2rg8 - Revision history

OCA at 04:24, 2 July 2021

2021-07-02T04:24:31Z

←Older revision		Revision as of 04:24, 2 July 2021
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	==Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain==		==Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain==
-	<StructureSection load='2rg8' size='340' side='right' caption='[[2rg8]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2rg8' size='340' side='right'caption='[[2rg8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rg8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rg8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RG8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD4, H731 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD4, H731 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rg8 OCA], [~~http~~://pdbe.org/2rg8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rg8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rg8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rg8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rg8 OCA], [https://pdbe.org/2rg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rg8 RCSB], [https://www.ebi.ac.uk/pdbsum/2rg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rg8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>	+	[[https://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rg/2rg8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rg/2rg8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2rg8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2rg8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cell death protein 3D structures\|Cell death protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Garces, R]]		[[Category: Garces, R]]
	[[Category: Suzuki, C]]		[[Category: Suzuki, C]]

OCA at 07:51, 25 October 2017

2017-10-25T07:51:09Z

←Older revision		Revision as of 07:51, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain==		==Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain==
	<StructureSection load='2rg8' size='340' side='right' caption='[[2rg8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2rg8' size='340' side='right' caption='[[2rg8]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD4, H731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD4, H731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rg8 OCA], [http://pdbe.org/2rg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rg8 RCSB], [http://www.ebi.ac.uk/pdbsum/2rg8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rg8 OCA], [http://pdbe.org/2rg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rg8 RCSB], [http://www.ebi.ac.uk/pdbsum/2rg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rg8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 2rg8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2rg8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cell death protein\|Cell death protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 43:		Line 41:
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
		+	[[Category: Cytoplasm]]
	[[Category: Heat repeat]]		[[Category: Heat repeat]]
	[[Category: Ma3 domain]]		[[Category: Ma3 domain]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
		+	[[Category: Polymorphism]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Translation]]		[[Category: Translation]]

OCA at 04:06, 8 February 2016

2016-02-08T04:06:52Z

←Older revision		Revision as of 04:06, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2rg8' size='340' side='right' caption='[[2rg8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2rg8' size='340' side='right' caption='[[2rg8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RG8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD4, H731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD4, H731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rg8 RCSB], [http://www.ebi.ac.uk/pdbsum/2rg8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rg8 OCA], [http://pdbe.org/2rg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rg8 RCSB], [http://www.ebi.ac.uk/pdbsum/2rg8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rg8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rg8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Garces, R]]		[[Category: Garces, R]]
	[[Category: Suzuki, C]]		[[Category: Suzuki, C]]

OCA at 20:30, 24 December 2014

2014-12-24T20:30:00Z

←Older revision		Revision as of 20:30, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RG8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RG8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD4, H731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD4, H731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rg8 RCSB], [http://www.ebi.ac.uk/pdbsum/2rg8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rg8 RCSB], [http://www.ebi.ac.uk/pdbsum/2rg8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Garces, R.]]	+	[[Category: Garces, R]]
-	[[Category: Suzuki, C.]]	+	[[Category: Suzuki, C]]
-	[[Category: Wagner, G.]]	+	[[Category: Wagner, G]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA at 04:12, 3 October 2014

2014-10-03T04:12:03Z

←Older revision		Revision as of 04:12, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2rg8\| PDB=2rg8 \| SCENE= }}~~	+	==Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain==
-	===Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain===	+	<StructureSection load='2rg8' size='340' side='right' caption='[[2rg8]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18296639}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RG8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD4, H731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rg8 RCSB], [http://www.ebi.ac.uk/pdbsum/2rg8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rg/2rg8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Programmed Cell Death 4 (PDCD4) is a protein known to bind eukaryotic initiation factor 4A (eIF4A), inhibit translation initiation, and act as a tumor suppressor. PDCD4 contains two C-terminal MA3 domains, which are thought to be responsible for its inhibitory function. Here, we analyze the structures and inhibitory functions of these two PDCD4 MA3 domains by x-ray crystallography, NMR, and surface plasmon resonance. We show that both MA3 domains are structurally and functionally very similar and bind specifically to the eIF4A N-terminal domain (eIF4A-NTD) using similar binding interfaces. We found that the PDCD4 MA3 domains compete with the eIF4G MA3 domain and RNA for eIF4A binding. Our data provide evidence that PDCD4 inhibits translation initiation by displacing eIF4G and RNA from eIF4A. The PDCD4 MA3 domains act synergistically to form a tighter and more stable complex with eIF4A, which explains the need for two tandem MA3 domains.

-	~~==Function==~~	+	PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.,Suzuki C, Garces RG, Edmonds KA, Hiller S, Hyberts SG, Marintchev A, Wagner G Proc Natl Acad Sci U S A. 2008 Feb 22;. PMID:18296639<ref>PMID:18296639</ref>
-	~~[[http://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN]] Inhibits~~ translation initiation ~~and cap-dependent translation. May excert~~ its ~~function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase~~. ~~Down-regulates the expression of MAP4K1~~, ~~thus inhibiting events important in driving invasion~~, ~~namely~~, ~~MAPK85 activation and consequent JUN-dependent transcription~~. ~~May play a role in apoptosis~~. ~~Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>~~PMID:~~16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref>~~ <ref>PMID:18296639</ref> ~~<ref>PMID:19153607</ref> <ref>PMID:19204291</ref>~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2rg8]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:018296639</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Cell death protein\|Cell death protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Garces, R.]]		[[Category: Garces, R.]]

OCA at 07:47, 30 June 2013

2013-06-30T07:47:09Z

←Older revision		Revision as of 07:47, 30 June 2013
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-	[[Image:2rg8.png\|left\|200px]]
-
	{{STRUCTURE_2rg8\| PDB=2rg8 \| SCENE= }}		{{STRUCTURE_2rg8\| PDB=2rg8 \| SCENE= }}
-
	===Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain===		===Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain===
-
	{{ABSTRACT_PUBMED_18296639}}		{{ABSTRACT_PUBMED_18296639}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>

	==About this Structure==		==About this Structure==
	[[2rg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA].		[[2rg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA].
-
-	==See Also==
-	*[[Cell death protein\|Cell death protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018296639</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018296639</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Garces, R.]]		[[Category: Garces, R.]]

OCA: Protected "2rg8" [edit=sysop:move=sysop]

2012-10-20T08:51:27Z

Protected "2rg8" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:51, 20 October 2012

OCA at 08:51, 20 October 2012

2012-10-20T08:51:24Z

←Older revision		Revision as of 08:51, 20 October 2012
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-	{{Seed}}
	[[Image:2rg8.png\|left\|200px]]		[[Image:2rg8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rg8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rg8\| PDB=2rg8 \| SCENE= }}		{{STRUCTURE_2rg8\| PDB=2rg8 \| SCENE= }}

	===Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain===		===Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18296639}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18296639 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18296639}}		{{ABSTRACT_PUBMED_18296639}}

	==About this Structure==		==About this Structure==
-	~~2RG8~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA].	+	[[2rg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA].
		+
		+	==See Also==
		+	*[[Cell death protein\|Cell death protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18296639~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018296639</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Garces, R.]]		[[Category: Garces, R.]]
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	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
-	[[Category: Cytoplasm]]
	[[Category: Heat repeat]]		[[Category: Heat repeat]]
	[[Category: Ma3 domain]]		[[Category: Ma3 domain]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
-	[[Category: Polymorphism]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Translation]]		[[Category: Translation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:41:23 2009''

OCA at 16:41, 16 February 2009

2009-02-16T16:41:24Z

←Older revision		Revision as of 16:41, 16 February 2009
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	==About this Structure==		==About this Structure==
-	2RG8 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA].	+	2RG8 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RG8 OCA].

	==Reference==		==Reference==
-	PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains., Suzuki C, Garces RG, Edmonds KA, Hiller S, Hyberts SG, Marintchev A, Wagner G, Proc Natl Acad Sci U S A. 2008 Feb 22;. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18296639 18296639]~~	+	<ref group="xtra">PMID:18296639</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Garces, R.]]		[[Category: Garces, R.]]
	[[Category: Suzuki, C.]]		[[Category: Suzuki, C.]]
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	[[Category: Translation]]		[[Category: Translation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 22~~:57:~~18 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:41:23 2009''

OCA at 19:57, 27 July 2008

2008-07-27T19:57:18Z

←Older revision		Revision as of 19:57, 27 July 2008
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-	[[Image:2rg8.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2rg8.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2rg8\| PDB=2rg8 \| SCENE= }}		{{STRUCTURE_2rg8\| PDB=2rg8 \| SCENE= }}

-	~~'''~~Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain~~'''~~	+	===Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain===


-	~~==Overview==~~	+	<!--
-	~~Programmed Cell Death 4 (PDCD4) is a protein known to bind eukaryotic initiation factor 4A (eIF4A)~~, ~~inhibit translation initiation~~, ~~and act as a tumor suppressor. PDCD4 contains two C-terminal MA3 domains, which are thought to be responsible for its inhibitory function. Here, we analyze~~ the structures and inhibitory functions of these two PDCD4 MA3 domains by x-ray crystallography, NMR, and surface plasmon resonance. We show that both MA3 domains are structurally and functionally very similar and bind specifically to the ~~eIF4A N-terminal domain~~ (~~eIF4A-NTD) using similar binding interfaces~~. ~~We found that the PDCD4 MA3 domains compete with the eIF4G MA3 domain and RNA for eIF4A binding~~. Our data provide evidence that PDCD4 inhibits translation initiation by displacing eIF4G and RNA from eIF4A. The PDCD4 MA3 domains act synergistically to form a tighter and more stable complex with eIF4A, ~~which explains~~ the ~~need for two tandem MA3 domains~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_18296639}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18296639 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18296639}}

	==About this Structure==		==About this Structure==
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	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Translation]]		[[Category: Translation]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 16~~:51:28 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:57:18 2008''