2ope - Revision history

OCA at 00:21, 28 December 2023

2023-12-28T00:21:29Z

←Older revision		Revision as of 00:21, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ope]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ope]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [https://pdbe.org/2ope PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [https://www.ebi.ac.uk/pdbsum/2ope PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ope ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [https://pdbe.org/2ope PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [https://www.ebi.ac.uk/pdbsum/2ope PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ope ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 2ope" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ope" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pilin 3D structures\|Pilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:29, 15 March 2023

2023-03-15T10:29:22Z

←Older revision		Revision as of 10:29, 15 March 2023
Line 3:		Line 3:
	<StructureSection load='2ope' size='340' side='right'caption='[[2ope]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ope' size='340' side='right'caption='[[2ope]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ope]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis~~ meningitidis~~" (sic) weichselbaum 1887~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ope]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPE FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2pil\|2pil]], [[2hi2\|2hi2]], [[2opd\|2opd]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [https://pdbe.org/2ope PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [https://www.ebi.ac.uk/pdbsum/2ope PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ope ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 "Diplokokkus intracellularis meningitidis" (sic) Weichselbaum 1887])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [https://pdbe.org/2ope PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [https://www.ebi.ac.uk/pdbsum/2ope PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ope ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Dyer, D H~~]]	+	[[Category: Neisseria meningitidis]]
-	[[Category: ~~Forest, K T~~]]	+	[[Category: Dyer DH]]
-	[[Category: ~~Helaine, S~~]]	+	[[Category: Forest KT]]
-	[[Category: ~~Pelicic, V~~]]	+	[[Category: Helaine S]]
-	[[Category: ~~Adhesion]]~~	+	[[Category: Pelicic V]]
-	~~[[Category: Aggregation]]~~	+
-	~~[[Category: Bacterial pathogenesis]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Filament]]~~	+
-	~~[[Category: Minor pilin]]~~	+
-	~~[[Category: Neisseria meningitidi]]~~	+
-	~~[[Category: Pilx]]~~	+
-	~~[[Category: Type iv pilin~~]]	+

OCA at 13:02, 9 June 2021

2021-06-09T13:02:28Z

←Older revision		Revision as of 13:02, 9 June 2021
Line 1:		Line 1:

	==Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43==		==Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43==
-	<StructureSection load='2ope' size='340' side='right' caption='[[2ope]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2ope' size='340' side='right'caption='[[2ope]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ope]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis meningitidis" (sic) weichselbaum 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OPE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ope]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis meningitidis" (sic) weichselbaum 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPE FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pil\|2pil]], [[2hi2\|2hi2]], [[2opd\|2opd]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2pil\|2pil]], [[2hi2\|2hi2]], [[2opd\|2opd]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilX ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 "Diplokokkus intracellularis meningitidis" (sic) Weichselbaum 1887])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 "Diplokokkus intracellularis meningitidis" (sic) Weichselbaum 1887])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [~~http~~://pdbe.org/2ope PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ope PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ope ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [https://pdbe.org/2ope PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [https://www.ebi.ac.uk/pdbsum/2ope PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ope ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Dyer, D H]]		[[Category: Dyer, D H]]
	[[Category: Forest, K T]]		[[Category: Forest, K T]]

OCA at 09:06, 18 October 2017

2017-10-18T09:06:11Z

←Older revision		Revision as of 09:06, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43==		==Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43==
	<StructureSection load='2ope' size='340' side='right' caption='[[2ope]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ope' size='340' side='right' caption='[[2ope]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pil\|2pil]], [[2hi2\|2hi2]], [[2opd\|2opd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pil\|2pil]], [[2hi2\|2hi2]], [[2opd\|2opd]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 "Diplokokkus intracellularis meningitidis" (sic) Weichselbaum 1887])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 "Diplokokkus intracellularis meningitidis" (sic) Weichselbaum 1887])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [http://pdbe.org/2ope PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [http://www.ebi.ac.uk/pdbsum/2ope PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [http://pdbe.org/2ope PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [http://www.ebi.ac.uk/pdbsum/2ope PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ope ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:06, 11 September 2015

2015-09-11T03:06:28Z

←Older revision		Revision as of 03:06, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ope' size='340' side='right' caption='[[2ope]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ope' size='340' side='right' caption='[[2ope]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ope]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Neisseria_meningitidis Neisseria~~ meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ope]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis meningitidis" (sic) weichselbaum 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pil\|2pil]], [[2hi2\|2hi2]], [[2opd\|2opd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pil\|2pil]], [[2hi2\|2hi2]], [[2opd\|2opd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 ~~Neisseria~~ meningitidis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 "Diplokokkus intracellularis meningitidis" (sic) Weichselbaum 1887])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [http://www.ebi.ac.uk/pdbsum/2ope PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [http://pdbe.org/2ope PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [http://www.ebi.ac.uk/pdbsum/2ope PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ope" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Neisseria meningitidis]]
	[[Category: Dyer, D H]]		[[Category: Dyer, D H]]
	[[Category: Forest, K T]]		[[Category: Forest, K T]]

OCA at 06:36, 22 January 2015

2015-01-22T06:36:16Z

←Older revision		Revision as of 06:36, 22 January 2015
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Neisseria meningitidis]]		[[Category: Neisseria meningitidis]]
-	[[Category: Dyer, D H.]]	+	[[Category: Dyer, D H]]
-	[[Category: Forest, K T.]]	+	[[Category: Forest, K T]]
-	[[Category: Helaine, S.]]	+	[[Category: Helaine, S]]
-	[[Category: Pelicic, V.]]	+	[[Category: Pelicic, V]]
	[[Category: Adhesion]]		[[Category: Adhesion]]
	[[Category: Aggregation]]		[[Category: Aggregation]]

OCA at 11:25, 20 October 2014

2014-10-20T11:25:05Z

←Older revision		Revision as of 11:25, 20 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2ope.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43==
		+	<StructureSection load='2ope' size='340' side='right' caption='[[2ope]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ope]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPE FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2pil\|2pil]], [[2hi2\|2hi2]], [[2opd\|2opd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pilX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 Neisseria meningitidis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ope OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ope RCSB], [http://www.ebi.ac.uk/pdbsum/2ope PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type IV pili (Tfp) are widespread filamentous bacterial organelles that mediate multiple virulence-related phenotypes. They are composed mainly of pilin subunits, which are processed before filament assembly by dedicated prepilin peptidases. Other proteins processed by these peptidases, whose molecular nature and mode of action remain enigmatic, play critical roles in Tfp biology. We have performed a detailed structure/function analysis of one such protein, PilX from Neisseria meningitidis, which is crucial for formation of bacterial aggregates and adhesion to human cells. The x-ray crystal structure of PilX reveals the alpha/beta roll fold shared by all pilins, and we show that this protein colocalizes with Tfp. These observations suggest that PilX is a minor, or low abundance, pilin that assembles within the filaments in a similar way to pilin. Deletion of a PilX distinctive structural element, which is predicted to be exposed on the filament surface, abolishes aggregation and adhesion. Our results support a model in which surface-exposed motifs in PilX subunits stabilize bacterial aggregates against the disruptive force of pilus retraction and illustrate how a minor pilus component can enhance the functional properties of pili of rather simple composition and structure.

-	~~{{STRUCTURE_2ope\| PDB=2ope \| SCENE= }}~~	+	3D structure/function analysis of PilX reveals how minor pilins can modulate the virulence properties of type IV pili.,Helaine S, Dyer DH, Nassif X, Pelicic V, Forest KT Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15888-93. Epub 2007 Sep 24. PMID:17893339<ref>PMID:17893339</ref>

-	~~===Crystal structure~~ of the ~~Neisseria meningitidis minor Type IV pilin, PilX, in space group P43===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17893339}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2ope]] is a 4 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA].~~	+	</StructureSection>
	[[Category: Neisseria meningitidis]]		[[Category: Neisseria meningitidis]]
	[[Category: Dyer, D H.]]		[[Category: Dyer, D H.]]

OCA: Protected "2ope" [edit=sysop:move=sysop]

2013-01-07T14:13:34Z

Protected "2ope" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:13, 7 January 2013

OCA at 14:13, 7 January 2013

2013-01-07T14:13:32Z

←Older revision		Revision as of 14:13, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2ope.png\|left\|200px]]		[[Image:2ope.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ope", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ope\| PDB=2ope \| SCENE= }}		{{STRUCTURE_2ope\| PDB=2ope \| SCENE= }}

	===Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43===		===Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17893339}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17893339 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17893339}}		{{ABSTRACT_PUBMED_17893339}}

	==About this Structure==		==About this Structure==
-	~~2OPE is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA].	+	[[2ope]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPE OCA].
-		+
-	~~==Reference==~~	+
-	3D structure/function analysis of PilX reveals how minor pilins can modulate the virulence properties of type IV pili., Helaine S, Dyer DH, Nassif X, Pelicic V, Forest KT, Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15888-93. Epub 2007 Sep 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17893339 17893339]	+
	[[Category: Neisseria meningitidis]]		[[Category: Neisseria meningitidis]]
-	[[Category: Single protein]]
	[[Category: Dyer, D H.]]		[[Category: Dyer, D H.]]
	[[Category: Forest, K T.]]		[[Category: Forest, K T.]]
Line 39:		Line 23:
	[[Category: Pilx]]		[[Category: Pilx]]
	[[Category: Type iv pilin]]		[[Category: Type iv pilin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:31 2008''

OCA at 15:48, 28 July 2008

2008-07-28T15:48:32Z

←Older revision		Revision as of 15:48, 28 July 2008
Line 1:		Line 1:
-	[[Image:2ope.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2ope.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2ope\| PDB=2ope \| SCENE= }}		{{STRUCTURE_2ope\| PDB=2ope \| SCENE= }}

-	~~'''~~Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43~~'''~~	+	===Crystal structure of the Neisseria meningitidis minor Type IV pilin, PilX, in space group P43===


-	~~==Overview==~~	+	<!--
-	Type IV pili (Tfp) are widespread filamentous bacterial organelles that mediate multiple virulence-related phenotypes. They are composed mainly of pilin subunits, which are processed before filament assembly by dedicated prepilin peptidases. Other proteins processed by these peptidases, whose molecular nature and mode of action remain enigmatic, play critical roles in Tfp biology. We have performed a detailed structure/function analysis of one such protein, PilX from Neisseria meningitidis, which is crucial for formation of bacterial aggregates and adhesion to human cells. The ~~x-ray crystal structure of PilX reveals the alpha/beta roll fold shared by all pilins, and we show that~~ this ~~protein colocalizes with Tfp. These observations suggest that PilX is a minor~~, ~~or low abundance~~, ~~pilin that assembles within~~ the ~~filaments in a similar way~~ to ~~pilin~~. ~~Deletion of a PilX distinctive structural element~~, ~~which~~ is ~~predicted to be exposed on~~ the ~~filament surface, abolishes aggregation and adhesion~~. ~~Our results support a model in which surface~~-exposed motifs in PilX subunits stabilize bacterial aggregates against the disruptive force of pilus retraction and illustrate how a minor pilus component can enhance the functional properties of pili of rather simple composition and structure.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17893339}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17893339 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17893339}}

	==About this Structure==		==About this Structure==
Line 35:		Line 39:
	[[Category: Pilx]]		[[Category: Pilx]]
	[[Category: Type iv pilin]]		[[Category: Type iv pilin]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 11~~:23:03 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:31 2008''