2ow4 - Revision history

OCA at 09:06, 21 February 2024

2024-02-21T09:06:37Z

←Older revision		Revision as of 09:06, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='2ow4' size='340' side='right'caption='[[2ow4]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2ow4' size='340' side='right'caption='[[2ow4]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Canavalia_maritima~~ Canavalia ~~maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~"><~~scene name~~='~~pdbligand~~=CA:~~CALCIUM+ION'~~>CA</~~scene~~>, <scene name='pdbligand=MN:~~MANGANESE+(II)~~+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[2ovu\|2ovu]], [[2p2k\|2p2k]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [https://pdbe.org/2ow4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ow4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ow4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [https://pdbe.org/2ow4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ow4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ow4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CONA_CANRO CONA_CANRO]] Glucose/D-mannose specific lectin.	+	[https://www.uniprot.org/uniprot/CONA_CANRO CONA_CANRO] Glucose/D-mannose specific lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ow4 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ow4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Plant lectins, especially those purified from species of the Leguminosae family, represent the best studied group of carbohydrate-binding proteins. The legume lectins from Diocleinae subtribe are highly similar proteins that present significant differences in the potency/efficacy of their biological activities. The structural studies of the interactions between lectins and sugars may clarify the origin of the distinct biological activities observed in this high similar class of proteins. In this way, this work presents a crystallographic study of the ConM and CGL (agglutinins from Canavalia maritima and Canavalia gladiata, respectively) in the following complexes: ConM/CGL:Man(alpha1-2)Man(alpha1-O)Me, ConM/CGL:Man(alpha1-3)Man(alpha1-O)Me and ConM/CGL:Man(alpha1-4)Man(alpha1-O)Me, which crystallized in different conditions and space group from the native proteins. The structures were solved by molecular replacement, presenting satisfactory values for R(factor) and R(free). Comparisons between ConM, CGL and ConA (Canavalia ensiformis lectin) binding mode with the dimannosides in subject, presented different interactions patterns, which may account for a structural explanation of the distincts biological properties observed in the lectins of Diocleinae subtribe.
-
-	Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins.,Bezerra GA, Oliveira TM, Moreno FB, de Souza EP, da Rocha BA, Benevides RG, Delatorre P, de Azevedo WF Jr, Cavada BS J Struct Biol. 2007 Nov;160(2):168-76. Epub 2007 Aug 16. PMID:17881248<ref>PMID:17881248</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2ow4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Concanavalin 3D structures\|Concanavalin 3D structures]]		*[[Concanavalin 3D structures\|Concanavalin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Canavalia ~~maritima~~]]	+	[[Category: Canavalia rosea]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Azevedo, W F.de]]~~	+	[[Category: Benevides RG]]
-	[[Category: Benevides~~, R G~~]]	+	[[Category: Bezerra GA]]
-	[[Category: Bezerra~~, G A~~]]	+	[[Category: Cavada BS]]
-	[[Category: Cavada~~, B S~~]]	+	[[Category: Delatorre P]]
-	[[Category: Delatorre, P]]	+	[[Category: Moreno FBMB]]
-	[[Category: Moreno~~, F B.M B]]~~	+	[[Category: Da Rocha BAM]]
-	~~[[Category: Oliveira, T M.de~~]]	+	[[Category: De Azevedo Jr WF]]
-	[[Category: Rocha~~, B A.M da~~]]	+	[[Category: De Oliveira TM]]
-	[[Category: ~~Souza, E M.de~~]]	+	[[Category: De Souza EM]]
-	[[Category: ~~Lectin~~]]	+
-	[[Category: ~~Man1-2man-ome]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 13:07, 9 June 2021

2021-06-09T13:07:37Z

←Older revision		Revision as of 13:07, 9 June 2021
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	<StructureSection load='2ow4' size='340' side='right'caption='[[2ow4]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2ow4' size='340' side='right'caption='[[2ow4]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Beach_bean Beach bean~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:O1-~~METHYL~~-MANNOSE'>~~MMA~~</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ovu\|2ovu]], [[2p2k\|2p2k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ovu\|2ovu]], [[2p2k\|2p2k]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [~~http~~://pdbe.org/2ow4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ow4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ow4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [https://pdbe.org/2ow4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ow4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ow4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CONA_CANRO CONA_CANRO]] Glucose/D-mannose specific lectin.	+	[[https://www.uniprot.org/uniprot/CONA_CANRO CONA_CANRO]] Glucose/D-mannose specific lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beach bean~~]]	+	[[Category: Canavalia maritima]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Azevedo, W F.de]]		[[Category: Azevedo, W F.de]]
Line 47:		Line 47:
	[[Category: Rocha, B A.M da]]		[[Category: Rocha, B A.M da]]
	[[Category: Souza, E M.de]]		[[Category: Souza, E M.de]]
-	[[Category: Canavalia maritima]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Man1-2man-ome]]		[[Category: Man1-2man-ome]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 08:04, 31 July 2019

2019-07-31T08:04:37Z

←Older revision		Revision as of 08:04, 31 July 2019
Line 1:		Line 1:

	==Crystal structure of a lectin from Canavalia maritima seeds (ConM) in complex with man1-2man-OMe==		==Crystal structure of a lectin from Canavalia maritima seeds (ConM) in complex with man1-2man-OMe==
-	<StructureSection load='2ow4' size='340' side='right' caption='[[2ow4]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='2ow4' size='340' side='right'caption='[[2ow4]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Beach_bean Beach bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Beach_bean Beach bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/2ow4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/2ow4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2ow4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ow4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Concanavalin 3D structures\|Concanavalin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Beach bean]]		[[Category: Beach bean]]
		+	[[Category: Large Structures]]
	[[Category: Azevedo, W F.de]]		[[Category: Azevedo, W F.de]]
	[[Category: Benevides, R G]]		[[Category: Benevides, R G]]

OCA at 09:11, 18 October 2017

2017-10-18T09:11:23Z

←Older revision		Revision as of 09:11, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of a lectin from Canavalia maritima seeds (ConM) in complex with man1-2man-OMe==		==Crystal structure of a lectin from Canavalia maritima seeds (ConM) in complex with man1-2man-OMe==
	<StructureSection load='2ow4' size='340' side='right' caption='[[2ow4]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2ow4' size='340' side='right' caption='[[2ow4]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Canavalia_rosea Canavalia rosea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Beach_bean Beach bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-MANNOSE'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:~~O1-METHYL-MANNOSE~~'>~~MMA~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ovu\|2ovu]], [[2p2k\|2p2k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ovu\|2ovu]], [[2p2k\|2p2k]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [http://pdbe.org/2ow4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ow4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [http://pdbe.org/2ow4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ow4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ow4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2ow4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ow4" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Concanavalin A\|Concanavalin A]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canavalia rosea~~]]	+	[[Category: Beach bean]]
	[[Category: Azevedo, W F.de]]		[[Category: Azevedo, W F.de]]
	[[Category: Benevides, R G]]		[[Category: Benevides, R G]]

OCA at 16:00, 7 February 2016

2016-02-07T16:00:29Z

←Older revision		Revision as of 16:00, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ow4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:01, 10 September 2015

2015-09-10T03:01:43Z

←Older revision		Revision as of 03:01, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ovu\|2ovu]], [[2p2k\|2p2k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ovu\|2ovu]], [[2p2k\|2p2k]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ow4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [http://pdbe.org/2ow4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ow4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~CONA_CANMR CONA_CANMR~~]] Glucose/D-mannose specific lectin.	+	[[http://www.uniprot.org/uniprot/CONA_CANRO CONA_CANRO]] Glucose/D-mannose specific lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ow4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:28, 24 December 2014

2014-12-24T16:28:52Z

←Older revision		Revision as of 16:28, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ovu\|2ovu]], [[2p2k\|2p2k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ovu\|2ovu]], [[2p2k\|2p2k]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ow4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ow4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CONA_CANMR CONA_CANMR]] Glucose/D-mannose specific lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Canavalia rosea]]		[[Category: Canavalia rosea]]
-	[[Category: Azevedo, W F.de.]]	+	[[Category: Azevedo, W F.de]]
-	[[Category: Benevides, R G.]]	+	[[Category: Benevides, R G]]
-	[[Category: Bezerra, G A.]]	+	[[Category: Bezerra, G A]]
-	[[Category: Cavada, B S.]]	+	[[Category: Cavada, B S]]
-	[[Category: Delatorre, P.]]	+	[[Category: Delatorre, P]]
-	[[Category: Moreno, F B.M B.]]	+	[[Category: Moreno, F B.M B]]
-	[[Category: Oliveira, T M.de.]]	+	[[Category: Oliveira, T M.de]]
-	[[Category: Rocha, B A.M da.]]	+	[[Category: Rocha, B A.M da]]
-	[[Category: Souza, E M.de.]]	+	[[Category: Souza, E M.de]]
	[[Category: Canavalia maritima]]		[[Category: Canavalia maritima]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Man1-2man-ome]]		[[Category: Man1-2man-ome]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 19:46, 30 September 2014

2014-09-30T19:46:21Z

←Older revision		Revision as of 19:46, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2ow4.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of a lectin from Canavalia maritima seeds (ConM) in complex with man1-2man-OMe==
		+	<StructureSection load='2ow4' size='340' side='right' caption='[[2ow4]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ow4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OW4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ovu\|2ovu]], [[2p2k\|2p2k]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ow4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ow4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ow4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/2ow4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plant lectins, especially those purified from species of the Leguminosae family, represent the best studied group of carbohydrate-binding proteins. The legume lectins from Diocleinae subtribe are highly similar proteins that present significant differences in the potency/efficacy of their biological activities. The structural studies of the interactions between lectins and sugars may clarify the origin of the distinct biological activities observed in this high similar class of proteins. In this way, this work presents a crystallographic study of the ConM and CGL (agglutinins from Canavalia maritima and Canavalia gladiata, respectively) in the following complexes: ConM/CGL:Man(alpha1-2)Man(alpha1-O)Me, ConM/CGL:Man(alpha1-3)Man(alpha1-O)Me and ConM/CGL:Man(alpha1-4)Man(alpha1-O)Me, which crystallized in different conditions and space group from the native proteins. The structures were solved by molecular replacement, presenting satisfactory values for R(factor) and R(free). Comparisons between ConM, CGL and ConA (Canavalia ensiformis lectin) binding mode with the dimannosides in subject, presented different interactions patterns, which may account for a structural explanation of the distincts biological properties observed in the lectins of Diocleinae subtribe.

-	~~{{STRUCTURE_2ow4\| PDB=2ow4 \| SCENE= }}~~	+	Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins.,Bezerra GA, Oliveira TM, Moreno FB, de Souza EP, da Rocha BA, Benevides RG, Delatorre P, de Azevedo WF Jr, Cavada BS J Struct Biol. 2007 Nov;160(2):168-76. Epub 2007 Aug 16. PMID:17881248<ref>PMID:17881248</ref>

-	~~===Crystal structure~~ of ~~a lectin from Canavalia maritima seeds (ConM) in complex with man1-2man-OMe===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17881248}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2ow4]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Canavalia_rosea Canavalia rosea]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA].~~	+

	==See Also==		==See Also==
	*[[Concanavalin A\|Concanavalin A]]		*[[Concanavalin A\|Concanavalin A]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017881248<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Canavalia rosea]]		[[Category: Canavalia rosea]]
	[[Category: Azevedo, W F.de.]]		[[Category: Azevedo, W F.de.]]

OCA at 13:22, 30 January 2013

2013-01-30T13:22:49Z

←Older revision		Revision as of 13:22, 30 January 2013
Line 1:		Line 1:
	[[Image:2ow4.png\|left\|200px]]		[[Image:2ow4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ow4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ow4\| PDB=2ow4 \| SCENE= }}		{{STRUCTURE_2ow4\| PDB=2ow4 \| SCENE= }}

	===Crystal structure of a lectin from Canavalia maritima seeds (ConM) in complex with man1-2man-OMe===		===Crystal structure of a lectin from Canavalia maritima seeds (ConM) in complex with man1-2man-OMe===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17881248}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17881248 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17881248}}		{{ABSTRACT_PUBMED_17881248}}

	==About this Structure==		==About this Structure==
	[[2ow4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA].		[[2ow4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW4 OCA].
		+
		+	==See Also==
		+	*[[Concanavalin A\|Concanavalin A]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17881248~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017881248</ref><references group="xtra"/>
	[[Category: Canavalia rosea]]		[[Category: Canavalia rosea]]
	[[Category: Azevedo, W F.de.]]		[[Category: Azevedo, W F.de.]]
Line 33:		Line 25:
	[[Category: Rocha, B A.M da.]]		[[Category: Rocha, B A.M da.]]
	[[Category: Souza, E M.de.]]		[[Category: Souza, E M.de.]]
		+	[[Category: Canavalia maritima]]
		+	[[Category: Lectin]]
		+	[[Category: Man1-2man-ome]]
		+	[[Category: Sugar binding protein]]

OCA: Protected "2ow4" [edit=sysop:move=sysop]

2011-03-16T07:48:47Z

Protected "2ow4" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:48, 16 March 2011