2p7q - Revision history

OCA at 10:56, 30 August 2023

2023-08-30T10:56:58Z

←Older revision		Revision as of 10:56, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2p7q' size='340' side='right'caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2p7q' size='340' side='right'caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lismo Lismo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GG6:[(1S,2S)~~-1,2~~-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;'>~~[~~[2p7k\|2p7k]]~~, ~~[[2p7l\|2p7l]]~~, ~~[[2p7m\|2p7m]~~], ~~[[2p7o\|2p7o]], [[2p7p\|2p7p]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [https://pdbe.org/2p7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [https://www.ebi.ac.uk/pdbsum/2p7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [https://pdbe.org/2p7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [https://www.ebi.ac.uk/pdbsum/2p7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7q ProSAT]</span></td></tr>
	</table>		</table>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lismo~~]]	+	[[Category: Listeria monocytogenes EGD-e]]
-	[[Category: Armstrong~~, R N~~]]	+	[[Category: Armstrong RN]]
-	[[Category: Fillgrove~~, K L~~]]	+	[[Category: Fillgrove KL]]
-	[[Category: Newcomer~~, M E~~]]	+	[[Category: Newcomer ME]]
-	[[Category: Pakhomova, S]]	+	[[Category: Pakhomova S]]
-	[[Category: Schaab, M]]	+	[[Category: Schaab M]]
-	~~[[Category: Antibiotic resistance]]~~	+
-	~~[[Category: Fosfomycin resistance protein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Mn binding~~]]	+

OCA at 18:23, 20 October 2021

2021-10-20T18:23:34Z

←Older revision		Revision as of 18:23, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='2p7q' size='340' side='right'caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2p7q' size='340' side='right'caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [~~http~~://pdbe.org/2p7q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2p7q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [https://pdbe.org/2p7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [https://www.ebi.ac.uk/pdbsum/2p7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7q ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:09, 27 May 2020

2020-05-27T08:09:46Z

←Older revision		Revision as of 08:09, 27 May 2020
Line 1:		Line 1:

	==Crystal structure of E126Q mutant of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and 1S,2S-dihydroxypropylphosphonic acid==		==Crystal structure of E126Q mutant of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and 1S,2S-dihydroxypropylphosphonic acid==
-	<StructureSection load='2p7q' size='340' side='right' caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2p7q' size='340' side='right'caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [http://pdbe.org/2p7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [http://www.ebi.ac.uk/pdbsum/2p7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [http://pdbe.org/2p7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [http://www.ebi.ac.uk/pdbsum/2p7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7q ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lismo]]		[[Category: Lismo]]
	[[Category: Armstrong, R N]]		[[Category: Armstrong, R N]]

OCA at 06:48, 22 August 2018

2018-08-22T06:48:04Z

←Older revision		Revision as of 06:48, 22 August 2018
Line 1:		Line 1:
		+
	==Crystal structure of E126Q mutant of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and 1S,2S-dihydroxypropylphosphonic acid==		==Crystal structure of E126Q mutant of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and 1S,2S-dihydroxypropylphosphonic acid==
	<StructureSection load='2p7q' size='340' side='right' caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2p7q' size='340' side='right' caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [http://pdbe.org/2p7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [http://www.ebi.ac.uk/pdbsum/2p7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [http://pdbe.org/2p7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [http://www.ebi.ac.uk/pdbsum/2p7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7q ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p7q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p7q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:07, 8 February 2016

2016-02-08T07:07:41Z

←Older revision		Revision as of 07:07, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p7q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:06, 10 September 2015

2015-09-10T09:06:56Z

←Older revision		Revision as of 09:06, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2p7q' size='340' side='right' caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2p7q' size='340' side='right' caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Listeria_monocytogenes Listeria monocytogenes~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [http://www.ebi.ac.uk/pdbsum/2p7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [http://pdbe.org/2p7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [http://www.ebi.ac.uk/pdbsum/2p7q PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2p7q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Listeria monocytogenes~~]]	+	[[Category: Lismo]]
	[[Category: Armstrong, R N]]		[[Category: Armstrong, R N]]
	[[Category: Fillgrove, K L]]		[[Category: Fillgrove, K L]]

OCA at 17:18, 19 January 2015

2015-01-19T17:18:51Z

←Older revision		Revision as of 17:18, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [http://www.ebi.ac.uk/pdbsum/2p7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [http://www.ebi.ac.uk/pdbsum/2p7q PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Listeria monocytogenes]]		[[Category: Listeria monocytogenes]]
-	[[Category: Armstrong, R N.]]	+	[[Category: Armstrong, R N]]
-	[[Category: Fillgrove, K L.]]	+	[[Category: Fillgrove, K L]]
-	[[Category: Newcomer, M E.]]	+	[[Category: Newcomer, M E]]
-	[[Category: Pakhomova, S.]]	+	[[Category: Pakhomova, S]]
-	[[Category: Schaab, M.]]	+	[[Category: Schaab, M]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Fosfomycin resistance protein]]		[[Category: Fosfomycin resistance protein]]

OCA at 19:51, 30 September 2014

2014-09-30T19:51:13Z

←Older revision		Revision as of 19:51, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2p7q.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of E126Q mutant of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and 1S,2S-dihydroxypropylphosphonic acid==
		+	<StructureSection load='2p7q' size='340' side='right' caption='[[2p7q]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2p7q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P7Q FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p7k\|2p7k]], [[2p7l\|2p7l]], [[2p7m\|2p7m]], [[2p7o\|2p7o]], [[2p7p\|2p7p]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p7q RCSB], [http://www.ebi.ac.uk/pdbsum/2p7q PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p7q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The fosfomycin resistance protein, FosX, catalyzes the hydration of the antibiotic fosfomycin, (1R,2S)-epoxypropylphosphonic acid. Genes encoding the enzyme are found in several pathogenic microorganisms. The structure and mechanism of action of the genomically encoded FosX enzyme from Listeria monocytogenes (FosXLMATCC) obtained from the American Type Culture Collection are reported. The gene harbors 31 point mutations, and as a consequence, the protein differs in 10 amino acid residues from the previously reported FosX encoded in the genome of the EGD strain of L. monocytogenes (FosXLMEGD). The FosXLMATCC enzyme is shown to catalyze the addition of water to the C1 position of the antibiotic with inversion of configuration at C1. The reaction involves Mn(II) activation of the oxirane oxygen and E44 acting as a general base. The structure of the enzyme has been determined from six different crystal forms of the protein. The structures of the enzyme without metal bound are similar but differ in the loop regions. Perhaps the most informative structure is the one with the product bound. This structure shows that the phosphonate group of the product is bound in an orientation that is different than that of fosfomycin bound to the related enzyme, FosA. The implication is that the substrate may also be bound in a different orientation in FosX. A high-resolution structure (1.44 A resolution) of the enzyme reveals a unique conformation in which the C-terminal tail of the protein coordinates to the Mn(II) center via the carboxylate of E126. The kinetic characterization of the E126Q mutant indicates that this conformation of the protein is probably not relevant to the function of the enzyme. Kinetic analysis of mutants of active site residue E44 is consistent with its proposed roll as a general base catalyst in the addition of water to the antibiotic.

-	~~{{STRUCTURE_2p7q\| PDB=2p7q \| SCENE= }}~~	+	Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes.,Fillgrove KL, Pakhomova S, Schaab MR, Newcomer ME, Armstrong RN Biochemistry. 2007 Jul 10;46(27):8110-20. Epub 2007 Jun 13. PMID:17567049<ref>PMID:17567049</ref>

-	~~===Crystal structure of E126Q mutant of genomically encoded fosfomycin resistance protein~~, ~~FosX, from Listeria monocytogenes complexed with MN(II) and 1S,2S-dihydroxypropylphosphonic acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17567049}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2p7q]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Listeria_monocytogenes Listeria monocytogenes]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017567049<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Listeria monocytogenes]]		[[Category: Listeria monocytogenes]]
	[[Category: Armstrong, R N.]]		[[Category: Armstrong, R N.]]

OCA: Protected "2p7q" [edit=sysop:move=sysop]

2013-01-07T14:50:08Z

Protected "2p7q" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:50, 7 January 2013

OCA at 14:50, 7 January 2013

2013-01-07T14:50:03Z

←Older revision		Revision as of 14:50, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2p7q.png\|left\|200px]]		[[Image:2p7q.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2p7q", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2p7q\| PDB=2p7q \| SCENE= }}		{{STRUCTURE_2p7q\| PDB=2p7q \| SCENE= }}

	===Crystal structure of E126Q mutant of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and 1S,2S-dihydroxypropylphosphonic acid===		===Crystal structure of E126Q mutant of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and 1S,2S-dihydroxypropylphosphonic acid===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17567049}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17567049 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17567049}}		{{ABSTRACT_PUBMED_17567049}}

	==About this Structure==		==About this Structure==
-	~~2P7Q~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA].	+	[[2p7q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Q OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17567049~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017567049</ref><references group="xtra"/>
	[[Category: Listeria monocytogenes]]		[[Category: Listeria monocytogenes]]
	[[Category: Armstrong, R N.]]		[[Category: Armstrong, R N.]]
Line 32:		Line 20:
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Fosfomycin resistance protein]]		[[Category: Fosfomycin resistance protein]]
		+	[[Category: Hydrolase]]
		+	[[Category: Metal binding protein]]
	[[Category: Mn binding]]		[[Category: Mn binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:04:12 2009''