2r5j - Revision history

OCA at 09:19, 21 February 2024

2024-02-21T09:19:56Z

←Older revision		Revision as of 09:19, 21 February 2024
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	<StructureSection load='2r5j' size='340' side='right'caption='[[2r5j]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='2r5j' size='340' side='right'caption='[[2r5j]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r5j]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hpv35 Hpv35~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r5j]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_35 Human papillomavirus 35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5J FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2r5h\|2r5h]], [[2r5i\|2r5i]], [[2r5k\|2r5k]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">L1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10587 HPV35])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [https://pdbe.org/2r5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [https://www.ebi.ac.uk/pdbsum/2r5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [https://pdbe.org/2r5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [https://www.ebi.ac.uk/pdbsum/2r5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VL1_HPV35 VL1_HPV35]] Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell (By similarity).	+	[https://www.uniprot.org/uniprot/VL1_HPV35 VL1_HPV35] Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5j ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5j ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Human papillomaviruses (HPVs) are known etiologic agents of cervical cancer. Vaccines that contain virus-like particles (VLPs) made of L1 capsid protein from several high risk HPV types have proven to be effective against HPV infections. Raising high levels of neutralizing antibodies against each HPV type is believed to be the primary mechanism of protection, gained by vaccination. Antibodies elicited by a particular HPV type are highly specific to that particular HPV type and show little or no cross-reactivity between HPV types. With an intention to understand the interplay between the L1 structure of different HPV types and the type specificity of neutralizing antibodies, we have prepared the L1 pentamers of four different HPV types, HPV11, HPV16, HPV18, and HPV35. The pentamers only bind the type-specific neutralizing monoclonal antibodies (NmAbs) that are raised against the VLP of the corresponding HPV type, implying that the surface loop structures of the pentamers from each type are distinctive and functionally active as VLPs in terms of antibody binding. We have determined the crystal structures of all four L1 pentamers, and their comparisons revealed characteristic conformational differences of the surface loops that contain the known epitopes for the NmAbs. On the basis of these distinct surface loop structures, we have provided a molecular explanation for the type specificity of NmAbs against HPV infection.
-
-	Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies.,Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS J Biol Chem. 2007 Oct 26;282(43):31803-11. Epub 2007 Sep 4. PMID:17804402<ref>PMID:17804402</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2r5j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]		*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hpv35~~]]	+	[[Category: Human papillomavirus 35]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bishop, B]]	+	[[Category: Bishop B]]
-	[[Category: Chen~~, X S~~]]	+	[[Category: Chen XS]]
-	[[Category: Dasgupta, J]]	+	[[Category: Dasgupta J]]
-	~~[[Category: Capsid]]~~	+
-	~~[[Category: Capsid protein]]~~	+
-	~~[[Category: Late protein]]~~	+
-	~~[[Category: Pentamer]]~~	+
-	~~[[Category: Type specific epitope]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virion~~]]	+

OCA at 04:15, 2 July 2021

2021-07-02T04:15:08Z

←Older revision		Revision as of 04:15, 2 July 2021
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	==Pentamer Structure of Major Capsid protein L1 of Human Papilloma Virus Type 35==		==Pentamer Structure of Major Capsid protein L1 of Human Papilloma Virus Type 35==
-	<StructureSection load='2r5j' size='340' side='right' caption='[[2r5j]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='2r5j' size='340' side='right'caption='[[2r5j]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r5j]] is a 15 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hpv35 Hpv35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2R5J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r5j]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Hpv35 Hpv35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5J FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5h\|2r5h]], [[2r5i\|2r5i]], [[2r5k\|2r5k]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2r5h\|2r5h]], [[2r5i\|2r5i]], [[2r5k\|2r5k]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10587 HPV35])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10587 HPV35])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [~~http~~://pdbe.org/2r5j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2r5j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [https://pdbe.org/2r5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [https://www.ebi.ac.uk/pdbsum/2r5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VL1_HPV35 VL1_HPV35]] Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell (By similarity).	+	[[https://www.uniprot.org/uniprot/VL1_HPV35 VL1_HPV35]] Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5j_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5j_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2r5j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2r5j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Hpv35]]		[[Category: Hpv35]]
		+	[[Category: Large Structures]]
	[[Category: Bishop, B]]		[[Category: Bishop, B]]
	[[Category: Chen, X S]]		[[Category: Chen, X S]]

OCA at 02:13, 16 November 2017

2017-11-16T02:13:42Z

←Older revision		Revision as of 02:13, 16 November 2017
Line 1:		Line 1:
		+
	==Pentamer Structure of Major Capsid protein L1 of Human Papilloma Virus Type 35==		==Pentamer Structure of Major Capsid protein L1 of Human Papilloma Virus Type 35==
	<StructureSection load='2r5j' size='340' side='right' caption='[[2r5j]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='2r5j' size='340' side='right' caption='[[2r5j]], [[Resolution\|resolution]] 3.30Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5h\|2r5h]], [[2r5i\|2r5i]], [[2r5k\|2r5k]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5h\|2r5h]], [[2r5i\|2r5i]], [[2r5k\|2r5k]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10587 HPV35])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10587 HPV35])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [http://pdbe.org/2r5j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [http://www.ebi.ac.uk/pdbsum/2r5j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [http://pdbe.org/2r5j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [http://www.ebi.ac.uk/pdbsum/2r5j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 2r5j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2r5j" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Virus coat protein\|Virus coat protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:07, 10 February 2016

2016-02-10T03:07:25Z

←Older revision		Revision as of 03:07, 10 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5j ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:46, 11 September 2015

2015-09-11T04:46:45Z

←Older revision		Revision as of 04:46, 11 September 2015
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	<StructureSection load='2r5j' size='340' side='right' caption='[[2r5j]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='2r5j' size='340' side='right' caption='[[2r5j]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2r5j]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_papillomavirus_type_35 Human papillomavirus type 35~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2r5j]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv35 Hpv35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5J FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5h\|2r5h]], [[2r5i\|2r5i]], [[2r5k\|2r5k]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5h\|2r5h]], [[2r5i\|2r5i]], [[2r5k\|2r5k]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10587 ~~Human papillomavirus type 35~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10587 HPV35])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [http://www.ebi.ac.uk/pdbsum/2r5j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [http://pdbe.org/2r5j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [http://www.ebi.ac.uk/pdbsum/2r5j PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2r5j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human papillomavirus type 35~~]]	+	[[Category: Hpv35]]
	[[Category: Bishop, B]]		[[Category: Bishop, B]]
	[[Category: Chen, X S]]		[[Category: Chen, X S]]
Line 40:		Line 41:
	[[Category: Capsid]]		[[Category: Capsid]]
	[[Category: Capsid protein]]		[[Category: Capsid protein]]
-	[[Category: Hpv35]]
	[[Category: Late protein]]		[[Category: Late protein]]
	[[Category: Pentamer]]		[[Category: Pentamer]]

OCA at 11:22, 25 December 2014

2014-12-25T11:22:30Z

←Older revision		Revision as of 11:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2r5j]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_35 Human papillomavirus type 35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5J FirstGlance]. <br>		<table><tr><td colspan='2'>[[2r5j]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_35 Human papillomavirus type 35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5J FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5h\|2r5h]], [[2r5i\|2r5i]], [[2r5k\|2r5k]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5h\|2r5h]], [[2r5i\|2r5i]], [[2r5k\|2r5k]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10587 Human papillomavirus type 35])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10587 Human papillomavirus type 35])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [http://www.ebi.ac.uk/pdbsum/2r5j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [http://www.ebi.ac.uk/pdbsum/2r5j PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VL1_HPV35 VL1_HPV35]] Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human papillomavirus type 35]]		[[Category: Human papillomavirus type 35]]
-	[[Category: Bishop, B.]]	+	[[Category: Bishop, B]]
-	[[Category: Chen, X S.]]	+	[[Category: Chen, X S]]
-	[[Category: Dasgupta, J.]]	+	[[Category: Dasgupta, J]]
	[[Category: Capsid]]		[[Category: Capsid]]
	[[Category: Capsid protein]]		[[Category: Capsid protein]]

OCA at 06:48, 29 September 2014

2014-09-29T06:48:34Z

←Older revision		Revision as of 06:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2r5j.~~png~~\|~~left~~\|200px]]	+	==Pentamer Structure of Major Capsid protein L1 of Human Papilloma Virus Type 35==
		+	<StructureSection load='2r5j' size='340' side='right' caption='[[2r5j]], [[Resolution\|resolution]] 3.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2r5j]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_35 Human papillomavirus type 35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R5J FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r5h\|2r5h]], [[2r5i\|2r5i]], [[2r5k\|2r5k]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10587 Human papillomavirus type 35])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r5j RCSB], [http://www.ebi.ac.uk/pdbsum/2r5j PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5j_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human papillomaviruses (HPVs) are known etiologic agents of cervical cancer. Vaccines that contain virus-like particles (VLPs) made of L1 capsid protein from several high risk HPV types have proven to be effective against HPV infections. Raising high levels of neutralizing antibodies against each HPV type is believed to be the primary mechanism of protection, gained by vaccination. Antibodies elicited by a particular HPV type are highly specific to that particular HPV type and show little or no cross-reactivity between HPV types. With an intention to understand the interplay between the L1 structure of different HPV types and the type specificity of neutralizing antibodies, we have prepared the L1 pentamers of four different HPV types, HPV11, HPV16, HPV18, and HPV35. The pentamers only bind the type-specific neutralizing monoclonal antibodies (NmAbs) that are raised against the VLP of the corresponding HPV type, implying that the surface loop structures of the pentamers from each type are distinctive and functionally active as VLPs in terms of antibody binding. We have determined the crystal structures of all four L1 pentamers, and their comparisons revealed characteristic conformational differences of the surface loops that contain the known epitopes for the NmAbs. On the basis of these distinct surface loop structures, we have provided a molecular explanation for the type specificity of NmAbs against HPV infection.

-	~~{{STRUCTURE_2r5j\| PDB=2r5j \| SCENE= }}~~	+	Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies.,Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS J Biol Chem. 2007 Oct 26;282(43):31803-11. Epub 2007 Sep 4. PMID:17804402<ref>PMID:17804402</ref>

-	~~===Pentamer Structure~~ of ~~Major Capsid protein L1 of Human Papilloma Virus Type 35===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17804402}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2r5j]] is a 15 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_papillomavirus_type_35 Human papillomavirus type 35]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA].~~	+

	==See Also==		==See Also==
	*[[Virus coat protein\|Virus coat protein]]		*[[Virus coat protein\|Virus coat protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017804402<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Human papillomavirus type 35]]		[[Category: Human papillomavirus type 35]]
	[[Category: Bishop, B.]]		[[Category: Bishop, B.]]

OCA: Protected "2r5j" [edit=sysop:move=sysop]

2012-10-20T16:06:57Z

Protected "2r5j" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:06, 20 October 2012

OCA at 16:06, 20 October 2012

2012-10-20T16:06:55Z

←Older revision		Revision as of 16:06, 20 October 2012
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-	{{Seed}}
	[[Image:2r5j.png\|left\|200px]]		[[Image:2r5j.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2r5j", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2r5j\| PDB=2r5j \| SCENE= }}		{{STRUCTURE_2r5j\| PDB=2r5j \| SCENE= }}

	===Pentamer Structure of Major Capsid protein L1 of Human Papilloma Virus Type 35===		===Pentamer Structure of Major Capsid protein L1 of Human Papilloma Virus Type 35===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17804402}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17804402 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17804402}}		{{ABSTRACT_PUBMED_17804402}}

	==About this Structure==		==About this Structure==
-	~~2R5J~~ is a 15 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_35 Human papillomavirus type 35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA].	+	[[2r5j]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_35 Human papillomavirus type 35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA].
		+
		+	==See Also==
		+	*[[Virus coat protein\|Virus coat protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17804402~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017804402</ref><references group="xtra"/>
	[[Category: Human papillomavirus type 35]]		[[Category: Human papillomavirus type 35]]
	[[Category: Bishop, B.]]		[[Category: Bishop, B.]]
Line 33:		Line 24:
	[[Category: Late protein]]		[[Category: Late protein]]
	[[Category: Pentamer]]		[[Category: Pentamer]]
-	[[Category: Structure]]
	[[Category: Type specific epitope]]		[[Category: Type specific epitope]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
	[[Category: Virion]]		[[Category: Virion]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:56:09 2009''

OCA at 12:56, 17 February 2009

2009-02-17T12:56:10Z

←Older revision		Revision as of 12:56, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2R5J is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_35 Human papillomavirus type 35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA].	+	2R5J is a 15 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_35 Human papillomavirus type 35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5J OCA].

	==Reference==		==Reference==
-	Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies., Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS, J Biol Chem. 2007 Oct 26;282(43):31803-11. Epub 2007 Sep 4. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17804402 17804402]~~	+	<ref group="xtra">PMID:17804402</ref><references group="xtra"/>
	[[Category: Human papillomavirus type 35]]		[[Category: Human papillomavirus type 35]]
-	[[Category: Single protein]]
	[[Category: Bishop, B.]]		[[Category: Bishop, B.]]
	[[Category: Chen, X S.]]		[[Category: Chen, X S.]]
Line 39:		Line 38:
	[[Category: Virion]]		[[Category: Virion]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 20~~:28:~~48 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:56:09 2009''