2nx6 - Revision history

OCA at 12:52, 20 December 2023

2023-12-20T12:52:38Z

←Older revision		Revision as of 12:52, 20 December 2023
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	==Structure of NOWA cysteine rich domain 6==		==Structure of NOWA cysteine rich domain 6==
-	<StructureSection load='2nx6' size='340' side='right'caption='[[2nx6~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2nx6' size='340' side='right'caption='[[2nx6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nx6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hydvu Hydvu~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nx6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NX6 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2hm3\|2hm3]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NOWA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6087 HYDVU])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx6 OCA], [https://pdbe.org/2nx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2nx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nx6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx6 OCA], [https://pdbe.org/2nx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2nx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nx6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8IT70_HYDVU Q8IT70_HYDVU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hydvu~~]]	+	[[Category: Hydra vulgaris]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adamczyk, P]]	+	[[Category: Adamczyk P]]
-	[[Category: Bachinger~~, H P~~]]	+	[[Category: Bachinger HP]]
-	[[Category: Engel, J]]	+	[[Category: Engel J]]
-	[[Category: Grzesiek, S]]	+	[[Category: Grzesiek S]]
-	[[Category: Holstein~~, T W~~]]	+	[[Category: Holstein TW]]
-	[[Category: Jensen~~, P R~~]]	+	[[Category: Jensen PR]]
-	[[Category: Meier, S]]	+	[[Category: Meier S]]
-	[[Category: Ozbek, S]]	+	[[Category: Ozbek S]]
-	~~[[Category: Disulfide rich]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Turn~~]]	+

OCA at 15:53, 8 June 2021

2021-06-08T15:53:13Z

←Older revision		Revision as of 15:53, 8 June 2021
Line 1:		Line 1:

	==Structure of NOWA cysteine rich domain 6==		==Structure of NOWA cysteine rich domain 6==
-	<StructureSection load='2nx6' size='340' side='right' caption='[[2nx6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2nx6' size='340' side='right'caption='[[2nx6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nx6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hydvu Hydvu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2NX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nx6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hydvu Hydvu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NX6 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hm3\|2hm3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hm3\|2hm3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NOWA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6087 HYDVU])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NOWA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6087 HYDVU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx6 OCA], [~~http~~://pdbe.org/2nx6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2nx6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2nx6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2nx6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx6 OCA], [https://pdbe.org/2nx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2nx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nx6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Hydvu]]		[[Category: Hydvu]]
		+	[[Category: Large Structures]]
	[[Category: Adamczyk, P]]		[[Category: Adamczyk, P]]
	[[Category: Bachinger, H P]]		[[Category: Bachinger, H P]]

OCA at 17:35, 15 August 2018

2018-08-15T17:35:00Z

←Older revision		Revision as of 17:35, 15 August 2018
Line 1:		Line 1:
		+
	==Structure of NOWA cysteine rich domain 6==		==Structure of NOWA cysteine rich domain 6==
	<StructureSection load='2nx6' size='340' side='right' caption='[[2nx6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2nx6' size='340' side='right' caption='[[2nx6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hm3\|2hm3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hm3\|2hm3]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NOWA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6087 HYDVU])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NOWA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6087 HYDVU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx6 OCA], [http://pdbe.org/2nx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2nx6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx6 OCA], [http://pdbe.org/2nx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2nx6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nx6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:40, 11 September 2015

2015-09-11T15:40:13Z

←Older revision		Revision as of 15:40, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2nx6' size='340' side='right' caption='[[2nx6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2nx6' size='340' side='right' caption='[[2nx6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2nx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Hydra_vulgaris Hydra vulgaris~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NX6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2nx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hydvu Hydvu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NX6 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hm3\|2hm3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hm3\|2hm3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NOWA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6087 ~~Hydra vulgaris~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NOWA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6087 HYDVU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2nx6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx6 OCA], [http://pdbe.org/2nx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2nx6 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2nx6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hydra vulgaris~~]]	+	[[Category: Hydvu]]
	[[Category: Adamczyk, P]]		[[Category: Adamczyk, P]]
	[[Category: Bachinger, H P]]		[[Category: Bachinger, H P]]

OCA at 06:49, 22 January 2015

2015-01-22T06:49:07Z

←Older revision		Revision as of 06:49, 22 January 2015
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Hydra vulgaris]]		[[Category: Hydra vulgaris]]
-	[[Category: Adamczyk, P.]]	+	[[Category: Adamczyk, P]]
-	[[Category: Bachinger, H P.]]	+	[[Category: Bachinger, H P]]
-	[[Category: Engel, J.]]	+	[[Category: Engel, J]]
-	[[Category: Grzesiek, S.]]	+	[[Category: Grzesiek, S]]
-	[[Category: Holstein, T W.]]	+	[[Category: Holstein, T W]]
-	[[Category: Jensen, P R.]]	+	[[Category: Jensen, P R]]
-	[[Category: Meier, S.]]	+	[[Category: Meier, S]]
-	[[Category: Ozbek, S.]]	+	[[Category: Ozbek, S]]
	[[Category: Disulfide rich]]		[[Category: Disulfide rich]]
	[[Category: Structural protein]]		[[Category: Structural protein]]
	[[Category: Turn]]		[[Category: Turn]]

OCA at 11:33, 20 October 2014

2014-10-20T11:33:20Z

←Older revision		Revision as of 11:33, 20 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2nx6.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of NOWA cysteine rich domain 6==
		+	<StructureSection load='2nx6' size='340' side='right' caption='[[2nx6]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2nx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NX6 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hm3\|2hm3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NOWA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6087 Hydra vulgaris])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nx6 RCSB], [http://www.ebi.ac.uk/pdbsum/2nx6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nematocyst wall of cnidarians is a unique biomaterial that withstands extreme osmotic pressures, allowing an ultrafast discharge of the nematocyst capsules. Assembly of the highly robust nematocyst wall is achieved by covalent linkage of cysteine-rich domains (CRDs) from two main protein components, minicollagens and nematocyst outer wall antigen (NOWA). The bipolar minicollagens have different disulfide patterns and topologies in their N and C-terminal CRDs. The functional significance of this polarity has been elusive. Here, we show by NMR structural analysis that all representative cysteine-rich domains of NOWA are structurally related to N-terminal minicollagen domains. Natural sequence insertions in NOWA CRDs have very little effect on the tightly knit domain structures, nor do they preclude the efficient folding to a single native conformation. The different folds in NOWA CRDs and the atypical C-terminal minicollagen domain on the other hand can be directly related to different conformational preferences in the reduced states. Ultrastructural analysis in conjunction with aggregation studies argues for an association between the similar NOWA and N-terminal minicollagen domains in early stages of the nematocyst wall assembly, which is followed by the controlled association between the unusual structures of C-terminal minicollagen domains.

-	~~{{STRUCTURE_2nx6\| PDB=2nx6 \| SCENE= }}~~	+	Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.,Meier S, Jensen PR, Adamczyk P, Bachinger HP, Holstein TW, Engel J, Ozbek S, Grzesiek S J Mol Biol. 2007 May 4;368(3):718-28. Epub 2007 Feb 24. PMID:17362991<ref>PMID:17362991</ref>

-	~~===Structure~~ of ~~NOWA cysteine rich domain 6===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17362991}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2nx6]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Hydra_vulgaris Hydra vulgaris]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017362991<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Hydra vulgaris]]		[[Category: Hydra vulgaris]]
	[[Category: Adamczyk, P.]]		[[Category: Adamczyk, P.]]

OCA: Protected "2nx6" [edit=sysop:move=sysop]

2013-01-07T14:45:04Z

Protected "2nx6" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:45, 7 January 2013

OCA at 14:45, 7 January 2013

2013-01-07T14:45:01Z

←Older revision		Revision as of 14:45, 7 January 2013
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-	{{Seed}}
	[[Image:2nx6.png\|left\|200px]]		[[Image:2nx6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2nx6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2nx6\| PDB=2nx6 \| SCENE= }}		{{STRUCTURE_2nx6\| PDB=2nx6 \| SCENE= }}

	===Structure of NOWA cysteine rich domain 6===		===Structure of NOWA cysteine rich domain 6===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17362991}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17362991 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17362991}}		{{ABSTRACT_PUBMED_17362991}}

	==About this Structure==		==About this Structure==
-	~~2NX6 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA].	+	[[2nx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA].

	==Reference==		==Reference==
-	Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall., Meier S, Jensen PR, Adamczyk P, Bachinger HP, Holstein TW, Engel J, Ozbek S, Grzesiek S, J Mol Biol. 2007 May 4;368(3):718-28. Epub 2007 Feb 24. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~17362991 17362991]~~	+	<ref group="xtra">PMID:017362991</ref><references group="xtra"/>
	[[Category: Hydra vulgaris]]		[[Category: Hydra vulgaris]]
-	[[Category: Single protein]]
	[[Category: Adamczyk, P.]]		[[Category: Adamczyk, P.]]
	[[Category: Bachinger, H P.]]		[[Category: Bachinger, H P.]]
Line 37:		Line 24:
	[[Category: Structural protein]]		[[Category: Structural protein]]
	[[Category: Turn]]		[[Category: Turn]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:10:17 2008''

OCA at 06:10, 29 July 2008

2008-07-29T06:10:29Z

←Older revision		Revision as of 06:10, 29 July 2008
Line 1:		Line 1:
-	[[Image:2nx6.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2nx6.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2nx6\| PDB=2nx6 \| SCENE= }}		{{STRUCTURE_2nx6\| PDB=2nx6 \| SCENE= }}

-	~~'''~~Structure of NOWA cysteine rich domain 6~~'''~~	+	===Structure of NOWA cysteine rich domain 6===


-	~~==Overview==~~	+	<!--
-	The nematocyst wall of cnidarians is a unique biomaterial that withstands extreme osmotic pressures, allowing an ultrafast discharge of the nematocyst capsules. Assembly of the highly robust nematocyst wall is achieved by covalent linkage of cysteine-rich domains (CRDs) from two main protein components, minicollagens and nematocyst outer wall antigen (NOWA). The bipolar minicollagens have different disulfide patterns and topologies in their N and C-~~terminal CRDs.~~ The ~~functional significance of~~ this ~~polarity has been elusive. Here~~, we show by NMR structural analysis that all representative cysteine-rich domains of NOWA are structurally related to N-terminal minicollagen domains. Natural sequence insertions in NOWA CRDs have very little effect on the tightly knit domain structures, ~~nor do they preclude~~ the ~~efficient folding~~ to ~~a single native conformation. The different folds in NOWA CRDs and~~ the ~~atypical C-terminal minicollagen domain~~ on ~~the other hand can be directly related to different conformational preferences in the reduced states~~. ~~Ultrastructural analysis in conjunction with aggregation studies argues for an association between the similar NOWA and N-terminal minicollagen domains in early stages of the nematocyst wall assembly~~, ~~which~~ is ~~followed by~~ the ~~controlled association between the unusual structures of C~~-~~terminal minicollagen domains.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17362991}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17362991 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17362991}}

	==About this Structure==		==About this Structure==
-	2NX6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA].	+	2NX6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX6 OCA].

	==Reference==		==Reference==
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	[[Category: Structural protein]]		[[Category: Structural protein]]
	[[Category: Turn]]		[[Category: Turn]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 10~~:01:31 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:10:17 2008''

OCA at 07:01, 4 May 2008

2008-05-04T07:01:32Z

←Older revision		Revision as of 07:01, 4 May 2008
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	[[Image:2nx6.jpg\|left\|200px]]		[[Image:2nx6.jpg\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 2nx6 \|SIZE=350\|CAPTION= <scene name='initialview01'>2nx6</scene>~~	+	The line below this paragraph, containing "STRUCTURE_2nx6", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND=~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY=~~	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE= NOWA~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6087 Hydra vulgaris]~~)	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_2nx6\| PDB=2nx6 \| SCENE= }}
-	~~\|RELATEDENTRY=[[2hm3\|2HM3]]~~	+
-	\|~~RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol~~=2nx6 ~~FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id~~=~~2nx6 OCA], [http://www.ebi.ac.uk/pdbsum/2nx6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nx6 RCSB]</span>~~	+
-	}}	+

	'''Structure of NOWA cysteine rich domain 6'''		'''Structure of NOWA cysteine rich domain 6'''
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	[[Category: Meier, S.]]		[[Category: Meier, S.]]
	[[Category: Ozbek, S.]]		[[Category: Ozbek, S.]]
-	[[Category: ~~disulfide~~ rich]]	+	[[Category: Disulfide rich]]
-	[[Category: ~~structural~~ protein]]	+	[[Category: Structural protein]]
-	[[Category: ~~turn~~]]	+	[[Category: Turn]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:01:31 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 04~~:09:43 2008''	+