2oan - Revision history

OCA at 10:33, 30 August 2023

2023-08-30T10:33:58Z

←Older revision		Revision as of 10:33, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.606Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [https://pdbe.org/2oan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [https://www.ebi.ac.uk/pdbsum/2oan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oan ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [https://pdbe.org/2oan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [https://www.ebi.ac.uk/pdbsum/2oan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oan ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:28, 15 March 2023

2023-03-15T10:28:19Z

←Older revision		Revision as of 10:28, 15 March 2023
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	<StructureSection load='2oan' size='340' side='right'caption='[[2oan]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='2oan' size='340' side='right'caption='[[2oan]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~CSD~~:~~3-SULFINOALANINE~~'>~~CSD~~</scene></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [https://pdbe.org/2oan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [https://www.ebi.ac.uk/pdbsum/2oan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oan ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [https://pdbe.org/2oan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [https://www.ebi.ac.uk/pdbsum/2oan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oan ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACTB_BOVIN ACTB_BOVIN]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	+	[https://www.uniprot.org/uniprot/ACTB_BOVIN ACTB_BOVIN] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lassing, I]]	+	[[Category: Lassing I]]
-	[[Category: Lindberg, U]]	+	[[Category: Lindberg U]]
-	[[Category: Nordlund, P]]	+	[[Category: Nordlund P]]
-	[[Category: Schmitzberger, F]]	+	[[Category: Schmitzberger F]]
-	~~[[Category: Cysteine covalently modified by oxidation]]~~	+
-	~~[[Category: Disulfide]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 12:51, 9 June 2021

2021-06-09T12:51:13Z

←Older revision		Revision as of 12:51, 9 June 2021
Line 3:		Line 3:
	<StructureSection load='2oan' size='340' side='right'caption='[[2oan]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='2oan' size='340' side='right'caption='[[2oan]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OAN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [~~http~~://pdbe.org/2oan PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2oan PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2oan ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [https://pdbe.org/2oan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [https://www.ebi.ac.uk/pdbsum/2oan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oan ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACTB_BOVIN ACTB_BOVIN]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	+	[[https://www.uniprot.org/uniprot/ACTB_BOVIN ACTB_BOVIN]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:37, 31 July 2019

2019-07-31T07:37:47Z

←Older revision		Revision as of 07:37, 31 July 2019
Line 1:		Line 1:

	==Structure of oxidized beta-actin==		==Structure of oxidized beta-actin==
-	<StructureSection load='2oan' size='340' side='right' caption='[[2oan]], [[Resolution\|resolution]] 2.61Å' scene=''>	+	<StructureSection load='2oan' size='340' side='right'caption='[[2oan]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OAN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OAN FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 2oan" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2oan" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Actin 3D structures\|Actin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Lassing, I]]		[[Category: Lassing, I]]
	[[Category: Lindberg, U]]		[[Category: Lindberg, U]]

OCA at 08:55, 18 October 2017

2017-10-18T08:55:50Z

←Older revision		Revision as of 08:55, 18 October 2017
Line 1:		Line 1:
		+
	==Structure of oxidized beta-actin==		==Structure of oxidized beta-actin==
	<StructureSection load='2oan' size='340' side='right' caption='[[2oan]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='2oan' size='340' side='right' caption='[[2oan]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OAN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OAN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [http://pdbe.org/2oan PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [http://www.ebi.ac.uk/pdbsum/2oan PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [http://pdbe.org/2oan PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [http://www.ebi.ac.uk/pdbsum/2oan PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2oan ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 2oan" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2oan" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Actin\|Actin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Lassing, I]]		[[Category: Lassing, I]]
	[[Category: Lindberg, U]]		[[Category: Lindberg, U]]

OCA at 23:26, 10 September 2015

2015-09-10T23:26:47Z

←Older revision		Revision as of 23:26, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [http://www.ebi.ac.uk/pdbsum/2oan PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [http://pdbe.org/2oan PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [http://www.ebi.ac.uk/pdbsum/2oan PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2oan" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:36, 25 December 2014

2014-12-25T07:36:44Z

←Older revision		Revision as of 07:36, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [http://www.ebi.ac.uk/pdbsum/2oan PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [http://www.ebi.ac.uk/pdbsum/2oan PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACTB_BOVIN ACTB_BOVIN]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:19, 12 November 2014

2014-11-12T07:19:04Z

←Older revision		Revision as of 07:19, 12 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OAN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OAN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~CSW~~:~~CYSTEINE~~-~~S-DIOXIDE~~'>~~CSW~~</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [http://www.ebi.ac.uk/pdbsum/2oan PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [http://www.ebi.ac.uk/pdbsum/2oan PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Lassing, I.]]	+	[[Category: Lassing, I]]
-	[[Category: Lindberg, U.]]	+	[[Category: Lindberg, U]]
-	[[Category: Nordlund, P.]]	+	[[Category: Nordlund, P]]
-	[[Category: Schmitzberger, F.]]	+	[[Category: Schmitzberger, F]]
	[[Category: Cysteine covalently modified by oxidation]]		[[Category: Cysteine covalently modified by oxidation]]
	[[Category: Disulfide]]		[[Category: Disulfide]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 03:00, 29 September 2014

2014-09-29T03:00:15Z

←Older revision		Revision as of 03:00, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2oan.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of oxidized beta-actin==
		+	<StructureSection load='2oan' size='340' side='right' caption='[[2oan]], [[Resolution\|resolution]] 2.61Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2oan]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OAN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSW:CYSTEINE-S-DIOXIDE'>CSW</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oan RCSB], [http://www.ebi.ac.uk/pdbsum/2oan PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An essential consequence of growth factor-mediated signal transduction is the generation of intracellular H(2)O(2). It operates as a second messenger in the control of actin microfilament dynamics, causing rapid and dramatic changes in the morphology and motile activity of stimulated cells. Little is understood about the molecular mechanisms causing these changes in the actin system. Here, it is shown that H(2)O(2) acts directly upon several levels of this system, and some of the mechanistic effects are detailed. We describe the impact of oxidation on the polymerizability of non-muscle beta/gamma-actin and compare with that of muscle alpha-actin. Oxidation of beta/gamma-actin can cause a complete loss of polymerizability, crucially, reversible by the thioredoxin system. Further, oxidation of the actin impedes its interaction with profilin and causes depolymerization of filamentous actin. The effects of oxidation are critically dependent on the nucleotide state and the concentration of Ca(2+). We have determined the crystal structure of oxidized beta-actin to a resolution of 2.6 A. The arrangement in the crystal implies an antiparallel homodimer connected by an intermolecular disulfide bond involving cysteine 374. Our data indicate that this dimer forms under non-polymerizing and oxidizing conditions. We identify oxidation of cysteine 272 in the crystallized actin dimer, likely to a cysteine sulfinic acid. In beta/gamma-actin, this is the cysteine residue most reactive towards H(2)O(2) in solution, and we suggest plausible structural determinants for its reactivity. No other oxidative modification was obvious in the structure, highlighting the specificity of the oxidation by H(2)O(2). Possible consequences of the observed effects in a cellular context and their potential relevance are discussed.

-	~~{{STRUCTURE_2oan\| PDB=2oan \| SCENE= }}~~	+	Molecular and structural basis for redox regulation of beta-actin.,Lassing I, Schmitzberger F, Bjornstedt M, Holmgren A, Nordlund P, Schutt CE, Lindberg U J Mol Biol. 2007 Jul 6;370(2):331-48. Epub 2007 May 4. PMID:17521670<ref>PMID:17521670</ref>

-	~~===Structure~~ of ~~oxidized beta-actin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17521670}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2oan]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA].~~	+

	==See Also==		==See Also==
	*[[Actin\|Actin]]		*[[Actin\|Actin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017521670<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Lassing, I.]]		[[Category: Lassing, I.]]

OCA at 14:15, 20 October 2012

2012-10-20T14:15:34Z

←Older revision		Revision as of 14:15, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2oan]] is a 4 chain structure ~~of [[Actin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA].	+	[[2oan]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAN OCA].

	==See Also==		==See Also==