2nrt - Revision history

OCA at 10:19, 30 August 2023

2023-08-30T10:19:09Z

←Older revision		Revision as of 10:19, 30 August 2023
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	<StructureSection load='2nrt' size='340' side='right'caption='[[2nrt]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2nrt' size='340' side='right'caption='[[2nrt]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nrt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43589 Atcc 43589~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NRT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nrt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NRT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2nrr\|2nrr]], [[1ycz\|1ycz]], [[2nrv\|2nrv]], [[2nrw\|2nrw]], [[2nrx\|2nrx]], [[2nrz\|2nrz]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">uvrC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [https://pdbe.org/2nrt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [https://www.ebi.ac.uk/pdbsum/2nrt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nrt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [https://pdbe.org/2nrt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [https://www.ebi.ac.uk/pdbsum/2nrt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nrt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/UVRC_THEMA UVRC_THEMA]] The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity).	+	[https://www.uniprot.org/uniprot/UVRC_THEMA UVRC_THEMA] The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43589]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Karakas, E~~]]	+	[[Category: Thermotoga maritima]]
-	[[Category: ~~Kisker, C~~]]	+	[[Category: Karakas E]]
-	[[Category: ~~Truglio, J J~~]]	+	[[Category: Kisker C]]
-	[[Category: ~~Endonuclease]]~~	+	[[Category: Truglio JJ]]
-	~~[[Category: Helix hairpin helix]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Ner]]~~	+
-	~~[[Category: Rnase h]]~~	+
-	~~[[Category: Uvrabc]]~~	+
-	~~[[Category: Uvrc~~]]	+

OCA at 15:49, 8 June 2021

2021-06-08T15:49:37Z

←Older revision		Revision as of 15:49, 8 June 2021
Line 1:		Line 1:

	==Crystal structure of the C-terminal half of UvrC==		==Crystal structure of the C-terminal half of UvrC==
-	<StructureSection load='2nrt' size='340' side='right' caption='[[2nrt]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='2nrt' size='340' side='right'caption='[[2nrt]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nrt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NRT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nrt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NRT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nrr\|2nrr]], [[1ycz\|1ycz]], [[2nrv\|2nrv]], [[2nrw\|2nrw]], [[2nrx\|2nrx]], [[2nrz\|2nrz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nrr\|2nrr]], [[1ycz\|1ycz]], [[2nrv\|2nrv]], [[2nrw\|2nrw]], [[2nrx\|2nrx]], [[2nrz\|2nrz]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uvrC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uvrC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [~~http~~://pdbe.org/2nrt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nrt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nrt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [https://pdbe.org/2nrt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [https://www.ebi.ac.uk/pdbsum/2nrt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nrt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/UVRC_THEMA UVRC_THEMA]] The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity).	+	[[https://www.uniprot.org/uniprot/UVRC_THEMA UVRC_THEMA]] The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/2nrt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/2nrt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2nrt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2nrt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[UvrABC\|UvrABC]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43589]]		[[Category: Atcc 43589]]
		+	[[Category: Large Structures]]
	[[Category: Karakas, E]]		[[Category: Karakas, E]]
	[[Category: Kisker, C]]		[[Category: Kisker, C]]

OCA at 08:40, 18 October 2017

2017-10-18T08:40:28Z

←Older revision		Revision as of 08:40, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of the C-terminal half of UvrC==		==Crystal structure of the C-terminal half of UvrC==
	<StructureSection load='2nrt' size='340' side='right' caption='[[2nrt]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2nrt' size='340' side='right' caption='[[2nrt]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nrr\|2nrr]], [[1ycz\|1ycz]], [[2nrv\|2nrv]], [[2nrw\|2nrw]], [[2nrx\|2nrx]], [[2nrz\|2nrz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nrr\|2nrr]], [[1ycz\|1ycz]], [[2nrv\|2nrv]], [[2nrw\|2nrw]], [[2nrx\|2nrx]], [[2nrz\|2nrz]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uvrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uvrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [http://pdbe.org/2nrt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [http://www.ebi.ac.uk/pdbsum/2nrt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [http://pdbe.org/2nrt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [http://www.ebi.ac.uk/pdbsum/2nrt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nrt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nrt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2nrt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2nrt" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[UvrABC\|UvrABC]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:41, 11 September 2015

2015-09-11T08:41:35Z

←Older revision		Revision as of 08:41, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2nrt' size='340' side='right' caption='[[2nrt]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2nrt' size='340' side='right' caption='[[2nrt]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nrt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermotoga_maritima Thermotoga maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NRT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nrt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NRT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nrr\|2nrr]], [[1ycz\|1ycz]], [[2nrv\|2nrv]], [[2nrw\|2nrw]], [[2nrx\|2nrx]], [[2nrz\|2nrz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nrr\|2nrr]], [[1ycz\|1ycz]], [[2nrv\|2nrv]], [[2nrw\|2nrw]], [[2nrx\|2nrx]], [[2nrz\|2nrz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uvrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ~~Thermotoga maritima~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uvrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [http://www.ebi.ac.uk/pdbsum/2nrt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [http://pdbe.org/2nrt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [http://www.ebi.ac.uk/pdbsum/2nrt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2nrt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermotoga maritima~~]]	+	[[Category: Atcc 43589]]
	[[Category: Karakas, E]]		[[Category: Karakas, E]]
	[[Category: Kisker, C]]		[[Category: Kisker, C]]

OCA at 14:00, 25 December 2014

2014-12-25T14:00:30Z

←Older revision		Revision as of 14:00, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2nrt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NRT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2nrt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NRT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nrr\|2nrr]], [[1ycz\|1ycz]], [[2nrv\|2nrv]], [[2nrw\|2nrw]], [[2nrx\|2nrx]], [[2nrz\|2nrz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nrr\|2nrr]], [[1ycz\|1ycz]], [[2nrv\|2nrv]], [[2nrw\|2nrw]], [[2nrx\|2nrx]], [[2nrz\|2nrz]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uvrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uvrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [http://www.ebi.ac.uk/pdbsum/2nrt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [http://www.ebi.ac.uk/pdbsum/2nrt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UVRC_THEMA UVRC_THEMA]] The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
-	[[Category: Karakas, E.]]	+	[[Category: Karakas, E]]
-	[[Category: Kisker, C.]]	+	[[Category: Kisker, C]]
-	[[Category: Truglio, J J.]]	+	[[Category: Truglio, J J]]
	[[Category: Endonuclease]]		[[Category: Endonuclease]]
	[[Category: Helix hairpin helix]]		[[Category: Helix hairpin helix]]

OCA at 18:56, 30 September 2014

2014-09-30T18:56:53Z

←Older revision		Revision as of 18:56, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2nrt.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the C-terminal half of UvrC==
		+	<StructureSection load='2nrt' size='340' side='right' caption='[[2nrt]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2nrt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NRT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2nrr\|2nrr]], [[1ycz\|1ycz]], [[2nrv\|2nrv]], [[2nrw\|2nrw]], [[2nrx\|2nrx]], [[2nrz\|2nrz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uvrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nrt RCSB], [http://www.ebi.ac.uk/pdbsum/2nrt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/2nrt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Removal and repair of DNA damage by the nucleotide excision repair pathway requires two sequential incision reactions, which are achieved by the endonuclease UvrC in eubacteria. Here, we describe the crystal structure of the C-terminal half of UvrC, which contains the catalytic domain responsible for 5' incision and a helix-hairpin-helix-domain that is implicated in DNA binding. Surprisingly, the 5' catalytic domain shares structural homology with RNase H despite the lack of sequence homology and contains an uncommon DDH triad. The structure also reveals two highly conserved patches on the surface of the protein, which are not related to the active site. Mutations of residues in one of these patches led to the inability of the enzyme to bind DNA and severely compromised both incision reactions. Based on our results, we suggest a model of how UvrC forms a productive protein-DNA complex to excise the damage from DNA.

-	~~{{STRUCTURE_2nrt\| PDB=2nrt \| SCENE= }}~~	+	Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad.,Karakas E, Truglio JJ, Croteau D, Rhau B, Wang L, Van Houten B, Kisker C EMBO J. 2007 Jan 24;26(2):613-22. PMID:17245438<ref>PMID:17245438</ref>

-	~~===Crystal structure~~ of the ~~C-terminal half~~ of ~~UvrC===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_17245438}}~~	+	==See Also==
-		+	*[[UvrABC\|UvrABC]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2nrt~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:017245438<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
	[[Category: Karakas, E.]]		[[Category: Karakas, E.]]

OCA: Protected "2nrt" [edit=sysop:move=sysop]

2013-01-07T13:51:44Z

Protected "2nrt" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:51, 7 January 2013

OCA at 13:51, 7 January 2013

2013-01-07T13:51:41Z

←Older revision		Revision as of 13:51, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2nrt.png\|left\|200px]]		[[Image:2nrt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2nrt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2nrt\| PDB=2nrt \| SCENE= }}		{{STRUCTURE_2nrt\| PDB=2nrt \| SCENE= }}

	===Crystal structure of the C-terminal half of UvrC===		===Crystal structure of the C-terminal half of UvrC===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17245438}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17245438 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17245438}}		{{ABSTRACT_PUBMED_17245438}}

	==About this Structure==		==About this Structure==
-	~~2NRT~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA].	+	[[2nrt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17245438~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017245438</ref><references group="xtra"/>
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
	[[Category: Karakas, E.]]		[[Category: Karakas, E.]]
Line 30:		Line 18:
	[[Category: Endonuclease]]		[[Category: Endonuclease]]
	[[Category: Helix hairpin helix]]		[[Category: Helix hairpin helix]]
		+	[[Category: Hydrolase]]
	[[Category: Ner]]		[[Category: Ner]]
	[[Category: Rnase h]]		[[Category: Rnase h]]
	[[Category: Uvrabc]]		[[Category: Uvrabc]]
	[[Category: Uvrc]]		[[Category: Uvrc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:06:43 2009''

OCA at 16:06, 17 February 2009

2009-02-17T16:06:44Z

←Older revision		Revision as of 16:06, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2NRT is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA].	+	2NRT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRT OCA].

	==Reference==		==Reference==
-	Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad., Karakas E, Truglio JJ, Croteau D, Rhau B, Wang L, Van Houten B, Kisker C, EMBO J. 2007 Jan 24;26(2):613-22. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17245438 17245438]~~	+	<ref group="xtra">PMID:17245438</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
	[[Category: Karakas, E.]]		[[Category: Karakas, E.]]
Line 36:		Line 35:
	[[Category: Uvrc]]		[[Category: Uvrc]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 01~~:39:~~55 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:06:43 2009''

OCA at 22:40, 28 July 2008

2008-07-28T22:40:01Z

←Older revision		Revision as of 22:40, 28 July 2008
Line 1:		Line 1:
-	[[Image:2nrt.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2nrt.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2nrt\| PDB=2nrt \| SCENE= }}		{{STRUCTURE_2nrt\| PDB=2nrt \| SCENE= }}

-	~~'''~~Crystal structure of the C-terminal half of UvrC~~'''~~	+	===Crystal structure of the C-terminal half of UvrC===


-	~~==Overview==~~	+	<!--
-	~~Removal and repair of DNA damage by the nucleotide excision repair pathway requires two sequential incision reactions~~, ~~which are achieved by the endonuclease UvrC in eubacteria. Here~~, ~~we describe~~ the ~~crystal structure of~~ the ~~C-terminal half of UvrC, which contains the catalytic domain responsible for 5' incision and a helix-hairpin-helix-domain that is implicated in DNA binding~~. ~~Surprisingly, the 5' catalytic domain shares structural homology with RNase H despite the lack of sequence homology and contains an uncommon DDH triad~~. ~~The structure also reveals two highly conserved patches on the surface of the protein~~, ~~which are not related to~~ the ~~active site~~. Mutations of residues in one of these patches led to the inability of the enzyme to bind DNA and severely compromised both incision reactions. Based on our results, we suggest a model of how UvrC forms a productive protein-~~DNA complex to excise the damage from DNA.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17245438}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17245438 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17245438}}

	==About this Structure==		==About this Structure==
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	[[Category: Uvrabc]]		[[Category: Uvrabc]]
	[[Category: Uvrc]]		[[Category: Uvrc]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 09~~:49:56 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:39:55 2008''