2r2i - Revision history

OCA at 04:12, 2 July 2021

2021-07-02T04:12:06Z

←Older revision		Revision as of 04:12, 2 July 2021
Line 1:		Line 1:

	==Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound==		==Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound==
-	<StructureSection load='2r2i' size='340' side='right' caption='[[2r2i]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2r2i' size='340' side='right'caption='[[2r2i]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r2i]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2R2I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r2i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R2I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GUCA1A, GCAP1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GUCA1A, GCAP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2i OCA], [~~http~~://pdbe.org/2r2i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2r2i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2r2i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2r2i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2i OCA], [https://pdbe.org/2r2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r2i RCSB], [https://www.ebi.ac.uk/pdbsum/2r2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r2i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GUC1A_CHICK GUC1A_CHICK]] Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).	+	[[https://www.uniprot.org/uniprot/GUC1A_CHICK GUC1A_CHICK]] Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/2r2i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/2r2i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Chick]]		[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Stephen, R]]		[[Category: Stephen, R]]
	[[Category: Calcium]]		[[Category: Calcium]]

OCA at 07:41, 25 October 2017

2017-10-25T07:41:21Z

←Older revision		Revision as of 07:41, 25 October 2017
Line 1:		Line 1:
		+
	==Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound==		==Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound==
	<StructureSection load='2r2i' size='340' side='right' caption='[[2r2i]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2r2i' size='340' side='right' caption='[[2r2i]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GUCA1A, GCAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GUCA1A, GCAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2i OCA], [http://pdbe.org/2r2i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r2i RCSB], [http://www.ebi.ac.uk/pdbsum/2r2i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2i OCA], [http://pdbe.org/2r2i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r2i RCSB], [http://www.ebi.ac.uk/pdbsum/2r2i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r2i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 35:
	[[Category: Chick]]		[[Category: Chick]]
	[[Category: Stephen, R]]		[[Category: Stephen, R]]
		+	[[Category: Calcium]]
	[[Category: Ef hand]]		[[Category: Ef hand]]
	[[Category: Gcap]]		[[Category: Gcap]]

OCA at 07:05, 7 February 2016

2016-02-07T07:05:12Z

←Older revision		Revision as of 07:05, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r2i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:59, 9 September 2015

2015-09-09T22:59:23Z

←Older revision		Revision as of 22:59, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='2r2i' size='340' side='right' caption='[[2r2i]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2r2i' size='340' side='right' caption='[[2r2i]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r2i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R2I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r2i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R2I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GUCA1A, GCAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 ~~Gallus gallus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GUCA1A, GCAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r2i RCSB], [http://www.ebi.ac.uk/pdbsum/2r2i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2i OCA], [http://pdbe.org/2r2i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r2i RCSB], [http://www.ebi.ac.uk/pdbsum/2r2i PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2r2i" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Stephen, R]]		[[Category: Stephen, R]]
	[[Category: Ef hand]]		[[Category: Ef hand]]

OCA at 08:50, 24 December 2014

2014-12-24T08:50:56Z

←Older revision		Revision as of 08:50, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r2i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R2I FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r2i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R2I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GUCA1A, GCAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GUCA1A, GCAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r2i RCSB], [http://www.ebi.ac.uk/pdbsum/2r2i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r2i RCSB], [http://www.ebi.ac.uk/pdbsum/2r2i PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GUC1A_CHICK GUC1A_CHICK]] Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Stephen, R.]]	+	[[Category: Stephen, R]]
	[[Category: Ef hand]]		[[Category: Ef hand]]
	[[Category: Gcap]]		[[Category: Gcap]]

OCA at 19:28, 30 September 2014

2014-09-30T19:28:00Z

←Older revision		Revision as of 19:28, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2r2i.~~png~~\|~~left~~\|200px]]	+	==Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound==
		+	<StructureSection load='2r2i' size='340' side='right' caption='[[2r2i]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2r2i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R2I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GUCA1A, GCAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r2i RCSB], [http://www.ebi.ac.uk/pdbsum/2r2i PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/2r2i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Guanylate cyclase-activating proteins (GCAPs) are Ca(2+)-binding proteins myristoylated at the N terminus that regulate guanylate cyclases in photoreceptor cells and belong to the family of neuronal calcium sensors (NCS). Many NCS proteins display a recoverin-like "calcium-myristoyl switch" whereby the myristoyl group, buried inside the protein in the Ca(2+)-free state, becomes fully exposed upon Ca(2+) binding. Here we present a 2.0 A resolution crystal structure of myristoylated GCAP1 with Ca(2+) bound. The acyl group is buried inside Ca(2+)-bound GCAP1. This is in sharp contrast to Ca(2+)-bound recoverin, where the myristoyl group is solvent exposed. Furthermore, we provide direct evidence that the acyl group in GCAP1 remains buried in the Ca(2+)-free state and does not undergo switching. A pronounced kink in the C-terminal helix and the presence of the myristoyl group allow clustering of sequence elements crucial for GCAP1 activity.

-	~~{{STRUCTURE_2r2i\| PDB=2r2i \| SCENE= }}~~	+	Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1.,Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC Structure. 2007 Nov;15(11):1392-402. PMID:17997965<ref>PMID:17997965</ref>

-	~~===Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17997965}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2r2i]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017997965<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Stephen, R.]]		[[Category: Stephen, R.]]

OCA: Protected "2r2i" [edit=sysop:move=sysop]

2013-01-07T19:31:58Z

Protected "2r2i" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:31, 7 January 2013

OCA at 19:31, 7 January 2013

2013-01-07T19:31:56Z

←Older revision		Revision as of 19:31, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2r2i.png\|left\|200px]]		[[Image:2r2i.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2r2i", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2r2i\| PDB=2r2i \| SCENE= }}		{{STRUCTURE_2r2i\| PDB=2r2i \| SCENE= }}

	===Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound===		===Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17997965}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17997965 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17997965}}		{{ABSTRACT_PUBMED_17997965}}

	==About this Structure==		==About this Structure==
-	~~2R2I~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA].	+	[[2r2i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17997965~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017997965</ref><references group="xtra"/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Stephen, R.]]		[[Category: Stephen, R.]]
-	[[Category: Calcium]]
	[[Category: Ef hand]]		[[Category: Ef hand]]
	[[Category: Gcap]]		[[Category: Gcap]]
Line 37:		Line 24:
	[[Category: Sensory transduction]]		[[Category: Sensory transduction]]
	[[Category: Vision]]		[[Category: Vision]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:09:11 2009''

OCA at 10:09, 16 February 2009

2009-02-16T10:09:12Z

←Older revision		Revision as of 10:09, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2R2I is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA].	+	2R2I is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2I OCA].

	==Reference==		==Reference==
-	~~Stabilizing function for myristoyl~~ group ~~revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1., Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC, Structure. 2007 Nov;15(11):1392-402.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17997965 17997965]~~	+	<ref group="xtra">PMID:17997965</ref><references group="xtra"/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Single protein]]
	[[Category: Stephen, R.]]		[[Category: Stephen, R.]]
	[[Category: Calcium]]		[[Category: Calcium]]
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	[[Category: Vision]]		[[Category: Vision]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 14~~:19:~~07 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:09:11 2009''

OCA at 11:19, 27 July 2008

2008-07-27T11:19:15Z

←Older revision		Revision as of 11:19, 27 July 2008
Line 1:		Line 1:
-	[[Image:2r2i.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2r2i.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2r2i\| PDB=2r2i \| SCENE= }}		{{STRUCTURE_2r2i\| PDB=2r2i \| SCENE= }}

-	~~'''~~Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound~~'''~~	+	===Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound===


-	~~==Overview==~~	+	<!--
-	~~Guanylate cyclase~~-~~activating proteins (GCAPs) are Ca(2+)~~-~~binding proteins myristoylated at~~ the ~~N terminus that regulate guanylate cyclases in photoreceptor cells and belong~~ to the ~~family of neuronal calcium sensors~~ (~~NCS)~~. ~~Many NCS proteins display a recoverin-like "calcium-myristoyl switch" whereby the myristoyl group, buried inside the protein in the Ca(2+)-free state, becomes fully exposed upon Ca(2+) binding~~. ~~Here we present a 2.0 A resolution crystal structure of myristoylated GCAP1 with Ca(2+~~) ~~bound. The acyl group is buried inside Ca(2+)-bound GCAP1. This is in sharp contrast to Ca(2+)-bound recoverin~~, where ~~the myristoyl group~~ is ~~solvent exposed. Furthermore, we provide direct evidence that~~ the ~~acyl group in GCAP1 remains buried in the Ca(2+)-free state and does not undergo switching~~. ~~A pronounced kink in the C~~-~~terminal helix and the presence of the myristoyl group allow clustering of sequence elements crucial for GCAP1 activity.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17997965}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17997965 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17997965}}

	==About this Structure==		==About this Structure==
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	[[Category: Sensory transduction]]		[[Category: Sensory transduction]]
	[[Category: Vision]]		[[Category: Vision]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 16~~:07:31 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:19:07 2008''