2r5e - Revision history

OCA at 11:47, 30 August 2023

2023-08-30T11:47:22Z

←Older revision		Revision as of 11:47, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2r5e' size='340' side='right'caption='[[2r5e]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='2r5e' size='340' side='right'caption='[[2r5e]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aedae Aedae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5E FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=QLP:N~2~-({3-HYDROXY-2-METHYL-5~~-[~~(PHOSPHONOOXY)METHYL~~]~~PYRIDIN-4-YL}METHYL)-L-GLUTAMINE'>QLP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.84Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[2r5c\|2r5c~~]~~]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QLP:N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-GLUTAMINE'>QLP</scene></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">KAT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [https://pdbe.org/2r5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [https://www.ebi.ac.uk/pdbsum/2r5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [https://pdbe.org/2r5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [https://www.ebi.ac.uk/pdbsum/2r5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5e ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KAT_AEDAE KAT_AEDAE] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) (PubMed:12110301, PubMed:15556614). Also catalyzes the irreversible transamination of several amino acids including cysteine, tyrosine, glutamine, methionine, histidine and phenylalanine (PubMed:15556614). Can use various keto-acids as the amino group acceptor (PubMed:15556614, PubMed:12110301).<ref>PMID:12110301</ref> <ref>PMID:15556614</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aedae~~]]	+	[[Category: Aedes aegypti]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao~~, Y G~~]]	+	[[Category: Gao YG]]
-	[[Category: Han, Q]]	+	[[Category: Han Q]]
-	[[Category: Li, J]]	+	[[Category: Li J]]
-	[[Category: Robinson, H]]	+	[[Category: Robinson H]]
-	~~[[Category: Alpha and beta protein]]~~	+
-	~~[[Category: Aminotransferase]]~~	+
-	~~[[Category: Pyridoxal 5-phosphate]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 04:14, 2 July 2021

2021-07-02T04:14:58Z

←Older revision		Revision as of 04:14, 2 July 2021
Line 1:		Line 1:

	==Aedes kynurenine aminotransferase in complex with glutamine==		==Aedes kynurenine aminotransferase in complex with glutamine==
-	<StructureSection load='2r5e' size='340' side='right' caption='[[2r5e]], [[Resolution\|resolution]] 1.84Å' scene=''>	+	<StructureSection load='2r5e' size='340' side='right'caption='[[2r5e]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r5e]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aedae Aedae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2R5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedae Aedae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QLP:N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-GLUTAMINE'>QLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QLP:N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-GLUTAMINE'>QLP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5c\|2r5c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2r5c\|2r5c]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [~~http~~://pdbe.org/2r5e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2r5e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [https://pdbe.org/2r5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [https://www.ebi.ac.uk/pdbsum/2r5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5e ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Aedae]]		[[Category: Aedae]]
		+	[[Category: Large Structures]]
	[[Category: Gao, Y G]]		[[Category: Gao, Y G]]
	[[Category: Han, Q]]		[[Category: Han, Q]]

OCA at 10:50, 5 September 2018

2018-09-05T10:50:27Z

←Older revision		Revision as of 10:50, 5 September 2018
Line 1:		Line 1:
		+
	==Aedes kynurenine aminotransferase in complex with glutamine==		==Aedes kynurenine aminotransferase in complex with glutamine==
	<StructureSection load='2r5e' size='340' side='right' caption='[[2r5e]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='2r5e' size='340' side='right' caption='[[2r5e]], [[Resolution\|resolution]] 1.84Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5c\|2r5c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5c\|2r5c]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [http://pdbe.org/2r5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [http://www.ebi.ac.uk/pdbsum/2r5e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [http://pdbe.org/2r5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [http://www.ebi.ac.uk/pdbsum/2r5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5e ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5e_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5e_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:41, 9 February 2016

2016-02-09T21:41:04Z

←Older revision		Revision as of 21:41, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5e ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:17, 11 September 2015

2015-09-11T02:17:57Z

←Older revision		Revision as of 02:17, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2r5e' size='340' side='right' caption='[[2r5e]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='2r5e' size='340' side='right' caption='[[2r5e]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aedes_aegypti Aedes aegypti~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedae Aedae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QLP:N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-GLUTAMINE'>QLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QLP:N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-GLUTAMINE'>QLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5c\|2r5c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5c\|2r5c]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 ~~Aedes aegypti~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [http://www.ebi.ac.uk/pdbsum/2r5e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [http://pdbe.org/2r5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [http://www.ebi.ac.uk/pdbsum/2r5e PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2r5e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aedes aegypti~~]]	+	[[Category: Aedae]]
	[[Category: Gao, Y G]]		[[Category: Gao, Y G]]
	[[Category: Han, Q]]		[[Category: Han, Q]]

OCA at 14:54, 19 January 2015

2015-01-19T14:54:21Z

←Older revision		Revision as of 14:54, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5E FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QLP:N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-GLUTAMINE'>QLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QLP:N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-GLUTAMINE'>QLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5c\|2r5c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5c\|2r5c]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 Aedes aegypti])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 Aedes aegypti])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [http://www.ebi.ac.uk/pdbsum/2r5e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [http://www.ebi.ac.uk/pdbsum/2r5e PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Aedes aegypti]]		[[Category: Aedes aegypti]]
-	[[Category: Gao, Y G.]]	+	[[Category: Gao, Y G]]
-	[[Category: Han, Q.]]	+	[[Category: Han, Q]]
-	[[Category: Li, J.]]	+	[[Category: Li, J]]
-	[[Category: Robinson, H.]]	+	[[Category: Robinson, H]]
	[[Category: Alpha and beta protein]]		[[Category: Alpha and beta protein]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	[[Category: Pyridoxal 5-phosphate]]		[[Category: Pyridoxal 5-phosphate]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 18:37, 30 September 2014

2014-09-30T18:37:13Z

←Older revision		Revision as of 18:37, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2r5e.~~png~~\|~~left~~\|200px]]	+	==Aedes kynurenine aminotransferase in complex with glutamine==
		+	<StructureSection load='2r5e' size='340' side='right' caption='[[2r5e]], [[Resolution\|resolution]] 1.84Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2r5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5E FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QLP:N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-GLUTAMINE'>QLP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5c\|2r5c]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 Aedes aegypti])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5e RCSB], [http://www.ebi.ac.uk/pdbsum/2r5e PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5e_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aedes aegypti kynurenine aminotransferase (AeKAT) is a multifunctional aminotransferase. It catalyzes the transamination of a number of amino acids and uses many biologically relevant alpha-keto acids as amino group acceptors. AeKAT also is a cysteine S-conjugate beta-lyase. The most important function of AeKAT is the biosynthesis of kynurenic acid, a natural antagonist of NMDA and alpha7-nicotinic acetylcholine receptors. Here, we report the crystal structures of AeKAT in complex with its best amino acid substrates, glutamine and cysteine. Glutamine is found in both subunits of the biological dimer, and cysteine is found in one of the two subunits. Both substrates form external aldemines with pyridoxal 5-phosphate in the structures. This is the first instance in which one pyridoxal 5-phosphate enzyme has been crystallized with cysteine or glutamine forming external aldimine complexes, cysteinyl aldimine and glutaminyl aldimine. All the units with substrate are in the closed conformation form, and the unit without substrate is in the open form, which suggests that the binding of substrate induces the conformation change of AeKAT. By comparing the active site residues of the AeKAT-cysteine structure with those of the human KAT I-phenylalanine structure, we determined that Tyr286 in AeKAT is changed to Phe278 in human KAT I, which may explain why AeKAT transaminates hydrophilic amino acids more efficiently than human KAT I does.

-	~~{{STRUCTURE_2r5e\| PDB=2r5e \| SCENE= }}~~	+	Structural insight into the mechanism of substrate specificity of aedes kynurenine aminotransferase.,Han Q, Gao YG, Robinson H, Li J Biochemistry. 2008 Feb 12;47(6):1622-30. Epub 2008 Jan 11. PMID:18186649<ref>PMID:18186649</ref>

-	~~===Aedes kynurenine aminotransferase in complex with glutamine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18186649}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2r5e]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aedes_aegypti Aedes aegypti]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018186649<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Aedes aegypti]]		[[Category: Aedes aegypti]]
	[[Category: Gao, Y G.]]		[[Category: Gao, Y G.]]

OCA: Protected "2r5e" [edit=sysop:move=sysop]

2013-01-07T21:17:35Z

Protected "2r5e" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:17, 7 January 2013

OCA at 21:17, 7 January 2013

2013-01-07T21:17:31Z

←Older revision		Revision as of 21:17, 7 January 2013
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-	{{Seed}}
	[[Image:2r5e.png\|left\|200px]]		[[Image:2r5e.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2r5e\| PDB=2r5e \| SCENE= }}		{{STRUCTURE_2r5e\| PDB=2r5e \| SCENE= }}

	===Aedes kynurenine aminotransferase in complex with glutamine===		===Aedes kynurenine aminotransferase in complex with glutamine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18186649}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18186649 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_18186649}}		{{ABSTRACT_PUBMED_18186649}}

	==About this Structure==		==About this Structure==
-	~~2R5E~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA].	+	[[2r5e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18186649~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018186649</ref><references group="xtra"/>
	[[Category: Aedes aegypti]]		[[Category: Aedes aegypti]]
	[[Category: Gao, Y G.]]		[[Category: Gao, Y G.]]
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	[[Category: Pyridoxal 5-phosphate]]		[[Category: Pyridoxal 5-phosphate]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:57:37 2009''

OCA at 10:57, 17 February 2009

2009-02-17T10:57:37Z

←Older revision		Revision as of 10:57, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2R5E is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA].	+	2R5E is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5E OCA].

	==Reference==		==Reference==
-	~~Structural insight into the mechanism of substrate specificity of aedes kynurenine aminotransferase., Han Q, Gao YG, Robinson H, Li J, Biochemistry. 2008 Feb 12;47(6):1622-30. Epub 2008 Jan 11.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18186649 18186649]~~	+	<ref group="xtra">PMID:18186649</ref><references group="xtra"/>
	[[Category: Aedes aegypti]]		[[Category: Aedes aegypti]]
-	[[Category: Single protein]]
	[[Category: Gao, Y G.]]		[[Category: Gao, Y G.]]
	[[Category: Han, Q.]]		[[Category: Han, Q.]]
Line 35:		Line 34:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28~~ 17:25:~~17 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:57:37 2009''