2ntv - Revision history

OCA at 10:20, 30 August 2023

2023-08-30T10:20:41Z

←Older revision		Revision as of 10:20, 30 August 2023
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	<StructureSection load='2ntv' size='340' side='right'caption='[[2ntv]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ntv' size='340' side='right'caption='[[2ntv]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ntv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_leprae"_hansen_1880 "bacillus~~ leprae~~" hansen 1880~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ntv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P1H:{(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}~~METHYL~~+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>P1H</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2h9i\|2h9i]], [[2ntj\|2ntj]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P1H:{(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}M+ETHYL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>P1H</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 "Bacillus leprae" Hansen 1880])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [https://pdbe.org/2ntv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [https://www.ebi.ac.uk/pdbsum/2ntv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [https://pdbe.org/2ntv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [https://www.ebi.ac.uk/pdbsum/2ntv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9CBM1_MYCLE Q9CBM1_MYCLE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus leprae hansen 1880]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Sacchettini, J C~~]]	+	[[Category: Mycobacterium leprae]]
-	[[Category: ~~Wang, F~~]]	+	[[Category: Sacchettini JC]]
-	[[Category: ~~Inha]]~~	+	[[Category: Wang F]]
-	~~[[Category: Leprosy]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Prothionamide~~]]	+

OCA at 15:50, 8 June 2021

2021-06-08T15:50:58Z

←Older revision		Revision as of 15:50, 8 June 2021
Line 1:		Line 1:

	==Mycobacterium leprae InhA bound with PTH-NAD adduct==		==Mycobacterium leprae InhA bound with PTH-NAD adduct==
-	<StructureSection load='2ntv' size='340' side='right' caption='[[2ntv]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2ntv' size='340' side='right'caption='[[2ntv]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ntv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_leprae"_hansen_1880 "bacillus leprae" hansen 1880]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ntv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_leprae"_hansen_1880 "bacillus leprae" hansen 1880]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P1H:{(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}METHYL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>P1H</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P1H:{(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}METHYL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>P1H</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h9i\|2h9i]], [[2ntj\|2ntj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2h9i\|2h9i]], [[2ntj\|2ntj]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 "Bacillus leprae" Hansen 1880])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 "Bacillus leprae" Hansen 1880])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [~~http~~://pdbe.org/2ntv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ntv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [https://pdbe.org/2ntv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [https://www.ebi.ac.uk/pdbsum/2ntv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2ntv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2ntv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2ntv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ntv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures\|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus leprae hansen 1880]]		[[Category: Bacillus leprae hansen 1880]]
		+	[[Category: Large Structures]]
	[[Category: Sacchettini, J C]]		[[Category: Sacchettini, J C]]
	[[Category: Wang, F]]		[[Category: Wang, F]]

OCA at 08:41, 18 October 2017

2017-10-18T08:41:28Z

←Older revision		Revision as of 08:41, 18 October 2017
Line 1:		Line 1:
		+
	==Mycobacterium leprae InhA bound with PTH-NAD adduct==		==Mycobacterium leprae InhA bound with PTH-NAD adduct==
	<StructureSection load='2ntv' size='340' side='right' caption='[[2ntv]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ntv' size='340' side='right' caption='[[2ntv]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h9i\|2h9i]], [[2ntj\|2ntj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h9i\|2h9i]], [[2ntj\|2ntj]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 "Bacillus leprae" Hansen 1880])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 "Bacillus leprae" Hansen 1880])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [http://pdbe.org/2ntv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [http://www.ebi.ac.uk/pdbsum/2ntv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [http://pdbe.org/2ntv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [http://www.ebi.ac.uk/pdbsum/2ntv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ntv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2ntv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ntv" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:24, 11 September 2015

2015-09-11T16:24:32Z

←Older revision		Revision as of 16:24, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ntv' size='340' side='right' caption='[[2ntv]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ntv' size='340' side='right' caption='[[2ntv]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ntv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_leprae Mycobacterium~~ leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ntv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_leprae"_hansen_1880 "bacillus leprae" hansen 1880]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P1H:{(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}METHYL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>P1H</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P1H:{(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}METHYL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>P1H</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h9i\|2h9i]], [[2ntj\|2ntj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h9i\|2h9i]], [[2ntj\|2ntj]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 ~~Mycobacterium~~ leprae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 "Bacillus leprae" Hansen 1880])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [http://www.ebi.ac.uk/pdbsum/2ntv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [http://pdbe.org/2ntv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [http://www.ebi.ac.uk/pdbsum/2ntv PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ntv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium~~ leprae]]	+	[[Category: Bacillus leprae hansen 1880]]
	[[Category: Sacchettini, J C]]		[[Category: Sacchettini, J C]]
	[[Category: Wang, F]]		[[Category: Wang, F]]

OCA at 18:38, 19 January 2015

2015-01-19T18:38:53Z

←Older revision		Revision as of 18:38, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ntv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ntv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P1H:{(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}METHYL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>P1H</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P1H:{(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}METHYL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>P1H</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h9i\|2h9i]], [[2ntj\|2ntj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h9i\|2h9i]], [[2ntj\|2ntj]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 Mycobacterium leprae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 Mycobacterium leprae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [http://www.ebi.ac.uk/pdbsum/2ntv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [http://www.ebi.ac.uk/pdbsum/2ntv PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium leprae]]		[[Category: Mycobacterium leprae]]
-	[[Category: Sacchettini, J C.]]	+	[[Category: Sacchettini, J C]]
-	[[Category: Wang, F.]]	+	[[Category: Wang, F]]
	[[Category: Inha]]		[[Category: Inha]]
	[[Category: Leprosy]]		[[Category: Leprosy]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Prothionamide]]		[[Category: Prothionamide]]

OCA at 10:29, 29 September 2014

2014-09-29T10:29:37Z

←Older revision		Revision as of 10:29, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2ntv.~~png~~\|~~left~~\|200px]]	+	==Mycobacterium leprae InhA bound with PTH-NAD adduct==
		+	<StructureSection load='2ntv' size='340' side='right' caption='[[2ntv]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ntv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P1H:{(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-PROPYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}METHYL+[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>P1H</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h9i\|2h9i]], [[2ntj\|2ntj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1769 Mycobacterium leprae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ntv RCSB], [http://www.ebi.ac.uk/pdbsum/2ntv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2ntv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thioamide drugs, ethionamide (ETH) and prothionamide (PTH), are clinically effective in the treatment of Mycobacterium tuberculosis, M. leprae, and M. avium complex infections. Although generally considered second-line drugs for tuberculosis, their use has increased considerably as the number of multidrug resistant and extensively drug resistant tuberculosis cases continues to rise. Despite the widespread use of thioamide drugs to treat tuberculosis and leprosy, their precise mechanisms of action remain unknown. Using a cell-based activation method, we now have definitive evidence that both thioamides form covalent adducts with nicotinamide adenine dinucleotide (NAD) and that these adducts are tight-binding inhibitors of M. tuberculosis and M. leprae InhA. The crystal structures of the inhibited M. leprae and M. tuberculosis InhA complexes provide the molecular details of target-drug interactions. The purified ETH-NAD and PTH-NAD adducts both showed nanomolar Kis against M. tuberculosis and M. leprae InhA. Knowledge of the precise structures and mechanisms of action of these drugs provides insights into designing new drugs that can overcome drug resistance.

-	~~{{STRUCTURE_2ntv\| PDB=2ntv \| SCENE= }}~~	+	Mechanism of thioamide drug action against tuberculosis and leprosy.,Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16. PMID:17227913<ref>PMID:17227913</ref>

-	~~===Mycobacterium leprae InhA bound with PTH-NAD adduct===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17227913}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2ntv]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_leprae Mycobacterium leprae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA].~~	+

	==See Also==		==See Also==
	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]		*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017227913<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium leprae]]		[[Category: Mycobacterium leprae]]
	[[Category: Sacchettini, J C.]]		[[Category: Sacchettini, J C.]]

OCA at 20:16, 20 October 2012

2012-10-20T20:16:19Z

←Older revision		Revision as of 20:16, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2ntv]] is a 2 chain structure ~~of [[Enoyl-Acyl-Carrier Protein Reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA].	+	[[2ntv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA].

	==See Also==		==See Also==

OCA: Protected "2ntv" [edit=sysop:move=sysop]

2012-07-27T09:56:40Z

Protected "2ntv" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:56, 27 July 2012

OCA at 09:56, 27 July 2012

2012-07-27T09:56:38Z

←Older revision		Revision as of 09:56, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2ntv.png\|left\|200px]]		[[Image:2ntv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ntv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ntv\| PDB=2ntv \| SCENE= }}		{{STRUCTURE_2ntv\| PDB=2ntv \| SCENE= }}

	===Mycobacterium leprae InhA bound with PTH-NAD adduct===		===Mycobacterium leprae InhA bound with PTH-NAD adduct===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17227913}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17227913 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17227913}}		{{ABSTRACT_PUBMED_17227913}}

	==About this Structure==		==About this Structure==
-	~~2NTV~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA].	+	[[2ntv]] is a 2 chain structure of [[Enoyl-Acyl-Carrier Protein Reductase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA].
		+
		+	==See Also==
		+	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17227913~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017227913</ref><references group="xtra"/>
	[[Category: Mycobacterium leprae]]		[[Category: Mycobacterium leprae]]
	[[Category: Sacchettini, J C.]]		[[Category: Sacchettini, J C.]]
Line 29:		Line 20:
	[[Category: Inha]]		[[Category: Inha]]
	[[Category: Leprosy]]		[[Category: Leprosy]]
		+	[[Category: Oxidoreductase]]
	[[Category: Prothionamide]]		[[Category: Prothionamide]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:42:07 2009''

OCA at 01:42, 18 February 2009

2009-02-18T01:42:15Z

←Older revision		Revision as of 01:42, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2NTV is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA].	+	2NTV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTV OCA].

	==Reference==		==Reference==
-	Mechanism of thioamide drug action against tuberculosis and leprosy., Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC, J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17227913 17227913]~~	+	<ref group="xtra">PMID:17227913</ref><references group="xtra"/>
	[[Category: Mycobacterium leprae]]		[[Category: Mycobacterium leprae]]
-	[[Category: Single protein]]
	[[Category: Sacchettini, J C.]]		[[Category: Sacchettini, J C.]]
	[[Category: Wang, F.]]		[[Category: Wang, F.]]
Line 32:		Line 31:
	[[Category: Prothionamide]]		[[Category: Prothionamide]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 09~~:56:~~25 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:42:07 2009''