2qic - Revision history

OCA at 11:33, 30 August 2023

2023-08-30T11:33:15Z

←Older revision		Revision as of 11:33, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2qic' size='340' side='right'caption='[[2qic]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2qic' size='340' side='right'caption='[[2qic]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QIC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ING1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [https://pdbe.org/2qic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [https://www.ebi.ac.uk/pdbsum/2qic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qic ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [https://pdbe.org/2qic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [https://www.ebi.ac.uk/pdbsum/2qic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qic ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[https://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:10866301</ref>	+	[https://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN] Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[https://omim.org/entry/275355 275355]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:10866301</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.<ref>PMID:9440695</ref>	+	[https://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN] Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.<ref>PMID:9440695</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Champagne, K]]	+	[[Category: Champagne K]]
-	[[Category: Kutateladze~~, T G~~]]	+	[[Category: Kutateladze TG]]
-	[[Category: Pena~~, P V~~]]	+	[[Category: Pena PV]]
-	[[Category: Zhao, R]]	+	[[Category: Zhao R]]
-	~~[[Category: Antitumor protein]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Chromatin]]~~	+
-	~~[[Category: H3k4me3]]~~	+
-	~~[[Category: Histone]]~~	+
-	~~[[Category: Ing1]]~~	+
-	~~[[Category: Phd~~]]	+

OCA at 08:21, 25 June 2021

2021-06-25T08:21:03Z

←Older revision		Revision as of 08:21, 25 June 2021
Line 1:		Line 1:

	==Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide==		==Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide==
-	<StructureSection load='2qic' size='340' side='right' caption='[[2qic]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2qic' size='340' side='right'caption='[[2qic]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qic]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QIC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ING1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ING1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [~~http~~://pdbe.org/2qic PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qic PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qic ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [https://pdbe.org/2qic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [https://www.ebi.ac.uk/pdbsum/2qic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qic ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[~~http~~://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:10866301</ref>	+	[[https://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[https://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:10866301</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.<ref>PMID:9440695</ref>	+	[[https://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.<ref>PMID:9440695</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Champagne, K]]		[[Category: Champagne, K]]
	[[Category: Kutateladze, T G]]		[[Category: Kutateladze, T G]]

OCA at 11:27, 5 September 2018

2018-09-05T11:27:17Z

←Older revision		Revision as of 11:27, 5 September 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide==		==Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide==
	<StructureSection load='2qic' size='340' side='right' caption='[[2qic]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2qic' size='340' side='right' caption='[[2qic]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ING1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ING1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [http://pdbe.org/2qic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [http://www.ebi.ac.uk/pdbsum/2qic PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [http://pdbe.org/2qic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [http://www.ebi.ac.uk/pdbsum/2qic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qic ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/2qic_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/2qic_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:30, 8 February 2016

2016-02-08T22:30:11Z

←Older revision		Revision as of 22:30, 8 February 2016
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qic ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:58, 10 September 2015

2015-09-10T15:58:28Z

←Older revision		Revision as of 15:58, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2qic' size='340' side='right' caption='[[2qic]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2qic' size='340' side='right' caption='[[2qic]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ING1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ING1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [http://www.ebi.ac.uk/pdbsum/2qic PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [http://pdbe.org/2qic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [http://www.ebi.ac.uk/pdbsum/2qic PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qic" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Champagne, K]]		[[Category: Champagne, K]]
	[[Category: Kutateladze, T G]]		[[Category: Kutateladze, T G]]

OCA at 18:35, 19 January 2015

2015-01-19T18:35:27Z

←Older revision		Revision as of 18:35, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ING1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ING1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [http://www.ebi.ac.uk/pdbsum/2qic PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [http://www.ebi.ac.uk/pdbsum/2qic PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:10866301</ref>		[[http://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:10866301</ref>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Champagne, K.]]	+	[[Category: Champagne, K]]
-	[[Category: Kutateladze, T G.]]	+	[[Category: Kutateladze, T G]]
-	[[Category: Pena, P V.]]	+	[[Category: Pena, P V]]
-	[[Category: Zhao, R.]]	+	[[Category: Zhao, R]]
	[[Category: Antitumor protein]]		[[Category: Antitumor protein]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA at 20:18, 30 September 2014

2014-09-30T20:18:03Z

←Older revision		Revision as of 20:18, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2qic\| PDB=2qic \| SCENE= }}~~	+	==Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide==
-	===Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide===	+	<StructureSection load='2qic' size='340' side='right' caption='[[2qic]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18533182}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ING1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qic RCSB], [http://www.ebi.ac.uk/pdbsum/2qic PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:10866301</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.<ref>PMID:9440695</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/2qic_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibitor of growth 1 (ING1) is implicated in oncogenesis, DNA damage repair, and apoptosis. Mutations within the ING1 gene and altered expression levels of ING1 are found in multiple human cancers. Here, we show that both DNA repair and apoptotic activities of ING1 require the interaction of the C-terminal plant homeodomain (PHD) finger with histone H3 trimethylated at Lys4 (H3K4me3). The ING1 PHD finger recognizes methylated H3K4 but not other histone modifications as revealed by the peptide microarrays. The molecular mechanism of the histone recognition is elucidated based on a 2.1 A-resolution crystal structure of the PHD-H3K4me3 complex. The K4me3 occupies a deep hydrophobic pocket formed by the conserved Y212 and W235 residues that make cation-pi contacts with the trimethylammonium group. Both aromatic residues are essential in the H3K4me3 recognition, as substitution of these residues with Ala disrupts the interaction. Unlike the wild-type ING1, the W235A mutant, overexpressed in the stable clones of melanoma cells or in HT1080 cells, was unable to stimulate DNA repair after UV irradiation or promote DNA-damage-induced apoptosis, indicating that H3K4me3 binding is necessary for these biological functions of ING1. Furthermore, N216S, V218I, and G221V mutations, found in human malignancies, impair the ability of ING1 to associate with H3K4me3 or to induce nucleotide repair and cell death, linking the tumorigenic activity of ING1 with epigenetic regulation. Together, our findings reveal the critical role of the H3K4me3 interaction in mediating cellular responses to genotoxic stresses and offer new insight into the molecular mechanism underlying the tumor suppressive activity of ING1.

-	~~==Disease==~~	+	Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.,Pena PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RP, Subach OM, Champagne KS, Zhao R, Verkhusha VV, Li G, Gozani O, Kutateladze TG J Mol Biol. 2008 Jul 4;380(2):303-12. Epub 2008 May 2. PMID:18533182<ref>PMID:18533182</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/ING1_HUMAN ING1_HUMAN]] Defects in ING1 are a cause of head and neck squamous cell carcinomas~~ (~~HNSCC~~) ~~[MIM~~:~~[http://omim~~.~~org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck~~.<ref>PMID:~~10866301~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/ING1_HUMAN ING1_HUMAN]] Cooperates with p53/TP53 in the negative regulatory pathway~~ of ~~cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene~~.<~~ref~~>~~PMID:9440695~~</~~ref~~>	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[2qic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:018533182</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Champagne, K.]]		[[Category: Champagne, K.]]

OCA at 22:30, 24 March 2013

2013-03-24T22:30:36Z

←Older revision		Revision as of 22:30, 24 March 2013
Line 1:		Line 1:
-	[[Image:2qic.png\|left\|200px]]
-
	{{STRUCTURE_2qic\| PDB=2qic \| SCENE= }}		{{STRUCTURE_2qic\| PDB=2qic \| SCENE= }}
-
	===Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide===		===Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide===
		+	{{ABSTRACT_PUBMED_18533182}}

-	~~{{ABSTRACT_PUBMED_18533182}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:10866301</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.<ref>PMID:9440695</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018533182</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018533182</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Champagne, K.]]		[[Category: Champagne, K.]]

OCA: Protected "2qic" [edit=sysop:move=sysop]

2013-01-07T23:14:10Z

Protected "2qic" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:14, 7 January 2013

OCA at 23:14, 7 January 2013

2013-01-07T23:14:08Z

←Older revision		Revision as of 23:14, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2qic.png\|left\|200px]]		[[Image:2qic.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qic", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qic\| PDB=2qic \| SCENE= }}		{{STRUCTURE_2qic\| PDB=2qic \| SCENE= }}

	===Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide===		===Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18533182}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18533182 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18533182}}		{{ABSTRACT_PUBMED_18533182}}
-
-	==Disease==
-	Known disease associated with this structure: Squamous cell carcinoma, head and neck OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601566 601566]]

	==About this Structure==		==About this Structure==
-	~~2QIC~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA].	+	[[2qic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18533182~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018533182</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Champagne, K.]]		[[Category: Champagne, K.]]
Line 39:		Line 24:
	[[Category: Ing1]]		[[Category: Ing1]]
	[[Category: Phd]]		[[Category: Phd]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:02:10 2009''