2pni - Revision history

OCA at 07:05, 1 May 2024

2024-05-01T07:05:09Z

←Older revision		Revision as of 07:05, 1 May 2024
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	==SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE==		==SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE==
-	<StructureSection load='2pni' size='340' side='right'caption='[[2pni~~]], [[NMR_Ensembles_of_Models \| 26 NMR models~~]]' scene=''>	+	<StructureSection load='2pni' size='340' side='right'caption='[[2pni]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PNI FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1pnj\|1pnj]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [https://pdbe.org/2pni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [https://www.ebi.ac.uk/pdbsum/2pni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pni ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [https://pdbe.org/2pni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [https://www.ebi.ac.uk/pdbsum/2pni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pni ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).	+	[https://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pni ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pni ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	SH3 domains are found in proteins associated with receptor tyrosine kinase signal transduction complexes. The solution structure of the SH3 domain of the 85 kd regulatory subunit of phosphatidylinositol 3-kinase is shown to be a compact beta barrel consisting of five beta strands arranged in two beta sheets of three and two strands. The structure is similar to that of chicken brain alpha spectrin but represents a distinct class of SH3 domain, with an insertion between the second and third beta strands that may influence binding specificity. 1H chemical shift changes induced by complex formation with a synthetic peptide derived from the SH3-binding protein dynamin, together with amino acid sequence comparisons, suggest that the ligand-binding site consists of a hydrophobic surface flanked by two charged loops.
-
-	Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase.,Booker GW, Gout I, Downing AK, Driscoll PC, Boyd J, Waterfield MD, Campbell ID Cell. 1993 May 21;73(4):813-22. PMID:7684655<ref>PMID:7684655</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2pni" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Phosphoinositide 3-kinase 3D structures\|Phosphoinositide 3-kinase 3D structures]]		*[[Phosphoinositide 3-kinase 3D structures\|Phosphoinositide 3-kinase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Booker~~, G W~~]]	+	[[Category: Booker GW]]
-	[[Category: Boyd, J]]	+	[[Category: Boyd J]]
-	[[Category: Campbell~~, I D~~]]	+	[[Category: Campbell ID]]
-	[[Category: Downing~~, A K~~]]	+	[[Category: Downing AK]]
-	[[Category: Driscoll~~, P C~~]]	+	[[Category: Driscoll PC]]
-	[[Category: Gout, I]]	+	[[Category: Gout I]]
-	[[Category: Waterfield~~, M D]]~~	+	[[Category: Waterfield MD]]
-	~~[[Category: Phosphotransferase~~]]	+

OCA at 20:52, 20 October 2021

2021-10-20T20:52:28Z

←Older revision		Revision as of 20:52, 20 October 2021
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	<StructureSection load='2pni' size='340' side='right'caption='[[2pni]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>		<StructureSection load='2pni' size='340' side='right'caption='[[2pni]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2PNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PNI FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pnj\|1pnj]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pnj\|1pnj]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [~~http~~://pdbe.org/2pni PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2pni PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2pni ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [https://pdbe.org/2pni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [https://www.ebi.ac.uk/pdbsum/2pni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pni ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).	+	[[https://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:50, 18 December 2019

2019-12-18T13:50:12Z

←Older revision		Revision as of 13:50, 18 December 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE==		==SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE==
-	<StructureSection load='2pni' size='340' side='right' caption='[[2pni]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>	+	<StructureSection load='2pni' size='340' side='right'caption='[[2pni]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PNI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PNI FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/2pni_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/2pni_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2pni" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2pni" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoinositide 3-kinase 3D structures\|Phosphoinositide 3-kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Booker, G W]]		[[Category: Booker, G W]]
	[[Category: Boyd, J]]		[[Category: Boyd, J]]

OCA at 07:10, 29 November 2017

2017-11-29T07:10:54Z

←Older revision		Revision as of 07:10, 29 November 2017
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE==		==SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE==
	<StructureSection load='2pni' size='340' side='right' caption='[[2pni]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>		<StructureSection load='2pni' size='340' side='right' caption='[[2pni]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PNI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PNI FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pnj\|1pnj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pnj\|1pnj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [http://pdbe.org/2pni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [http://www.ebi.ac.uk/pdbsum/2pni PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [http://pdbe.org/2pni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [http://www.ebi.ac.uk/pdbsum/2pni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pni ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pni ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2pni" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2pni" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phosphoinositide 3-Kinases\|Phosphoinositide 3-Kinases]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:56, 11 September 2015

2015-09-11T22:56:50Z

←Older revision		Revision as of 22:56, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2pni' size='340' side='right' caption='[[2pni]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>		<StructureSection load='2pni' size='340' side='right' caption='[[2pni]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PNI FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pnj\|1pnj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pnj\|1pnj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [http://www.ebi.ac.uk/pdbsum/2pni PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [http://pdbe.org/2pni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [http://www.ebi.ac.uk/pdbsum/2pni PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2pni" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Booker, G W]]		[[Category: Booker, G W]]
	[[Category: Boyd, J]]		[[Category: Boyd, J]]

OCA at 20:33, 25 December 2014

2014-12-25T20:33:29Z

←Older revision		Revision as of 20:33, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PNI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PNI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pnj\|1pnj]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pnj\|1pnj]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [http://www.ebi.ac.uk/pdbsum/2pni PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [http://www.ebi.ac.uk/pdbsum/2pni PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Booker, G W.]]	+	[[Category: Booker, G W]]
-	[[Category: Boyd, J.]]	+	[[Category: Boyd, J]]
-	[[Category: Campbell, I D.]]	+	[[Category: Campbell, I D]]
-	[[Category: Downing, A K.]]	+	[[Category: Downing, A K]]
-	[[Category: Driscoll, P C.]]	+	[[Category: Driscoll, P C]]
-	[[Category: Gout, I.]]	+	[[Category: Gout, I]]
-	[[Category: Waterfield, M D.]]	+	[[Category: Waterfield, M D]]
	[[Category: Phosphotransferase]]		[[Category: Phosphotransferase]]

OCA at 04:09, 3 October 2014

2014-10-03T04:09:55Z

←Older revision		Revision as of 04:09, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2pni\| PDB=2pni \| SCENE= }}~~	+	==SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE==
-	===SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE===	+	<StructureSection load='2pni' size='340' side='right' caption='[[2pni]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_7684655}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PNI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pnj\|1pnj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pni RCSB], [http://www.ebi.ac.uk/pdbsum/2pni PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/2pni_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SH3 domains are found in proteins associated with receptor tyrosine kinase signal transduction complexes. The solution structure of the SH3 domain of the 85 kd regulatory subunit of phosphatidylinositol 3-kinase is shown to be a compact beta barrel consisting of five beta strands arranged in two beta sheets of three and two strands. The structure is similar to that of chicken brain alpha spectrin but represents a distinct class of SH3 domain, with an insertion between the second and third beta strands that may influence binding specificity. 1H chemical shift changes induced by complex formation with a synthetic peptide derived from the SH3-binding protein dynamin, together with amino acid sequence comparisons, suggest that the ligand-binding site consists of a hydrophobic surface flanked by two charged loops.

-	~~==About this Structure==~~	+	Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase.,Booker GW, Gout I, Downing AK, Driscoll PC, Boyd J, Waterfield MD, Campbell ID Cell. 1993 May 21;73(4):813-22. PMID:7684655<ref>PMID:7684655</ref>
-	~~[[2pni]] is a 1 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full experimental information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA].~~	+

-	~~==See Also==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	*[[Phsphatidylinositol 3-kinase\|Phsphatidylinositol 3-kinase]]	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:007684655~~</~~ref~~><~~references group="xtra"~~/>	+	*[[Phosphoinositide 3-Kinases\|Phosphoinositide 3-Kinases]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Booker, G W.]]		[[Category: Booker, G W.]]

OCA at 10:52, 11 March 2013

2013-03-11T10:52:29Z

←Older revision		Revision as of 10:52, 11 March 2013
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-	[[Image:2pni.png\|left\|200px]]
-
	{{STRUCTURE_2pni\| PDB=2pni \| SCENE= }}		{{STRUCTURE_2pni\| PDB=2pni \| SCENE= }}
-
	===SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE===		===SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE===
-
	{{ABSTRACT_PUBMED_7684655}}		{{ABSTRACT_PUBMED_7684655}}

OCA: Protected "2pni" [edit=sysop:move=sysop]

2013-01-07T12:20:10Z

Protected "2pni" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:20, 7 January 2013

OCA at 12:20, 7 January 2013

2013-01-07T12:20:07Z

←Older revision		Revision as of 12:20, 7 January 2013
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-	{{Seed}}
	[[Image:2pni.png\|left\|200px]]		[[Image:2pni.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2pni", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2pni\| PDB=2pni \| SCENE= }}		{{STRUCTURE_2pni\| PDB=2pni \| SCENE= }}

	===SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE===		===SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_7684655}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 7684655 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_7684655}}		{{ABSTRACT_PUBMED_7684655}}

	==About this Structure==		==About this Structure==
-	~~2PNI~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA].	+	[[2pni]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNI OCA].
		+
		+	==See Also==
		+	*[[Phsphatidylinositol 3-kinase\|Phsphatidylinositol 3-kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~7684655~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007684655</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Booker, G W.]]		[[Category: Booker, G W.]]
Line 33:		Line 24:
	[[Category: Waterfield, M D.]]		[[Category: Waterfield, M D.]]
	[[Category: Phosphotransferase]]		[[Category: Phosphotransferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:23:14 2009''