2nqu - Revision history

OCA at 00:10, 28 December 2023

2023-12-28T00:10:06Z

←Older revision		Revision as of 00:10, 28 December 2023
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	<StructureSection load='2nqu' size='340' side='right'caption='[[2nqu]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2nqu' size='340' side='right'caption='[[2nqu]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>[[1g8r\|1g8r]], [[1g8l\|1g8l]], [[1fc5\|1fc5]], [[1uz5\|1uz5]], [[1wu2\|1wu2]], [[2nqk\|2nqk]], [[2nqm\|2nqm]], [[2nqn\|2nqn]], [[2nqq\|2nqq]], [[2nqr\|2nqr]], [[2nqs\|2nqs]], [[2nqv\|2nqv]], [[2nro\|2nro]], [[2nrp\|2nrp]], [[2nrs\|2nrs]]<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">moeA, bisB, chlE, narE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [https://pdbe.org/2nqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [https://www.ebi.ac.uk/pdbsum/2nqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [https://pdbe.org/2nqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [https://www.ebi.ac.uk/pdbsum/2nqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MOEA_ECOLI MOEA_ECOLI]] Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.<ref>PMID:15632135</ref>	+	[https://www.uniprot.org/uniprot/MOEA_ECOLI MOEA_ECOLI] Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.<ref>PMID:15632135</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Nicolas, J]]	+	[[Category: Nicolas J]]
-	[[Category: Rajagopalan~~, K V~~]]	+	[[Category: Rajagopalan KV]]
-	[[Category: Schindelin, H]]	+	[[Category: Schindelin H]]
-	[[Category: Xiang, S]]	+	[[Category: Xiang S]]
-	~~[[Category: Biosynthetic protein]]~~	+
-	~~[[Category: Cinnamon]]~~	+
-	~~[[Category: Cnx1]]~~	+
-	~~[[Category: Gephyrin]]~~	+
-	~~[[Category: Moco]]~~	+
-	~~[[Category: Moea]]~~	+
-	~~[[Category: Moga]]~~	+
-	~~[[Category: Molybdenum]]~~	+
-	~~[[Category: Molybdopterin]]~~	+
-	~~[[Category: Mpt~~]]	+

OCA at 15:48, 8 June 2021

2021-06-08T15:48:55Z

←Older revision		Revision as of 15:48, 8 June 2021
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	==MoeA E188Q==		==MoeA E188Q==
-	<StructureSection load='2nqu' size='340' side='right' caption='[[2nqu]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='2nqu' size='340' side='right'caption='[[2nqu]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nqu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NQU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8r\|1g8r]], [[1g8l\|1g8l]], [[1fc5\|1fc5]], [[1uz5\|1uz5]], [[1wu2\|1wu2]], [[2nqk\|2nqk]], [[2nqm\|2nqm]], [[2nqn\|2nqn]], [[2nqq\|2nqq]], [[2nqr\|2nqr]], [[2nqs\|2nqs]], [[2nqv\|2nqv]], [[2nro\|2nro]], [[2nrp\|2nrp]], [[2nrs\|2nrs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g8r\|1g8r]], [[1g8l\|1g8l]], [[1fc5\|1fc5]], [[1uz5\|1uz5]], [[1wu2\|1wu2]], [[2nqk\|2nqk]], [[2nqm\|2nqm]], [[2nqn\|2nqn]], [[2nqq\|2nqq]], [[2nqr\|2nqr]], [[2nqs\|2nqs]], [[2nqv\|2nqv]], [[2nro\|2nro]], [[2nrp\|2nrp]], [[2nrs\|2nrs]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">moeA, bisB, chlE, narE ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">moeA, bisB, chlE, narE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [~~http~~://pdbe.org/2nqu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nqu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [https://pdbe.org/2nqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [https://www.ebi.ac.uk/pdbsum/2nqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MOEA_ECOLI MOEA_ECOLI]] Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.<ref>PMID:15632135</ref>	+	[[https://www.uniprot.org/uniprot/MOEA_ECOLI MOEA_ECOLI]] Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.<ref>PMID:15632135</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Nicolas, J]]		[[Category: Nicolas, J]]
	[[Category: Rajagopalan, K V]]		[[Category: Rajagopalan, K V]]

OCA at 17:29, 15 August 2018

2018-08-15T17:29:22Z

←Older revision		Revision as of 17:29, 15 August 2018
Line 1:		Line 1:
		+
	==MoeA E188Q==		==MoeA E188Q==
	<StructureSection load='2nqu' size='340' side='right' caption='[[2nqu]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2nqu' size='340' side='right' caption='[[2nqu]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8r\|1g8r]], [[1g8l\|1g8l]], [[1fc5\|1fc5]], [[1uz5\|1uz5]], [[1wu2\|1wu2]], [[2nqk\|2nqk]], [[2nqm\|2nqm]], [[2nqn\|2nqn]], [[2nqq\|2nqq]], [[2nqr\|2nqr]], [[2nqs\|2nqs]], [[2nqv\|2nqv]], [[2nro\|2nro]], [[2nrp\|2nrp]], [[2nrs\|2nrs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8r\|1g8r]], [[1g8l\|1g8l]], [[1fc5\|1fc5]], [[1uz5\|1uz5]], [[1wu2\|1wu2]], [[2nqk\|2nqk]], [[2nqm\|2nqm]], [[2nqn\|2nqn]], [[2nqq\|2nqq]], [[2nqr\|2nqr]], [[2nqs\|2nqs]], [[2nqv\|2nqv]], [[2nro\|2nro]], [[2nrp\|2nrp]], [[2nrs\|2nrs]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">moeA, bisB, chlE, narE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">moeA, bisB, chlE, narE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [http://pdbe.org/2nqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [http://www.ebi.ac.uk/pdbsum/2nqu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [http://pdbe.org/2nqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [http://www.ebi.ac.uk/pdbsum/2nqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/2nqu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/2nqu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:27, 8 February 2016

2016-02-08T08:27:01Z

←Older revision		Revision as of 08:27, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nqu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:42, 10 September 2015

2015-09-10T09:42:36Z

←Older revision		Revision as of 09:42, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2nqu' size='340' side='right' caption='[[2nqu]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2nqu' size='340' side='right' caption='[[2nqu]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8r\|1g8r]], [[1g8l\|1g8l]], [[1fc5\|1fc5]], [[1uz5\|1uz5]], [[1wu2\|1wu2]], [[2nqk\|2nqk]], [[2nqm\|2nqm]], [[2nqn\|2nqn]], [[2nqq\|2nqq]], [[2nqr\|2nqr]], [[2nqs\|2nqs]], [[2nqv\|2nqv]], [[2nro\|2nro]], [[2nrp\|2nrp]], [[2nrs\|2nrs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8r\|1g8r]], [[1g8l\|1g8l]], [[1fc5\|1fc5]], [[1uz5\|1uz5]], [[1wu2\|1wu2]], [[2nqk\|2nqk]], [[2nqm\|2nqm]], [[2nqn\|2nqn]], [[2nqq\|2nqq]], [[2nqr\|2nqr]], [[2nqs\|2nqs]], [[2nqv\|2nqv]], [[2nro\|2nro]], [[2nrp\|2nrp]], [[2nrs\|2nrs]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">moeA, bisB, chlE, narE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">moeA, bisB, chlE, narE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [http://www.ebi.ac.uk/pdbsum/2nqu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [http://pdbe.org/2nqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [http://www.ebi.ac.uk/pdbsum/2nqu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2nqu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Nicolas, J]]		[[Category: Nicolas, J]]
	[[Category: Rajagopalan, K V]]		[[Category: Rajagopalan, K V]]

OCA at 21:57, 24 December 2014

2014-12-24T21:57:56Z

←Older revision		Revision as of 21:57, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8r\|1g8r]], [[1g8l\|1g8l]], [[1fc5\|1fc5]], [[1uz5\|1uz5]], [[1wu2\|1wu2]], [[2nqk\|2nqk]], [[2nqm\|2nqm]], [[2nqn\|2nqn]], [[2nqq\|2nqq]], [[2nqr\|2nqr]], [[2nqs\|2nqs]], [[2nqv\|2nqv]], [[2nro\|2nro]], [[2nrp\|2nrp]], [[2nrs\|2nrs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8r\|1g8r]], [[1g8l\|1g8l]], [[1fc5\|1fc5]], [[1uz5\|1uz5]], [[1wu2\|1wu2]], [[2nqk\|2nqk]], [[2nqm\|2nqm]], [[2nqn\|2nqn]], [[2nqq\|2nqq]], [[2nqr\|2nqr]], [[2nqs\|2nqs]], [[2nqv\|2nqv]], [[2nro\|2nro]], [[2nrp\|2nrp]], [[2nrs\|2nrs]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">moeA, bisB, chlE, narE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">moeA, bisB, chlE, narE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [http://www.ebi.ac.uk/pdbsum/2nqu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [http://www.ebi.ac.uk/pdbsum/2nqu PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MOEA_ECOLI MOEA_ECOLI]] Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.<ref>PMID:15632135</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Nicolas, J.]]	+	[[Category: Nicolas, J]]
-	[[Category: Rajagopalan, K V.]]	+	[[Category: Rajagopalan, K V]]
-	[[Category: Schindelin, H.]]	+	[[Category: Schindelin, H]]
-	[[Category: Xiang, S.]]	+	[[Category: Xiang, S]]
	[[Category: Biosynthetic protein]]		[[Category: Biosynthetic protein]]
	[[Category: Cinnamon]]		[[Category: Cinnamon]]

OCA at 20:17, 30 September 2014

2014-09-30T20:17:02Z

←Older revision		Revision as of 20:17, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2nqu.~~png~~\|~~left~~\|200px]]	+	==MoeA E188Q==
		+	<StructureSection load='2nqu' size='340' side='right' caption='[[2nqu]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2nqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NQU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g8r\|1g8r]], [[1g8l\|1g8l]], [[1fc5\|1fc5]], [[1uz5\|1uz5]], [[1wu2\|1wu2]], [[2nqk\|2nqk]], [[2nqm\|2nqm]], [[2nqn\|2nqn]], [[2nqq\|2nqq]], [[2nqr\|2nqr]], [[2nqs\|2nqs]], [[2nqv\|2nqv]], [[2nro\|2nro]], [[2nrp\|2nrp]], [[2nrs\|2nrs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">moeA, bisB, chlE, narE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nqu RCSB], [http://www.ebi.ac.uk/pdbsum/2nqu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/2nqu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The molybdenum cofactor is ubiquitous in nature, and the pathway for Moco biosynthesis is conserved in all three domains of life. Recent work has helped to illuminate one of the most enigmatic steps in Moco biosynthesis, ligation of metal to molybdopterin (the organic component of the cofactor) to form the active cofactor. In Escherichia coli, the MoeA protein mediates ligation of Mo to molybdopterin while the MogA protein enhances this process in an ATP-dependent manner. The X-ray crystal structures for both proteins have been previously described as well as two essential MogA residues, Asp49 and Asp82. Here we describe a detailed mutational analysis of the MoeA protein. Variants of conserved residues at the putative active site of MoeA were analyzed for a loss of function in two different, previously described assays, one employing moeA- crude extracts and the other utilizing a defined system. Oddly, no correlation was observed between the activity in the two assays. In fact, our results showed a general trend toward an inverse relationship between the activity in each assay. Moco binding studies indicated a strong correlation between a variant's ability to bind Moco and its activity in the purified component assay. Crystal structures of the functionally characterized MoeA variants revealed no major structural changes, indicating that the functional differences observed are not due to disruption of the protein structure. On the basis of these results, two different functional areas were assigned to regions at or near the MoeA active site cleft.

-	~~{{STRUCTURE_2nqu\| PDB=2nqu \| SCENE= }}~~	+	Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft.,Nichols JD, Xiang S, Schindelin H, Rajagopalan KV Biochemistry. 2007 Jan 9;46(1):78-86. PMID:17198377<ref>PMID:17198377</ref>

-	~~===MoeA E188Q===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17198377}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2nqu]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017198377<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Nicolas, J.]]		[[Category: Nicolas, J.]]

OCA: Protected "2nqu" [edit=sysop:move=sysop]

2013-01-07T15:20:12Z

Protected "2nqu" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:20, 7 January 2013

OCA at 15:20, 7 January 2013

2013-01-07T15:20:09Z

←Older revision		Revision as of 15:20, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2nqu.png\|left\|200px]]		[[Image:2nqu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2nqu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2nqu\| PDB=2nqu \| SCENE= }}		{{STRUCTURE_2nqu\| PDB=2nqu \| SCENE= }}

	===MoeA E188Q===		===MoeA E188Q===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17198377}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17198377 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17198377}}		{{ABSTRACT_PUBMED_17198377}}

	==About this Structure==		==About this Structure==
-	~~2NQU~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA].	+	[[2nqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17198377~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017198377</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Nicolas, J.]]		[[Category: Nicolas, J.]]
Line 29:		Line 17:
	[[Category: Schindelin, H.]]		[[Category: Schindelin, H.]]
	[[Category: Xiang, S.]]		[[Category: Xiang, S.]]
		+	[[Category: Biosynthetic protein]]
	[[Category: Cinnamon]]		[[Category: Cinnamon]]
	[[Category: Cnx1]]		[[Category: Cnx1]]
Line 38:		Line 27:
	[[Category: Molybdopterin]]		[[Category: Molybdopterin]]
	[[Category: Mpt]]		[[Category: Mpt]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:35:53 2009''

OCA at 18:35, 16 February 2009

2009-02-16T18:35:58Z

←Older revision		Revision as of 18:35, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2NQU is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA].	+	2NQU is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQU OCA].

	==Reference==		==Reference==
-	~~Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft., Nichols JD, Xiang S, Schindelin H, Rajagopalan KV, Biochemistry. 2007 Jan 9;46(1):78-86.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17198377 17198377]~~	+	<ref group="xtra">PMID:17198377</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Nicolas, J.]]		[[Category: Nicolas, J.]]
	[[Category: Rajagopalan, K V.]]		[[Category: Rajagopalan, K V.]]
Line 40:		Line 39:
	[[Category: Mpt]]		[[Category: Mpt]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 00~~:45:~~48 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:35:53 2009''