2rm6 - Revision history

OCA at 19:13, 29 May 2024

2024-05-29T19:13:59Z

←Older revision		Revision as of 19:13, 29 May 2024
Line 1:		Line 1:

	==Glutathione peroxidase-type tryparedoxin peroxidase, reduced form==		==Glutathione peroxidase-type tryparedoxin peroxidase, reduced form==
-	<StructureSection load='2rm6' size='340' side='right'caption='[[2rm6~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rm6' size='340' side='right'caption='[[2rm6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rm6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trypanosoma_(trypanozoon)_brucei~~ Trypanosoma ~~(trypanozoon)~~ brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RM6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rm6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RM6 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>gpx3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [https://pdbe.org/2rm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [https://www.ebi.ac.uk/pdbsum/2rm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rm6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [https://pdbe.org/2rm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [https://www.ebi.ac.uk/pdbsum/2rm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rm6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q869A5_9TRYP Q869A5_9TRYP]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glutathione peroxidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Diechtierow, M]]	+	[[Category: Trypanosoma brucei]]
-	[[Category: Feher, K]]	+	[[Category: Diechtierow M]]
-	[[Category: Krauth-Siegel, L]]	+	[[Category: Feher K]]
-	[[Category: Melchers, J]]	+	[[Category: Krauth-Siegel L]]
-	[[Category: Muhle-Goll, C]]	+	[[Category: Melchers J]]
-	~~[[Category: Oxidoreductase]]~~	+	[[Category: Muhle-Goll C]]
-	~~[[Category: Peroxidase]]~~	+
-	~~[[Category: Reuced]]~~	+
-	~~[[Category: Tryparedoxin~~]]	+

OCA at 10:33, 7 July 2021

2021-07-07T10:33:18Z

←Older revision		Revision as of 10:33, 7 July 2021
Line 1:		Line 1:

	==Glutathione peroxidase-type tryparedoxin peroxidase, reduced form==		==Glutathione peroxidase-type tryparedoxin peroxidase, reduced form==
-	<StructureSection load='2rm6' size='340' side='right' caption='[[2rm6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rm6' size='340' side='right'caption='[[2rm6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rm6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RM6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rm6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RM6 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpx3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpx3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [~~http~~://pdbe.org/2rm6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rm6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rm6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [https://pdbe.org/2rm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [https://www.ebi.ac.uk/pdbsum/2rm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rm6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Glutathione peroxidase]]		[[Category: Glutathione peroxidase]]
		+	[[Category: Large Structures]]
	[[Category: Diechtierow, M]]		[[Category: Diechtierow, M]]
	[[Category: Feher, K]]		[[Category: Feher, K]]

OCA at 11:05, 5 September 2018

2018-09-05T11:05:18Z

←Older revision		Revision as of 11:05, 5 September 2018
Line 1:		Line 1:
		+
	==Glutathione peroxidase-type tryparedoxin peroxidase, reduced form==		==Glutathione peroxidase-type tryparedoxin peroxidase, reduced form==
	<StructureSection load='2rm6' size='340' side='right' caption='[[2rm6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rm6' size='340' side='right' caption='[[2rm6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpx3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpx3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [http://pdbe.org/2rm6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [http://www.ebi.ac.uk/pdbsum/2rm6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [http://pdbe.org/2rm6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [http://www.ebi.ac.uk/pdbsum/2rm6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rm6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/2rm6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/2rm6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:27, 10 February 2016

2016-02-10T01:27:41Z

←Older revision		Revision as of 01:27, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2rm6' size='340' side='right' caption='[[2rm6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rm6' size='340' side='right' caption='[[2rm6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei~~ Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RM6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RM6 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpx3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpx3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [http://www.ebi.ac.uk/pdbsum/2rm6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [http://pdbe.org/2rm6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [http://www.ebi.ac.uk/pdbsum/2rm6 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rm6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rm6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Glutathione peroxidase]]		[[Category: Glutathione peroxidase]]
-	[[Category: Trypanosoma brucei]]
	[[Category: Diechtierow, M]]		[[Category: Diechtierow, M]]
	[[Category: Feher, K]]		[[Category: Feher, K]]

OCA at 17:45, 19 January 2015

2015-01-19T17:45:24Z

←Older revision		Revision as of 17:45, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RM6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RM6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpx3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpx3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [http://www.ebi.ac.uk/pdbsum/2rm6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [http://www.ebi.ac.uk/pdbsum/2rm6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Glutathione peroxidase]]		[[Category: Glutathione peroxidase]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
-	[[Category: Diechtierow, M.]]	+	[[Category: Diechtierow, M]]
-	[[Category: Feher, K.]]	+	[[Category: Feher, K]]
-	[[Category: Krauth-Siegel, L.]]	+	[[Category: Krauth-Siegel, L]]
-	[[Category: Melchers, J.]]	+	[[Category: Melchers, J]]
-	[[Category: Muhle-Goll, C.]]	+	[[Category: Muhle-Goll, C]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Peroxidase]]		[[Category: Peroxidase]]
	[[Category: Reuced]]		[[Category: Reuced]]
	[[Category: Tryparedoxin]]		[[Category: Tryparedoxin]]

OCA at 05:24, 3 October 2014

2014-10-03T05:24:06Z

←Older revision		Revision as of 05:24, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2rm6~~\| ~~PDB~~=2rm6 \| ~~SCENE~~= }}	+	==Glutathione peroxidase-type tryparedoxin peroxidase, reduced form==
-	===Glutathione peroxidase-~~type tryparedoxin peroxidase~~, ~~reduced form~~===	+	<StructureSection load='2rm6' size='340' side='right' caption='[[2rm6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_18684708}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RM6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpx3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rm6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rm6 RCSB], [http://www.ebi.ac.uk/pdbsum/2rm6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/2rm6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Trypanosoma brucei, the causative agent of African sleeping sickness, encodes three cysteine homologues (Px I-III) of classical selenocysteine-containing glutathione peroxidases. The enzymes obtain their reducing equivalents from the unique trypanothione (bis(glutathionyl)spermidine)/tryparedoxin system. During catalysis, these tryparedoxin peroxidases cycle between an oxidized form with an intramolecular disulfide bond between Cys(47) and Cys(95) and the reduced peroxidase with both residues in the thiol state. Here we report on the three-dimensional structures of oxidized T. brucei Px III at 1.4A resolution obtained by x-ray crystallography and of both the oxidized and the reduced protein determined by NMR spectroscopy. Px III is a monomeric protein unlike the homologous poplar thioredoxin peroxidase (TxP). The structures of oxidized and reduced Px III are essentially identical in contrast to what was recently found for TxP. In Px III, Cys(47), Gln(82), and Trp(137) do not form the catalytic triad observed in the selenoenzymes, and related proteins and the latter two residues are unaffected by the redox state of the protein. The mutational analysis of three conserved lysine residues in the vicinity of the catalytic cysteines revealed that exchange of Lys(107) against glutamate abrogates the reduction of hydrogen peroxide, whereas Lys(97) and Lys(99) play a crucial role in the interaction with tryparedoxin.

-	~~==About this Structure==~~	+	Structural basis for a distinct catalytic mechanism in Trypanosoma brucei tryparedoxin peroxidase.,Melchers J, Diechtierow M, Feher K, Sinning I, Tews I, Krauth-Siegel RL, Muhle-Goll C J Biol Chem. 2008 Oct 31;283(44):30401-11. Epub 2008 Aug 6. PMID:18684708<ref>PMID:18684708</ref>
-	~~[[2rm6]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei~~ Trypanosoma brucei]. ~~Full experimental information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2RM6 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:018684708</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Glutathione peroxidase]]		[[Category: Glutathione peroxidase]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]

OCA at 06:54, 16 October 2013

2013-10-16T06:54:00Z

←Older revision		Revision as of 06:54, 16 October 2013
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-	[[Image:2rm6.png\|left\|200px]]
-
	{{STRUCTURE_2rm6\| PDB=2rm6 \| SCENE= }}		{{STRUCTURE_2rm6\| PDB=2rm6 \| SCENE= }}
-
	===Glutathione peroxidase-type tryparedoxin peroxidase, reduced form===		===Glutathione peroxidase-type tryparedoxin peroxidase, reduced form===
-		+	{{ABSTRACT_PUBMED_18684708}}
-	{{~~ABSTRACT_PUBMED_018684708~~}}	+

	==About this Structure==		==About this Structure==
	[[2rm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA].		[[2rm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:018684708</ref><references group="xtra"/><references/>
	[[Category: Glutathione peroxidase]]		[[Category: Glutathione peroxidase]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]

OCA: Protected "2rm6" [edit=sysop:move=sysop]

2013-01-07T22:55:17Z

Protected "2rm6" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:55, 7 January 2013

OCA at 22:55, 7 January 2013

2013-01-07T22:55:15Z

←Older revision		Revision as of 22:55, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2rm6.png\|left\|200px]]		[[Image:2rm6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rm6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rm6\| PDB=2rm6 \| SCENE= }}		{{STRUCTURE_2rm6\| PDB=2rm6 \| SCENE= }}

	===Glutathione peroxidase-type tryparedoxin peroxidase, reduced form===		===Glutathione peroxidase-type tryparedoxin peroxidase, reduced form===

		+	{{ABSTRACT_PUBMED_018684708}}

	==About this Structure==		==About this Structure==
-	~~2RM6~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA].	+	[[2rm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA].
	[[Category: Glutathione peroxidase]]		[[Category: Glutathione peroxidase]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
Line 26:		Line 20:
	[[Category: Reuced]]		[[Category: Reuced]]
	[[Category: Tryparedoxin]]		[[Category: Tryparedoxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:18:53 2009''

OCA at 12:18, 17 February 2009

2009-02-17T12:18:55Z

←Older revision		Revision as of 12:18, 17 February 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2rm6.png\|left\|200px]]

-	The ~~entry 2rm6~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2rm6", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2rm6\| PDB=2rm6 \| SCENE= }}

-	~~Authors: Melchers, J., Feher, K., Diechtierow, M., Krauth-Siegel, L., Muhle~~-~~Goll~~, C.	+	===Glutathione peroxidase-type tryparedoxin peroxidase, reduced form===

-	Description: Glutathione peroxidase-type tryparedoxin peroxidase, reduced form

		+	==About this Structure==
		+	2RM6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RM6 OCA].
		+	[[Category: Glutathione peroxidase]]
		+	[[Category: Trypanosoma brucei]]
		+	[[Category: Diechtierow, M.]]
		+	[[Category: Feher, K.]]
		+	[[Category: Krauth-Siegel, L.]]
		+	[[Category: Melchers, J.]]
		+	[[Category: Muhle-Goll, C.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Peroxidase]]
		+	[[Category: Reuced]]
		+	[[Category: Tryparedoxin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jun 11 08~~:49:~~29 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:18:53 2009''