2qm8 - Revision history

OCA at 08:24, 25 June 2021

2021-06-25T08:24:58Z

←Older revision		Revision as of 08:24, 25 June 2021
Line 1:		Line 1:

	==MeaB, A Bacterial Homolog of MMAA, in the Nucleotide Free Form==		==MeaB, A Bacterial Homolog of MMAA, in the Nucleotide Free Form==
-	<StructureSection load='2qm8' size='340' side='right' caption='[[2qm8]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2qm8' size='340' side='right'caption='[[2qm8]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qm8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Metea Metea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2QM8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qm8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Metea Metea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QM8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf8\|2hf8]], [[2hf9\|2hf9]], [[2qm7\|2qm7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hf8\|2hf8]], [[2hf9\|2hf9]], [[2qm7\|2qm7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 METEA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 METEA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2qm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qm8 OCA], [~~http~~://pdbe.org/2qm8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2qm8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2qm8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2qm8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qm8 OCA], [https://pdbe.org/2qm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qm8 RCSB], [https://www.ebi.ac.uk/pdbsum/2qm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qm8 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Metea]]		[[Category: Metea]]
	[[Category: Banerjee, R]]		[[Category: Banerjee, R]]

OCA at 11:30, 5 September 2018

2018-09-05T11:30:58Z

←Older revision		Revision as of 11:30, 5 September 2018
Line 1:		Line 1:
		+
	==MeaB, A Bacterial Homolog of MMAA, in the Nucleotide Free Form==		==MeaB, A Bacterial Homolog of MMAA, in the Nucleotide Free Form==
	<StructureSection load='2qm8' size='340' side='right' caption='[[2qm8]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2qm8' size='340' side='right' caption='[[2qm8]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf8\|2hf8]], [[2hf9\|2hf9]], [[2qm7\|2qm7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf8\|2hf8]], [[2hf9\|2hf9]], [[2qm7\|2qm7]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 METEA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 METEA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qm8 OCA], [http://pdbe.org/2qm8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2qm8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qm8 OCA], [http://pdbe.org/2qm8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2qm8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qm8 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qm/2qm8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qm/2qm8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:08, 9 February 2016

2016-02-09T14:08:33Z

←Older revision		Revision as of 14:08, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qm8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:58, 10 September 2015

2015-09-10T22:58:50Z

←Older revision		Revision as of 22:58, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2qm8' size='340' side='right' caption='[[2qm8]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2qm8' size='340' side='right' caption='[[2qm8]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2qm8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Methylobacterium_extorquens_am1 Methylobacterium extorquens am1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QM8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2qm8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Metea Metea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QM8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf8\|2hf8]], [[2hf9\|2hf9]], [[2qm7\|2qm7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf8\|2hf8]], [[2hf9\|2hf9]], [[2qm7\|2qm7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 ~~Methylobacterium extorquens AM1~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 METEA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2qm8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qm8 OCA], [http://pdbe.org/2qm8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2qm8 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2qm8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Methylobacterium extorquens am1~~]]	+	[[Category: Metea]]
	[[Category: Banerjee, R]]		[[Category: Banerjee, R]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]

OCA at 14:29, 19 January 2015

2015-01-19T14:29:31Z

←Older revision		Revision as of 14:29, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2qm8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylobacterium_extorquens_am1 Methylobacterium extorquens am1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QM8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2qm8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylobacterium_extorquens_am1 Methylobacterium extorquens am1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QM8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf8\|2hf8]], [[2hf9\|2hf9]], [[2qm7\|2qm7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf8\|2hf8]], [[2hf9\|2hf9]], [[2qm7\|2qm7]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 Methylobacterium extorquens AM1])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 Methylobacterium extorquens AM1])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2qm8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2qm8 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Methylobacterium extorquens am1]]		[[Category: Methylobacterium extorquens am1]]
-	[[Category: Banerjee, R.]]	+	[[Category: Banerjee, R]]
-	[[Category: Drennan, C L.]]	+	[[Category: Drennan, C L]]
-	[[Category: Hubbard, P A.]]	+	[[Category: Hubbard, P A]]
-	[[Category: Labunska, T.]]	+	[[Category: Labunska, T]]
-	[[Category: Mahlstedt, S A.]]	+	[[Category: Mahlstedt, S A]]
-	[[Category: Padovani, D.]]	+	[[Category: Padovani, D]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: G protein]]		[[Category: G protein]]

OCA at 18:29, 30 September 2014

2014-09-30T18:29:59Z

←Older revision		Revision as of 18:29, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2qm8.~~png~~\|~~left~~\|200px]]	+	==MeaB, A Bacterial Homolog of MMAA, in the Nucleotide Free Form==
		+	<StructureSection load='2qm8' size='340' side='right' caption='[[2qm8]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2qm8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylobacterium_extorquens_am1 Methylobacterium extorquens am1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QM8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf8\|2hf8]], [[2hf9\|2hf9]], [[2qm7\|2qm7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 Methylobacterium extorquens AM1])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qm8 RCSB], [http://www.ebi.ac.uk/pdbsum/2qm8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qm/2qm8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MeaB is an auxiliary protein that plays a crucial role in the protection and assembly of the B(12)-dependent enzyme methylmalonyl-CoA mutase. Impairments in the human homologue of MeaB, MMAA, lead to methylmalonic aciduria, an inborn error of metabolism. To explore the role of this metallochaperone, its structure was solved in the nucleotide-free form, as well as in the presence of product, GDP. MeaB is a homodimer, with each subunit containing a central alpha/beta-core G domain that is typical of the GTPase family, as well as alpha-helical extensions at the N and C termini that are not found in other metalloenzyme chaperone GTPases. The C-terminal extension appears to be essential for nucleotide-independent dimerization, and the N-terminal region is implicated in protein-protein interaction with its partner protein, methylmalonyl-CoA mutase. The structure of MeaB confirms that it is a member of the G3E family of P-loop GTPases, which contains other putative metallochaperones HypB, CooC, and UreG. Interestingly, the so-called switch regions, responsible for signal transduction following GTP hydrolysis, are found at the dimer interface of MeaB instead of being positioned at the surface of the protein where its partner protein methylmalonyl-CoA mutase should bind. This observation suggests a large conformation change of MeaB must occur between the GDP- and GTP-bound forms of this protein. Because of their high sequence homology, the missense mutations in MMAA that result in methylmalonic aciduria have been mapped onto MeaB and, in conjunction with mutagenesis data, provide possible explanations for the pathology of this disease.

-	~~{{STRUCTURE_2qm8\| PDB=2qm8 \| SCENE= }}~~	+	Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria.,Hubbard PA, Padovani D, Labunska T, Mahlstedt SA, Banerjee R, Drennan CL J Biol Chem. 2007 Oct 26;282(43):31308-16. Epub 2007 Aug 28. PMID:17728257<ref>PMID:17728257</ref>

-	~~===MeaB~~, ~~A Bacterial Homolog~~ of ~~MMAA, in~~ the ~~Nucleotide Free Form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17728257}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2qm8]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Methylobacterium_extorquens_am1 Methylobacterium extorquens am1]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017728257<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Methylobacterium extorquens am1]]		[[Category: Methylobacterium extorquens am1]]
	[[Category: Banerjee, R.]]		[[Category: Banerjee, R.]]

OCA: Protected "2qm8" [edit=sysop:move=sysop]

2013-01-07T18:24:16Z

Protected "2qm8" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:24, 7 January 2013

OCA at 18:24, 7 January 2013

2013-01-07T18:24:13Z

←Older revision		Revision as of 18:24, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2qm8.png\|left\|200px]]		[[Image:2qm8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2qm8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2qm8\| PDB=2qm8 \| SCENE= }}		{{STRUCTURE_2qm8\| PDB=2qm8 \| SCENE= }}

	===MeaB, A Bacterial Homolog of MMAA, in the Nucleotide Free Form===		===MeaB, A Bacterial Homolog of MMAA, in the Nucleotide Free Form===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17728257}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17728257 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17728257}}		{{ABSTRACT_PUBMED_17728257}}

	==About this Structure==		==About this Structure==
-	~~2QM8~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Thermomicrobium_roseum Thermomicrobium roseum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA].	+	[[2qm8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylobacterium_extorquens_am1 Methylobacterium extorquens am1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17728257~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017728257</ref><references group="xtra"/>
-	[[Category: ~~Thermomicrobium roseum~~]]	+	[[Category: Methylobacterium extorquens am1]]
	[[Category: Banerjee, R.]]		[[Category: Banerjee, R.]]
	[[Category: Drennan, C L.]]		[[Category: Drennan, C L.]]
Line 31:		Line 19:
	[[Category: Mahlstedt, S A.]]		[[Category: Mahlstedt, S A.]]
	[[Category: Padovani, D.]]		[[Category: Padovani, D.]]
		+	[[Category: Chaperone]]
	[[Category: G protein]]		[[Category: G protein]]
	[[Category: G3e]]		[[Category: G3e]]
	[[Category: Gtpase]]		[[Category: Gtpase]]
	[[Category: Metallochaperone]]		[[Category: Metallochaperone]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:22:04 2009''

OCA at 08:22, 17 February 2009

2009-02-17T08:22:05Z

←Older revision		Revision as of 08:22, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2QM8 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA].	+	2QM8 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QM8 OCA].

	==Reference==		==Reference==
-	Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria., Hubbard PA, Padovani D, Labunska T, Mahlstedt SA, Banerjee R, Drennan CL, J Biol Chem. 2007 Oct 26;282(43):31308-16. Epub 2007 Aug 28. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17728257 17728257]~~	+	<ref group="xtra">PMID:17728257</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Thermomicrobium roseum]]		[[Category: Thermomicrobium roseum]]
	[[Category: Banerjee, R.]]		[[Category: Banerjee, R.]]
Line 37:		Line 36:
	[[Category: Metallochaperone]]		[[Category: Metallochaperone]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 14~~:11:~~20 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:22:04 2009''

OCA at 11:11, 28 July 2008

2008-07-28T11:11:23Z

←Older revision		Revision as of 11:11, 28 July 2008
Line 1:		Line 1:
-	[[Image:2qm8.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2qm8.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2qm8\| PDB=2qm8 \| SCENE= }}		{{STRUCTURE_2qm8\| PDB=2qm8 \| SCENE= }}

-	~~'''~~MeaB, A Bacterial Homolog of MMAA, in the Nucleotide Free Form~~'''~~	+	===MeaB, A Bacterial Homolog of MMAA, in the Nucleotide Free Form===


-	~~==Overview==~~	+	<!--
-	~~MeaB is an auxiliary protein that plays a crucial role in the protection and assembly of the B(12)~~-~~dependent enzyme methylmalonyl~~-~~CoA mutase. Impairments in the human homologue of MeaB, MMAA, lead to methylmalonic aciduria, an inborn error of metabolism. To explore the role of~~ this ~~metallochaperone~~, ~~its structure was solved in the nucleotide-free form~~, ~~as well as in~~ the ~~presence of product, GDP. MeaB is a homodimer, with each subunit containing a central alpha/beta-core G domain that is typical of~~ the ~~GTPase family,~~ as ~~well as alpha-helical extensions~~ at ~~the N and C termini that are not found in other metalloenzyme chaperone GTPases~~. ~~The C-terminal extension appears to be essential for nucleotide-independent dimerization~~, ~~and the N-terminal region~~ is ~~implicated in protein-protein interaction with its partner protein, methylmalonyl-CoA mutase. The structure of MeaB confirms that it is a member of~~ the ~~G3E family of P-loop GTPases, which contains other putative metallochaperones HypB, CooC, and UreG~~. ~~Interestingly, the so~~-called switch regions, responsible for signal transduction following GTP hydrolysis, are found at the dimer interface of MeaB instead of being positioned at the surface of the protein where its partner protein methylmalonyl-CoA mutase should bind. This observation suggests a large conformation change of MeaB must occur between the GDP- and GTP-bound forms of this protein. Because of their high sequence homology, the missense mutations in MMAA that result in methylmalonic aciduria have been mapped onto MeaB and, in conjunction with mutagenesis data, provide possible explanations for the pathology of this disease.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17728257}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17728257 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17728257}}

	==About this Structure==		==About this Structure==
Line 32:		Line 36:
	[[Category: Gtpase]]		[[Category: Gtpase]]
	[[Category: Metallochaperone]]		[[Category: Metallochaperone]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 15~~:11:44 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:11:20 2008''