2r4n - Revision history

OCA at 11:45, 30 August 2023

2023-08-30T11:45:37Z

←Older revision		Revision as of 11:45, 30 August 2023
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	<StructureSection load='2r4n' size='340' side='right'caption='[[2r4n]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2r4n' size='340' side='right'caption='[[2r4n]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE~~-~~N-OXIDE'>LDA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1t16\|1t16]], [[1t1l\|1t1l]], [[2r4l\|2r4l]], [[2r4m\|2r4m]], [[2r4o\|2r4o]], [[2r4p\|2r4p]], [[2r88\|2r88]], [[2r89\|2r89]], [[2r8a\|2r8a]], [[3dwo\|3dwo]], [[3dwn\|3dwn]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadL, ttr ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [https://pdbe.org/2r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [https://www.ebi.ac.uk/pdbsum/2r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [https://pdbe.org/2r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [https://www.ebi.ac.uk/pdbsum/2r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FADL_ECOLI FADL_ECOLI]] Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.	+	[https://www.uniprot.org/uniprot/FADL_ECOLI FADL_ECOLI] Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Berg, B van den]]~~	+	[[Category: Hearn EM]]
-	[[Category: Hearn~~, E M~~]]	+	[[Category: Indic M]]
-	[[Category: Indic, M]]	+	[[Category: Lepore BW]]
-	[[Category: Lepore~~, B W~~]]	+	[[Category: Patel DR]]
-	[[Category: Patel~~, D R~~]]	+	[[Category: Van den Berg B]]
-	[[Category: ~~Beta barrel]]~~	+
-	~~[[Category: Lipid transport]]~~	+
-	~~[[Category: Outer membrane protein]]~~	+
-	~~[[Category: Phage recognition]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 04:14, 2 July 2021

2021-07-02T04:14:09Z

←Older revision		Revision as of 04:14, 2 July 2021
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	==Crystal structure of the long-chain fatty acid transporter FadL mutant N33A==		==Crystal structure of the long-chain fatty acid transporter FadL mutant N33A==
-	<StructureSection load='2r4n' size='340' side='right' caption='[[2r4n]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='2r4n' size='340' side='right'caption='[[2r4n]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r4n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2R4N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t16\|1t16]], [[1t1l\|1t1l]], [[2r4l\|2r4l]], [[2r4m\|2r4m]], [[2r4o\|2r4o]], [[2r4p\|2r4p]], [[2r88\|2r88]], [[2r89\|2r89]], [[2r8a\|2r8a]], [[3dwo\|3dwo]], [[3dwn\|3dwn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t16\|1t16]], [[1t1l\|1t1l]], [[2r4l\|2r4l]], [[2r4m\|2r4m]], [[2r4o\|2r4o]], [[2r4p\|2r4p]], [[2r88\|2r88]], [[2r89\|2r89]], [[2r8a\|2r8a]], [[3dwo\|3dwo]], [[3dwn\|3dwn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadL, ttr ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadL, ttr ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [~~http~~://pdbe.org/2r4n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2r4n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [https://pdbe.org/2r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [https://www.ebi.ac.uk/pdbsum/2r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FADL_ECOLI FADL_ECOLI]] Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.	+	[[https://www.uniprot.org/uniprot/FADL_ECOLI FADL_ECOLI]] Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Berg, B van den]]		[[Category: Berg, B van den]]
	[[Category: Hearn, E M]]		[[Category: Hearn, E M]]

OCA at 11:05, 5 September 2018

2018-09-05T11:05:59Z

←Older revision		Revision as of 11:05, 5 September 2018
Line 1:		Line 1:
		+
	==Crystal structure of the long-chain fatty acid transporter FadL mutant N33A==		==Crystal structure of the long-chain fatty acid transporter FadL mutant N33A==
	<StructureSection load='2r4n' size='340' side='right' caption='[[2r4n]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2r4n' size='340' side='right' caption='[[2r4n]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t16\|1t16]], [[1t1l\|1t1l]], [[2r4l\|2r4l]], [[2r4m\|2r4m]], [[2r4o\|2r4o]], [[2r4p\|2r4p]], [[2r88\|2r88]], [[2r89\|2r89]], [[2r8a\|2r8a]], [[3dwo\|3dwo]], [[3dwn\|3dwn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t16\|1t16]], [[1t1l\|1t1l]], [[2r4l\|2r4l]], [[2r4m\|2r4m]], [[2r4o\|2r4o]], [[2r4p\|2r4p]], [[2r88\|2r88]], [[2r89\|2r89]], [[2r8a\|2r8a]], [[3dwo\|3dwo]], [[3dwn\|3dwn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadL, ttr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadL, ttr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [http://pdbe.org/2r4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [http://www.ebi.ac.uk/pdbsum/2r4n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [http://pdbe.org/2r4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [http://www.ebi.ac.uk/pdbsum/2r4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:40, 12 September 2015

2015-09-12T00:40:59Z

←Older revision		Revision as of 00:40, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2r4n' size='340' side='right' caption='[[2r4n]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2r4n' size='340' side='right' caption='[[2r4n]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t16\|1t16]], [[1t1l\|1t1l]], [[2r4l\|2r4l]], [[2r4m\|2r4m]], [[2r4o\|2r4o]], [[2r4p\|2r4p]], [[2r88\|2r88]], [[2r89\|2r89]], [[2r8a\|2r8a]], [[3dwo\|3dwo]], [[3dwn\|3dwn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t16\|1t16]], [[1t1l\|1t1l]], [[2r4l\|2r4l]], [[2r4m\|2r4m]], [[2r4o\|2r4o]], [[2r4p\|2r4p]], [[2r88\|2r88]], [[2r89\|2r89]], [[2r8a\|2r8a]], [[3dwo\|3dwo]], [[3dwn\|3dwn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadL, ttr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadL, ttr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [http://www.ebi.ac.uk/pdbsum/2r4n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [http://pdbe.org/2r4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [http://www.ebi.ac.uk/pdbsum/2r4n PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2r4n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Berg, B van den]]		[[Category: Berg, B van den]]
	[[Category: Hearn, E M]]		[[Category: Hearn, E M]]

OCA at 21:32, 25 December 2014

2014-12-25T21:32:47Z

←Older revision		Revision as of 21:32, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t16\|1t16]], [[1t1l\|1t1l]], [[2r4l\|2r4l]], [[2r4m\|2r4m]], [[2r4o\|2r4o]], [[2r4p\|2r4p]], [[2r88\|2r88]], [[2r89\|2r89]], [[2r8a\|2r8a]], [[3dwo\|3dwo]], [[3dwn\|3dwn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t16\|1t16]], [[1t1l\|1t1l]], [[2r4l\|2r4l]], [[2r4m\|2r4m]], [[2r4o\|2r4o]], [[2r4p\|2r4p]], [[2r88\|2r88]], [[2r89\|2r89]], [[2r8a\|2r8a]], [[3dwo\|3dwo]], [[3dwn\|3dwn]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadL, ttr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadL, ttr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [http://www.ebi.ac.uk/pdbsum/2r4n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [http://www.ebi.ac.uk/pdbsum/2r4n PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FADL_ECOLI FADL_ECOLI]] Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Berg, B van den.]]	+	[[Category: Berg, B van den]]
-	[[Category: Hearn, E M.]]	+	[[Category: Hearn, E M]]
-	[[Category: Indic, M.]]	+	[[Category: Indic, M]]
-	[[Category: Lepore, B W.]]	+	[[Category: Lepore, B W]]
-	[[Category: Patel, D R.]]	+	[[Category: Patel, D R]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Lipid transport]]		[[Category: Lipid transport]]

OCA at 18:47, 30 September 2014

2014-09-30T18:47:15Z

←Older revision		Revision as of 18:47, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2r4n.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the long-chain fatty acid transporter FadL mutant N33A==
		+	<StructureSection load='2r4n' size='340' side='right' caption='[[2r4n]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2r4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4N FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1t16\|1t16]], [[1t1l\|1t1l]], [[2r4l\|2r4l]], [[2r4m\|2r4m]], [[2r4o\|2r4o]], [[2r4p\|2r4p]], [[2r88\|2r88]], [[2r89\|2r89]], [[2r8a\|2r8a]], [[3dwo\|3dwo]], [[3dwn\|3dwn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadL, ttr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4n RCSB], [http://www.ebi.ac.uk/pdbsum/2r4n PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Membrane proteins that transport hydrophobic compounds have important roles in multi-drug resistance and can cause a number of diseases, underscoring the importance of protein-mediated transport of hydrophobic compounds. Hydrophobic compounds readily partition into regular membrane lipid bilayers, and their transport through an aqueous protein channel is energetically unfavourable. Alternative transport models involving acquisition from the lipid bilayer by lateral diffusion have been proposed for hydrophobic substrates. So far, all transport proteins for which a lateral diffusion mechanism has been proposed function as efflux pumps. Here we present the first example of a lateral diffusion mechanism for the uptake of hydrophobic substrates by the Escherichia coli outer membrane long-chain fatty acid transporter FadL. A FadL mutant in which a lateral opening in the barrel wall is constricted, but which is otherwise structurally identical to wild-type FadL, does not transport substrates. A crystal structure of FadL from Pseudomonas aeruginosa shows that the opening in the wall of the beta-barrel is conserved and delineates a long, hydrophobic tunnel that could mediate substrate passage from the extracellular environment, through the polar lipopolysaccharide layer and, by means of the lateral opening in the barrel wall, into the lipid bilayer from where the substrate can diffuse into the periplasm. Because FadL homologues are found in pathogenic and biodegrading bacteria, our results have implications for combating bacterial infections and bioremediating xenobiotics in the environment.

-	~~{{STRUCTURE_2r4n\| PDB=2r4n \| SCENE= }}~~	+	Transmembrane passage of hydrophobic compounds through a protein channel wall.,Hearn EM, Patel DR, Lepore BW, Indic M, van den Berg B Nature. 2009 Mar 19;458(7236):367-70. Epub 2009 Feb 1. PMID:19182779<ref>PMID:19182779</ref>

-	~~===Crystal structure~~ of the ~~long-chain fatty acid transporter FadL mutant N33A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19182779}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2r4n]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019182779<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Berg, B van den.]]		[[Category: Berg, B van den.]]

OCA: Protected "2r4n" [edit=sysop:move=sysop]

2013-01-30T13:19:39Z

Protected "2r4n" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:19, 30 January 2013

OCA at 13:19, 30 January 2013

2013-01-30T13:19:36Z

←Older revision		Revision as of 13:19, 30 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2r4n.png\|left\|200px]]		[[Image:2r4n.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2r4n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2r4n\| PDB=2r4n \| SCENE= }}		{{STRUCTURE_2r4n\| PDB=2r4n \| SCENE= }}

	===Crystal structure of the long-chain fatty acid transporter FadL mutant N33A===		===Crystal structure of the long-chain fatty acid transporter FadL mutant N33A===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19182779}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19182779 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19182779}}		{{ABSTRACT_PUBMED_19182779}}

	==About this Structure==		==About this Structure==
-	~~2R4N~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA].	+	[[2r4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19182779~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019182779</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Berg, B van den.]]		[[Category: Berg, B van den.]]
Line 37:		Line 25:
	[[Category: Transport]]		[[Category: Transport]]
	[[Category: Transport protein]]		[[Category: Transport protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 16:20:05 2009''

OCA at 13:20, 2 April 2009

2009-04-02T13:20:06Z

←Older revision		Revision as of 13:20, 2 April 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2R4N is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA].	+	2R4N is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA].

	==Reference==		==Reference==
-	~~Transmembrane passage of hydrophobic compounds through a protein channel wall., Hearn EM, Patel DR, Lepore BW, Indic M, van den Berg B, Nature. 2009 Feb 1.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19182779 19182779]~~	+	<ref group="xtra">PMID:19182779</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Berg, B van den.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Hearn, E M.]]
		+	[[Category: Indic, M.]]
		+	[[Category: Lepore, B W.]]
		+	[[Category: Patel, D R.]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Lipid transport]]		[[Category: Lipid transport]]
Line 35:		Line 38:
	[[Category: Transport protein]]		[[Category: Transport protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Mar 25 21~~:04:47 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 16:20:05 2009''

OCA at 19:04, 25 March 2009

2009-03-25T19:04:47Z

←Older revision		Revision as of 19:04, 25 March 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2R4N is a ~~2 chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA].	+	2R4N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4N OCA].

	==Reference==		==Reference==
-	~~<ref group="xtra">~~PMID:~~19182779<~~/~~ref><references group="xtra"~~/>	+	Transmembrane passage of hydrophobic compounds through a protein channel wall., Hearn EM, Patel DR, Lepore BW, Indic M, van den Berg B, Nature. 2009 Feb 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19182779 19182779]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: ~~Berg, B van den.~~]]	+	[[Category: Single protein]]
-	[[Category: ~~Hearn~~, ~~E M.]]~~	+	[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
-	~~[[Category~~: ~~Indic, M.]]~~	+
-	~~[[Category: Lepore, B W.]]~~	+
-	~~[[Category: Patel, D R~~.]]	+
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Lipid transport]]		[[Category: Lipid transport]]
Line 38:		Line 35:
	[[Category: Transport protein]]		[[Category: Transport protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 11:28:38 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 21:04:47 2009''