2okz - Revision history

OCA at 06:29, 3 April 2024

2024-04-03T06:29:17Z

←Older revision		Revision as of 06:29, 3 April 2024
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [https://pdbe.org/2okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [https://www.ebi.ac.uk/pdbsum/2okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [https://pdbe.org/2okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [https://www.ebi.ac.uk/pdbsum/2okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okz ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. The atomic architecture of a spine, from the fibril-forming segment GNNQQNY of the yeast prion protein Sup35, was recently revealed by X-ray microcrystallography. It is a pair of beta-sheets, with the facing side chains of the two sheets interdigitated in a dry 'steric zipper'. Here we report some 30 other segments from fibril-forming proteins that form amyloid-like fibrils, microcrystals, or usually both. These include segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. Structures of 13 of these microcrystals all reveal steric zippers, but with variations that expand the range of atomic architectures for amyloid-like fibrils and offer an atomic-level hypothesis for the basis of prion strains.
-
-	Atomic structures of amyloid cross-beta spines reveal varied steric zippers.,Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:17468747<ref>PMID:17468747</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2okz" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 00:20, 28 December 2023

2023-12-28T00:20:05Z

←Older revision		Revision as of 00:20, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [https://pdbe.org/2okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [https://www.ebi.ac.uk/pdbsum/2okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [https://pdbe.org/2okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [https://www.ebi.ac.uk/pdbsum/2okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:28, 15 March 2023

2023-03-15T10:28:46Z

←Older revision		Revision as of 10:28, 15 March 2023
Line 3:		Line 3:
	<StructureSection load='2okz' size='340' side='right'caption='[[2okz]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2okz' size='340' side='right'caption='[[2okz]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ol9\|2ol9]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [https://pdbe.org/2okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [https://www.ebi.ac.uk/pdbsum/2okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [https://pdbe.org/2okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [https://www.ebi.ac.uk/pdbsum/2okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okz ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eisenberg, D]]	+	[[Category: Eisenberg D]]
-	[[Category: Sambashivan, S]]	+	[[Category: Sambashivan S]]
-	[[Category: Sawaya~~, M R]]~~	+	[[Category: Sawaya MR]]
-	~~[[Category: Protein fibril]]~~	+
-	~~[[Category: Steric zipper~~]]	+

OCA at 12:59, 9 June 2021

2021-06-09T12:59:10Z

←Older revision		Revision as of 12:59, 9 June 2021
Line 3:		Line 3:
	<StructureSection load='2okz' size='340' side='right'caption='[[2okz]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2okz' size='340' side='right'caption='[[2okz]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ol9\|2ol9]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ol9\|2ol9]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [~~http~~://pdbe.org/2okz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2okz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2okz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [https://pdbe.org/2okz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [https://www.ebi.ac.uk/pdbsum/2okz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:15, 31 July 2019

2019-07-31T07:15:07Z

←Older revision		Revision as of 07:15, 31 July 2019
Line 1:		Line 1:

	==MVGGVV peptide derived from Alzheimer's A-beta==		==MVGGVV peptide derived from Alzheimer's A-beta==
-	<StructureSection load='2okz' size='340' side='right' caption='[[2okz]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2okz' size='340' side='right'caption='[[2okz]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Sambashivan, S]]		[[Category: Sambashivan, S]]

OCA at 09:02, 18 October 2017

2017-10-18T09:02:45Z

←Older revision		Revision as of 09:02, 18 October 2017
Line 1:		Line 1:
		+
	==MVGGVV peptide derived from Alzheimer's A-beta==		==MVGGVV peptide derived from Alzheimer's A-beta==
	<StructureSection load='2okz' size='340' side='right' caption='[[2okz]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2okz' size='340' side='right' caption='[[2okz]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ol9\|2ol9]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ol9\|2ol9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [http://pdbe.org/2okz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [http://www.ebi.ac.uk/pdbsum/2okz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [http://pdbe.org/2okz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [http://www.ebi.ac.uk/pdbsum/2okz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2okz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:19, 10 September 2015

2015-09-10T05:19:40Z

←Older revision		Revision as of 05:19, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ol9\|2ol9]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ol9\|2ol9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [http://www.ebi.ac.uk/pdbsum/2okz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [http://pdbe.org/2okz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [http://www.ebi.ac.uk/pdbsum/2okz PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2okz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:27, 22 January 2015

2015-01-22T06:27:24Z

←Older revision		Revision as of 06:27, 22 January 2015
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Eisenberg, D.]]	+	[[Category: Eisenberg, D]]
-	[[Category: Sambashivan, S.]]	+	[[Category: Sambashivan, S]]
-	[[Category: Sawaya, M R.]]	+	[[Category: Sawaya, M R]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]
	[[Category: Steric zipper]]		[[Category: Steric zipper]]

OCA at 11:16, 20 October 2014

2014-10-20T11:16:54Z

←Older revision		Revision as of 11:16, 20 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2okz.~~png~~\|~~left~~\|~~200px~~]]	+	==MVGGVV peptide derived from Alzheimer's A-beta==
		+	<StructureSection load='2okz' size='340' side='right' caption='[[2okz]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2okz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OKZ FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ol9\|2ol9]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2okz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2okz RCSB], [http://www.ebi.ac.uk/pdbsum/2okz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. The atomic architecture of a spine, from the fibril-forming segment GNNQQNY of the yeast prion protein Sup35, was recently revealed by X-ray microcrystallography. It is a pair of beta-sheets, with the facing side chains of the two sheets interdigitated in a dry 'steric zipper'. Here we report some 30 other segments from fibril-forming proteins that form amyloid-like fibrils, microcrystals, or usually both. These include segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. Structures of 13 of these microcrystals all reveal steric zippers, but with variations that expand the range of atomic architectures for amyloid-like fibrils and offer an atomic-level hypothesis for the basis of prion strains.

-	~~{{STRUCTURE_2okz\| PDB=2okz \| SCENE= }}~~	+	Atomic structures of amyloid cross-beta spines reveal varied steric zippers.,Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:17468747<ref>PMID:17468747</ref>

-	~~===MVGGVV peptide derived from Alzheimer's A-beta===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17468747}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2okz]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2OKZ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017468747<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
	[[Category: Sambashivan, S.]]		[[Category: Sambashivan, S.]]

OCA: Protected "2okz" [edit=sysop:move=sysop]

2013-01-07T11:27:54Z

Protected "2okz" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:27, 7 January 2013