, Wu WG, Huang TH J Mol Biol. 2007 Mar 23;367(2):456-72. Epub 2007 Jan 9. PMID:17270212<ref>PMID:17270212</ref>

-	~~===Domain-Swapped Dimer~~ of the ~~PWWP Module of Human Hepatoma-derived Growth Factor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17270212}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2nlu]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017270212<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Huang, T H.]]		[[Category: Huang, T H.]]

OCA: Protected "2nlu" [edit=sysop:move=sysop]

2013-01-07T15:00:19Z

Protected "2nlu" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:00, 7 January 2013

OCA at 15:00, 7 January 2013

2013-01-07T15:00:17Z

←Older revision		Revision as of 15:00, 7 January 2013
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-	{{Seed}}
	[[Image:2nlu.png\|left\|200px]]		[[Image:2nlu.png\|left\|200px]]

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	{{STRUCTURE_2nlu\| PDB=2nlu \| SCENE= }}		{{STRUCTURE_2nlu\| PDB=2nlu \| SCENE= }}

	===Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor===		===Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor===

-
-	<!--
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	{{ABSTRACT_PUBMED_17270212}}		{{ABSTRACT_PUBMED_17270212}}

	==About this Structure==		==About this Structure==
-	~~2NLU~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA].	+	[[2nlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17270212~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017270212</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Huang, T H.]]		[[Category: Huang, T H.]]
Line 33:		Line 21:
	[[Category: Heparin]]		[[Category: Heparin]]
	[[Category: Hhdgf]]		[[Category: Hhdgf]]
-	[[Category: Hormone/growth factor complex]]	+	[[Category: Hormone-growth factor complex]]
	[[Category: Hrp]]		[[Category: Hrp]]
	[[Category: Pwwp]]		[[Category: Pwwp]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:16:38 2009''