2qhe - Revision history

OCA at 09:01, 25 October 2023

2023-10-25T09:01:26Z

←Older revision		Revision as of 09:01, 25 October 2023
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	<StructureSection load='2qhe' size='340' side='right'caption='[[2qhe]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2qhe' size='340' side='right'caption='[[2qhe]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Echca Echca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QHE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QHE FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2qhd\|2qhd]]~~, [[~~2qhg~~\|~~2qhg~~]]~~</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(~~2~~) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [https://pdbe.org/2qhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [https://www.ebi.ac.uk/pdbsum/2qhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qhe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [https://pdbe.org/2qhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [https://www.ebi.ac.uk/pdbsum/2qhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qhe ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PA2HS_ECHCA PA2HS_ECHCA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Echca~~]]	+	[[Category: Echis carinatus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Go~~, M L~~]]	+	[[Category: Go ML]]
-	[[Category: Kini~~, R M~~]]	+	[[Category: Kini RM]]
-	[[Category: Sivaraman, J]]	+	[[Category: Sivaraman J]]
-	[[Category: Valiyaveettil, S]]	+	[[Category: Valiyaveettil S]]
-	[[Category: Zhou, X]]	+	[[Category: Zhou X]]
-	~~[[Category: Beta sheet]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Three helice~~]]	+

OCA at 08:20, 25 June 2021

2021-06-25T08:20:15Z

←Older revision		Revision as of 08:20, 25 June 2021
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	<StructureSection load='2qhe' size='340' side='right'caption='[[2qhe]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2qhe' size='340' side='right'caption='[[2qhe]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Echca Echca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QHE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Echca Echca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QHE FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qhd\|2qhd]], [[2qhg\|2qhg]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qhd\|2qhd]], [[2qhg\|2qhg]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [~~http~~://pdbe.org/2qhe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qhe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qhe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [https://pdbe.org/2qhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [https://www.ebi.ac.uk/pdbsum/2qhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qhe ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]	+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:33, 31 July 2019

2019-07-31T07:33:51Z

←Older revision		Revision as of 07:33, 31 July 2019
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	==Crystal structure of Ser49-PLA2 (ecarpholin S) from Echis carinatus sochureki snake venom==		==Crystal structure of Ser49-PLA2 (ecarpholin S) from Echis carinatus sochureki snake venom==
-	<StructureSection load='2qhe' size='340' side='right' caption='[[2qhe]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2qhe' size='340' side='right'caption='[[2qhe]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echca Echca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QHE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echca Echca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QHE FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qh/2qhe_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qh/2qhe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Echca]]		[[Category: Echca]]
		+	[[Category: Large Structures]]
	[[Category: Go, M L]]		[[Category: Go, M L]]
	[[Category: Kini, R M]]		[[Category: Kini, R M]]

OCA at 09:48, 18 October 2017

2017-10-18T09:48:06Z

←Older revision		Revision as of 09:48, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of Ser49-PLA2 (ecarpholin S) from Echis carinatus sochureki snake venom==		==Crystal structure of Ser49-PLA2 (ecarpholin S) from Echis carinatus sochureki snake venom==
	<StructureSection load='2qhe' size='340' side='right' caption='[[2qhe]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2qhe' size='340' side='right' caption='[[2qhe]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Echis_carinatus Echis carinatus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QHE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echca Echca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QHE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qhd\|2qhd]], [[2qhg\|2qhg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qhd\|2qhd]], [[2qhg\|2qhg]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [http://pdbe.org/2qhe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [http://www.ebi.ac.uk/pdbsum/2qhe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [http://pdbe.org/2qhe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [http://www.ebi.ac.uk/pdbsum/2qhe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qhe ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Echis carinatus~~]]	+	[[Category: Echca]]
	[[Category: Go, M L]]		[[Category: Go, M L]]
	[[Category: Kini, R M]]		[[Category: Kini, R M]]

OCA at 05:58, 8 February 2016

2016-02-08T05:58:03Z

←Older revision		Revision as of 05:58, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qhe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:34, 10 September 2015

2015-09-10T08:34:36Z

←Older revision		Revision as of 08:34, 10 September 2015
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qhd\|2qhd]], [[2qhg\|2qhg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qhd\|2qhd]], [[2qhg\|2qhg]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [http://www.ebi.ac.uk/pdbsum/2qhe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [http://pdbe.org/2qhe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [http://www.ebi.ac.uk/pdbsum/2qhe PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qhe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 21:08, 24 December 2014

2014-12-24T21:08:18Z

←Older revision		Revision as of 21:08, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QHE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QHE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qhd\|2qhd]], [[2qhg\|2qhg]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qhd\|2qhd]], [[2qhg\|2qhg]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [http://www.ebi.ac.uk/pdbsum/2qhe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [http://www.ebi.ac.uk/pdbsum/2qhe PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Echis carinatus]]		[[Category: Echis carinatus]]
-	[[Category: Go, M L.]]	+	[[Category: Go, M L]]
-	[[Category: Kini, R M.]]	+	[[Category: Kini, R M]]
-	[[Category: Sivaraman, J.]]	+	[[Category: Sivaraman, J]]
-	[[Category: Valiyaveettil, S.]]	+	[[Category: Valiyaveettil, S]]
-	[[Category: Zhou, X.]]	+	[[Category: Zhou, X]]
	[[Category: Beta sheet]]		[[Category: Beta sheet]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Three helice]]		[[Category: Three helice]]

OCA at 08:41, 29 September 2014

2014-09-29T08:41:11Z

←Older revision		Revision as of 08:41, 29 September 2014
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-	[[~~Image:~~2qhe.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Ser49-PLA2 (ecarpholin S) from Echis carinatus sochureki snake venom==
		+	<StructureSection load='2qhe' size='340' side='right' caption='[[2qhe]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qhe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QHE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qhd\|2qhd]], [[2qhg\|2qhg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qhe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qhe RCSB], [http://www.ebi.ac.uk/pdbsum/2qhe PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qh/2qhe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phospholipase A(2) (PLA(2)), a common toxic component of snake venom, has been implicated in various pharmacological effects. Ecarpholin S, isolated from the venom of the snake Echis carinatus sochureki, is a phospholipase A(2) (PLA(2)) belonging to the Ser(49)-PLA(2) subgroup. It has been characterized as having low enzymatic but potent myotoxic activities. The crystal structures of native ecarpholin S and its complexes with lauric acid, and its inhibitor suramin, were elucidated. This is the first report of the structure of a member of the Ser(49)-PLA(2) subgroup. We also examined interactions of ecarpholin S with phosphatidylglycerol and lauric acid, using surface plasmon resonance, and of suramin with isothermal titration calorimetry. Most Ca(2+)-dependent PLA(2) enzymes have Asp in position 49, which plays a crucial role in Ca(2+) binding. The three-dimensional structure of ecarpholin S reveals a unique conformation of the Ca(2+)-binding loop that is not favorable for Ca(2+) coordination. Furthermore, the endogenously bound fatty acid (lauric acid) in the hydrophobic channel may also interrupt the catalytic cycle. These two observations may account for the low enzymatic activity of ecarpholin S, despite full retention of the catalytic machinery. These observations may also be applicable to other non-Asp(49)-PLA(2) enzymes. The interaction of suramin in its complex with ecarpholin S is quite different from that reported for the Lys(49)-PLA(2)/suramin complex(,) where the interfacial recognition face (i-face), C-terminal region, and N-terminal region of ecarpholin S play important roles. This study provides significant structural and functional insights into the myotoxic activity of ecarpholin S and, in general, of non-Asp(49)-PLA(2) enzymes.

-	~~{{STRUCTURE_2qhe\| PDB=2qhe \| SCENE= }}~~	+	Structural characterization of myotoxic ecarpholin S from Echis carinatus venom.,Zhou X, Tan TC, Valiyaveettil S, Go ML, Kini RM, Velazquez-Campoy A, Sivaraman J Biophys J. 2008 Oct;95(7):3366-80. Epub 2008 Jun 27. PMID:18586854<ref>PMID:18586854</ref>

-	~~===Crystal structure~~ of ~~Ser49-PLA2 (ecarpholin~~ S~~) from Echis carinatus sochureki snake venom===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18586854}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2qhe]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA].~~	+

	==See Also==		==See Also==
	*[[Phospholipase A2\|Phospholipase A2]]		*[[Phospholipase A2\|Phospholipase A2]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018586854<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Echis carinatus]]		[[Category: Echis carinatus]]
	[[Category: Go, M L.]]		[[Category: Go, M L.]]

OCA at 09:09, 20 October 2012

2012-10-20T09:09:29Z

←Older revision		Revision as of 09:09, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2qhe]] is a 1 chain structure ~~of [[Phospholipase A2]]~~ with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA].	+	[[2qhe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QHE OCA].

	==See Also==		==See Also==

OCA: Protected "2qhe" [edit=sysop:move=sysop]

2012-07-25T21:55:49Z

Protected "2qhe" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:55, 25 July 2012