2q9a - Revision history

OCA at 09:14, 21 February 2024

2024-02-21T09:14:38Z

←Older revision		Revision as of 09:14, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='2q9a' size='340' side='right'caption='[[2q9a]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='2q9a' size='340' side='right'caption='[[2q9a]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_25104 Atcc 25104~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q9A FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.24Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2q9b\|2q9b]], [[2q9c\|2q9c]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ftsY ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [https://pdbe.org/2q9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [https://www.ebi.ac.uk/pdbsum/2q9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [https://pdbe.org/2q9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [https://www.ebi.ac.uk/pdbsum/2q9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FTSY_THEAQ FTSY_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity).	+	[https://www.uniprot.org/uniprot/FTSY_THEAQ FTSY_THEAQ] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q9a ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q9a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The signal recognition particle (SRP) and its conjugate receptor (SR) mediate cotranslational targeting of a subclass of proteins destined for secretion to the endoplasmic reticulum membrane in eukaryotes or to the plasma membrane in prokaryotes. Conserved active site residues in the GTPase domains of both SRP and SR mediate discrete conformational changes during formation and dissociation of the SRP.SR complex. Here, we describe structures of the prokaryotic SR, FtsY, as an apo protein and in two different complexes with a non-hydrolysable GTP analog (GMPPNP). These structures reveal intermediate conformations of FtsY containing GMPPNP and explain how the conserved active site residues position the nucleotide into a non-catalytic conformation. The basis for the lower specificity of binding of nucleotide in FtsY prior to heterodimerization with the SRP conjugate Ffh is also shown. We propose that these structural changes represent discrete conformational states assumed by FtsY during targeting complex formation and dissociation.
-
-	X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates.,Reyes CL, Rutenber E, Walter P, Stroud RM PLoS ONE. 2007 Jul 11;2(7):e607. PMID:17622352<ref>PMID:17622352</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2q9a" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Signal recognition particle receptor\|Signal recognition particle receptor]]	+	*[[Signal recognition particle receptor 3D structures\|Signal recognition particle receptor 3D structures]]
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 25104]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Reyes, C L~~]]	+	[[Category: Thermus aquaticus]]
-	[[Category: ~~Stroud, R M~~]]	+	[[Category: Reyes CL]]
-	[[Category: ~~Cell cycle]]~~	+	[[Category: Stroud RM]]
-	~~[[Category: Cell division]]~~	+
-	~~[[Category: Ffh]]~~	+
-	~~[[Category: Ftsy]]~~	+
-	~~[[Category: Gdp]]~~	+
-	~~[[Category: Gtp-binding]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Inner membrane]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Ribonucleoprotein]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Signal recognition particle]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Srp~~]]	+

OCA at 08:12, 25 June 2021

2021-06-25T08:12:46Z

←Older revision		Revision as of 08:12, 25 June 2021
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	==Structure of Apo FTSY==		==Structure of Apo FTSY==
-	<StructureSection load='2q9a' size='340' side='right' caption='[[2q9a]], [[Resolution\|resolution]] 2.24Å' scene=''>	+	<StructureSection load='2q9a' size='340' side='right'caption='[[2q9a]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q9a]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Q9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q9A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9b\|2q9b]], [[2q9c\|2q9c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2q9b\|2q9b]], [[2q9c\|2q9c]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ftsY ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ftsY ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [~~http~~://pdbe.org/2q9a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2q9a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [https://pdbe.org/2q9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [https://www.ebi.ac.uk/pdbsum/2q9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FTSY_THEAQ FTSY_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity).	+	[[https://www.uniprot.org/uniprot/FTSY_THEAQ FTSY_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 25104]]		[[Category: Atcc 25104]]
		+	[[Category: Large Structures]]
	[[Category: Reyes, C L]]		[[Category: Reyes, C L]]
	[[Category: Stroud, R M]]		[[Category: Stroud, R M]]

OCA at 08:47, 29 August 2018

2018-08-29T08:47:55Z

←Older revision		Revision as of 08:47, 29 August 2018
Line 1:		Line 1:
		+
	==Structure of Apo FTSY==		==Structure of Apo FTSY==
	<StructureSection load='2q9a' size='340' side='right' caption='[[2q9a]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='2q9a' size='340' side='right' caption='[[2q9a]], [[Resolution\|resolution]] 2.24Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9b\|2q9b]], [[2q9c\|2q9c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9b\|2q9b]], [[2q9c\|2q9c]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ftsY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ftsY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [http://pdbe.org/2q9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [http://www.ebi.ac.uk/pdbsum/2q9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [http://pdbe.org/2q9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [http://www.ebi.ac.uk/pdbsum/2q9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/2q9a_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/2q9a_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:23, 7 February 2016

2016-02-07T09:23:26Z

←Older revision		Revision as of 09:23, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q9a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:00, 10 September 2015

2015-09-10T00:00:52Z

←Older revision		Revision as of 00:00, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2q9a' size='340' side='right' caption='[[2q9a]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='2q9a' size='340' side='right' caption='[[2q9a]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2q9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_aquaticus Thermus aquaticus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2q9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q9A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9b\|2q9b]], [[2q9c\|2q9c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9b\|2q9b]], [[2q9c\|2q9c]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ftsY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ~~Thermus aquaticus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ftsY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [http://www.ebi.ac.uk/pdbsum/2q9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [http://pdbe.org/2q9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [http://www.ebi.ac.uk/pdbsum/2q9a PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2q9a" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermus aquaticus~~]]	+	[[Category: Atcc 25104]]
	[[Category: Reyes, C L]]		[[Category: Reyes, C L]]
	[[Category: Stroud, R M]]		[[Category: Stroud, R M]]

OCA at 14:01, 24 December 2014

2014-12-24T14:01:31Z

←Older revision		Revision as of 14:01, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2q9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q9A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2q9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q9A FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9b\|2q9b]], [[2q9c\|2q9c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9b\|2q9b]], [[2q9c\|2q9c]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ftsY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 Thermus aquaticus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ftsY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 Thermus aquaticus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [http://www.ebi.ac.uk/pdbsum/2q9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [http://www.ebi.ac.uk/pdbsum/2q9a PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FTSY_THEAQ FTSY_THEAQ]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Thermus aquaticus]]		[[Category: Thermus aquaticus]]
-	[[Category: Reyes, C L.]]	+	[[Category: Reyes, C L]]
-	[[Category: Stroud, R M.]]	+	[[Category: Stroud, R M]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Cell division]]		[[Category: Cell division]]

OCA at 20:12, 30 September 2014

2014-09-30T20:12:28Z

←Older revision		Revision as of 20:12, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2q9a.~~png~~\|~~left~~\|200px]]	+	==Structure of Apo FTSY==
		+	<StructureSection load='2q9a' size='340' side='right' caption='[[2q9a]], [[Resolution\|resolution]] 2.24Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2q9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q9A FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2q9b\|2q9b]], [[2q9c\|2q9c]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ftsY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 Thermus aquaticus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q9a RCSB], [http://www.ebi.ac.uk/pdbsum/2q9a PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/2q9a_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The signal recognition particle (SRP) and its conjugate receptor (SR) mediate cotranslational targeting of a subclass of proteins destined for secretion to the endoplasmic reticulum membrane in eukaryotes or to the plasma membrane in prokaryotes. Conserved active site residues in the GTPase domains of both SRP and SR mediate discrete conformational changes during formation and dissociation of the SRP.SR complex. Here, we describe structures of the prokaryotic SR, FtsY, as an apo protein and in two different complexes with a non-hydrolysable GTP analog (GMPPNP). These structures reveal intermediate conformations of FtsY containing GMPPNP and explain how the conserved active site residues position the nucleotide into a non-catalytic conformation. The basis for the lower specificity of binding of nucleotide in FtsY prior to heterodimerization with the SRP conjugate Ffh is also shown. We propose that these structural changes represent discrete conformational states assumed by FtsY during targeting complex formation and dissociation.

-	~~{{STRUCTURE_2q9a\| PDB=2q9a \| SCENE= }}~~	+	X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates.,Reyes CL, Rutenber E, Walter P, Stroud RM PLoS ONE. 2007 Jul 11;2(7):e607. PMID:17622352<ref>PMID:17622352</ref>

-	~~===Structure~~ of ~~Apo FTSY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_17622352}}~~	+	==See Also==
-		+	*[[Signal recognition particle receptor\|Signal recognition particle receptor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2q9a~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:017622352<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermus aquaticus]]		[[Category: Thermus aquaticus]]
	[[Category: Reyes, C L.]]		[[Category: Reyes, C L.]]

OCA: Protected "2q9a" [edit=sysop:move=sysop]

2013-01-07T20:20:48Z

Protected "2q9a" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:20, 7 January 2013

OCA at 20:20, 7 January 2013

2013-01-07T20:20:45Z

←Older revision		Revision as of 20:20, 7 January 2013
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-	{{Seed}}
	[[Image:2q9a.png\|left\|200px]]		[[Image:2q9a.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2q9a\| PDB=2q9a \| SCENE= }}		{{STRUCTURE_2q9a\| PDB=2q9a \| SCENE= }}

	===Structure of Apo FTSY===		===Structure of Apo FTSY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17622352}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17622352 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_17622352}}		{{ABSTRACT_PUBMED_17622352}}

	==About this Structure==		==About this Structure==
-	~~2Q9A~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA].	+	[[2q9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17622352~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017622352</ref><references group="xtra"/>
	[[Category: Thermus aquaticus]]		[[Category: Thermus aquaticus]]
	[[Category: Reyes, C L.]]		[[Category: Reyes, C L.]]
Line 40:		Line 28:
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Signal recognition particle]]		[[Category: Signal recognition particle]]
		+	[[Category: Signaling protein]]
	[[Category: Srp]]		[[Category: Srp]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:52:14 2009''

OCA at 10:52, 16 February 2009

2009-02-16T10:52:16Z

←Older revision		Revision as of 10:52, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2Q9A is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA].	+	2Q9A is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9A OCA].

	==Reference==		==Reference==
-	~~X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates., Reyes CL, Rutenber E, Walter P, Stroud RM, PLoS ONE. 2007 Jul 11;2(7):e607.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17622352 17622352]~~	+	<ref group="xtra">PMID:17622352</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Thermus aquaticus]]		[[Category: Thermus aquaticus]]
	[[Category: Reyes, C L.]]		[[Category: Reyes, C L.]]
Line 43:		Line 42:
	[[Category: Srp]]		[[Category: Srp]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 15~~:09:~~32 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:52:14 2009''